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超声空化处理Al-5Ti-1B合金中第二相形貌的演变

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特种铸造及有色合金 2018年第9期38卷 929-933页

作者：赵建华屈伸蒋文君叶未重庆大学材料科学与工程学院、机械传动国家重点实验室重庆400044 重庆大学国家镁合金材料工程技术研究中心

研究了超声空化处理对Al-5Ti-1B合金中第二相粒子形貌演变的影响。结果表明,超声空化处理能显著改善第二相粒子的形貌和尺寸。随着超声空化处理时间延长,TiAl_3颗粒平均尺寸减小,形貌由大块状向小块状过渡,最终形成树枝状;TiB_2.粒由... 详细信息

研究了超声空化处理对Al-5Ti-1B合金中第二相粒子形貌演变的影响。结果表明,超声空化处理能显著改善第二相粒子的形貌和尺寸。随着超声空化处理时间延长,TiAl_3颗粒平均尺寸减小,形貌由大块状向小块状过渡,最终形成树枝状;TiB_2.粒由原本在α-Al晶界处的带状聚集转变为基体中的弥散分布,少量附着在TiAl_3的表面。超声处理时间为12.s时,第二相粒子形貌最佳,TiAl_3颗粒平均尺寸为19.3μm,TiB_2.粒平均面积为14.5μm^2.

关键词：超声空化 Al-5Ti-1B合金第二相形貌演变

臭氧水杀菌对冰温贮藏牡蛎新鲜度和品质的影响

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中国食品学报 2024年第6期24卷 308-318页

作者：李秀霞郑凯泷张德福励建荣陈笑俏曲杨郭晓华渤海大学食品科学与工程学院生鲜农产品贮藏加工及安全控制技术国家地方联合工程研究中心辽宁锦州121013 山东美佳集团有限公司山东日照276815

为明确臭氧水杀菌处理对生食水产品新鲜度和品质的影响,以新鲜牡蛎为研究对象,分析不同质量浓度(2.4,6,8mg/L和10 mg/L)臭氧水作用不同时间(1,2.3,4 min和5 min)后,冰温贮藏牡蛎pH值、色差、感官指标、挥发性盐基氮(TVB-N)值和挥发性化... 详细信息

为明确臭氧水杀菌处理对生食水产品新鲜度和品质的影响,以新鲜牡蛎为研究对象,分析不同质量浓度(2.4,6,8mg/L和10 mg/L)臭氧水作用不同时间(1,2.3,4 min和5 min)后,冰温贮藏牡蛎pH值、色差、感官指标、挥发性盐基氮(TVB-N)值和挥发性化合物等的变化情况。结果表明,质量浓度为4 mg/L的臭氧水作用2.min后,牡蛎肉的菌落总数(TVC)降至最低(3.58 CFU/g)。随着贮藏时间的增加,未处理组在第6天后TVB-N值>10 mg/(100 g),且增长速度显著大于处理组(P34后上升至6.86,上升趋势明显。冰藏期间,牡蛎肉的L^(*)值逐渐下降,a^(*)和b^(*)上升,与对照组相比,臭氧水杀菌处理保持了牡蛎肉的亮度。臭氧处理后牡蛎肉挥发性主成分贡献率为90.057%,能够反映牡蛎贮藏期间的主要特征信息及总体风味轮廓。结论:臭氧质量浓度4 mg/L为牡蛎适合的臭氧水杀菌浓度(作用时间2.min),且对风味无影响。臭氧处理是适用生食水产品加工的一种良好的非热杀菌处理方式。

关键词：臭氧水杀菌牡蛎品质新鲜度

TyG指数及其结合肥胖指标与高血压人群新发心力衰竭的关联研究

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现代预防医学 2024年第17期51卷 3248-3253页

作者：兑欣阳马天佩万洋姜侠龙璐廖加强樊萌语汪川陶成琳章文强瞿阳胡琳阳静朱晨燕袁璐杜君华西健康老龄与重大慢性病医防融合研究课题组四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系四川大学华西公共卫生学院/华西第四医院神经内科成都市郫都区红光街道社区卫生服务中心

目的探讨甘油三酯葡萄糖指数（triglyceride glucose index,TyG）及其结合肥胖指标的衍生指数（triglyceride glucose-body mass index,TyG-BMI;triglyceride glucose-waist circumference,TyG-WC;triglyceride glucose-waist-to-height ratio,TyG-WHt R）与高血压患者心力衰竭（heart failure）的相关性。方法以2.17—2.2.年在成都市某社区卫生服务中心至少完成2.国家基本公共卫生服务健康体检的中老年（年龄≥35岁）高血压患者作为研究对象。采用多因素Cox比例风险回归模型评价TyG及其衍生指数与心力衰竭发生风险的关联。结果研究共纳入603名参与者，平均年龄（66.42.8.68）岁，其中40.8%为男性。中位随访时间为2.66年，34名患者新发心力衰竭。研究结果显示TyG-WHt R、TyG-WC、TyG-BMI及TyG指数与心力衰竭发病风险呈线性关联(PNonlinear>0.05)且每升高1个标准差，心力衰竭发病风险分别增加51.9%（HR=1.519,95%CI:1.050～2.2.0）、47.8%（HR=1.478,95%CI:1.013～2.156）、33.6%（HR=1.336,95%CI:0.944～1.892.和33.5%（HR=1.335,95%CI:0.900～1.981）。TyG衍生指数对心力衰竭的区分效果优于TyG指数，其中TyG-WHt R对心力衰竭发病的预测效果最好。结论应对中老年高血压人群开展TyG-WHt R指标监测，当TyG-WHt R≥3.62.心力衰竭发病风险显著增加，该指标有助于识别中老年高血压患者中心衰发病的高风险人群。

关键词：甘油三酯葡萄糖指数心力衰竭肥胖胰岛素抵抗

Porous FeAl alloys via powder sintering:Phase transformation,microstructure and aqueous corrosion behavior

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Journal of Materials Science & Technology 2021年第27期86卷 64-69页

作者： gang chen Klaus-Dieter Liss Chao chen Yuehui He Xuanhui qu Peng Cao beijing Advanced Innovation center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083PR China Materials and Engineering Science Program Guangdong Technion-Israel Institute of TechnologyShantouGuangdong515063PR China Technion-Israel Institute of Technology Haifa32000Israel School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering&Information SciencesUniversity of WollongongWollongongNSW2522Australia State Key Laboratory for Powder Metallurgy Central South UniversityChangsha410083PR China Department of Chemical and Materials Engineering The University of AucklandPrivate Bag 92019Auckland1142New Zealand MacDiarmid Institute of Advanced Materials and Nanotechnology Victoria University of WellingtonPO Box 600Wellington6140New Zealand

This study investigates the phase transformation and microstructure of porous Fe Al parts sintered from elemental powder mixtures using in-situ neutron diffraction and in-situ thermal dilatometry.A single B2.structured Fe Al phase was determined in the sintered Fe Al *** combined effects of the Kirkendall porosity,transient liquid phase,and phase transformations associated with powder sintering all contribute to the swelling phenomenon of the final sintered *** aqueous corrosion test indicates that the corrosion products include iron oxides in the porous Fe Al *** accumulation of corrosion products blocks the pore channel and decreases pore size and permeability over the soaking time.

关键词： Powder sintering Intermetallic Porous Corrosion Neutron diffraction

Geochemistry of Platinum Group and Rare Earth Elements of the Polymetallic Layer in the Lower Cambrian,Weng'an,Guizhou Province

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Acta Geologica Sinica(English Edition) 2009年第3期83卷 618-627页

作者： FU Yong WU Chaodong GUAN Ping qu wenjun chen Jiafu Key Laboratory of Orogenic Belts and Crustal Evolution MOE Peking University Beijing 100871 China national research {2. of geoanalysis Beijing 100037 China

The black shales of the Lower Cambrian Niutitang Formation in Weng＇an, on the yangtze platform of south China, contain voluminous polymetallic sulfide deposits. A comprehensive geochemical investigation of trace, rare earth, and platinum group elements （PGE） has been undertaken in order to discuss its ore genesis and correlation with the tectono-depositional setting. The ore-bearing layers enrich molybdenum （Mo）, nickel （Ni）, vanadium （V）, lead （Pb）, strontium （Sr）, barium （Ba）, uranium （U）, arsenic （As）, and rare earth elements （REE） in abundance. High uranium/ thorium （U/Th） ratios （U/Th〉I） indicated that mineralization was mainly influenced by the hydrothermal process. The 8U value was above 1.9, showing a reducing sedimentary condition. The REE patterns showed high enrichment in light rare earth elements （LREE）（heavy rare earth elements （HREE）（LREE/HREE=5-17）, slightly negative europium （Eu） and cerium （Ce） anomalies （δEu=0.81- 0.93）, and positive Ce anomalies （δCe=0.76-1.12.. PGE abundance was characterized by the PGE-type distribution patterns, enriching platinum （Pt）, palladium （Pd）, ruthenium （Ru） and osmium （Os）. The Pt/Pd ratio was 0.8, which is close to the ratios of seawater and ultramafic rocks. All of these geochemical features suggest that the mineralization was triggered by hydrothermal activity in an extensional setting in the context of break-up of the Rodinian supercontinent.

关键词： geochemistry polymetallic layer hydrothermal activity Lower Cambrian

Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-disubstituted alkenes enabling the modular synthesis of 1,1,2.2.tetraarylethanes

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Science China Chemistry 2023年第12期66卷 3539-3545页

作者： chengxi Zhang yang Xi Jingping qu Yifeng chen Key Laboratory for Advanced Materials and Joint International research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China

The highly diastereoselective dicarbofunctionalization of substituted olefins still remains a daunting challenge in synthetic ***,we report a Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-diarylethylene with chelation group free to enable the modular synthesis of smart material candidates,1,1,2.2.tetraarylethanes(TAEs),which represent the first protocol by assembling four different aryl groups into ethane *** mechanistic experiments suggest that the crucial Pd–H species generated in situ do not disengage from the alkene intermediate during the reaction.

关键词： 1,1,2.2.tetraarylethane palladium cross-coupling reaction alkene multicomponent reactions

Resolving the sintering conundrum of high-rhenium tungsten alloys

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Journal of Materials Science & Technology 2023年第35期166卷 78-85页

作者： Zhongyou que Xingyu Li Lin Zhang Xuanhui qu Zichen Wei chenguang Guo Haishen Sun Mingli Qin {2. chen Peinan du Yanhao Dong beijing Advanced Innovation center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610213China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Tungsten-rhenium(W-Re)alloys with high-Re contents are the preferred refractory metal materials in many applications because of the improved ductility and processability over pure W and low-Re tung-sten ***,the sintering concurrently becomes increasingly more difficult with increasing Re *** we proposed that the sintering conundrum is caused by the lowered crystal symmetry and the wider dihedral angle distribution when body-center-cubic(BCC)W is alloyed with more hexagonal-close-packed(HCP)Re,which results in inefficient pore removal in the final stage *** showed that the conundrum can be resolved by pressureless two-step sintering(TSS)which suppresses acceler-ating final-stage grain growth,and our proposal is supported by the data of the critical densityρc that is required to start the second step for successful TSS at different W-Re *** ultrafine-grained W-Re alloys with∼300 nm average grain size and up to 2. wt%Re were successfully *** work demonstrates the unique opportunities offered by two-step sintering to advance the scientific understanding and technological practices in powder metallurgy and related fields.

关键词： W-Re alloys Two-step sintering Grain growth Ultrafine-grained materials

Molecular identification of bloom-forming species Phaeocystis globosa (Pryninesiophyta) and its dispersal based on rDNA ITS sequence analysis

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Acta Oceanologica Sinica 2003年第2期22卷 243-254页

作者： chenYueqin ShaoPeng WangNing ZhouHui quLianghu LindaK.Medlin KeyLaboratoryofGeneEngineeringofEducationMinistry BiotechnologyReserachCenterZhongshanUniversityGuangzhou510275China AlfredWegenerInstituteforPolarandMarineresearch Postfach120161Columbusstrasse27525BremerhavenGermany

The colony-forming Phaeocystis species are causative agents of dense bloom occurrences incoastal waters worldwide. It is difficult to separate them because of the different morphologies associated with their colonial stages. In this study we applied molecular approaches to analyze the genetic variation of Phaeocystis globosa and Phaeocystis pouchetii from several geographic regions, and to assist in tracing the dispersal of bloom-forming Phaeocystis species in coastal waters of China. The sequences of the internal transcribed spacers (ITS1 and ITS2. of rDNA and the 5. 8S ribosomal RNA gene of Phaeocystis strains were determined. Sequence comparison shows that *** was the most divergent to P. pouchetii, exhibiting sequence divergence higher than 0.08. However, lower genetic divergences existed between strains of P. globosa. The sequence comparison of the Phaeocystis rDNA ITS clearly shows that the species isolated from the southeast coast of China is identified as P. globosa rather than P. cf. pouchetii or other species. Furthermore, the significance of rDNA variation in distinct global populations of P. globosa suggested it might have had sufficient time to accumulate detectable mutations at the rDNA locus, supporting the hypothesis of ancient dispersal of P .globosa to many areas, meaning that P. globosa blooms in the coastal waters of China are endemic rather than a newly introduced species or a foreign source. Finally, based on the high divergent region of rDNA ITS, a pair of species-specific primers for P. globosa were designed, they could be useful to detect the presence of this species in mixed plankton assemblages or flagellate stages that are recognized with diffculties by means of conventional microscopy.

关键词： Genetic variation Phaeocystis globosa Phaeocystis pouchetii population dispersal rDNA ITS

Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis:a multi-omics study with drug exploration

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Signal Transduction and Targeted Therapy 2022年第6期7卷 2066-2078页

作者： Mingyao Wang Zhe Zhang jiangfeng Liu Meiyue Song Tiantian Zhang Yiling chen Huiyuan Hu Peiran {2. Bolun Li Xiaomin Song Junling Pang Yanjiang Xing Zhujie Cao wenjun Guo Hao {2. Jing Wang Juntao {2. chen Wang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610041China Department of Pulmonary and Critical Care Medicine The First Hospital of Shanxi Medical UniversityTaiyuan 030001China NHC Key Laboratory of Pneumoconiosis Taiyuan 030001China Shanxi Province Key Laboratory of Respiratory Disease Taiyuan 030001China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Xi’an Jiao tong UniversityXi’an 710061China Key Lab of Transplant Engineering and Immunology MOHRegenerative Medical Research CenterWest China HospitalSichuan UniversityChengdu 610041China

Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics,and currently used drugs cannot reverse the disease *** still,there are still challenges to be addressed to fully decipher the intricated ***,specifying the essential mechanisms and targets in silicosis progression then exploring anti-silicosis pharmacuticals are desperately *** this work,multi-omics atlas was constructed to depict the pivotal abnormalities of silicosis and develop targeted *** utilizing an unbiased and time-resolved analysis of the transcriptome,proteome and phosphoproteome of a silicosis mouse model,we have verified the significant differences in transcript,protein,kinase activity and signaling pathway level during silicosis progression,in which the importance of essential biological processes such as macrophage activation,chemotaxis,immune cell recruitment and chronic inflammation were ***,the phosphorylation of EGFR(p-EGFR)and SYK(pSYK)were identified as potential therapeutic targets in the progression of *** inhibit and validate these targets,we tested fostamatinib(targeting SYK)and Gefitinib(targeting EGFR),and both drugs effectively ameliorated pulmonary dysfunction and inhibited the progression of inflammation and ***,our drug discovery with multi-omics approach provides novel and viable therapeutic strategies for the treatment of silicosis.

关键词： silicosis SYK drugs