检索结果-南通市图书馆

Absorption Spectroscopy of （8,1） Band in d^3△-a^3П System of CS Radical

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2012年第5期25卷 513-518,I0003页

作者： Chuan-liang Li Lun-hua Deng Yan Zhang ji-lin Wei Ya ng-qin Chen Department of Physics School of Applied ScienceTaiyuan University of Science and TechnoloEyTaiyuan 030024China State Key Laboratory of Precision Spectroscopy and Department of Physics East China NormalUniversityShanghai 200052China

The CS radical was generated by discharging the mixture gas of CS2 and Helium. The Doppler limited spectra of CS were recorded in the region of 12350-12950 cm^-1 using optical heterodyne concentration modulation absorption spectroscopy. Three hundred and twenty-six lines were recorded and assigned to the d^3△-a^3П （8,1） band, in which eighty-three transitions were first observed. A set of improved molecular constants for the d^3△（v=8） and a^3П（v=1） levels were determined by a non-linear least-squares fitting of all the lines to the effective Hamiltonian.

关键词： CS radical Concentration modulation absorption spectroscopy Molecularconstant

Inokosterone Is a Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients:Analysis from Active Ingredient of Cyathula Officinalis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2021年第10期27卷 767-773页

作者： MO ji-hao XIE Han-kun ZHOU Ye-mian ng Sihan-benjamin LI Shao-xia WAng Lei Department of Medical Laboratory Luoyang Orthopedic Hospital of Henan ProvinceOrthopedic Institute of Henan ProvinceLuoyangHenan Province(471002)China Miller School of Medicine University of Miami(33136)MiamiFLUSA Institute of Technical Biology&Agriculture Engineering Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei(230031)China Eatobe Pte.Limited(573969) Singapore

Objective:To elucidate the active compounds and the molecular mechanism of Cyathula Off/c/na//s as a drug treatment for rheumatoid arthritis(RA).Methods:The target genes of active ingredients from Cyathula Officinalis were obtained from bioinformatics analysis tool for the molecular mechanism of traditional Chinese *** protein-protein interaction between the target genes were analyzed using STRIng and *** transcriptome of RA patients compared to healthy people(GSE121894)were analyzed using R program package *** relative expression of the target genes was obtained from the RNA-seq *** molecular docking analyses were processed based on the molecular model of estrogen receptor 1(ESR1)binding with estradiol(PDB ID:1A52).The binding details were analyzed by ***:Inokosterone,ecdysterone,and cyaterone were the 3 active ingredients from Cyathula Officinalis that bind to target *** all the significantly changed genes from RA patients,ESR1,ADORA1,and ANXA1 were significantly increased in mRNA samples of RA ***:ESR1,the transcription factor that binds inokosterone in the molecular binding analysis,is the target protein of Cyathula Officinalis.

关键词： rheumatoid arthritis estrogen receptor 1 inokosterone Cyathula Officinalis Chinese medicine

Adsorption/Desorption of Low-density Lipoprotein on a Heparinized Surface of Gold Sensors

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2012年第2期28卷 323-328页

作者： LAN Ping ji jing HUAng Xiao-Jun GUDURU Deepak GROTH Thomas VIENKEN Jorg D1ng Hui College of Materials and Textiles Jiaxing UniversityJiaxing 314001P.R.China Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027P.R.China Biomedical Materials Group Department of Pharmaceutics and BiopharmaeeuticsInstitute of PharmacyMartin Luther University Halle-WittenbergHalle(Saale)06120Germany Fresenius Medical Care of Deutschland GmbH BioSciences DepartmentBad Homburg 61352Germany College of Mathematics Physics and Information Engineering Jiaxing UniversityJiaxing 314001P.R.China

Heparin has been considered to be a potentially useful ligand for low-density lipoprotein（LDL） detection and analysis in a clinical *** order to construct an affinity surface for preferential adsorption of LDL,heparin-modified gold surface（GS-Hep） was fabricated by a self-assembling method and hydrophobic-modified gold surfaces（GS-Hydro） was used as a *** morphologies of the modified gold surfaces were investigated by atomic force microscopy（AFM） and the quantity of heparin bound to gold surface was assayed by the toluidine blue（TB） colorimetric *** contact angles were determined to investigate wettability on GS-Hep and *** plasmon resonance（SPR） technique was used subsequently to detect the selective binding of LDL with *** the investigation on the effect of pH on LDL adsorption suggests that lower pH lead to higher quantities of LDL adsorption on *** with GS-Hydro,GS-Hep is selective for LDL from both single and binary protein ***,adsorbed LDL on GS-Hep could be washed off by injecting elution solution,such as NaCl solution,for the purpose of the regeneration of GS-Hep for further LDL adsorption.

关键词： Adsorption/desorption Low-density lipoprotein(LDL) Heparinized surface Surface plasmon resonance

变分模态分解方法及其在滚动轴承早期故障诊断中的应用

在线全文

学校读者我要写书评

暂无评论

振动工程学报 2016年第4期29卷 638-648页

作者：唐贵基王晓龙华北电力大学能源动力与机械工程学院河北保定071003

介绍了一种自适应信号分解新方法——变分模态分解(Variational mode decomposition,VMD),并且针对滚动轴承早期故障识别困难这一问题,提出了基于VMD的诊断方法。首先通过基于分数高斯噪声的数值模拟试验对VMD方法的等效滤波特性进行研... 详细信息

介绍了一种自适应信号分解新方法——变分模态分解(Variational mode decomposition,VMD),并且针对滚动轴承早期故障识别困难这一问题,提出了基于VMD的诊断方法。首先通过基于分数高斯噪声的数值模拟试验对VMD方法的等效滤波特性进行研究,验证了其类似于小波包分析的频域剖分特性,继而分析了惩罚因子及分量个数的设置对VMD方法滤波特性的影响。为了在轴承故障检测过程中,减少人为主观选择影响参数存在的弊端,提出了基于包络谱特征因子(Feature factor of envelope spectrum,EFF)的影响参数自动搜寻策略,最后通过仿真信号及试验信号对所述方法进行验证。分析结果表明:该方法能够有效提取轴承早期故障信号中的微弱特征信息,实现故障类型的准确判别。

关键词：故障诊断滚动轴承早期故障变分模态分解等效滤波特性

Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2017年第10期15卷 775-784页

作者： WAng Shu-Yao A ji-Ye FEI Fei GEng jian-Liang PEng Ying OUYAng Bing-Chen WAng Pei jiN Xiao-Liang ZHAO Yu-Qing WAng jian-Kun GEng Ting LI Yan-jing HUA ng Wen-Zhe WAng Zhen-Zhong XIAO Wei WAng Guang-ji School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China jiangsu Kanion Modern Chinese Medicine Institute Nanjing 210017 China State Key Labonatory of Pharmaceutical New-Techfor Chinese Medicine Jiangsu Kanion Pharmaceutical Co. Ltd. Lianyungang222001 China Key Lab of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009 China

Ginkgo diterpene lactones meglumine injection(GDLI)is a commercially available product used for ***,the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI,i.e.,ginkgolide A(GA),ginkgolide B(GB),and ginkgolide K(GK),have never been fully evaluated in beagle *** this work,a simple,sensitive,and reliable method based on ultra-fast liquid chromatography-tandem mass spectrometry(UFLC-MS/MS)was developed,and the prototypes and total amounts of GA,GB,and GK were determined in beagle dog *** plasma concentrations of the hydrolyzed carboxylic forms were calculated by subtracting the prototype concentrations from the total lactone *** the first time,the pharmacokinetics of GA,GB,and GK were fully assessed in three forms,i.e.,the prototypes,the hydrolyzed carboxylic forms,and the total amounts,after intravenous administration of GDLI in beagle *** was shown that ginkgolides primarily existed in the hydrolyzed form in plasma,and the ratio of hydrolysates to prototype forms of GA and GB decreased gradually to a homeostatic *** of the three forms of the three ginkgolides showed linear exposure of AUC to the ***,GB,and GK showed a constant half-life approximately 2.7,3.4,and 1.2 h,respectively,which were consistent for the forms at three dose levels(0.3,1.0,and 3.0 mg·kg^(-1))and after a consecutive injection of GDLI for 7 days(1.0 mg·kg^(-1)).

关键词： Hydrolysates of ginkgolides LC-MS/MS Pharmacokinetics Ginkgo diterpene lactones Beagle dog

在线全文

学校读者我要写书评

暂无评论

西方消费文化理论研究的发展、演变与反思

消费经济 2005年第6期21卷 84-88页

作者：蒋建国中国人民大学新闻学院北京100872

西方消费文化理论运用了社会学、哲学、历史学、政治学等跨学科研究方法,经历了传统社会、现代社会到后现代社会的深刻变化,形成了炫耀性消费、符号消费等诸多理论,对其进行全面评述,并加以批判性运用,是当前西方消费文化研究的重要任务。

关键词：西方消费文化评述反思

在线全文

学校读者我要写书评

暂无评论

科技成果转化的理性思考

科研管理 2019年第5期40卷 175-181页

作者：文剑英江苏大学马克思主义学院江苏镇江212013

知识经济时代凸显了知识和经济的相关性,同时也加剧了知识生产和使用间的矛盾。推动科技成果转化,是走出知识悖论、增加科学技术的社会福祉的必由之路。然而科技成果转化并非径情直遂。经验研究和理论分析均表明,若要科技成果转化真正... 详细信息

知识经济时代凸显了知识和经济的相关性,同时也加剧了知识生产和使用间的矛盾。推动科技成果转化,是走出知识悖论、增加科学技术的社会福祉的必由之路。然而科技成果转化并非径情直遂。经验研究和理论分析均表明,若要科技成果转化真正取得成效,其先决条件是保持知识和人才的自由流动、提升大学的内在品质和提高学院科学研究的卓越性。

关键词：科技成果转化知识悖论

Nomore blind dates with calcite: Fluid-flow vs. fault-slip along the Očkov thrust, Prague Basin

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2021年第4期12卷 163-174页

作者： Nick M.W.Roberts jiříŽák František Vacek jiříSláma Geochronology and Tracers Facility British Geological SurveyEnvironmental Science CentreNottingham NG125GGUK Institute of Geology and Paleontology Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic Department of Mineralogy and Petrology National MuseumVáclavskénáměstí68Prague 11579Czech Republic Institute of Geology Czech Academy of Sciencesv.v.i.Rozvojová269Prague 16500Czech Republic

Dating of fracture-filling calcitewith U-Pb geochronology is becoming a rapidly adopted technique for determining the absolute timing of brittle deformation in the upper *** calcite is a desirable target,as it precipitates between individual fault slip displacement events,and provides additional kinematic *** we present a case study of slickenfibres formed on the Očkov thrust in the Lower Palaezoic Prague Basin,Bohemian Massif,utilising a combination of petrographic and in situ *** demonstrate that slickenfibre external textures can be preserved,whilst internally primary textures are removed by fluid infiltration and recrystallization,leading to variable U and Pb *** slickenfibre yielded a date of ca.250 Ma,which we interpret as recording fault slip along the Očkov *** cross-cutting slickenfibre yielded more scattered U-Pb data,with an imprecise apparent age around ca.95 *** slickenfibre is recrystallised,destroying the primary textures,and exhibits element *** meaning of this younger apparent age is therefore questionable;whereas it likely reflects Cretaceous U and Pb mobility assisted by fluid-flow along the fault plane,it may not reflect a period of fault *** results demonstrate that slickenfibre-based U-Pb dates do not unequivocally relate to fault motion,and that petrographic and elemental analyses are important requirements for interpreting calcite U-Pb data.

关键词： U-Pb geochronology Calcite Fault dating Fluid-flow Prague Basin LA-ICP-MS

Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2022年第1期20卷 110-128页

作者： Sue Yu jia Li Guanxu ji Zhen Long ng jiamin Siew Wan Ning Lo Ying Ye Yuan Yuan Chew Yun Chau Long Wensheng Zhang Ernesto Guccione Yuin Han Loh Zhi-Hong jiang Henry Yang Qiang Wu Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Cancer Science Institute of Singapore Centre for Translational MedicineSingapore 117599Singapore The State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao Special Administrative Region 999078China Cam-Su Genomic Resource Center Soochow UniversitySuzhou 215123China Institute of Molecular and Cell Biology Singapore 138673Singapore

Chromatin modification contributes to pluripotency maintenance in embryonic stem cells(ESCs).However,the related mechanisms remain ***,we show that Npac,a"reader"of histone H3 lysine 36 trimethylation(H3K36me3),is required to maintain mouse ESC(mESC)pluripotency since knockdown of Npac causes mESC *** of Npac in mouse embryonic fibroblasts(MEFs)inhibits reprogramming ***,our chromatin immunoprecipitation followed by sequencing(ChIP-seq)results of Npac reveal that Npac co-localizes with histone H3K36me3 in gene bodies of actively transcribed genes in ***,we find that Npac interacts with positive transcription elongation factor b(p-TEFb),Ser2-phosphorylated RNA PolⅡ(RNA PolⅡSer2P),and Ser5-phosphorylated RNA PolⅡ(RNA PolⅡSer5 P).Furthermore,depletion of Npac disrupts transcriptional elongation of the pluripotency genes Nanog and *** together,we propose that Npac is essential for the transcriptional elongation of pluripotency genes by recruiting p-TEFb and interacting with RNA PolⅡSer2P and Ser5P.

关键词： Npac Pluripotency Reprogramming Histone H3K36me3 Transcriptional elongation