Roles and functions of Atp6ap2 in the brain

作     者：Alexander Bracke Oliver von Bohlen und Halbach 

作者机构：Institute of Anatomy and Cell Biology Universit?tsmedizin Greifswald 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第12期

页      面：2038-2043页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

主　　题：prorenin receptor renin-angiotensin X-linked intellectual disability hippocampus behaviour adult neurogenesis animal model human 

摘      要：The classical renin-angiotensin system（RAS） in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure. Since nearly all members of the classical RAS have also been identified within the brain in the last decades and due to the existence of the blood-brain barrier, a RAS within the brain（bRAS） that is largely independent from the peripheral RAS has been postulated. All members of the angiotensin family as e.g., angiotensin II, angiotensin IV and angiotensin II（1-7） along with the respective receptors（e.g., angiotensin II receptor type 1（AT1）, angiotensin II receptor type 2（AT2）, angiotensin IV receptor（AT4）, angiotensin II（1-7） receptor（Mas）） have been identified within the brain. Moreover, a receptor capable of binding renin and the renin precursor prorenin with high affinity has also been detected within the brain. This protein functions as a membrane receptor for（pro）renin and also represents a V-ATPase subunit and is therefore termed（P）RR or Atp6 ap2, respectively. In this review we shed light on the（known as well as putative） roles and functions of Atp6 ap2 in the brain under physiological and pathophysiological conditions.