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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

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Cellular & Molecular Immunology 2011年第3期8卷 193-198页

作者： Urs Christen Matthias G von Herrath Pharmazentrum Frankfurt/ZAFES Klinikum der Goethe UniversitaätFrankfurt am MainGermany La Jolla Institute for Allergy and Immunology La JollaCAUSA

Virus infections have been implicated in both initiation of and protection from autoimmune diseases,such as type 1 diabetes(T1D).In this review we intend to reflect on recent evidence how viruses might on the one hand be involved in the pathogenesis of T1D and on the other hand induce a state of protection from autoimmune-mediated *** is important to acknowledge that human individuals encounter more than just one virus infection in their ***,it is important to integrate more than just one possible environmental triggering factor for autoimmune diseases to occur.

关键词： animal model enterovirus hygiene hypothesis molecular mimicry pathogens

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Book review “Wattles: Australian Acacia species around the world” by David M. Richardson, Johannes J. Le Roux and Elizabete Marchante

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Forest Ecosystems 2024年第2期11卷 140-141页

作者： Klaus von Gadow Faculty of Forestry and Forest Ecology Georg-August-University GöttingenBüsgenweg 5D-37077GöttingenGermany Department of Forestry and Wood Science Faculty of AgriSciencesStellenbosch UniversityStellenbosch Private Bag X1Stellenbosch7602South Africa

In a world of Google and AI, developing an encyclopedic coverage of a theme that is of great interest to biologists, social scientists, politicians and environmental managers, is a daunting challenge. Wattles is a book that presents new knowledge, makes interesting reading, and has the potential to stimulate research in a variety of disciplines. We learn that Acacia, commonly known as the wattles or acacias, is a genus of shrubs and trees comprising 1,083 species of which 417 are known to have been introduced to areas outside their native range. We are surprised to read that Australian acacias are found almost everywhere, in virtually all terrestrial habitats, including woodlands, grasslands, alpine settings,rainforests, coastal dunes and deserts, causing major environmental and socio-economic changes in the invaded regions. Until recently, Acacia comprised a group of plant species native to Africa, South America and Australasia, but the name is now reserved for species predominantly from Australia, including some from Southeast Asia. The genus name Acacia is Neo-Latin, and refers to a preparation extracted from the leaves and fruit pods of Vachellia nilotica, the original type of the genus.

关键词： Richardson outside Latin

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Nature-based recreation for the elderly in urban areas:assessing opportunities and demand as planning support

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Ecological Processes 2022年第1期11卷 587-603页

作者： Chen Wen Christian Albert Christina von Haaren School of Architecture and Urban Planning Huazhong University of Science and TechnologyLuoyu Road430074 WuhanChina Institute of Environmental Planning Leibniz University HannoverHannoverGermany Institute of Geography Ruhr University BochumBochumGermany

Background:With elderly people comprising a growing share of the population,landscape planners need to consider their specific requirements to enhance the opportunities for them to engage in nature-based recreation(NBR).However,few studies have spatially assessed the recreation potential,demand,and opportunities for elderly people in ***,this paper aimed to spatially model and investigate the NBR opportunities for and demand of elderly people in urban areas.A spatial framework based on the ESTIMAP recreation model was developed,considering special factors to better reflect elderly people’s preferences regarding NBR at the city *** particular,NBR opportunities were assessed considering landscape aesthetics,various types of facilities,and *** street network was used to understand elderly people’s walking behaviours regarding green spaces and related ***:A case study in Hannover,Germany,demonstrated the applicability of the proposed *** results illustrate the spatial heterogeneity of recreation options for the *** parts of Hannover’s green spaces offer high recreation opportunities for elderly *** of the existing green spaces lack diverse landscape compo-nents and sufficient supply of facilities,resulting in a compromise to aesthetics and recreational ***:The proposed method contributes to research on spatial planning and environmental justice by incorporating vulnerable groups’preferences and needs in spatially assessing *** planning implications highlight pocket gardens and greenways connecting communities and parks as development opportunities in the city.

关键词： Sustainability Nature-based recreation Population aging Landscape architecture GIS mapping Urban design

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Effect of HDL and apo AI on PGE_2 Production by Monocyte-Derived Macrophages

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第4期22卷 270-272页

作者：周小琴 Arnold von Eckardstein DepartmentofInternalMedicine InstituteofClinicalChemistry&LaboratoryMedicine

Effect of antiatherogenic high density lipoprotein (HDL) and apolipoprotein AI (apo AI) on production of prostaglandin E2 (PGE2 ) by human m onocyte- derived macrophages was *** were loaded with acetylated low density lipoprotein followed by incuba- tion with HDL3or apo ***2 produced and secreted in culture supernatant was quantified by en- zyme im ***3induced production of PGE2 by m acrophages in a time- dependent m an- ner.2 4 h after incubation,PGE2 production by HDL3- treated macrophages increased 3.7- fold of that by control *** AI also induced PGE2 secretion to 2 .1- fold,which was significantly less than *** data indicate that both HDL3and lipid- free apo AI enhance PGE2 synthesis and se- cretion by hum an m acrophages and this may further contribute to the protection from atheroscle- rosis.

关键词： prostaglandin E2 high density lipoprotein m acrophage,m onocyte- derived apolipoprotein AI atherosclerosi

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Neurogenesis within the adult hippocampus under physiological conditions and in depression

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Neural Regeneration Research 2012年第7期7卷 552-559页

作者： Martin Dokter Oliver von Bohlen und Halbach Institute of Anatomy and Cell Biology Ernst Moritz Arndt University of GreifswaldGermany

Adult neurogenesis can only be observed in some specific brain regions. One of these areas is the dentate gyrus of the hippocampal formation. The progenitor cells located in the subgranular layer of the dentate gyrus proliferate, differentiate, and give rise to young neurons that can become integrated into existing neuronal circuits. Under physiological conditions, hippocampal neurogenesis is linked to hippocampal-dependent learning, whereas deficits in adult hippocampal neurogenesis have been shown to correlate with disturbances in spatial learning and memory. This review summarizes the phenomenon of adult hippocampal neurogenesis and the use of suitable markers for the investigation of adult hippocampal neurogenesis. In addition, we focused on the disturbances in neurogenesis that can be seen in depression. Interestingly, several antidepressants have been found to be capable of increasing the rate of hippocampal neurogenesis. Based on that, it can be speculated that factors, which directly or indirectly increase the rate of hippocampal neurogenesis, may be helpful in the treatment of depression.

关键词： hippocampus dentate gyrus learning depression aging environment

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Preliminary multiproxy surface air temperature field reconstruction for China over the past millennium

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Science China Earth Sciences 2012年第12期55卷 2058-2067页

作者： SHI Feng yANG Bao Lucien von GUNTEN Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of SciencesLanzhou 730000China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Oeschger Centre for Climate Change Research&Institute of Geography University of BernBernSwitzerland

We present the first millennial-length gridded field reconstruction of annual temperature for China, and analyze the reconstruction for spatiotemporal changes and associated uncertainties, based on a network of 415 well-distributed and accurately dated climatic proxy *** new reconstruction method is a modified form of the point-by-point regression (PPR) *** main difference is the incorporation of the "composite plus scale" (CPS) and "Regularized errors-in-variables" (EIV) algorithms to allow for the assimilation of various types of the proxy ***, the search radius is restricted to a grid size; this restriction helps effectively exclude proxy data possibly correlated with temperature but belonging to a different climate *** results indicate that: 1) the past temperature record in China is spatially heterogenic, with variable correlations between cells in time; 2) the late 20th century warming in China probably exceeds mean temperature levels at any period of the past 1000 years, but the temperature anomalies of some grids in eastern China during the Medieval climate anomaly period are warmer than during the modern warming; 3) the climatic variability in the eastern and western regions of China was not synchronous during much of the last millennium, probably due to the influence of the Tibetan *** temperature reconstruction may serve as a reference to test simulation results over the past millennium, and help to finely analyze the spatial characteristics and the driving mechanism of the past temperature ***, the lower reconstruction skill scores for some grid points underline that the present set of available proxy data series is not yet sufficient to accurately reconstruct the heterogeneous climate of China in all regions, and that there is the need for more highly resolved temperature proxies, particularly in the Tibetan Plateau.

关键词： climate change global warming paleoclimatology temperature field reconstruction

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Roles and functions of Atp6ap2 in the brain

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Neural Regeneration Research 2018年第12期13卷 2038-2043页

作者： Alexander Bracke Oliver von Bohlen und Halbach Institute of Anatomy and Cell Biology Universit?tsmedizin Greifswald

The classical renin-angiotensin system（RAS） in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure. Since nearly all members of the classical RAS have also been identified within the brain in the last decades and due to the existence of the blood-brain barrier, a RAS within the brain（bRAS） that is largely independent from the peripheral RAS has been postulated. All members of the angiotensin family as e.g., angiotensin II, angiotensin IV and angiotensin II（1-7） along with the respective receptors（e.g., angiotensin II receptor type 1（AT1）, angiotensin II receptor type 2（AT2）, angiotensin IV receptor（AT4）, angiotensin II（1-7） receptor（Mas）） have been identified within the brain. Moreover, a receptor capable of binding renin and the renin precursor prorenin with high affinity has also been detected within the brain. This protein functions as a membrane receptor for（pro）renin and also represents a V-ATPase subunit and is therefore termed（P）RR or Atp6 ap2, respectively. In this review we shed light on the（known as well as putative） roles and functions of Atp6 ap2 in the brain under physiological and pathophysiological conditions.

关键词： prorenin receptor renin-angiotensin X-linked intellectual disability hippocampus behaviour adult neurogenesis animal model human

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First-principles search of hot superconductivity in La-X-H ternary hydrides

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npj Computational Materials 2022年第1期8卷 1-8页

作者： Simone Di Cataldo Wolfgang von der Linden Lilia Boeri Institute of Theoretical and Computational Physics Graz University of TechnologyNAWI Graz8010GrazAustria Dipartimento di Fisica Sapienza Universitàdi Roma00185RomaItaly Centro Ricerche Enrico Fermi Via Panisperna89a00184RomaItaly

Motivated by the recent claim of hot superconductivity with critical temperatures up to 550 K in La + x hydrides,we investigate the high-pressure phase diagram of compounds that may have formed in the experiment,using first-principles calculations for evolutionary crystal structure prediction and *** from the hypothesis that the observed T_(c) may be realized by successive heating upon a pre-formed LaH_(10) phase,we examine plausible ternaries of lanthanum,hydrogen and other elements present in the diamond anvil cell: boron,nitrogen,carbon,platinum,gallium,*** find that only boron and,to a lesser extent,gallium form metastable superhydride-like structures that can host high-T_(c) superconductivity,but the predicted T_(c)’s are incompatible with the experimental *** results indicate that,while the claims of hot superconductivity should be reconsidered,it is very likely that unknown H-rich ternary or multinary phases containing lanthanum,hydrogen,and possibly boron or gallium may have formed under the reported experimental conditions,and that these may exhibit superconducting properties comparable,or even superior,to those of currently known hydrides.

关键词： hydrides boron superconductivity

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Arterial mechanical properties after replacement or reconstruction of the aortic root

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World Journal of Cardiovascular Diseases 2012年第1期2卷 8-13页

作者： Kai Mortensen Muhammet Aydin Alexander M. J. Bernhardt Verena Appenzeller Peter N. Robinson Jürgen Berger Herman Reichenspurner yskert von kodolitsch 不详

Background: Alteration of arterial mechanical properties has adverse effects on cardiovascular disease in Marfan syndrome. Design: We compared central pulse pressure, augmentation index adjusted to a heart rate of 75 beats per minute (AIx@HR75) and pulse wave velocity in 25 Marfan patients who had under-gone an aortic valve-sparing reimplantation operation, in 15 Marfan patients after composite valve grafting operation, and in 40 age and sex-matched Mar-fan patients who had not undergone surgery. Results: Central pulse pressure, AIx@HR75 and pulse wave velocity were similar across all three patient groups. Exclusively AIx@HR75 was higher with conduit operations than in persons without any surgery (P = 0.03). Multivariate linear regression analysis documented association of AIx@HR75 with body height (P y of aortic valve-sparing reimplantation operation (P y mildly altered by surgery of the aortic root without difference between the reimplantation and conduit operation.

关键词： Arterial Stiffness Aortic Valve-Sparing Reimplantation Operation Composite Valve Grafting Operation Marfan Syndrome

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