Association between single nucleotide polymorphisms(SNPs) on the promoter of adiponcctin gene,hypoadiponectinemia, and diabetes
会议名称：《第八次全国医学遗传学学术会议(中华医学会2009年医学遗传学年会)》
会议日期：2009年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：adiponectin hypoadiponectinemia diabetes
摘 要：This study was going to investigate:*** and genetic factors leading to hypoadiponectinemia;*** from hypoadiponectinemia to diabetes;*** and treatment of hypoadiponectinemia-derived diabetes.A total of 186 subjects were involved in this study,including 81 men and 105 *** were all Chinese and lived in Yanbian for at least 5 years. Total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDLC), Fasting plasma glucose(FPG),fasting plasma insulin(FPI),and plasma adiponectin(PA)were *** and sequencing were used for screening of single nucleotide polymorphisms(SNPs).ANOVA and regression were used for analysis of relations of *** significant difference of PA between genotypes or haplotypes of SNPs of-11426AG and-11377CG which are on the promoter of adipoctin *** was inversely proportional to body mass index(BMI)(b=-0.17).FPI was direcdy proportional to PA (b=1.19).HDL-C is directly proportional to PA(b=0.03).60%of hypoadiponectinemia patients suffered from diabetes and 69%of diabetic patients were hypoadiponectinemia-derived diabetic *** in simple hypoadiponectinemia group and in hypoadiponectinemia-derived diabetic group was significantly lower than in normal group(p=0.021 and p0.001 respectively).Homeostasis model assessment of insulin resistance(HOMA-IR)in other cause-derived diabetic group was significantly higher than in normal group (p0.001).But there was no significant difference of HOMA-IR between hypoadiponectinemia-derived diabetic group and normal group(p=0.093).Following conclusions had been drawn:*** could decrease *** could stimulate HDL and insulin secretion and the hypoinsulinemia was the direct cause of hypoadiponectinemia-derived ***≥7.0 mmol/1 and PA4.68μg/ml could be the diagnosis criterion of hypoadiponectinemia-derived diabetes in Yanbian Chinese and the relative ways to treat the hypo