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Heterogeneous reactions of gaseous methanesulfonic acid with calcium carbonate and kaolinite particles

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Science china Chemistry 2010年第12期53卷 2657-2662页

作者： TANG MingJin,li MengQiu & ZHU Tong State Key Joint Laboratory of Environmental Simulation and Pollution Control college of Environmental sciences and Engineering,peking university,beijing 100871,china State Key Joint Laboratory of Environmental Simulation and Pollution Control college of Environmental sciences and Engineering Peking University Beijing China

Heterogeneous reactions of gaseous methanesulfonic acid (MSA) with calcium carbonate (CaCO3) and kaolinite particles at room temperature were investigated using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and ion chromatography (IC).Methanesulfonate (MS-) was identified as the product in the condensed phase,in accordance with the product of the reaction of gaseous MSA with NaCl and sea salt *** the concentration of gaseous MSA was 1.34 × 10-13 molecules cm-3,the uptake coefficient was (1.21 ± 0.06) × 10-8 (1) for the reaction of gaseous MSA with CaCO3 and (4.10 ± 0.65) × 10 10 (1) for the reaction with *** uptake coefficients were significantly smaller than those of the reactions of gaseous MSA with NaCl and sea salt particles.

关键词： gaseous MSA heterogeneous reaction calcium carbonate kaolinite

Age of Information Based User Scheduling and Data Assignment in Multi-User Mobile Edge Computing Networks:An Online Algorithm

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china Communications 2024年第5期21卷 153-165页

作者： Ge Yiyang xiong Ke Dong Rui Lu yang Fan Pingyi Qu Gang School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China Engineering Research Center of Network Management Technology for High Speed Railway of Ministry of Education Beijing 100044China beijing Engineering Research Center of High-speed Railway Broadband Mobile Communications Beijing 100044China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Department of Electrical and Computer Engineering College ParkMarylandUSA

This paper investigates the age of information(AoI)-based multi-user mobile edge computing(MEC)network with partial offloading *** weighted sum AoI(WSA)is first analyzed and derived,and then a WSA minimization problem is formulated by jointly optimizing the user scheduling and data *** to the non-analytic expression of the WSA *** optimization variables and the unknowability of future network information,the problem cannot be solved with known solution ***,an online Joint Partial Offloading and User Scheduling Optimization(JPOUSO)algorithm is proposed by transforming the original problem into a single-slot data assignment subproblem and a single-slot user scheduling sub-problem and solving the two sub-problems *** analyze the computational complexity of the presented JPO-USO algorithm,which is of O(N),with N being the number of *** results show that the proposed JPO-USO algorithm is able to achieve better AoI performance compared with various baseline *** is shown that both the user’s data assignment and the user’s AoI should be jointly taken into account to decrease the system WSA when scheduling users.

关键词： age of information(aoi) mobile edge computing(mec) user scheduling

Role of inositol 1,4,5-trisphosphate receptors in α1-adrenergic receptorinduced cardiomyocyte hypertrophy

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Acta Pharmacologica Sinica 2006年第7期27卷 895-900页

作者： Da-li LUO~(2,3,5) Jian GAO~2 Xiao-mei LAN~3 Gang WANG~4 Sheng WEI~4 Rui-ping XIAO~4 Qi-de HAN~32 Department of Pharmacology,School of Chemical Biology & Pharmaceutical sciences,Capital university of Medical sciences,beijing 100069,china 3 Institute of Cardiovascular Science at Health Science Center,peking university beijing 100083,china 4 Institute of Molecular Medicine and college of life Science,peking university,beijing 100871,china Department of Pharmacology School of Chemical Biology & Pharmaceutical Sciences Capital University of Medical Sciences Beijing 100069 China

Aim:Intracellular Ca2+plays pivotal roles in diverse cellular functions,includinggene transcription that underlies cardiac remodeling during stress ***,the role of inositol 1,4,5-trisphosphate receptors（IP3Rs）in the media-tion of cardiac intracellular Ca2+and hypertrophic growth remains *** with neonatal rat ventricular myocytes suggests that activation of IP3Rsmay be linked to α1adrenergic receptor（α1AR）increased stereotyped Ca2+sparkoccurrence and global Ca2+***,we hypothesized that Ca2+releasethrough IP3Rs was necessary for α1AR-stimulated cardiac ***:We used myoinositol 1,4,5-trisphosphate hexakis（butyryloxymethyl）ester（IP3BM）,a membrane-permeant ester of IP3,to activate IP3Rs directly,and Fluo 4/AM tomeasure intracellular Ca2+***:IP3BM(10μmol·L-1)mimicked theeffects of phenylephrine,a selective agonist of α1AR,in increments in local Ca2+spark release（especially in the perinuclear area）and global Ca2+*** importantly,IP3R inhibitors,2-aminoethoxydiphenyl borateand Xestospongin C,abolished the IP3BM-induced Ca2+responses,and signifi-cantly suppressed α1AR-induced cardiomyocyte hypertrophy assayed by cellsize,[3H]leucine incorporation and atrial natriuretic factor gene expression,dur-ing sustained（48 h）phenylephrine ***:These results,therefore,provide cellular mechanisms that link IP3R signaling to α1AR-stimulatedgene expression and cardiomyocyte hypertrophy.

关键词： inositol 1,4,5-trisphosphate receptors Ca2+sparks α1 adrenergic stimulation cardiac hypertrophy

EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma

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Genes & Diseases 2024年第5期11卷 85-87页

作者： Qian liu Mingxuan li Yujia xiong Yutao Shen Tianshun Ma Tianhao Zhang Xiaohong R.yang Yazhuo Zhang Jiwei Bai beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Enhancer of zeste homolog 2(EZH2),an epigenetic regulator that inhibits transcription primarily through trimethylation of Lys-27 in histone 3(H3K27me3),has been reported to play an important role in the regulation of cell cycle,autophagy,and apoptosis,and DNA damage repair.1 EZH2 is highly expressed in a variety of cancers including prostate cancer,breast cancer,and renal clear cell carcinoma,and is associated with adverse prognosis.1 Moreover,it has been reported that EZH2 might increase tumor stemness and metastasis capacity and inhibit antitumor immunity by affecting T cells,NK cells,macrophages,and immune checkpoints.2,3 However,the prognostic value and the mechanism of EZH2 have not been investigated in *** this study,RNA sequencing and whole genome sequencing data based on 48 skull base chordomas as well as immunohistochemistry of paraffin sections were analyzed to elucidate the role of EZH2 in skull base *** found copy number gain mediated high EZH2 expression is associated with tumor stemness,M2 macrophage infiltration,and adverse prognosis in ***,we demonstrated that EZH2 promotes the proliferation,migration,and invasion of chordoma cells in in vitro cell experiments.

关键词： EZH2 immunity invasion

Nb-and Ta-doped(Hf,Zr,Ti)C multicomponent carbides with enhanced oxidation resistance at 2500℃

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Journal of Advanced Ceramics 2024年第3期13卷 332-344页

作者： Shiyan Chen Jinming Wang Zhaoke Chen Weilong Song Yi Zeng Xingchao li Tongqi li Xiang xiong State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Aerospace Research Institute of Materials&Processing Technology China Academy of Launch Vehicle TechnologyBeijing 100076China

Enhancing oxidation resistance of multicomponent carbides above 2000℃is critical for their thermal protection *** this purpose,novel Nb-and Ta-doped(Hf,Zr,Ti)C multicomponent carbides were designed to improve their oxidation resistance at 2500℃.The results demonstrated that Nb and Ta doping reduced the oxidation rate constant by 16.67%and 25.17%,respectively,thereby significantly improving the oxidation resistance of(Hf,Zr,Ti)*** enhancement was attributed to the changes in oxycarbide composition and distribution within the oxide layer by adding Nb and *** to the different oxidation tendencies of the constituent elements,a distinctive structure was formed in which(Hf,Zr)O_(2)served as a skeleton,and various oxycarbides were dispersed throughout the oxide *** doped Nb and Ta were retained within oxycarbides,retarding the diffusion of oxygen into the *** importantly,the addition of Nb and Ta reduced the size of oxycarbides,decreasing both size and quantity of the pores in the oxide layer and facilitating the formation of a more effective oxygen barrier.

关键词： (Hf,Zr,Ti)C oxidation behaviour ultra-high-temperature oxidation Nb and Ta doping oxycarbides

Non-alcoholic fatty liver disease and sleep disorders

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World Journal of Hepatology 2024年第3期16卷 304-315页

作者： Lu-Fang Bu Chong-Yu xiong Jie-Yi Zhong Yan xiong Dong-Ming li Fen-Fang Hong Shu-Long yang Department of Physiology Fuzhou Medical CollegeNanchang UniversityFuzhou 344000Jiangxi ProvinceChina Key Laboratory of Chronic Diseases Fuzhou Medical UniversityFuzhou 344000Jiangxi ProvinceChina Technology Innovation Center of Chronic Disease Research in Fuzhou City Fuzhou Science and Technology BureauFuzhou 344000Jiangxi ProvinceChina Experimental Center of Pathogen Biology College of MedicineNanchang UniversityNanchang 330006Jiangxi ProvinceChina

Studies have shown that non-alcoholic fatty liver disease(NAFLD)may be associated with sleep *** order to explore the explicit relationship between the two,we systematically reviewed the effects of sleep disorders,especially obstructive sleep apnea(OSA),on the incidence of NAFLD,and analyzed the possible mechanisms after adjusting for confounding *** is independently associated with sleep *** sleep disorders may be the cause of the onset and aggravation of *** excessive or insufficient sleep duration,poor sleep quality,insomnia,sleep-wake disorders,and OSA may increase the incidence of *** that some research suggests a unidirectional causal link between the two,specifically,the onset of NAFLD is identified as a result of changes in sleep characteristics,and the reverse relationship does not hold ***,there is still a lack of specific research elucidating the reasons behind the higher risk of developing sleep disorders in individuals with *** research is needed to establish a clear relationship between NAFLD and sleep *** will lay the groundwork for earlier identification of potential patients,which is crucial for earlier monitoring,diagnosis,effective prevention,and treatment of NAFLD.

关键词： Non-alcoholic fatty liver disease Sleep duration Sleep quality Sleep disorders Obstructive sleep apnea

Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： yang Ying QU Jin-yu GUO Hua ZHOU Hai-ying RUAN Xia PENG Ying-chun SHEN Xue-fang xiong Jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(EliSA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

PROPERTIES OF POLYURETHANE ELASTOMERS BASED ON POLY (OXYETHYLENE-co-OXYTETRAMETHYLENE) DIOL

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Chinese Journal of Polymer Science 2001年第4期19卷 371-376页

作者： Chen-yu Su Guang-li Zhang Hong-zhi Zhang Department of Polymer Science and Engineering college of Chemistry and Molecular Engineering peking university beijing 100871, china 北京大学北京

Polyurethane elastomers derived from 4,4 ' -methylene bis(phenyl isocyanate), butylene glycol and the low oxyethylene moiety content copolyether of tetrahydrofuran and ethylene oxide, obtained by copolymerization using heteropolyacid-ethylene oxide initiator system, were prepared. The polyurethanes exhibited an increased water absorption and much better low temperature resilience, which remained high even at a temperature of -3 degreesC, while that of polyurethane based upon poly(tetramethylene ether) glycol of the 'same molecular weight, i.e. being 2000, and molecular weight distribution, i.e, in the range of 1.4-1.5, starts to decrease dramatically at 5 degreesC.

关键词： polyurethane poly(oxyethylene-co-oxytetramethylene) diol low temperature resilience heteropolyacid-ethylene oxide initiator system

Systematic study of the transfer of amino acids across the water/1,2-dichloroethane interface facilitated by dibenzo-18-crown-6

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Science china Chemistry 2004年第1期47卷 24-33页

作者： CHEN Yong, YUAN Yi, ZHANG Meiqin, li Fei, SUN Peng, GAO Zhao & SHAO YuanhuaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of sciences, Changchun 130022, china college of Chemistry and Molecular Engineering, peking university, beijing 100871, china Lab. of Electroanalytical Chem. Changchun Inst. of Appl. Chem. Chinese Acad. of Sci. Changchun 130022 China Coll. of Chem. and Molecular Eng. Peking Univ. Beijing 100871 China

Facilitated ion transfer reactions of 20 amino acids with dibenzo-18-crown-6 (DB18C6) at the water/1,2-dichloroethane (W/DCE) interfaces supported at the tips of micro- and nano-pipets were investigated systematically using cyclic voltammetry. It was found that there were only 10 amino acids, that is, Leu, Val, lie, Phe, Trp, Met, Ala, Gly, Cys, Gin (in brief), whose protonated forms as cations can give well-defined facilitated ion transfer voltammograms within the potential window, and the reaction pathway was proven to be consistent with the transfer by interfacial complexation/dissociation (TIC/TID) mechanisms. The association constants of DB 18C6 with different amino acids in the DCE (β0), and the kinetic parameters of reaction were evaluated based on the steady-state voltammetry of micro- or nano-pipets, respectively. The experimental results demonstrated that the selectivity of complexation of protonated amino acid by DB18C6 compared with that of alkali metal cations was low, which can be attributed to the vicinal effect arising from steric hindrance introduced by their side group and the steric bulk effect by lipophilic stabilization. Moreover, the association constants and the standard rate constants for different amino acids showed good correlations with their hydrophobicity (π), except Gly and Met, which inferred that the selectivity of such heterogeneous complex reaction for different amino acids with DB18C6, was not only affected by discrimination in binding these ions to the crown ether macro-cycle, but also significantly modified by the ion transfer Gibbs energy which was closely related to the structure of the transferred ions, protonated amino acids.

关键词： micro-/nano-pipet, water/1,2-dichloroethane interface, facilitated ion transfer, cyclic voltammetry, amino acid.