Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

作     者：Urs Christen Matthias G von Herrath 

作者机构：Pharmazentrum Frankfurt/ZAFESKlinikum der Goethe UniversitaätFrankfurt am MainGermany La Jolla Institute for Allergy and ImmunologyLa JollaCAUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2011年第8卷第3期

页      面：193-198页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：UC is supported by grants of the German Research Foundation.MGvH is supported by a scholar award of the Juvenile Diabetes Research Foundation and a Program Project Grant of the National Institute of Health to the La Jolla Institute for Allergy and Immunology 

主　　题：animal model enterovirus hygiene hypothesis molecular mimicry pathogens 

摘      要：Virus infections have been implicated in both initiation of and protection from autoimmune diseases,such as type 1 diabetes(T1D).In this review we intend to reflect on recent evidence how viruses might on the one hand be involved in the pathogenesis of T1D and on the other hand induce a state of protection from autoimmune-mediated *** is important to acknowledge that human individuals encounter more than just one virus infection in their ***,it is important to integrate more than just one possible environmental triggering factor for autoimmune diseases to occur.