Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans

作     者：Ya-Ming Jiu Yang Yue Song Yang Lin Liu Jun-Wei Yu Zheng-Xing Wu Tao Xu 

作者机构：Key Laboratory of Molecular BiophysicsMinistry of Educationand Institute of Biophysics and BiochemistryHuazhong University of Science and TechnologyWuhan 430074China National Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2010年第1卷第1期

页      面：75-81页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China(Grant Nos.30770523 30630020 and 30670502) 

主　　题：C.elegans insulin signaling pathway sensory integration decision making behavior 

摘      要：Animals integrate various environmental stimuli within the nervous system to generate proper behavioral ***,the underlying neural circuits and molecular mechanisms are largely *** insulinlike signaling pathway is known to regulate dauer formation,fat metabolism,and longevity in Caenorhabditis elegans(***).Here,we show that this highly conserved signaling pathway also functions in the integrative response to an olfactory diacetyl and a gustatory Cu^(2+) *** of wild-type N2 Bristol displayed a strong avoidance to the Cu^(2+) barrier in the migration pathway to the attractive *** of daf-2(insulin receptor),daf-18(PTEN lipid phosphatase),pdk-1(phosphoinositide-dependent kinase),akt-1/-2(Akt/PKB kinase)and sgk-1(serum-and glucocorticoidinducible kinase)show severe defects in the elusion from the Cu^(2+) .Mutations in DAF-16,a forkhead-type transcriptional factor,suppress the integrative defects of daf-2 and akt-1/-2 *** further report that neither cGMP nor TGFβpathways,two other dauer formation regulators,likely plays a role in the integrative *** results suggest that the insulin-like signaling pathway constitutes an essential component for sensory integration and decision-making behavior plasticity.