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The Multiple Roles of Autophagy in Neural Function and Diseases

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Neuroscience Bulletin 2024年第3期40卷 363-382页

作者： yan-yan li Zheng-Hong Qin Rui Sheng Department of Pharmacology and Laboratory of Aging and Nervous Diseases Jiangsu Key laboratory of Neuropsychiatric DiseasesCollege of Pharmaceutical Sciences of Soochow UniversitySuzhou 215123China

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,where proteins,lipids,and organelles are degraded and *** to the way the cytoplasmic components are engulfed,autophagy can be divided into macroautophagy,microautophagy,and chaperone-mediated ***,many studies have found that autophagy plays an important role in neurological diseases,including Alzheimer's disease,Parkinson's disease,Huntington's disease,neuronal excitotoxicity,and cerebral *** maintains cell homeostasis in the nervous system via degradation of misfolded proteins,elimination of damaged organelles,and regulation of apoptosis and ***-mTOR,Beclin 1,TP53,endoplasmic reticulum stress,and other signal pathways are involved in the regulation of autophagy and can be used as potential therapeutic targets for neurological ***,we discuss the role,functions,and signal pathways of autophagy in neurological diseases,which will shed light on the pathogenic mechanisms of neurological diseases and suggest novel targets for therapies.

关键词： Autophagy Neurodegenerative diseases Cerebral ischemia AMPK mTOR Beclin 1 TP53 Endoplasmic reticulum stress

Multi-layered fluorinated graphene cathode materials for lithium and sodium primary batteries

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Rare Metals 2023年第3期42卷 940-953页

作者： yan-yan li Chao liu Lei Chen Xiao-Zhong Wu Peng-Fei Zhou Xiang-yan Shen Jin Zhou School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China

Fluorinated graphene has a promising application prospect in lithium primary batteries(LPBs)and sodium primary batteries(SPBs).Herein,five fluorinated graphene materials with different fluorine contents(FG-x)are prepared by a large-scale gas fluorination *** is found that the structural characteristics of FG-x strongly depend on the fluorination temperature:the fluorine content(i.e.,F/C ratio)gradually increases with the fluorination temperature rising,resulting in the enlargement of interlayer spacing and the increase of average bonding strength between C and ***-0.75 sample with the intermediate degree of fluorination achieves the maximum energy densities in LPBs(2239.8 Wh·kg^(-1))and SPBs(1939.2 Wh·kg^(-1)).The interlayer distance is critical to the rate capability of FG-x,and FG-0.95 with the largest lattice spacing exhibits the best rate performance in both li/CFx and Na/CFx *** electrochemical reaction mechanism and the structural evolution of FG material revealed by ex situ X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD)characterization,and in situ Raman spectra further confirm the effect of interlayer distance.

关键词： lithium batteries Sodium batteries Fluorocarbon Fluorinated graphene

Investigation of Spontaneous Condensation of an Amino Acid Based Amphiphile on Cast Film by in situ Transmission FT-IR Spectroscopy

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Chinese Chemical Letters 2005年第12期16卷 1637-1640页

作者： Hai yan WANG yan Mei li Yi XIAO Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084

The spontaneous condensation of the amphiphilic N-（O,O-dihexadecyl）phosphorylalanine on the cast film was observed by in situ investigation of transmission infrared spectroscopy The particular orientation and ordered packing of the monomers within the multilayers of the cast film is concluded to attribute to the spontaneous condensation between the monomers.

关键词： Amphiphile cast film condensation FT-IR N-(O O-dihexadecyl)phosphoryl alanine

Dbx2 exhibits a tumor-promoting function in hepatocellular carcinoma cell lines via regulating Shh-Gli1 signaling

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World Journal of Gastroenterology 2019年第8期25卷 923-940页

作者： yan-Ting Hu Bei-Fang li Peng-Jun Zhang Di Wu yan-yan li Zhong-Wu li lin Shen Bin Dong Jing Gao Xu Zhu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Interventional TherapyPeking University Cancer Hospital and InstituteBeijing 100142China Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China 不详

BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common cancer *** patients suffer from a high mortality-to-incidence ratio and low cure rate since we still have no specific and effective *** tremendous advances have been made in the investigation of HCC,the specific mechanisms of the progression of this disease are still only partially ***,more research is needed to elucidate the underlying potential mechanisms to develop effective strategies for *** To determine the role of developing brain homeobox 2(Dbx2)gene in promoting the development of *** Dbx2 expression in clinical specimens and HCC cell lines was detected by Western blot(WB)and *** and loss of Dbx2 function assays were performed in vitro and in *** viability assays were used to investigate cell growth,flow cytometry was employed to assess cell cycle and apoptosis,and trans-well assays were conducted to evaluate cell migration,invasion,and *** expression of key molecules in the sonic hedgehog(Shh)signaling was determined by *** Compared to matched adjacent non-tumorous tissues,Dbx2 was overexpressed in 5 HCC cell lines and 76 surgically resected HCC ***2 overexpression was correlated with large tumor *** gain and loss of function assays indicated that Dbx2 promoted HCC cell proliferation by facilitating the transition from G1 to S phase,attenuating apoptosis and promoted HCC proliferation,migration,and invasion in vitro and in ***,Dbx2 modulated Shh signaling by enhancing FTCH1 and Gli1 expression in HCC cells that overexpressed Dbx2,which was reversed in HCC cells with Dbx2 *** Our results indicate that Dbx2 is significantly upregulated in HCC tissues and plays significant roles in proliferation and metastasis of HCC cells by activating the Shh pathway.

关键词： Developing brain homeobox 2 Hepatocellular carcinoma Sonic Hedgehog pathway Expression Tumor tissues

Comparison Principles for Some Fully Nonlinear Sub-Elliptic Equations on the Heisenberg Group

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Analysis in Theory and Applications 2019年第3期35卷 312-334页

作者： yan yan li Bo Wang Department of Mathematics Rutgers Unioersity110 Frelinghuysen RdPiscatawayNJ 08854LUSA School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China

In this paper,we prove a form of the strong comparison principle for a class of fully nonlinear subelliptic operators of the form■H^2,sψ+L(·,ψ,■Hψ)on the Heisenberg group,which include the CR invariant operators.

关键词： Comparison principle subellipticity CR invariance Heisenberg group propagation of touching points

Dedication on the Occasion of Professor Xiaqi Ding's 80th Birthday

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 353-354页

作者： Dao-min Cao Gui-qiang Chen yan-yan li Xi-ping Zhu Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Mathematics Northwestern University Evanston USA Department of Mathematics Rutgers University Piscataway NJ 08854 USA Department of Mathematics Zhongshan University Guangzhou 510275 China

This volume is dedicated to Professor Xiaqi Ding, an academician of the Chinese Academy of Sciences, on the occasion of his eightieth birthday.

关键词： Professor Xiaqi Ding's 80th birthday Chinese Academy of Sciences

Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults

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Biomedical and Environmental Sciences 2009年第5期22卷 442-447页

作者： DONG-SHENG HU JING XIE DA-HAI YU GuO-HENG XU JIE LU JIN-XIU yanG CHUN-yanG li yan-yan li Department of Epidemiology College of Public Health Zhengzhou University Zhengzhou 450001 Henan China Population Health Unit Centre for Eye Research Australia University of Melbourne Level 132 Gisborne Street East Melbourne VIC 3002 Australia Department of Evidence-Based Medicine and Division of Population Genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Physiology Beijing University Medical Sciences Center Beijing 100083 China

Objective To identify the association between PliN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults （157 obese subjects, 322 overweight subjects, and 515 normal controls） were recruited from two rural communities. PliN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism （PCR-RFLP）. Association between PliN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of,PliN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PliN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PliN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PliN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC＋TC genotype was 0.8（0.4, 1.4） in women （P=-0.4） and 0.6 （0.3, 1.3） in men （P=-0.2） after adjustment for age, education, household income and alcohol consumption, smoking, and physicalactivity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PliN1237. PliN1237 T〉C polymorphism is not significantly associated with obesity in northern Chinese adults.

关键词： Perilipin Polymorphism Obesity

3D conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第45期20卷 17227-17234页

作者： li-Qun Zou Bing-Lan Zhang Qing Chang Fu-Ping Zhu yan-yan li Yu-Quan Wei Yong-Song Guan Department of Oncology Cancer Center State Key Laboratory of Biotherapy West China Hospital Sichuan University Department of Hepatobiliary Surgery The Ninth People’s Hospital of Chongqing

AIM: To compare transcatheter arterial chemoembolization (TACE) and 3D conformal radiotherapy (3D-CRT) with TACE monotherapy in hepatocellular carcinoma (HCC). METHODS: We searched all the eligible studies from the Cochrane library, PubMed, Medline, Embase, and CNKI. The meta-analysis was performed to assess the survival benefit, tumor response, and the decline in alpha-fetoprotein (AFP) level. According to the heterogeneity of the studies, pooled OR with 95% CI were calculated using the fixed-effects or random-effects model. An observed OR > 1 indicated that the addition of 3D-CRT to TACE offered survival benefits to patients that could be considered statistically significant. Statistical analyses were performed using Review Manager Software. RESULTS: Ten studies met the criteria to perform a meta-analysis including 908 HCC participants, with 400 patients in the TACE/3D-CRT combination group and 508 in the TACE alone group. TACE combined with 3D-CRT significantly improved 1-, 2- and 3-year overall survival compared with TACE monotherapy (OR = 1.87, 95% CI: 1.37-2.55, P line rates of AFP level (OR = 3.24, 95% CI: 2.09-5.02, P lishing Group Inc. All rights reserved.

关键词： Hepatocellular carcinoma Chemoembolization Three-dimensional conformal radiotherapy Meta-analysis

Pyrolysis of Glucose over Two Amphoteric Metal Oxides

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Chemical Research in Chinese Universities 2009年第2期25卷 234-238页

作者： yanG Yu XIANG Xi LUO Jia QI Wei-yan yan Hong-Peng li Gui-Ying HU Chang-Wei Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 P. R. China

The catalytic pyrolysis of glucose over amphoteric metal oxide, ZnO or γ-l2O3, was studied comparatively with direct pyrolysis. The effects of catalyst to glucose ratio on the yields of pyrolytic products and on the chemical composition of the liquid products were discussed. Compared with the pyrolytic products of direct pyrolysis, the amount of residual char decreased, whereas the gas yield increased in the presence of the catalysts. The highest liquid yield over ZNO（49.5%） was obtained when the ratio of ZnO to glucose was 5%, whereas over γ-Al2O3 the liquid yield increased with increasing the amount of γ-Al2O3 added. The presence of both the catalysts enhanced the selectivity to furans in liquid and reduced that of anhydro sugars. A selectivity of 69.7% to furans was obtained over 1% ZnO with a selectivity of 14.6% to 5-hydroxymethylfurfural（HMF）. The maximum selectivity to furans（74.9%） and that to HMF（25.6%） were obtained in the presence of 10% γ-Al2O3.

关键词： Glucose ZnO γ-Al2O3 Furans 5-Hydroxymethylfurfural