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Effect of molybdenum on interfacial properties of titanium carbide reinforced Fe composite

journal of Materials Science & Technology 2022年第12期107卷 252-258页

作者： Seungchan Cho junghwan Kim Ilguk jo jae hyun Park jaekwang Lee hyun-Uk Hong Bong Ho Lee Wook Ryol Hwang Dong-Woo Suh Sang-Kwan Lee Sang-Bok Lee Composites Research Division Korea Institute of Materials Science(KIMS)Changwon 51508South Korea Advanced Materials Engineering Dong-Eui UniversityBusan 47340South Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityJinju 52828South Korea Department of Physics Pusan National UniversityBusan 46241South Korea Department of Materials Convergence and System Engineering Changwon National UniversityChangwon 51140South Korea Center for Core Research Facilities Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea School of Mechanical Engineering Gyeongsang National UniversityJinju 52828South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyGyeongbuk 37673South Korea

This study shows that the mechanical strength of the composite of Fe matrix and titanium carbide(Ti C)ceramic particles is significantly enhanced with addition of molybdenum(Mo) atoms. Ti C reinforced Fe(Fe-0.2C-7Mn) composites with and without Mo were fabricated by a liquid pressing infiltration(LPI)process and the effect of Mo on interfacial properties of TiC–Fe composite was investigated using atomic probe tomography(APT) analysis, molecular dynamics(MD) simulations, first-principle density functional theory(DFT), and thermodynamic calculations. First, DFT calculations showed that total energies of the Mo-doped Ti C–Fe superlattices strongly depend on the position of Mo defects, and are minimized when the Mo atom is located at the TiC/Fe interface, supporting the probable formation of MoC-like interphase at the TiC/Fe interface region. Then, APT analysis confirmed the DFT predictions by finding that about6.5 wt.% Mo is incorporated in the Ti C–Fe(Mo) composite and that sub-micrometer thick(Ti,Mo)C interphase is indeed formed near the interface. The MD simulations show that Mo atoms migrate to the Mo-free TiC–Fe interface at elevated temperatures and the mechanical strength of the interface is considerably enhanced, which is in good agreement with experimental observations.

关键词： Metal matrix composites(MMCs) Titanium carbide Fe matrix composite Infiltration Molybdenum Interfacial property

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Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

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Bioactive Materials 2022年第3期7卷 239-250页

作者： Min-Kyu Lee hyun Lee Cheonil Park In-Gu Kang jinyoung Kim Hyoun-Ee Kim hyun-Do jung Tae-Sik jang Department of Materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL60208USA Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon14662Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju61452Republic of Korea

In recent years,pure iron(Fe)has attracted significant attention as a promising biodegradable orthopedic implant material due to its excellent mechanical and biological ***,in physiological conditions,Fe has an extremely slow degradation rate with localized and irregular degradation,which is problematic for practical *** this study,we developed a novel combination of a nanostructured surface topography and galvanic reaction to achieve uniform and accelerated degradation of an Fe *** target-ion induced plasma sputtering(TIPS)technique was applied on the Fe implant to introduce biologically compatible and electrochemically noble tantalum(Ta)onto its surface and develop surface nano-galvanic *** tests revealed that the uniformly distributed nano-galvanic corrosion cells of the TIPS-treated sample(nano Ta-Fe)led to relatively uniform and accelerated surface degradation compared to that of bare ***,the mechanical properties of nano Ta-Fe remained almost constant during a long-term in vitro immersion test(~40 weeks).Biocompatibility was also assessed on surfaces of bare Fe and nano Ta-Fe using in vitro osteoblast responses through direct and indirect contact assays and an in vivo rabbit femur medullary cavity implantation *** results revealed that nano Ta-Fe not only enhanced cell adhesion and spreading on its surface,but also exhibited no signs of cellular or tissue *** results demonstrate the immense potential of Ta-implanted surface nanostructures as an effective solution for the practical application of Fe-based orthopedic implants,ensuring long-term biosafety and clinical efficacy.

关键词： Iron Tantalum Ion implantation Biodegradation Orthopedic implants

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Lactobacillus salivarius HHuMin-U Activates Innate Immune Defense against Norovirus Infection through TBK1-IRF3 and NF-κB Signaling Pathways

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Research 2023年第3期2022卷 229-241页

作者： Da hyun Kim Minju jeong jae Hwan Kim joe Eun Son john jyLee Sang-jun Park juyeon Lee Minwoo Kim jong-Won Oh Myeong Soo Park Sanguine Byun Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea Program in Developmental and Stem Cell Biology The Hospital for Sick ChildrenTorontoOntarioCanada Research Center BIFIDO Co.Ltd.Hanam 12930Republic of Korea

The composition of commensal bacteria plays a critical role in controlling immune responses in the *** have shown that specific bacterial strains may have the capacity to enhance host immune defense against gastrointestinal viral *** norovirus is known to be the most common cause of gastroenteritis,leading to an estimated 200,000 deaths every year,identification of bacterial strains with protective effects against norovirus infection remains ***,we discovered Lactobacillus salivarius HHuMin-U(HHuMin-U)as a potent antiviral strain against norovirus ***-U significantly suppressed murine norovirus replication and lowered viral RNA titers in *** transcriptome sequencing(RNA sequencing)analysis revealed that HHuMin-U markedly enhanced the expression level of antiviral interferon-stimulated genes compared to mock ***-U treatment dose-dependently induced type I interferons(IFN-αand IFN-β)and tumor necrosis factor-αproduction in mouse and human macrophages,promoting antiviral innate responses against norovirus *** on the molecular mechanism demonstrated that HHuMin-U can activate nuclear factorκB and TANK-binding kinase 1(TBK1)–interferon regulatory factor 3 signaling pathways,leading to the phosphorylation of signal transducer and activator of transcription 1 and signal transducer and activator of transcription 2,the key mediators of interferon-stimulated ***,oral administration of HHuMin-U increased IFN-βlevels in the ileum of mice and altered the gut microbiome *** results suggest the species/strain-specific importance of gut microbial composition for antiviral immune responses and the potential use of HHuMin-U as a probiotic agent.

关键词： TBK1 interferon protective

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Sustained adenosine release:Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells

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Engineered Regeneration 2024年第2期5卷 255-268页

作者： Hadi Hajiali jane McLaren Cristina Gonzalez-García Salah Abdelrazig Dong-hyun Kim Matthew j.Dalby Manuel Salmerón-Sánchez Felicity R.A.j.Rose School of Pharmacy Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Healthcare Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellular Microenvironment University of GlasgowGlasgowUK Centre for Analytical Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Marine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

Non-healing fractures,a global health concern arising from trauma,osteoporosis,and tumours,can lead to severe ***,integral to cellular energy metabolism,gains prominence in bone regeneration via adeno-sine A2 B receptor *** study introduces a controlled-release system for localized adenosine delivery,fostering human mesenchymal stromal cell(hMSC)differentiation into functional bone *** study investi-gates how the ratio of lactic acid to glycolic acid in microparticles can influence adenosine release and explores the downstream effects on gene expression and metabolic profiles of osteogenic differentiation in hMSCs cultured in growth and osteoinductive *** into adenosine-modulated signalling pathways during MSC differenti-ation,with osteogenic factors,provide a comprehensive understanding of the pathways *** gene expression and metabolic profiles unravels adenosine’s regulatory mechanisms in MSC *** adenosine release from microparticles induces mineralization,synergizing with osteogenic media supplements,showcasing the potential of adenosine for treating critical bone defects and metabolic *** study high-lights the efficacy of a polymeric microparticle-based delivery system,offering novel strategies for bone *** adenosine’s roles and associated signalling pathways advances our comprehension of molecular mech-anisms steering bone regeneration,propelling innovative biomaterial,combined with metabolites,approaches for clinical use.

关键词： Adenosine release Osteogenic signalling pathways Human mesenchymal stromal cells Bone regeneration

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Degradation and resynthesis of chlorophyll during increased oxidative stress and prolonged darkness differ between annual and perennial flax(Linum L.)

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Oil Crop Science 2024年第2期9卷 121-130页

作者： Kenyon j. Nisbett Abida Alokozai Su hyun Elizabeth Ko G. Adam Mott jason C.L. Browna Department of Biological Sciences University of Toronto ScarboroughTorontoONCanada Department of Cell&Systems Biology University of TorontoTorontoONCanada Centre for the Analysis of Genome Evolution&Function University of TorontoTorontoONCanada

Among plants,there is considerable variation in lifespan:annuals live less than one year,whereas perennials live for several years,with the longest-living perennial having survived 43,600 *** proposed by the Disposable Soma Theory,this lifespan variation among plants likely reflects differential investment of limited energy and nutrient resources,with perennials investing more energy and nutrients into biomolecular maintenance compared to annuals in order to ensure persistence over multiple *** differential investment may be particularly important during periods of exogenous stress,which are known to accelerate biomolecular *** present study evaluated this hypothesis using annual and perennial flax(Linum L.)subjected to two exogenous stressors—increased oxidative stress(i.e.,foliar H2O2spraying)and complete prolonged *** chlorophyll has been shown to exhibit degradation in response to changes in environmental conditions,we utilized changes in chlorophyll levels during and after periods of exogenous stress to evaluate our *** predicted that i)perennials would exhibit a slower rate of chlorophyll degradation during exposure to exogenous stressors compared to annuals,and ii)perennials would exhibit a faster rate of chlorophyll resynthesis following such exposure compared to *** levels before,during,and after exposure to both exogenous stressors were measured in two separate trails,once using image colour analysis and once using *** chlorophyll degradation rates in response to oxidative stress did not differ between annuals and perennials,contrary to our predictions,chlorophyll resynthesis rates following such exposure were significantly higher in perennials,as *** plants were subjected to complete prolonged darkness,chlorophyll degradation rates were significantly lower in perennials than annuals,as predicted;however,when plants were subsequently reintroduced to natural photoperiod,ch

关键词： Ageing Life history Maximum lifespan Oxidative stress Somatic maintenance

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Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

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Asian journal of Pharmaceutical Sciences 2019年第6期14卷 621-630页

作者： ju-Hee Oh joo hyun Lee young-joo Lee Division of Biopharmaceutics College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea Department of Life and Nanopharmaceutical Sciences College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea

Quercetin is a biologically active flavonoid that has been used as a popular health *** is reported that quercetin may cause flavonoid-drug interaction mediated by P-glycoprotein,the most predominant efflux *** this study,we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2(MRP2),another major efflux ***2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in *** evaluate the induction effect of quercetin on Mrp2 in vivo,Mrp2 mRNA expression in rat liver,kidney,and small intestinal tissues was determined after the oral administration of quercetin(50,100,or 250 mg/kg)for seven ***2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of ***,the effect of quercetin on absorption of docetaxel,a P-glycoprotein and CyP3A4 substrate,was also *** inhibited the function of MRP2 at 10μM and induced the mRNA expression of MRP2 at 50μM in ***,at 100 mg/kg,quercetin markedly increased Mrp2 expression in the small intestine of ***,there was no significant change in phenolsulfonphthalein pharmacokinetics due to single-(50,100,or 250 mg/kg)or multiple-dose(50,100,or 250 mg/kg for seven days)quercetin *** contrast,a significant interaction caused by quercetin(100 mg/kg)was observed in the absorption of *** results suggested that although quercetin modulates the function and expression of MRP2 in vitro,it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.

关键词： Quercetin P-glycoprotein Multidrug resistance-associated protein 2 Pharmacokinetics Flavonoid-drug interaction

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Managing the lifecycle of perovskite solar cells: Addressing stability and environmental concerns from utilization to end-of-life

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eScience 2024年第2期4卷 1-27页

作者： Hee jung Kim Gill Sang Han hyun Suk jung School of Advanced Materials Science&Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Division of Advanced Materials Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Perovskite solar cells(PSCs)have shown remarkable advancements and achieved impressive power conversion efficiencies since their initial introduction in ***,challenges regarding stability,quality,and sustainability must be addressed for their successful commercial *** review analyses the recent studies and challenges related to the operating life and end-of-life utilization of *** to enhance the stability and mitigate the toxic Pb leakage in operational and recycling approaches of discarded PSCs post their end-of-life are examined to establish a viable and sustainable PSC ***,future research directions are proposed for the advancements in the PSC *** goal is to ensure high efficiency as well as economic and environmental sustainability throughout the lifecycle of PSCs.

关键词： Levelized cost of electricity Metal electrode Pb leakage Perovskite Power conversion efficiency Solar cell life cycle

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Aqueous levels of erythropoietin in acute retinal vein occlusion with macular edema

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International journal of Ophthalmology(English edition) 2014年第3期7卷 501-506页

作者： hyun jin Shin hyung Chan Kim jun Woong Moon Department of Ophthalmology Konkuk University Medical Center Konkuk University School of Medicine Gongdeok Seoul Eye Clinic

AIM:To investigate the aqueous erythropoietin(EPO)levels and associated factors in patients with acute retinal vein occlusion(RVO).METHODS:The aqueous EPO level was measured in patients with macular edema(ME)secondary to acute branched retinal vein occlusion(BRVO)or central retinal vein occlusion(CRVO).Aqueous fluid from cataract patients served as the *** also evaluated whether aqueous level of EPO was associated with factors such as serum EPO level,non-perfusion area,central macular thickness(CMT),and arterio-venous(AV)transit timeRESULTS:Twenty-seven RVO patients(16 BRVO,11CRVO)and 9 control subjects were enrolled in the *** aqueous EPO level(mU/mL)was higher in RVO(68.2±54.3)than that in the control subjects(12.9±5.9).More specifically,the aqueous EPO level was higher in CRVO(118.9±52.1)than that in BRVO(33.3±10.8).However,no differences were found in serum EPO levels among three *** in RVO patients had a positive correlation with the aqueous EPO level(r=0.66).Also,in terms of non-perfusion area,the aqueous EPO levels were more elevated in the ischemic subgroup than in the non-ischemic subgroup in both BRVO and ***:Aqueous EPO levels are elevated in patients with macular edema secondary to recent onset *** with CRVO have higher EPO levels than those with *** aqueous EPO level in RVO has a positive correlation with CMT and is associated with non-perfusion *** results suggest that the aqueous EPO level could be associated with retinal ischemia and may be involved in the pathogenesis of macular edema secondary to RVO.

关键词： aqueous level of erythropoietin acute retinal vein occlusion retinal ischemia macular edema

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Gost effectiveness of crack treatment methods:A field study

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journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 598-607页

作者： Mithil Mazumder hyun Hwan Kim Soon-jae Lee Moon-Sup Lee Materials Science Engineeringand Commercialization ProgramTexas State UniversitySan MarcosTX 78666USA Department of Engineering Technology Texas State UniversitySan MarcosTX 78666USA Korea Institute of Civil Engineering and Building Technology Gyeonggi-do 10223South Korea

In the United States,more than 94%highways are paved with asphalt materials and placing crack sealant materials has been a common pavement maintenance for *** sealing treatment includes the use of a router to create a reservoir on the intended cracks whereas crack filling is given without doing any modification to the crack *** the initial cost of crack sealing is higher,it is expected to have a longer service period compared to crack *** is little research on comparison of short and long term cost effectiveness between these two treatments using the real field cost data *** this study four test sites in Texas were treated with crack filling and sealing using the same sealant material and finishing *** effectiveness of both treatments was measured in terms of initial,annual average and life cycle cost based on the cost inputs during *** general,the results of this study indicated that(1)on an average approximately 45%initial cost increase was estimated with the two routing configurations of crack sealing;(2)material and labor cost is found to have the most significant effect on the higher initial cost of crack sealing compared to other associated costs;(3)annual average and life cycle costs have shown that crack sealing is more cost effective pavement maintenance compared to crack filling over a long period of time;(4)agency cost is observed to be reduced by approximately 24%with crack sealing treatment based on the35 year analysis period.

关键词： Crack sealing Crack filling Initial cost Annual average cost Life cycle cost

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Microstructure and Mechanical Properties of Mg-Al-Ca-Nd Alloys Fabricated by Gravity Casting

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journal of Materials Science & Technology 2008年第1期24卷 85-88页

作者： Hyeon-Taek Son jae-Seol Lee Ik-hyun Oh Chang-Seog Kang Korea Institute of Industrial Technology 1110-90ryong-dong Buk-gu Gwangju 500-480 South Korea

The aims of this study are to investigate the effects of Nd addition in the Mg-Al-Ca alloys on microstructure and mechanical *** of as-cast Mg-5Al-3Ca alloy containing Nd consists ofα-Mg matrix, eutectic phase and Al-Nd rich intermetallic *** Nd addition was increased,α-Mg matrix morphology was changed from dendritic to equiaxed grains and average value of grain size was *** addition to Mg-5Al-3Ca based alloys resulted in the formation of Al-Nd rich intermetallic compounds at grain boundary andα-Mg matrix *** these Al-Nd rich intermetallic compounds were dispersed *** these alloys,two kinds of eutectic phases were observed,*** irregular-shape structure at grain boundary and fine needle-shape structure in theα-Mg matrix *** is found that the ultimate strength showed the maximum value of 271 MPa at Mg-5Al-3Ca-2Nd alloy and elongation was decreased as the addition of Nd was increased.

关键词： Mg-AI-Ca alloy Neodymium (Nd) Rare earth element

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