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Backend Process for Cylindrical Ru/Ta2O5/Ru Capacitor for Future DRAM

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Backend Process for Cylindrical Ru/Ta2O5/Ru Capacitor for Fu...

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

2001 6～(th) International Conference on Solid-State and Integrated Circuit Technology

作者： J.Lin T.Suzuki H.Minakata A.Shimada K.Tsunoda M.Fukuda T.Kurahashi y.Fukuzumi A.Hatada A.Sato P.H.Sun y.ishibashi H.Tomita N.Nishikawa E.Ito W.C.Liu C.M.Chu R.Suzuki M.Nakabayashi D.Matsunaga K.Hieda K.Hashimoto S.Nakamura y.Kohyama C.M.Shiah Technology Development Division Fujitsu Limited Fujitsu Laboratories Limited Memory LSI R&D Center Toshiba Corporation DRAM Process Integration and Module Technology Department Winbond Electronics Corporation Process&Manufacturing Engineering Center Toshiba Corporation

A novel backend process is developed for thecylindrical Ru/TaO/Ru capacitor for 130nm generationDRAMs to achieve good electrical *** gas(3%H/97%N)anneal(FGA) induceddegradation can be effectively *** thecylindrical Ru/TaO/Ru capacitor with full backendprocesses,including passivation layer formation and aFGA,the cell leakage current and cell capacitance are1fA(at±0.8V at 85℃)and 15fF,respectively.

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Prototyping low-cost automatic weather stations for natural disaster monitoring

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Digital Communications and Networks 2023年第4期9卷 941-956页

作者： Gabriel F.L.R.Bernardes Rogerio ishibashi Andre A.S.Ivo Valerio Rosset Bruno y.L.Kimura Institute of Science and Technology Federal University of Sao Paulo(ICT/UNIFESP)Sao Jose dos CamposSPBrazil Brazilian National Center for Monitoring and Early Warnings of Natural Disasters(Cemaden) Sao Jose dos CamposSPBrazil

Weather events put human lives at risk mostly when people might occupy areas susceptible to natural *** Professional Weather Stations(PWS)in vulnerable areas is key for monitoring weather with reliable ***,such professional instrumentation is notably expensive while remote sensing from a number of stations is *** imposes challenges on the large-scale weather station deployment for broad monitoring from large observation networks such as in Cemaden—The Brazilian National Center for Monitoring and Early Warning of Natural *** this context,in this paper,we propose a Low-Cost Automatic Weather Station(LCAWS)system developed from Commercial Off-The-Shelf(COTS)and open-source Internet of Things(IoT)technologies,which provides measurements as reliable as a reference PWS for natural disaster *** being automatic,LCAWS is a stand-alone photovoltaic system connected wirelessly to the Internet in order to provide real-time reliable end-to-end weather *** achieve data reliability,we propose an intelligent sensor calibration method to correct *** a 30-day uninterrupted observation with sampling in minute resolution,we show that the calibrated LCAWS sensors have no statistically significant differences from the PWS *** such,LCAWS has opened opportunities for reducing maintenance costs in Cemaden's observational network.

关键词： Wireless automatic weather station Low-cost weather instrumentation Natural disaster monitoring Intelligent sensor calibration Internet of things

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen CS De Oliveira Luiz C Di Stasi Ligia y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Expression analyses of stress‑responsive genes in the hermatypic coral Acropora tenuis and its symbiotic dinofagellates after exposure to the herbicide Diuron

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Marine Life Science & Technology 2023年第3期5卷 289-299页

作者： Hiroshi ishibashi Seigo Minamide Ichiro Takeuchi Graduate School of Agriculture Ehime UniversityMatsuyamaEhime 790-8566Japan Center of Advanced Technology for the Environment Graduate School of AgricultureEhime UniversityMatsuyamaEhime 790-8566Japan

Diuron is one of the most frequently applied herbicides in sugarcane farming in southern Japan,and *** addition,it is used as a booster substance in copper-based antifouling *** to these various uses,Diuron is released into the marine environment;however,little information is available on gene expression in corals and their symbiotic algae exposed to *** investigated the efects of Diuron on stress-responsive gene expression in the hermatypic coral Acropora tenuis and its symbiotic *** seven days of exposure to 1µg/L and 10µg/L Diuron,no signifcant changes in the body colour of corals were ***,quantitative reverse transcription-polymerase chain reaction analyses revealed that the expression levels of stress-responsive genes,such as heat shock protein 90(HSP90),HSP70,and calreticulin(CALR),were signifcantly downregulated in corals exposed to 10µg/L of Diuron for seven ***,aquaglyceroporin was signifcantly downregulated in corals exposed to environmentally relevant concentrations of 1µg/L *** contrast,no such efects were observed on the expression levels of other stress-responsive genes,such as oxidative stress-responsive proteins,methionine adenosyltransferase,and green/red fuorescent *** exposure had no signifcant efect on the expression levels of HSP90,HSP70,or HSP40 in the symbiotic *** results suggest that stress-responsive genes,such as HSPs,respond diferently to Diuron in corals and their symbiotic dinofagellates and that *** HSPs and CALRs may be useful molecular biomarkers for predicting stress responses induced by the herbicide Diuron.

关键词： Acropora tenuis Calreticulin Coral bleaching Diuron Heat shock protein

Automated stopping criterion for spectral measurements with active learning

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npj Computational Materials 2021年第1期7卷 1252-1260页

作者： Tetsuro Ueno Hideaki ishibashi Hideitsu Hino Kanta Ono Synchrotron Radiation Research Center Kansai Photon Science InstituteQuantum Beam Science Research DirectorateNational Institutes for Quantum and Radiological Science and TechnologySayoHyogoJapan Department of Human Intelligence Systems Graduate School of Life Science and Systems EngineeringKyushu Institute of TechnologyKitakyushuFukuokaJapan The Institute of Statistical Mathematics Research Organization of Information and SystemsTachikawaTokyoJapan Department of Applied Physics Graduate School of EngineeringOsaka UniversitySuitaOsakaJapan Center for Integrative Quantum Beam Science Institute of Materials Structure ScienceHigh Energy Accelerator Research OrganizationTsukubaIbarakiJapan

The automated stopping of a spectral measurement with active learning is *** optimal stopping of the measurement is realised with a stopping criterion based on the upper bound of the posterior average of the generalisation error of the Gaussian process *** is revealed that the automated stopping criterion of the spectral measurement gives an approximated X-ray absorption spectrum with sufficient accuracy and reduced data *** proposed method is not only a proof-of-concept of the optimal stopping problem in active learning but also the key to enhancing the efficiency of spectral measurements for highthroughput experiments in the era of materials informatics.

关键词： criterion spectral optimal

Hydro-mechanical-electrical simulations of synthetic faults in two orthogonal directions with shear-induced anisotropy

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第11期16卷 4428-4439页

作者： Kazuki Sawayama Takuya ishibashi Fei Jiang Takeshi Tsuji Institute for Geothermal Sciences Kyoto UniversityBeppuJapan Fukushima Renewable Energy Institute AISTKoriyamaJapan Department of Engineering Yamaguchi UniversityUbeJapan School of Engineering University of TokyoTokyoJapan

Fluid flow in fractures controls subsurface heat and mass transport,which is essential for developing enhanced geothermal systems and radioactive waste *** permeability is controlled by fracture microstructure(***,roughness,and tortuosity),but in situ values and their anisotropy have not yet been *** advances in geophysical techniques allow the detection of changes in electrical conductivity due to changes in crustal stress and these techniques can be used to predict subsurface fluid ***,the paucity of data on fractured rocks hinders the quantitative interpretation of geophysical monitoring data in the ***,considering different shear displacements and chemical erosions,an investigation was conducted into the hydraulic-electric relationship as an elevated stress change in *** simulation of fracture flows was achieved using the lattice Boltzmann method,while the electrical properties were calculated through the finite element method,based on synthetic faults incorporating elastic-plastic *** results show that the hydraulic and electrical properties depend on the rock's geometric properties(*** length,roughness,and shear displacement).The permeability anisotropy in the direction parallel or perpendicular to the shear displacement is also notable in high stress ***,the permeability econductivity(i.e.,formation factor)relationship is unique under all conditions and follows a linear trend in logarithmic ***,both matrix porosity and fracture spacing alter this *** increase the slope of the linear trend,thereby changing the sensitivity of electrical observations to permeability changes.

关键词： Fracture flow Permeability Electrical conductivity Lattice Boltzmann method Anisotropy Chemical erosion Enhanced geothermal system