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Construction of high order balanced multiscaling functions via PTST

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Science in china(Series F) 2006年第4期49卷 504-515页

作者： yang shouzhi peng lizhong department of mathematics Shantou University Shantou 515063 China LMAM School of Mathematical Sciences Peking University Beijing 100871 China

The concept of paraunitary two-scale similarity transform （PTST） is introduced. We discuss the property of PTST, and prove that PTST preserves the orthogonal, approximation order and smoothness of the given orthogonal multiscaling functions. What is more, by applying PTST, we present an algorithm of constructing high order balanced multiscaling functions by balancing the already existing orthogonal nonbalanced multiscaling functions. The corresponding transform matrix is given explicitly. In addition, we also investigate the symmetry of the balanced multiscaling functions. Finally, construction examples are given.

关键词： PTST balanced order approximation order muitiscaling functions.

MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma

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Genes & Diseases 2024年第5期11卷 70-73页

作者： Haimin Song Bowen Ni Xuetao peng Weijuan Xu Shaochun yang Runwei yang Ziyu Wang Kaishu Li Rui Lin Yunxiao Zhang Jinglin Guo Kezhi Wu Guangwei Shi Jichao Sun Chunming He Yawei Liu department of Neurosurgery The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi 341000China department of Neurosurgery&Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Bidding and Procurement Office Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China department of Neurosurgery The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdong 511518China department of Neurosurgery The First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515041China department of Geriatrics Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China

The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 Here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely ***,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.

关键词： invasion prognosis Clinical

肝脏受累原发系统性轻链型淀粉样变性的临床表现及其预后分析

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中华肝脏病杂志 2024年第3期32卷 222-227页

作者：乔彤彤刘扬彭楠宫立众窦雪琳温磊路瑾北京大学人民医院血液科、北京大学血液病研究所、国家血液系统疾病临床医学研究中心北京100044 河北省中医院血液科石家庄050033

目的总结单中心肝脏淀粉样变性患者的临床表现及其预后相关因素。方法回顾性分析2012年10月至2023年1月期间的28例明确诊断为伴肝脏受累的原发系统性轻链型淀粉样变性患者的临床资料,总结其主要临床表现和预后因素;据数据不同采用χ2检... 详细信息

目的总结单中心肝脏淀粉样变性患者的临床表现及其预后相关因素。方法回顾性分析2012年10月至2023年1月期间的28例明确诊断为伴肝脏受累的原发系统性轻链型淀粉样变性患者的临床资料,总结其主要临床表现和预后因素;据数据不同采用χ2检验、Fisher精确检验,Wilcoxon秩检验或Kaplan-Meier生存曲线对数秩检验进行统计学分析。结果肝脏受累患者临床主要表现为腹胀、肝大、水肿。CD56、趋化因子受体4蛋白表达占52%(13/25)、56%(14/25),64.3%(9/14)患者t(11,14)阳性,21.4%(3/14)患者1q21扩增阳性,无患者检测出del(17p)。单因素分析显示梅奥2004、2012分期以及总胆红素(TBil)≥34.2μmol/L与患者无进展生存及总体生存相关。TBil≥34.2μmol/L组患者中位无进展生存及总生存期(0.178年及0.195年)明显短于TBil<34.2μmol/L组(0.750年及3.586年)(P<0.05)。结论梅奥分期、高胆红素血症是原发系统性轻链型淀粉样变性伴肝脏受累患者的预后不良因素。

关键词：淀粉样变性,肝脏总胆红素预后分析

Transglutaminase 2 serves as a pathogenic hub gene of KRAS mutant colon cancer based on integrated analysis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2074-2090页

作者： Wei-Bin peng Yu-Ping Li Yong Zeng Kai Chen First People’s Hospital of Foshan Foshan 528000Guangdong ProvinceChina department of Radiation Oncology Cancer Hospital of Shantou University Medical CollegeShantou 515031Guangdong ProvinceChina

BACKGROUND Colon cancer is acknowledged as one of the most common malignancies worldwide,ranking third in United States regarding incidence and ***,approximately 40%of colon cancer cases harbor oncogenic KRAS mutations,resulting in the continuous activation of epidermal growth factor receptor *** To investigate the key pathogenic genes in KRAS mutant colon cancer holds considerable *** Weighted gene co-expression network analysis,in combination with additional bioinformatics analysis,were conducted to screen the key factors driving the progression of KRAS mutant colon ***,various in vitro experiments were also conducted to explore the biological function of transglutaminase 2(TGM2).RESULTS Integrated analysis demonstrated that TGM2 acted as an independent prognostic factor for progression-free *** analysis on tissue microarrays revealed that TGM2 was associated with an elevated probability of perineural invasion in patients with KRAS mutant colon ***,biological roles of the key gene TGM2 was also assessed,suggesting that the downregulation of TGM2 attenuated the proliferation,invasion,and migration of the KRAS mutant colon cancer cell *** This study underscores the potential significance of TGM2 in the progression of KRAS mutant colon *** insight not only offers a theoretical foundation for therapeutic approaches but also highlights the need for additional clinical trials and fundamental research to support our preliminary findings.

关键词： Colon cancer KRAS mutation Transglutaminase 2 Weighted gene co-expression network analysis

用SiCl_4-H_2低温沉积多晶硅薄膜微结构的Raman分析

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物理学报 2004年第5期53卷 1558-1561页

作者：林璇英黄创君林揆训余运鹏余楚迎黄锐汕头大学物理系汕头515063

用拉曼散射谱研究以SiCl4 H2 为气源 ,用射频辉光放电等离子体增强化学气相沉积技术 ,在 2 0 0℃低温下沉积多晶硅薄膜的微结构特征 .结果表明 ,薄膜表层包含有大量微晶相的纳米硅晶粒和非晶相的硅聚合物 ,随射频功率增加 ,晶相结构的... 详细信息

用拉曼散射谱研究以SiCl4 H2 为气源 ,用射频辉光放电等离子体增强化学气相沉积技术 ,在 2 0 0℃低温下沉积多晶硅薄膜的微结构特征 .结果表明 ,薄膜表层包含有大量微晶相的纳米硅晶粒和非晶相的硅聚合物 ,随射频功率增加 ,晶相结构的成分增大 .另一方面 ,深度拉曼谱分布的研究也显示薄膜的晶化度和晶粒尺度随纵向深度的增加逐渐增大 .因此可以认为 ,在多晶硅薄膜生长的最初阶段 ,空间反应过程对低温晶化起重要作用 .

关键词：拉曼散射光谱多晶硅薄膜晶体结构射频辉光放电等离子体增强化学气相沉积技术晶化度

Role of Neutrophil Gelatinase-Associated Lipocalin(NGAL)in the Progression of Esophageal Carcinoma

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Role of Neutrophil Gelatinase-Associated Lipocalin(NGAL)in t...

第五届中国肿瘤学术大会暨第七届海峡两岸肿瘤学术会议、国际肿瘤细胞与基因治疗学会会议、第二届中日肿瘤介入治疗学术会议

作者： Fei Zhou a,1,yang-Min Xie b,1,Jian-Jun Xie a,1,Ze-peng Du a,Wei-Jia Cai c,Fa-Ren Zhang c Li-Yan Xu c~*,En-Min Li a,~* a department of Biochemistry and Molecular Biology,Medical College of shantou university,shantou 515041,PR china b department of Experimental Animal Center,Medical College of shantou university,shantou 515041,PR china c Institute of Oncologic Pathology,the Key Immunopathology Laboratory of Guangdong Province,Medical College of shantou university,shantou 515041,PR china

Objective:Neutrophil gelatinase-associated lipocalin(NGAL),a member of the lipocalin family,was implicated in the progression of several tumor ***, experimental evidence linking NGAL expression to the development of esophageal squamous cell carcinoma(ESCC) is ***,some experiments were designed to explore the role of NGAL in the progression of ***: NGAL was stably overexpressed in the human ESCC cell line EC109 which normally expresses only low levels of NGAL, and these cells were used to measure cell proliferation by MTT assay and colony formation assay,the ability of cell migration and invasion of Matrigel were evaluated by cell invasiveness and chamber-migration *** was used to measure matrix metalloproteinase-9(MMP-9) activity. Western blotting was used to assess phosphorylation of ERK,and immunofluorescence was used to visualize the Factin cytoskeleton.A mouse model established by injecting EC109 cells expressing NGAL into the tail vein of severe combined immunodeficiency(SCID) mice was employed to address the effect of NGAL on body weight,food intake, rate of cachexia,and survival of ***:NGAL overexpression increased the proliferation,migration,invasiveness, and matrix metalloproteinase-9(MMP-9) activity of EC109 cells and triggered rearrangement of the cytoskeleton and activation of ERK in the *** vivo experiments, many SCID mice inoculated with NGAL-transfected cells displayed a severe weakness,a hunchback,reduction in food intake and weight loss,all symptoms of cachexia,before dying. But,fewer SCID mice injected with the control cells appeared to have this cachexia-like syndrome,and there were significantly different in body weight loss,the rates of cachexia and the survival of ***:These data suggest a model for ESCC in which NGAL acts through the ERK/MAPK pathway to stimulate rearrangement of the cytoskeleton and alteration of cell proliferation,migration,and invasiveness,which results in a

关键词： cachexia ERK ESCC invasiveness NGAL

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基片光学特性对薄膜光强透过谱的影响

物理实验 2004年第5期24卷 37-39,41页

作者：余云鹏林舜辉黄翀林璇英汕头大学物理系广东汕头515063

在考虑基片与空气界面反射率以及基片吸收不能忽略的情况下 ,对常见的基片上薄膜的光强透过率公式进行了修正 ,导出了该情况下的透过率公式 .以非晶硅薄膜为研究对象 ,采用模拟计算说明基片光学特性对薄膜光强透过谱的影响 .

关键词：薄膜光强透过谱基底反射率非晶硅薄膜

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多晶硅薄膜低温生长中晶粒大小的控制

物理学报 2004年第11期53卷 3950-3955页

作者：黄锐林璇英余云鹏林揆训姚若河黄文勇魏俊红王照奎余楚迎汕头大学物理系汕头515063 华南理工大学应用物理系广州510641 广东韩山师范学院物理系潮州521041

以SiCl4 H2 为气源 ,用等离子体增强化学气相沉积 (PECVD)方法低温快速沉积多晶硅薄膜 .实验发现 ,在多晶硅薄膜的生长过程中 ,气相空间各种活性基团的相对浓度是影响晶粒大小的重要因素 ,随功率、H2 SiCl4 流量比的减小和反应室气压... 详细信息

以SiCl4 H2 为气源 ,用等离子体增强化学气相沉积 (PECVD)方法低温快速沉积多晶硅薄膜 .实验发现 ,在多晶硅薄膜的生长过程中 ,气相空间各种活性基团的相对浓度是影响晶粒大小的重要因素 ,随功率、H2 SiCl4 流量比的减小和反应室气压的增加 ,晶粒增大 .而各种活性基团的相对浓度依赖于PECVD工艺参数 ,通过工艺参数的改变 ,分析生长过程中空间各种活性基团相对浓度的变化 ,指出“气相结晶”

关键词：活性基团晶粒大小等离子体增强化学气相沉积结晶工艺参数反应室 PECVD 低温生长多晶硅薄膜功率

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长牡蛎碱性磷酸酶的分离纯化及部分性质研究

台湾海峡 2003年第4期22卷 482-486页

作者：李兴暖韩雅莉肖湘邓瑞鹏周小朋管云雁黄长江汕头大学理学院生物系广东汕头515063 汕头大学科技中心海洋生物研究室广东汕头515063

本文以长牡蛎为酶源提取材料,用正丁醇抽提,硫酸铵分级分离,DEAE-52和Sephadex G-100柱层析,得到一定纯度的碱性磷酸酶,提纯倍数为61.96,比活力达1.326U/mg.该酶的最适pH值9.6,最适温度38℃,初速度6.8μmol/(dm^3·min),米氏常数Km值为1... 详细信息

本文以长牡蛎为酶源提取材料,用正丁醇抽提,硫酸铵分级分离,DEAE-52和Sephadex G-100柱层析,得到一定纯度的碱性磷酸酶,提纯倍数为61.96,比活力达1.326U/mg.该酶的最适pH值9.6,最适温度38℃,初速度6.8μmol/(dm^3·min),米氏常数Km值为1.30mmol/dm^3.实验结果表明,Mg^(2+)对该酶有明显的激活作用;Zn^(2+)、Cu^(2+)、Hg^(2+)对该酶有明显的抑制作用.

关键词：长牡蛎碱性磷酸酶分离纯化海洋生物化学