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Substituent-regulated highly X-ray sensitive Os(Ⅵ)nitrido complex for low-toxicity radiotherapy

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Chinese Chemical Letters 2021年第1期32卷 158-161页

作者： mingkai Chen Xiaoting Huang Jie lai Li ma Tianfeng Chen Department of Chemistry Jinan UniversityGuangzhou 510632China

A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent *** the best of our knowledge,this is the first osmium-based coordination complex *** experimental results shown that this radiosensitizer induced G2/m cell cycle arrest mainly through induction of intracellular ROS overproduction.

关键词： Os(Ⅵ)nitrido Complex Radiotherapy Radiosensitizer G2/m cell cycle arrest

Comprehensive assessment on dynamic roof instability under fractured rock mass conditions in the excavation disturbed zone

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International Journal of minerals,metallurgy and materials 2009年第1期16卷 12-18页

作者： Xing-ping lai Fen-hua Ren yong-ping Wu mei-feng Cai Energy School Xi＇an University of Science ＆ Technology Xi＇an 710054 China School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Western mine ＆ Hazard Prevention China Ministry of Education Xi＇an 710054 China

The damage process of fractured rock mass showed that the fracture in rocks induced roof collapse in yangchangwan Coal mine, China. The rock mass was particularly weak and fractured. There occurred 6 large-scale dynamical roof falls in the excavation disturbed zone （EDZ） with the collapsing volume of 216 m^3. First, the field detailed geological environment, regional seismic dynamics, and dynamic instability of roadways were generally investigated. Second, the field multiple-index monitoring measurements for detecting the deep delamination of the roof, convergence deformation, bolt-cable load, acoustic emission （AE） characteristic parameters, total AE events, AE energy-releasing rate, rock mass fracture, and damage were arranged. Finally, according to the time-space-strength relations, a quantitative assessment of the influence of rock-mass damage on the dynamic roof instability was accomplished.

关键词： fractured rock mass excavation disturbed zone (EDZ) roof collapse acoustic emission (AE) quantitative assessment

Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins

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Neural Regeneration Research 2021年第6期16卷 1062-1067页

作者： Ning Liu Liang Zeng yi-ming Zhang Wang Pan Hong lai Department of Human Anatomy College of Basic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina Department of Radiology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina Department of Human Anatomy College of Basic MedicineShenyang Medical CollegeShenyangLiaoning ProvinceChina Department of Neurobiology of Jinzhou medical University JinzhouLiaoning ProvinceChina

Oxidative stress is currently considered to be the main cause of brain *** can improve oxidative stress under multiple pathological *** is therefore hypothesized that astaxanthin might have therapeutic effects on brain *** validate this hypothesis and investigate the underlying mechanisms,a mouse model of brain aging was established by injecting amyloid beta(Aβ)25-35(5μm,3μL/injection,six injections given every other day)into the right lateral *** 3 days of Aβ25-35 injections,the mouse models were intragastrically administered astaxanthin(0.1 mL/d,10 mg/kg)for 30 successive *** greatly reduced the latency to find the platform in the morris water maze,increased the number of crossings of the target platform,and increased the expression of brain-derived neurotrophic factor,synaptophysin,sirtuin 1,and peroxisome proliferator-activated receptor-γ coactivator 1α.Intraperitoneal injection of the sirtuin 1 inhibitor nicotinamide(500μm/d)for 7 successive days after astaxanthin intervention inhibited these *** findings suggest that astaxanthin can regulate the expression of synaptic proteins in mouse hippocampus through the sirtuin 1/peroxisome proliferator-activated receptor-γcoactivator 1αsignaling pathway,which leads to improvements in the learning,cognitive,and memory abilities of *** study was approved by the Animal Ethics Committee,China medical University,China(approval ***2019294)on January 15,2019.

关键词： brain aging cognitive factor hippocampus learning memory oxidative stress pathways synapse

A note on the discovery of a 2m_⊙ pulsar

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Research in Astronomy and Astrophysics 2011年第6期11卷 687-691页

作者： Xiao-yu lai Ren-Xin Xu School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

It is conventionally thought that the state equation of dense matter softens and thus cannot result in high maximum mass if pulsars are quark stars and that a recently discovered 2m⊙ pulsar （PSR J1614–2230） may make pulsars unlikely to be quark stars. However, this standard point of view would be revisited and updated if quark clustering could occur in cold quark matter because of the strong coupling be- tween quarks at realistic baryon densities in compact stars. It can be argued that the state equation of clustered quark matter stiffens to support compact stars with maxi- mum mass mmax 2m⊙. In this brief note, it is demonstrated that large parameter space ranges are allowed for mmax 2m⊙ in a Lennard-Jones model of clustered quark matter and the newly measured highest mass of PSR J1614–2230 would be meaningful for constraining the number of quarks inside a single quark-cluster to be Nq ≤ 103.

关键词： dense matter — elementary particles — pulsars: general — stars: neutron

Strong-field photoelectron holography in the subcycle limit

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Light(Science & Applications) 2024年第6期13卷 1032-1040页

作者： Tsendsuren Khurelbaatar Jaewuk Heo ShaoGang yu Xuanyang lai XiaoJun Liu Dong Eon Kim Center for Attosecond Science and Technology Department of PhysicsPohang University of Science and TechnologyPohangGyeongbuk37673Korea max Planck POSTECH/KOREA Research Initiative PohangGyeongbuk37673Korea State Key Laboratory of magnetic Resonance and Atomic and molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences430071WuhanChina Wuhan Institute of Quantum Technology 430206WuhanChina

Strong-field photoelectron holography is promising for the study of electron dynamics and structure in atoms and molecules,with superior spatiotemporal resolution compared to conventional electron and X-ray ***,the application of strong-field photoelectron holography has been hindered by inter-cycle interference from multicycle ***,we address this challenge by employing a near-single-cycle field to suppress the inter-cycle *** observed and separated two distinct holographic patterns for the first *** measurements allow us not only to identify the Gouy phase effect on electron wavepackets and holographic patterns but also to correctly extract the internuclear separation of the target molecule from the holographic *** work leads to a leap jump from theory to application in the field of strong-field photoelectron holography-based ultrafast imaging of molecular structures.

关键词： photoelectron holographic cycle

New photo-thermal-synthesized polymer for self-compacting concrete to increase productivity, minimize pollution, and eliminate steam curing in precast concrete

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Journal of Harbin Institute of Technology(New Series) 2006年第5期13卷 518-524页

作者： F. C. lai m. F. mohd Zain 王宝民 K. C. Lee Dept. of Civil and Structural Engineering Faculty of Engineering Universiti Kebangsaan Malaysia 43600 U.K.M Bangi Selangor Darul Ehsan Malaysia Dept. of Civil Engineering Dalian University of Technology Dalian 116024 China Sime Darby Technology Petaling Jaya Kuala Lumpur Malaysia

The objective in this study is to apply the sustainable chemistry and photo-thermal synthesis technology to produce the sustainable eco-superplasticiser for the sustainable high performance SCC concrete especially in hot tropical countries. A photo-thermal synthesized eco-superplasticiser （PSES） was produced by using photo-thermal catalyst in a solar chemical reactor. In this preliminary study, an unique high early strength of SCC concrete has been successfully produced by imposing an unique proportion of the photo-thermal-synthesized eco- Superplasticiser （PSES）, local fly ash, sand and aggregate. The SCC concrete is preliminary tried in the precast concrete product to produce the complicated geometries as Tunnel segment, U-shape beam, and Box girder which have the critical reinforcement and thin section concrete. Surprisingly, this SCC provide the benefits as eliminating steaming energy, increased productivity, and minimize pollution. These unique properties of sustainable SCC concrete can not be achieved by the convention concrete by using ligno, naphthalene and melamine base superplasficiser. The synthesized sustainable eco-superplasticiser is a perfect choice to fully utilized the renewable energy and improve the concrete working environment.

关键词： photo-chemical synthesis sustainable self-compacting concrete eco-superplasticiser eliminate steaming renewable solar energy

Decentralized mPC-Based Trajectory Generation for multiple Quadrotors in Cluttered Environments

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Guidance, Navigation and Control 2021年第2期1卷 40-59页

作者： Xinyi Wang Lele Xi yizhou Chen Shupeng lai Feng Lin Ben m.Chen Department of mechanical and Automation Engineering The Chinese University of Hong KongShatinN.T.Hong Kong School of Automation Beijing Institute of TechnologyBeijingP.R.China Peng Cheng Laboratory NanshanShenzhenGuangdongP.R.China

Challenges in motion planning for multiple quadrotors in complex environments lie in overall°ight e±ciency and the avoidance of obstacles,deadlock,and collisions among *** this paper,we present a gradient-free trajectory generation method for multiple quadrotors in dynamic obstacle-dense environments with the consideration of time consumption.A model predictive control(mPC)-based approach for each quadrotor is proposed to achieve distributed and asynchronous cooperative motion ***,the motion primitives of each quadrotor are formulated as the boundary state constrained primitives(BSCPs)which are constructed with jerk limited trajectory(JLT)generation method,a boundary value problem(BVP)solver,to obtain time-optimal *** are then approximated with a neural network(NN),pre-trained using this solver to reduce the computational *** NN is used for fast evaluation with the guidance of a navigation function during optimization to guarantee°ight safety without ***,the reference trajectories are generated using the same BVP *** simulation and experimental results demonstrate the superior performance of the proposed method.

关键词： multi-quadrotor systems motion planning motion primitive model predictive control

Synthesis and Crystal Structure of Dinuclear Copper Complex [Cu(CH_2O(C_6H_4)N=C(C_6H_4)O)(Py)]_2

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Chinese Journal of Structural Chemistry 2002年第1期21卷 55-59页

作者： NIU De-Zhong mU lai-Long LU Zai-Sheng WANG yu-Cheng Department of Chemistry Xuzhou Normal UniversityJiangsu 221009China Fujian Institute of Research on the Structure of matter Chinese Academy of Sciences Fuzhou350002China

The complex [Cu2L2(Py)2] (H2L=2-aminobenzoic alcohol condensation salicylaldehyde) was obtained. A single-crystal X-ray study shows that the complex is a binuclear compound (Cu2C38H32N4O4). The coordination geometry about each copper atom is best described as a distorted square pyramid. The compound [Cu2L2(Py)2] belongs to monoclinic system with space group P21, lattice constants: a = 10.3881(1), b = 17.9724(1), c = 17.5800(2) ? b =90.4880(1), V= 3282.05(5) 3, Z= 4, mr =735.75, Dc=1.489 g/cm3, m= 1.344mm-1, F(000) = 1512, R=0.0519, wR=0.1092 for 6725 reflections with I >2s(I). The distances between Cu(II) and O atoms are range from 1.898(6) to1.976(5)? between Cu(II) and N atoms are range from 1.990(6) to 2.369(7)? The Cu(1)Cu(2) bond length is 3.024(4) ?

关键词： copper (II) 2-aminobenzoic alcohol salicylaldehyde pyridine crystal structure

A revisited security evaluation of Simeck family ciphers against impossible differential cryptanalysis

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Science China(Information Sciences) 2023年第3期66卷 297-298页

作者： Kai ZHANG Xuejia lai Lei WANG Jie GUAN Bin HU PLA SSF Information Engineering University Department of Computer Science and Engineering Shanghai Jiao Tong University

Simeck is a family of lightweight block ciphers proposed at CHES 2015 [1]. The round function and key schedule of Simeck were inspired by SImON and SPECK, which were proposed by the U.S. National Security Agency in *** with these two lightweight ciphers, Simeck has a more compact hardware implementation. In addition,

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