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hypoadiponectinemia: Association with risk of varying degrees of gestational hyperglycemia and with maternal ethnicity

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Journal of Diabetes Mellitus 2012年第2期2卷 196-202页

作者： Xinhua Chen Theresa O. Scholl T. Peter Stein Department of Obstetrics and Gynecology University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine Stratford USA Department of Surgery University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine Stratford USA

Objective: The aims of this study were to examine the influence of maternal hypoadiponectinemia on the risk of varying degrees of gestational hyperglycemia as well as on ethnic differences in circulating levels of adiponectin. Methods: A case-control study nested within a prospective cohort of healthy pregnant women compared those who developed gestational diabetes mellitus (GDM, N = 80), or had an impaired glucose challenge test (GCT) non-GDM (defined as 1hr plasma glucose >140 mg/dl after a 50-g oral glucose load when screening for GDM but did not meet the diagnostic criteria for GDM by a diagnostic oral glucose tolerance test, N = 128) to normal controls (N = 557). Concentrations of serum adiponectin were determined at entry (~17 weeks) and during the 3rd trimester. Results: With multivariable adjustment, entry hypoadiponectinemia (the lowest tertile vs. other tertiles pooled) was strongly associated with an increased risk of GDM (AOR 2.68, 95% CI 1.62 - 4.41) and with impaired GCT non-GDM (AOR 1.58, 95% CI 1.05 - 2.38). This association persisted after adjustment for pregravid BMI despite the fact that the risk in obese women with low adiponectin was higher. Similar data were obtained during the 3rd trimester. The concentration of adiponectin during the 3rd trimester was significantly lower in African Americans compared to Hispanics or Caucasians and this difference was detectable in both cases and controls (p hypoadiponectinemia during early pregnancy with risk of GDM and less severe hyperglycemia non-GDM independent of maternal BMI. The relationship persisted to the 3rd trimester. African American women have lower adiponectin level than Caucasian or Hispanic women. hypoadiponectinemia may play a significant pathophysiological role in the development of GDM and of less severe gestational hyperglycemia.

关键词： Gestational Diabetes Mellitus Impaired Glucose Challenge Test Ethnic Difference hypoadiponectinemia

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Association between single nucleotide polymorphisms(SNPs) on the promoter of adiponcctin gene,hypoadiponectinemia, and diabetes

Association between single nucleotide polymorphisms(SNPs) on...

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第八次全国医学遗传学学术会议(中华医学会2009年医学遗传学年会)

作者： Tianxin Sheng,Zibo Zhang,Yanhua Jin,Xiongji Jin,Kangjuan Yang~* Teaching and Research Section for Cell Biol- ogy and Medical Genetics,School of Basic Medicine,Health Science Center,Yanbian University,Yanji 133000,China

This study was going to investigate:*** and genetic factors leading to hypoadiponectinemia;*** from hypoadiponectinemia to diabetes;*** and treatment of hypoadiponectinemia-derived diabetes.A total of 186 subjects were involved in this study,including 81 men and 105 *** were all Chinese and lived in Yanbian for at least 5 years. Total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDLC), Fasting plasma glucose(FPG),fasting plasma insulin(FPI),and plasma adiponectin(PA)were *** and sequencing were used for screening of single nucleotide polymorphisms(SNPs).ANOVA and regression were used for analysis of relations of *** significant difference of PA between genotypes or haplotypes of SNPs of-11426A>G and-11377C>G which are on the promoter of adipoctin *** was inversely proportional to body mass index(BMI)(b=-0.17).FPI was direcdy proportional to PA (b=1.19).HDL-C is directly proportional to PA(b=0.03).60%of hypoadiponectinemia patients suffered from diabetes and 69%of diabetic patients were hypoadiponectinemia-derived diabetic *** in simple hypoadiponectinemia group and in hypoadiponectinemia-derived diabetic group was significantly lower than in normal group(p=0.021 and phypoadiponectinemia-derived diabetic group and normal group(p=0.093).Following conclusions had been drawn:*** could decrease *** could stimulate HDL and insulin secretion and the hypoinsulinemia was the direct cause of hypoadiponectinemia-derived ***≥7.0 mmol/1 and PAhypoadiponectinemia-derived diabetes in Yanbian Chinese and the relative ways to treat the hypo

关键词： adiponectin hypoadiponectinemia diabetes

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Adiponectin and its association with insulin resistance and type 2 diabetes

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Journal of Genetics and Genomics 2008年第6期35卷 321-326页

作者： Tianxin Sheng Kangjuan Yang School of Basic Medicine Yanbian University Yanji 133000 China

Adiponectin is an adipokine, which is expressed in adipose tissue and is thought to play an important role in glucose metabolism. hypoadiponectinemia can cause reduction of fatty acid oxidation, decreased glucose uptake in skeletal muscle cells, and increased gluconeogenesis in hepatic cells. The level of plasma glucose can be increased. On the other hand, the decrease of fatty acid oxidation increases the level of free fatty acid （FFA）, which increases the insulin resistance, and then decreases the glucose uptake, which ultimately causes increased plasma glucose and type 2 diabetes （T2D）. This review describes the process from hypoadiponectinemia to T2D and the genesis of hypoadiponectinemia at a molecular level.

关键词： adiponectin insulin resistance type 2 diabetes hypoadiponectinemia

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Vascular insulin resistance and underlying mechanisms in prehypertensive young SHRs

Vascular insulin resistance and underlying mechanisms in pre...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：张海锋 Wenjuan Xing Xiangyan Liang Feng Gao Experiment Teaching Center Fourth Military Medical University Department of Physiology Fourth Military Medical University Department of Cardiology Xijing HospitalFourth Military Medical University

Aims:Vascular insulin resistance contributes to elevated peripheral vascular resistance and subsequent *** observation has revealed that a low plasma adiponectin concentration is associated with *** study aimed to determine whether and how hypoadiponectinemia induces vascular insulin resistance in ***:Four-week-age prehypertensive spontaneously hypertensive rats（y SHRs）and adiponectin knockout mice（APNKO）were used to evaluate the role of hypoadiponectinemia in insulin-induced ***:Mesenteric arteriole segments of y SHRs showed a markedly reduced vasorelaxation response to insulin compared with those of age-matched Wistar-Kyoto controls（WKY）（21.6%±3.2%vs.41.6%±4.4%to 1μmol/L insulin,n=8,P＜0.05）.Adiponectin levels in serum（7.52±0.86 vs.4.89±0.49μg/ml,P＜0.05）and APPL1expression in mesenteric arterioles of y SHRs were significantly ***,e NOS phosphorylation and NO production in vascular tissue were reduced,while ERK1/2 phosphorylation and ET-1 secretion were augmented in y *** mice also showed markedly decreased APPL1expression and vasodilation evoked by *** of y SHRs in vivo with the globular domain of adiponectin（g Ad）for 1 week increased insulin-induced vasodilation and APPL1 expression in arterioles,and restored the balance between insulin-stimulated Akt/e NOS/NO and ERK1/2/ET-1 *** human umbilical vein endothelial cells,g Ad upregulated APPL1 expression in a dose-dependent *** of APPL1 expression with si RNA blunted the modulation of insulin signaling by g Ad（all P＜0.05）.Conclusion:hypoadiponectinemia induces APPL1 downregulation in resistance vessels,contributing to the development of vascular insulin resistance by reciprocally modulating the Akt/e NOS/NO and ERK1/2/ET-1 pathways in vascular endothelium in prehypertensive SHRs.

关键词： hypoadiponectinemia APPL1 Vascular insulin resistance Prehypertension Endothelium

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