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Nano-phase transformation of composite precipitates in multicomponent Al-Mg-Si(-Sc)alloys

Journal of Materials Science & Technology 2022年第15期110卷 216-226页

作者： S.B.Wang C.F.Pan B.Wei x.Zheng y.x.lai J.H.Chen Key Laboratory of LCR Materials and Devices of yunnan Province National Center for International Research on Photoelectric and Energy MaterialsSchool of Materials and EnergyYunnan UniversityKunming 650091China Collaborative Innovation Center of Renewable Energy Materials and Department of Physics Guangxi UniversityNanning 530004China Center for High-Resolution Electron Microscopy College of Materials Science and EngineeringHunan UniversityChangsha 410082China

Sc-addition can significantly enhance the performance of the micro-alloyed Al-Mg-Si-Sc ***,the mechanisms by which the Sc element modifies the microstructure of the alloys are still unknown in many ***,using atomic-scale transmission electron microscopy and atomic-resolution spectroscopy,we have revealed the microstructural differences between two age-hardened Al-0.5Mg-0.4Si(wt.%)alloys with and without *** first significant effect of Sc-addition on the precipitation microstructure of the Al-Mg-Si-Sc alloy is that Sc-atoms may distribute at theβ"-precipitate/Al-matrix interface and therefore accelerate aging kinetics at the initial stage of *** second significant effect of Sc-addition is that in the transition from theβ"-hardened peak-age stage to theβ′-hardened late stage,Sc-atoms can greatly improve the stability of transitionalβ"/B'/β′composite precipitates by entering the B'-substructures and/or locating at the precipitate/Al *** such Sc-atoms effectively suppressβ"toβ'transformation and cross-sectional coarsening of bothβ"and composite precipitates,leading to much finer precipitate needles with smaller diameter but much larger length,as compared with those precipitate needles formed in the alloy without ***,the alloy with Sc-addition exhibits a much better thermal stability than that without Sc.

关键词： Al alloy Strengthening mechanism Phase transition Transmission electron microscopy

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Structures and formation mechanisms of dislocation-induced precipitates in relation to the age-hardening responses of Al-Mg-Si alloys

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Journal of Materials Science & Technology 2020年第6期41卷 127-138页

作者： y.x.lai W.Fan M.J.yin C.L.Wu J.H.Chen Center for High-Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha 410082China Electron Microscopy Center Shenzhen UniversityShenzhen 518060China

In the slightly deformed Al-Mg-Si alloys,dislocation-induced precipitates are frequently observed,and they usually line up,forming sophisticated precipitation *** atomic-resolution electron microscopy in association with hardness measurements,we systematically investigated these precipitates in relation to the age-hardening responses of the *** study reveals that the majority of dislocation-induced complex precipitates are actually short-range ordered while long-range disordered polycrystalline precipitates and multiphase composite precipitates,including polycrystalline U2 precipitates,B’/U2,B’-2/U2,B’/B’-2/U2 and’/U2 composite *** is suggested that the formation of these complex precipitates is mainly owing to a high nucleation rate and rapid growth of different precipitate phases parallel to the associated dislocation *** dislocation-induced precipitates consume more Mg than Si from the matrix and have a high formation kinetics,they will have different impacts on the matrix precipitation in different types of Al-Mg-Si *** results further demonstrate that for the"normally-β"-hardened"alloy,their formation leads to a coarser precipitate microstructure in the matrix,whereas for the"normally-β’-hardened"alloy,their formation reverses the precipitation pathway in the matrix,resulting in a reduced age-hardening potential of the former alloy and an improved age-hardening potential of the latter alloy.

关键词： Al-Mg-Si alloys Precipitation Dislocation Age-hardening Electron microscopy

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Anisotropic Inter-granular Corrosion Behaviors and Microstructures of AlMgSiCu Alloy Sheets Made by Thermal–Mechanical Treatments

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Acta Metallurgica Sinica(English Letters) 2022年第2期35卷 275-284页

作者： L.M.Liu y.x.lai C.L.Wu Z.Zhang J.H.Chen Center for High-Resolution Electron Microscopy College of Materials Science and EngineeringHunan UniversityChangsha 410082China

This study investigates the microstructure and local corrosion behavior of an Al-Mg-Si-Cu alloy,which has been subjected to cold-rolling with different deformation strain ratios(DSRs)and followed by artificial *** corrosion tests show that peak-aged samples with a small DSR(5-10%)are sensitive to inter-granular corrosion(IGC)along both the normal and rolling *** the DSR increases to medium strength(20-40%),IGC sensitivity decreases along both directions and corrosion propagates *** the DSR is 60-80%,IGC sensitivity along the normal direction continues to decrease,but increases along the rolling direction,indicating pronounced corrosion *** characterization reveals the decreased IGC sensitivity is mainly attributed to a reduction in element segregation at high-angle grain boundaries and the kinked and discontinuous grain boundary corrosion *** increased IGC sensitivity along the rolling direction could be related to the significantly flattened grains.

关键词： Al alloys Local corrosion Anisotropy Transmission electron microscopy(TEM) Electron backscattering diffraction(EBSD)

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Atomic-scale roles of Zn element in age-hardened AlMgSiZn alloys

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Journal of Materials Science & Technology 2021年第11期70卷 105-112页

作者： N.N.Jiao y.x.lai S.L.Chen P.Gao J.H.Chen Center for High-Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha410082China Electron Microscopy Laboratory and International Center for Quantum Materials School of PhysicsPeking UniversityBeijing100871China

Adding alloying elements to improve the performances or the manufacturing processes of Al-Mg-Si alloys has long been a serious issue in developing advanced automotive aluminum *** Zn element,among those promising ones,has demonstrated positive alloying effects on Al-Mg-Si ***,the atomic-scale roles of Zn in an age-hardened Al-Mg-Si-Zn alloy have not been adequately *** atomic-resolution electron microscopy,here we report the precise locations of Zn elements in all hardening precipitates involved and their alloying mechanism at the atomic scale when alloying the *** results show that Zn atoms enter all the major hardening phases to occupy specific featured atomic sites of the original elements,*** Si1 and Mg2 sites in theβ’-2 phase,and modify their crystal structures,interfacial structures and morphologies in characteristic *** is revealed that for theβ’-phase,Zn atoms occupy unique atomic sites,whereas for other phases,they demonstrate similar behaviors as other additive alloying elements such as Ag and Cu do.

关键词： Al-Mg-Si alloy Zn addition Precipitate Electron microscopy

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Population-Based and Personalized Design of Total Knee Replacement Prosthesis for Additive Manufacturing Based on Chinese Anthropometric Data

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Engineering 2021年第3期7卷 386-394页

作者： C.S.Chui K.S.Leung J.Qin D.Shi P.Augat R.M.y.Wong S.K.H.Chow x.y.Huang C.y.Chen y.x.lai P.S.H.yung L.Qin W.H.Cheung Department of Orthcpaedics and Traumatology Faculty of MdicineThe Chinese University of Hong KongHong Kong 999077China Genter for Transiational Medicine Resarch and Development herzhet Institues of Advaned TechnologyChinese Academy of ScenesShenzhen 518055China Department of Orthopedirs and Traumatology Nanjing Drum Tower Hospital The Affiliated HospitalNanjing University Medial SchoolNanjing 210008China Institute for Biomechanics Berufgenos senschaftliche Unfallklinik MurnauMurnanu am Staffelsee 82418Cermany Instinute for Biomechanic Paracelsus Medical University SazburgSatzburg 5020Austria

At present,most total knee replacement(TKR)prostheses on the market are designed according to the sizes of ***,extensive studies have indicated that human anatomies differ among different ethnicities.A number of reports have indicated that Chinese TKR patients do not match with available *** this study,computed tomography(CT)images of 52 knees of Chinese men and women were used for anthropometric *** and geometric measurements were definedand used for correlation *** parameters from the measurement results were *** geometries of knees were measured as coordinates.A deformable three-dimensional(3D)knee modelbased on anatomical coordinates correlating with the identified key parameters was generated.A pros-thesis was then designed according to the analyzed *** matching analysis,bone resectionanalysis,and cadaveric trials were conducted and compared with commercial products to validate theproposed *** femoral component designed by this study resulted in the highest accuracy(rootmean square point-to-surface(RMS PS),(1.08±0.20)mm)and lowest amount of resected bone volume(27412mm^(3))in comparison with two commercial knee *** study suggests a new approachfor population-based patient-specific femoral prosthesis design With a single,easilty acquired dimen-sion-namely,epicondyle width(ECW)-as input,a patient-specific femoral prosthesis can be designed according to the analyzed measured data and manufactured by additive manufacturing(AM)***,the reconstructed femoral condylar surface was compared with the femoral condylar surfacein the original CT scanning data The average RMS PS distance of the reconstructed femoral condylar surface among all data was(1.10±0.18)mm,which is comparable to other statistical shape modeling methods using multiple radiographs as input *** is a need to develop an anthropometric-based knee prosthesis for the Chinese *** on

关键词： Additive manufacturing Population-based design Total knee replacement Knee prosthesis Anthropometric measurement

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai xu Zhen Gu Hua yan Dingding Shen xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao xinyue Wang Shijie Su Weicheng Feng yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-xi lai Hua-Ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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Numerical Study of an Annular Gas Turbine Combustor with Dump Diffuser

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Journal of Thermal Science 1999年第1期8卷 59-64页

作者： J.x.Zhao y.B.lai DepartmentofPowerEngineering NanjingUniversityofAeronauticsandAstronautics210016NanjingChina Depar

A general numerical method is presented for calculating steady three-dimensional and two-phase turbulent reactive flows with a nonstaggered body-fitted coordinate system in an annular gas turbine combustor with the dump diffuser. The modified two-equation model and the EDC turbulent combustion model are used for the gas phase. The liquid phase equations are solved in a Lagrangian frame of reference by PSIC algorithm. The effect of different velocity profiles at the entry of the prediffuser on combustor flow characteristics is calculated.

关键词： numerical simulation annular combustor dump diffuser 3D body-fitted coordinate two phase combustion.

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Cauda equina syndrome with urinary retention as a postoperative complication of lumbar spine surgery:A case report

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World Journal of Clinical Cases 2025年第10期13卷 40-45页

作者： Kai-Wu yang Wei-Hong lai Da-Wei Huang Department of Urology Chiayi Christian HospitalChiayi 600566Taiwan Department of Neurosurgery Chiayi Christian HospitalChiayi 600566Taiwan

BACKGROUND Cauda equina syndrome(CES)is characterized by a group of symptoms that may be caused by inflammation,spinal cord compression,venous congestion,or *** syndrome is commonly an indication for surgical intervention but has not been determined as a postoperative complication following surgery for lumbar spine *** SUMMARy To report the case of a 54-year-old male patient who had CES following spinal surgery,with no obvious compression lesions found during re-exploration,suggesting that vascular insufficiency may have contributed to the ***,a series of urodynamic studies on bladder recovery patterns in such complications have also been *** Postoperative CES requires urgent imaging and exploration to rule out compression;noncompressive cases,including vascular insufficiency may performed conservative management.

关键词： Cauda equina syndrome Lumbar spine surgery Urinary retention Urodynamic study Postoperative complication Case report

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