检索结果-南通市图书馆

Biological factors driving colorectal cancer metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 259-272页

作者： Shuai-Xing An Zhao-jin yu Chen Fu Min-Jie Wei Long-hai Shen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina Liaoning Key Laboratory of Molecular Targeted Antitumor Drug Development and Evaluation Liaoning Cancer Immune Peptide Drug Engineering Technology Research CenterKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110122Liaoning ProvinceChina BD Department Greenpine Pharma Group Co.LtdTianjin 300020China Center of Oncology Genertec Liaoyou Gem Flower HospitalPanJin 124010Liaoning ProvinceChina

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at *** Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial *** median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 *** is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor *** patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological *** genomic and nongenomic events can induce subclone diversity,which leads to cancer and *** the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular ***,cancer cells presenting neoantigens can be recognized and eliminated by the immune *** this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle *** remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains *** review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

关键词： cancer Metastasis cascade Cancer immunity Genomic variation Epigenetic instability Lifestyle factor

Derivation of Expanded Isospectral-Nonisospectral Integrable Hierarchies via the Column-vector Loop Algebra

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第3期40卷 778-800页

作者： hai-feng WANG yu-feng ZHANG School of Science Jimei UniversityXiamen 361021China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A scheme for generating nonisospectral integrable hierarchies is *** on the method,we deduce a nonisospectral hierarchy of soliton equations by considering a linear spectral *** follows that the corresponding expanded isospectral and nonisospectral integrable hierarchies are deduced based on a 6 dimensional complex linear space ■.By reducing these integrable hierarchies,we obtain the expanded isospectral and nonisospectral derivative nonlinear Schr?dinger *** using the trace identity,the biHamiltonian structure of these two hierarchies are also ***,some symmetries and conserved quantities of the resulting hierarchy are discussed.

关键词： expanded isospectral-nonisospectral integrable hierarchies column-vector loop algebra bi-Hamiltonian structure symmetry

Applications of gastric peroral endoscopic myotomy in the treatment of upper gastrointestinal tract disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第3期16卷 658-669页

作者： Shi-yu Chang Guo-Hua jin hai-Bo Sun Dong Yang Tong-yu Tang Department of Gastroenterology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Gastric peroral endoscopic myotomy(G-POME)is an emerging minimally invasive endoscopic technique involving the establishment of a submucosal tun-nel around the pyloric *** 2013,Khashab et al used G-POME for the first time in the treatment of gastroparesis with enhanced therapeutic efficacy,prov-iding a new direction for the treatment of *** the recent and rapid development of G-POME therapy technology,progress has been made in the treatment of gastroparesis and other upper digestive tract diseases,such as congenital hypertrophic pyloric stenosis and gastric sleeve stricture,with *** article reviews the research progress and future prospects of G-POME for the treatment of upper digestive tract gastrointestinal diseases.

关键词： Gastric peroral endoscopic myotomy Upper digestive tract diseases Gastroparesis Congenital hypertrophic pyloric stenosis Gastric sleeve stricture

Experimental Study on Engineering Behavior of Solidified Soil for Scour Repair and Protection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第4期38卷 625-635页

作者： WU Xiao-ni LI Ru-yu SHU Jian TANG Chao CHEN jin-jian WANG Hui-li JIANG hai-li WANG Xiao State Key Laboratory of Ocean Engineering Department of Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Road and Bridge Group Co. Ltd.Shanghai 200433China Shanghai Engineering Research Center of Urban Infrastructure Renewal Shanghai 200032China Jiangsu Kunze Technology Co. Ltd.Nanjing 210000China

A new scour countermeasure using solidified slurry for offshore foundation has been proposed *** solidified slurry is pumped to seabed area around foundation for scour protection or pumped into the developed scour holes for scour repair as the fluidized material solidifies *** the pumping operation and solidification,the engineering behaviors of solidified slurry require to be considered synthetically for the reliable application in scour repair and protection of ocean engineering such as the pumpability related flow value,flow diffusion behavior related rheological property,anti-scour performance related retention rate in solidification and bearing capacity related strength property after *** this study,a series of laboratory tests are conducted to investigate the effects of mix proportion(initial water content and binder content)on the flow value,rheological properties,density,retention rate of solidified slurry and unconfined compressive strength(UCS).The results reveal that the flow value increases with the water content and decreases with the binder *** the solidified slurry exhibits Bingham plastic behavior when the shear rate is larger than 5 s^(-1).The Bingham model has been employed to fit the rheology test results,and empirical formulas for obtaining the density,yield stress and viscosity are established,providing scientific support for the numerical assessment of flow and diffusion of solidified *** rate of solidified slurry decreases with the water flow velocity and flow value,which means the pumpability of solidified slurry is contrary to anti-scour *** unconfined compressive strength after solidification reduces as the water content increases and binder content decreases.A design and application procedure of solidified soil for scour repair and protection is also proposed for engineering reference.

关键词： scour repair and protection solidified soil pumpability strength flow properties anti-scour performance

Effect of heat treatment on corrosion behaviors of Mg-6Gd-3Y-0.5Zr alloy

在线全文

学校读者我要写书评

暂无评论

China Foundry 2024年第5期21卷 599-612页

作者： Fei Wang Bin-guo Fu yu-feng Wang Tian-shun Dong Guo-lu Li jin-hai Liu Hebei Key Laboratory of New Functional Materials School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China Tianjin Institute of Aerospace Mechanical and Electrical Equipment Tianjin 300301China Tianjin Aerospace Long March Technology and Equipment Co. Ltd.Tianjin 300462China

The microstructures and corrosion behaviors of as-cast,T4-treated,and T6-treated Mg-6Gd-3Y-0.5Zr alloys were systematically investigated by SEM,TEM,immersion test,and electrochemical corrosion *** results show that the microstructure of the as-cast alloy is composed ofα-Mg and Mg_(24)(Gd,Y)_(5)eutectic phase,and in T4-treated alloy,Mg_(24)(Gd,Y)_(5)phase dissolves into theα-Mg matrix,leading to an increase in the(Y,Gd)H_(2)*** T6 treatment,nanoscale Mg_(24)(Gd,Y)_(5)phase dispersedly precipitates from theα-Mg matrix,and exhibits a specific orientation relationship with theα-Mg:(332)Mg_((24)(Gd,Y)_(5))//(1011)_(α-Mg),[136]Mg_((24)(Gd,Y)_(5))//[1210]_(α-Mg).The corrosion resistance of the Mg-6Gd-3Y-0.5Zr alloys can be ranked in the following order:T6-treated alloy exhibits the highest corrosion resistance,followed by the T4-treated alloy,and finally,the as-cast *** corrosion products of the alloys are all composed of MgO,Mg(OH)_(2),Gd_(2)O_(3),Y_(2)O_(3),and MgCl_(2).The corrosion behavior of Mg-6Gd-3Y-0.5Zr alloy is closely related to the precipitated *** establishing the relationship between corrosion rate,hydrogen evolution rate,and corrosion potential,it is further demonstrated that during the micro galvanic corrosion process,the coarse Mg_(24)(Gd,Y)_(5)phase in the as-cast alloy undergoes extensive dissolution,and(Y,Gd)H_(2)phase promotes the dissolution of theα-Mg matrix in the T4-treated alloy,intensifying the hydrogen evolution *** T6-treated alloy,with dispersive precipitation of nanoscale Mg_(24)(Gd,Y)_(5)phase,exhibits better corrosion resistance performance.

关键词： Mg-6Gd-3Y-0.5Zr alloy heat treatment microstructure precipitated phase corrosion resistance

A hybrid memory architecture supporting fine-grained data migration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第2期18卷 31-41页

作者： Ye CHI Jianhui yuE Xiaofei LIAO haikun LIU hai jin National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Computer Science Michigan Technological UniversityMichigan 49931USA

Hybrid memory systems composed of dynamic random access memory(DRAM)and Non-volatile memory(NVM)often exploit page migration technologies to fully take the advantages of different memory *** previous proposals usually migrate data at a granularity of 4 KB pages,and thus waste memory bandwidth and DRAM *** this paper,we propose Mocha,a non-hierarchical architecture that organizes DRAM and NVM in a flat address space physically,but manages them in a cache/memory *** the commercial NVM device-Intel Optane DC Persistent Memory Modules(DCPMM)actually access the physical media at a granularity of 256 bytes(an Optane block),we manage the DRAM cache at the 256-byte size to adapt to this feature of *** design not only enables fine-grained data migration and management for the DRAM cache,but also avoids write amplification for Intel Optane *** also create an Indirect Address Cache(IAC)in Hybrid Memory Controller(HMC)and propose a reverse address mapping table in the DRAM to speed up address translation and cache ***,we exploit a utility-based caching mechanism to filter cold blocks in the NVM,and further improve the efficiency of the DRAM *** implement Mocha in an architectural *** results show that Mocha can improve application performance by 8.2%on average(up to 24.6%),reduce 6.9%energy consumption and 25.9%data migration traffic on average,compared with a typical hybrid memory architecture-HSCC.

关键词： non-volatile memory hybrid memory system data migration fine-grained caching

Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG Ying QU jin-yu GUO Hua ZHOU hai-ying RUAN Xia PENG Ying-chun SHEN Xue-fang XIONG jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

Paraffin–CaCl_(2)·6H_(2)O dosage effects on the strength and heat transfer characteristics of cemented tailings backfill

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 60-70页

作者： hai Li Aibing jin Shuaijun Chen Yiqing Zhao You Ju Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mine University of Science and Technology BeijingBeijing 100083China School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China

The challenge of high temperatures in deep mining remains harmful to the health of workers and their production efficiency The addition of phase change materials (PCMs) to filling slurry and the use of the cold storage function of these materials to reduce downhole temperatures is an effective approach to alleviate the aforementioned ***–CaCl_(2)·6H_(2)O composite PCM was prepared in the *** composition,phase change latent heat,thermal conductivity,and cemented tailing backfill (CTB) compressive strength of the new material were *** heat transfer characteristics and endothermic effect of the PCM were simulated using Fluent *** results showed the following:(1) The new paraffin–CaCl_(2)·6H_(2)O composite PCM improved the thermal conductivity of native paraffin while avoiding the water solubility of CaCl_(2)·6H_(2)O.(2) The calculation formula of the thermal conductivity of CaCl_(2)·6H_(2)O combined with paraffin was deduced,and the reasons were explained in principle.(3) The“enthalpy–mass scale model”was applied to calculate the phase change latent heat of nonreactive composite PCMs.(4)The addition of the paraffin–CaCl_(2)·6H_(2)O composite PCM reduced the CTB strength but increased its heat absorption *** research can give a theoretical foundation for the use of heat storage backfill in green mines.

关键词： paraffin–CaCl_(2)·6H_(2)O heat transfer simulation heat calculation phase change material-based backfill latent heat of formula

Effect of navigation endoscopy combined with threedimensional printing technology in the treatment of orbital blowout fractures

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 570-576页

作者： jin-hai yu Yao-Hua Wang Qi-Hua Xu Chao Xiong An-An Wang Hong-Fei Liao School of Optometry Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Affiliated Eye Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Clinical Research Center for Ophthalmic Disease Nanchang 330006Jiangxi ProvinceChina Jiangxi Research Institute of Ophthalmology and Visual Science Nanchang 330006Jiangxi ProvinceChina Jiangxi Provincial Key Laboratory for Ophthalmology Nanchang 330006Jiangxi ProvinceChina

●AIM:To explore the combined application of surgical navigation nasal endoscopy(NNE)and three-dimensional printing technology(3DPT)for the adjunctive treatment of orbital blowout fractures(OBF).●METHODS:Retrospective analysis was conducted on the data of patients with OBF who underwent surgical treatment at the Affiliated Eye Hospital of Nanchang University between July 2012 and November *** control group consisted of patients who received traditional surgical treatment(n=43),while the new surgical group(n=52)consisted of patients who received NNE with *** difference in therapeutic effects between the two groups was evaluated by comparing the duration of the operation,best corrected visual acuity(BCVA),enophthalmos difference,recovery rate of eye movement disorder,recovery rate of diplopia,and incidence of postoperative complications.●RESULTS:The study included 95 cases(95 eyes),with 63 men and 32 *** patients’age ranged from 5 to 67y(35.21±15.75y).The new surgical group and the control group exhibited no statistically significant differences in the duration of the operation,BCVA and enophthalmos *** recovery rates of diplopia in the new surgical group were significantly higher than those in the control group at 1mo[OR=0.03,95%CI(0.01–0.15),P<0.0000]and 3mo[OR=0.11,95%CI(0.03–0.36),P<0.0000]***,the recovery rates of eye movement disorders at 1 and 3mo after surgery were OR=0.08,95%CI(0.03–0.24),P<0.0000;and OR=0.01,95%CI(0.00–0.18),P<*** incidence of postoperative complications was lower in the new surgical group compared to the control group[OR=4.86,95%CI(0.95–24.78),P<0.05].●CONCLUSION:The combination of NNE and 3DPT can shorten the recovery time of diplopia and eye movement disorder in patients with OBF.

关键词： orbital blowout fracture three-dimensional printing endoscopy surgical navigation