The Multiple Roles of Autophagy in Neural Function and Diseases

作     者：Yan-Yan Li Zheng-Hong Qin Rui Sheng 

作者机构：Department of Pharmacology and Laboratory of Aging and Nervous DiseasesJiangsu Key laboratory of Neuropsychiatric DiseasesCollege of Pharmaceutical Sciences of Soochow UniversitySuzhou 215123China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2024年第40卷第3期

页      面：363-382页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(82173811,81973315) Natural Science Foundation of Jiangsu Higher Education(20KJA310008) Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003) the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD) 

主　　题：Autophagy Neurodegenerative diseases Cerebral ischemia AMPK mTOR Beclin 1 TP53 Endoplasmic reticulum stress 

摘      要：Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,where proteins,lipids,and organelles are degraded and *** to the way the cytoplasmic components are engulfed,autophagy can be divided into macroautophagy,microautophagy,and chaperone-mediated ***,many studies have found that autophagy plays an important role in neurological diseases,including Alzheimer s disease,Parkinson s disease,Huntington s disease,neuronal excitotoxicity,and cerebral *** maintains cell homeostasis in the nervous system via degradation of misfolded proteins,elimination of damaged organelles,and regulation of apoptosis and ***-mTOR,Beclin 1,TP53,endoplasmic reticulum stress,and other signal pathways are involved in the regulation of autophagy and can be used as potential therapeutic targets for neurological ***,we discuss the role,functions,and signal pathways of autophagy in neurological diseases,which will shed light on the pathogenic mechanisms of neurological diseases and suggest novel targets for therapies.