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Enhanced osteogenic differentiation of human periodontal ligament stem cells by suberoylanilide hydroxamic acid

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BIOCELL 2020年第3期44卷 389-400页

作者： YUNZE XUAN BIN JIN SAYAN DEB DUTTA MENGMENG LIU ZAIXIAN SHEN XIWEN LIU yang kangjuan LIM KI-TAEK Department of Stomatology Affiliated Hospital of Yanbian UniversityYanji133000China Department of Immunology and Molecular Microbiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul08826South Korea Affiliated Hospital of Yanbian University Yanji133000China Department of Cell Biology and Medical Genetics Yanbian University Medical CollegeYanji133000China Department of Biosystems Engineering Kangwon National UniversityChuncheon24341South Korea

Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the surface of the teeth,leading to the destruction of tooth-supporting tissues and loss of alveolar *** hydroxamic acid(SAHA),a class of histone deacetylase(HDAC)inhibitor,has the potential to stimulate osteoblast differentiation by acetylating histone proteins,and thus suppressing the expression of adipogenic and chondrogenic ***,the effect of SAHA on the differentiation of human periodontal ligament stem cells(hPDLSCs)is yet to be ***,we investigated the effects of SAHA on in vitro proliferation and differentiation of hPDLSCs by MTT assay,Alizarin Red-S,and alkaline phosphatase staining,and real-time ***,300 ng/mL SAHA treatment enhanced the proliferation and mineralization of hPDLSCs,indicating their osteogenic ***,a significant enhancement of osteogenesis gene markers and proteins was *** also demonstrated that ERK is a positive regulator of Runx2 transcription factors during osteoblast *** results indicate that SAHA may be a useful osteogenic induction agent for periodontal bone regeneration.

关键词： Suberoylanilide hydroxamic acid Histone deacetylase Osteoblast hPDLSCs Alkaline phosphatase Periodontal bone regeneration

Effect　of　acety1－L－carnitine　on　choline　acetyltransferase　activity　in　streptozotocin－treated　rats

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延边大学医学学报 1996年第1期 1-5页

作者： Meng Fanping yang kangjuan J. Prickaerts J. Jolles (Department of Microbiology, Yanbian Medical College) (Department of Biology, Yanbian Medical College)(Department of Psychiatry and Neuropsychology, Section of Neuropsychology, Neuropsychiatry and Psyc

Ｅｆｆｅｃｔｏｆａｃｅｔｙ１－Ｌ－ｃａｒｎｉｔｉｎｅｏｎｃｈｏｌｉｎｅａｃｅｔｙｌｔｒａｎｓｆｅｒａｓｅａｃｔｉｖｉｔｙｉｎｓｔｒｅｐｔｏｚｏｔｏｃｉｎ－ｔｒｅａｔｅｄｒａｔｓＭｅｎｇＦａｎｐｉｎｇ；ＹａｎｇＫａｎｇ... 详细信息

Ｅｆｆｅｃｔｏｆａｃｅｔｙ１－Ｌ－ｃａｒｎｉｔｉｎｅｏｎｃｈｏｌｉｎｅａｃｅｔｙｌｔｒａｎｓｆｅｒａｓｅａｃｔｉｖｉｔｙｉｎｓｔｒｅｐｔｏｚｏｔｏｃｉｎ－ｔｒｅａｔｅｄｒａｔｓＭｅｎｇＦａｎｐｉｎｇ；ＹａｎｇＫａｎｇｊｕａｎ；Ｊ．Ｐｒｉｃｋａｅｒｔｓ...

关键词： streptozotocin acety1-L-carnitine choline acetyltransferase neurodegeneration Alzheimer’s disease animal model

Sequence analysis of a mouse mAb against AchR

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延边大学医学学报 1995年第2期 79-82页

作者： Meng Fanping yang kangjuan Y. Graus M. de Baets(Department of Microbiology, Yanbian Medical College)(Department of Biology, Yanbian Medical College)(Department of Immunology, Faculty of Medicine, University of Limburg, Maastricht,The Netherlands)

ＳｅｑｕｅｎｃｅａｎａｌｙｓｉｓｏｆａｍｏｕｓｅｍＡｂａｇａｉｎｓｔＡＣｈＲＭｅｎｇＦａｎｐｉｎｇ；ＹａｎｇＫａｎｇｊｕａｎ；Ｙ．Ｇｒａｕｓ；Ｍ．ｄｅＢａｅｔｓ（ＤｅｐａｒｔｍｅｎｔｏｆＭｉｃｒｏｂｉｏｌｏｇｙ，Ｙａ... 详细信息

ＳｅｑｕｅｎｃｅａｎａｌｙｓｉｓｏｆａｍｏｕｓｅｍＡｂａｇａｉｎｓｔＡＣｈＲＭｅｎｇＦａｎｐｉｎｇ；ＹａｎｇＫａｎｇｊｕａｎ；Ｙ．Ｇｒａｕｓ；Ｍ．ｄｅＢａｅｔｓ（ＤｅｐａｒｔｍｅｎｔｏｆＭｉｃｒｏｂｉｏｌｏｇｙ，ＹａｎｂｉａｎＭｅｄｉｃａｌＣｏｌｌｅ...

关键词： autoantibodies: AChR PCR nucleotide sequences myasthenia gravis

Association between single nucleotide polymorphisms (SNPs) on the promoter of adiponectin gene and type 2 diabetes in Yanbian Chinese and Yanbian Korean

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Association between single nucleotide polymorphisms (SNPs) o...

Association between single nucleotide polymorphisms(SNPs) on the promoter of adiponcctin gene,hypoadiponectinemia, and diabetes

中国遗传学会第八次代表大会暨学术讨论会

作者： Tianxin Sheng Zibo Zhang Xiongji Jin kangjuan yang~* School of Basic Medicine,Yanbian University,Yanji 133000,China

This study was going to find the association between single nucleotide polymorphisms(SNPs)on the promoter of adiponectin gene and type 2 diabetes in Yanbian Chinese and Yanbian Korean.A total of 97 subjects from Yanbian were involved in this study,including 55 Chinese(13 normal individuals and 42 type 2 diabetes patients)and 42 Koreans(16 normal individuals and 26 type 2 diabetes patients).Body mass index(BMI),fasting plasma glucose(FPG),total cholesterol(TC),and triglyceride(TG)were *** and DNA sequencing were used for screening of SNPs,as well as ANOVA and X test were used for analysis of *** FPG in type 2 diabetes group was greater than in normal group in both Yanbian Chinese and Yanbian Korean(p<0.001).The TG in type 2 diabetes group was greater than in normal group in Yanbian Korean(p=0.033).The FPG,TC,and TG in type 2 diabetes group of Yanbian Korean were greater than in type 2 diabetes in Yanbian Chinese(p=0.038,p=0.037,and p=0.047 respectively).The frequency of haplotype of-11426A-11377C in type 2 diabetes group was less than in normal group in Yanbian Korean(p=0.043).In Yanbian Chinese,BMI is relative to the genotype at locus of-11426, the BMI with allele of-11426G is less than with allele of-11426A(p=0.039).And the BMI with genotype of AA at locus of-11426 in Yanbian Chinese is greater than in Yanbian Korean(p=0.006).In Yanbian Chinese,FPG and TG are relative to the genotype at locus of-11156,the FPG and TG with allele of-111561(insert CA)are greater than with allele of-11156N(no insert)(p=0.009 and p=0.004 respectively).And the BMI with allele of-11156N in Yanbian Chinese is greater than in Yanbian Korean(p=0.004),the TG with allele of-111561 in Yanbian Chinese is less than in Yanbian Korean(p=0.006).Above all,three conclusions can be ***,Yanbain Chinese and Yanbian Korean have national difference in some relative ***,the haplotype of-11426A-11377C may be considered as a protective factor in the progression of type 2 diabete

关键词： type 2 diabetes adiponectin SNP

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Association between single nucleotide polymorphisms(SNPs) on...

第八次全国医学遗传学学术会议(中华医学会2009年医学遗传学年会)

作者： Tianxin Sheng,Zibo Zhang,Yanhua Jin,Xiongji Jin,kangjuan yang~* Teaching and Research Section for Cell Biol- ogy and Medical Genetics,School of Basic Medicine,Health Science Center,Yanbian University,Yanji 133000,China

This study was going to investigate:*** and genetic factors leading to hypoadiponectinemia;*** from hypoadiponectinemia to diabetes;*** and treatment of hypoadiponectinemia-derived diabetes.A total of 186 subjects were involved in this study,including 81 men and 105 *** were all Chinese and lived in Yanbian for at least 5 years. Total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDLC), Fasting plasma glucose(FPG),fasting plasma insulin(FPI),and plasma adiponectin(PA)were *** and sequencing were used for screening of single nucleotide polymorphisms(SNPs).ANOVA and regression were used for analysis of relations of *** significant difference of PA between genotypes or haplotypes of SNPs of-11426A>G and-11377C>G which are on the promoter of adipoctin *** was inversely proportional to body mass index(BMI)(b=-0.17).FPI was direcdy proportional to PA (b=1.19).HDL-C is directly proportional to PA(b=0.03).60%of hypoadiponectinemia patients suffered from diabetes and 69%of diabetic patients were hypoadiponectinemia-derived diabetic *** in simple hypoadiponectinemia group and in hypoadiponectinemia-derived diabetic group was significantly lower than in normal group(p=0.021 and p<0.001 respectively).Homeostasis model assessment of insulin resistance(HOMA-IR)in other cause-derived diabetic group was significantly higher than in normal group (p<0.001).But there was no significant difference of HOMA-IR between hypoadiponectinemia-derived diabetic group and normal group(p=0.093).Following conclusions had been drawn:*** could decrease *** could stimulate HDL and insulin secretion and the hypoinsulinemia was the direct cause of hypoadiponectinemia-derived ***≥7.0 mmol/1 and PA<4.68μg/ml could be the diagnosis criterion of hypoadiponectinemia-derived diabetes in Yanbian Chinese and the relative ways to treat the hypo

关键词： adiponectin hypoadiponectinemia diabetes

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先天性无子宫无阴道遗传学特征1例分析

中国性科学 2013年第9期22卷 29-30页

作者：铁缨金英子杨康鹃延边大学临床医学院吉林延吉133000 延边大学医学院细胞生物学与医学遗传学教研室吉林延吉133002

患者女性,23岁,因"原发性月经未来潮"于2013年6月来本院就诊。主诉原发性闭经,无周期性下腹疼痛。检查女性第二性征发育良好,前庭窝尚未见尿道口及处女膜,肛诊未触及子宫,但触及到左右附件。B超未探及子宫,但探及到左右卵巢和阴道黏膜... 详细信息

患者女性,23岁,因"原发性月经未来潮"于2013年6月来本院就诊。主诉原发性闭经,无周期性下腹疼痛。检查女性第二性征发育良好,前庭窝尚未见尿道口及处女膜,肛诊未触及子宫,但触及到左右附件。B超未探及子宫,但探及到左右卵巢和阴道黏膜线。性激素和垂体激素检测均正常,X染色质阳性,为正常女性核型(46,XX)。诊断为"先天性无子宫和阴道"。本文就其遗传学特征进行分析。

关键词：先天性无子宫无阴道

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重庆医学 2020年第1期49卷 7-12页

作者：玄云泽李书进金成日杨康鹃延边大学附属医院口腔科吉林延吉133000 延边大学医学院细胞生物学与医学遗传学教研室吉林延吉133000

目的探讨驱动蛋白家族成员3A(KIF3A)在口腔鳞状细胞癌上皮间充质转化(EMT)过程中的作用及其调控机制。方法以人舌鳞癌细胞Tca8113作为研究对象分为KIF3A-siRNA转染组、阴性对照(NC)组、对照组。在荧光显微镜下观察Tca8113细胞的初级纤... 详细信息

目的探讨驱动蛋白家族成员3A(KIF3A)在口腔鳞状细胞癌上皮间充质转化(EMT)过程中的作用及其调控机制。方法以人舌鳞癌细胞Tca8113作为研究对象分为KIF3A-siRNA转染组、阴性对照(NC)组、对照组。在荧光显微镜下观察Tca8113细胞的初级纤毛并计算其阳性检出率;采用Western blot和PCR检测各组KIF3A、Snail、E-钙黏蛋白、波形蛋白及mRNA的相对表达水平;Transwell实验观察Tca8113侵袭能力的变化;细胞划痕实验观察Tca8113迁移能力的变化。结果与对照组比较,KIF3A-siRNA转染组初级纤毛检出率明显降低(P<0.05);Western blot和PCR检测结果显示KIF3A-siRNA转染组KIF3A、Snail、波形蛋白及mRNA表达明显下调,而E-钙黏蛋白表达明显上调(P<0.05);细胞侵袭及划痕实验结果显示,与对照组比较,KIF3A-siRNA转染组Tca8113细胞侵袭、迁移能力明显降低(P<0.05)。结论沉默初级纤毛相关基因KIF3A可能通过调控Tca8113的EMT过程来抑制其侵袭、迁移能力。

关键词：口腔肿瘤癌,鳞状细胞纤毛上皮间充质转化驱动蛋白家族成员3A

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Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong Li Li Dan Jing Peng Qidong yang Fuqiang yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling Liao Quanhong yang Nianjun yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials