Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-disubstituted alkenes enabling the modular synthesis of 1,1,2,2-tetraarylethanes

作     者：Chengxi Zhang Yang Xi Jingping Qu Yifeng Chen Chengxi Zhang;Yang Xi;Jingping Qu;Yifeng Chen

作者机构：Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第12期

页      面：3539-3545页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (22171079) the Natural Science Foundation of Shanghai (21ZR1480400) the Shanghai Rising-Star Program (20QA1402300) the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03) the Program of Introducing Talents of Discipline to Universities (B16017) the Fundamental Research Funds for the Central Universities 

主　　题：1,1,2,2-tetraarylethane palladium cross-coupling reaction alkene multicomponent reactions 

摘      要：The highly diastereoselective dicarbofunctionalization of substituted olefins still remains a daunting challenge in synthetic ***,we report a Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-diarylethylene with chelation group free to enable the modular synthesis of smart material candidates,1,1,2,2-tetraarylethanes(TAEs),which represent the first protocol by assembling four different aryl groups into ethane *** mechanistic experiments suggest that the crucial Pd–H species generated in situ do not disengage from the alkene intermediate during the reaction.