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Extrapolating neurogenesis of mesenchymal stem/stromal cells on electroactive and electroconductive scaffolds to dental and oral-derived stem cells

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International Journal of Oral Science 2022年第2期14卷 123-131页

作者： Boon Chin Heng Yunyang Bai Xiaochan Li Xuehui Zhang xuliang deng Central Laboratory Peking University School and Hospital of StomatologyBeijingChina School of Medical and Life Sciences Sunway UniversitySubang JayaSelangor Darul EhsanMalaysia Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingChina Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingChina National Engineering Laboratory for Digital and Material Technology of Stomatology NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina

The high neurogenic potential of dental and oral-derived stem cells due to their embryonic neural crest origin,coupled with their ready accessibility and easy isolation from clinical waste,make these ideal cell sources for neuroregeneration therapy.Nevertheless,these cells also have high propensity to differentiate into the osteo-odontogenic lineage.One strategy to enhance neurogenesis of these cells may be to recapitulate the natural physiological electrical microenvironment of neural tissues via electroactive or electroconductive tissue engineering scaffolds.Nevertheless,to date,there had been hardly any such studies on these cells.Most relevant scientific information comes from neurogenesis of other mesenchymal stem/stromal cell lineages(particularly bone marrow and adipose tissue)cultured on electroactive and electroconductive scaffolds,which will therefore be the focus of this review.Although there are larger number of similar studies on neural cell lines(i.e.PC12),neural stem/progenitor cells,and pluripotent stem cells,the scientific data from such studies are much less relevant and less translatable to dental and oral-derived stem cells,which are of the mesenchymal lineage.Much extrapolation work is needed to validate that electroactive and electroconductive scaffolds can indeed promote neurogenesis of dental and oral-derived stem cells,which would thus facilitate clinical applications in neuroregeneration therapy.

关键词： mesenchymal conductive neural

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Diffusionmodels for time-series applications: a survey

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 19-41页

作者： Lequan LIN Zhengkun LI Ruikun LI xuliang LI Junbin GAO Discipline of Business Analytics The University of Sydney Business SchoolCamperdownNSW 2006Australia Postdoctoral Programme of Zhongtai Securities Co. Ltd.Jinan 250000China

Diffusion models, a family of generative models based on deep learning, have become increasinglyprominent in cutting-edge machine learning research. With distinguished performance in generating samples thatresemble the observed data, diffusion models are widely used in image, video, and text synthesis nowadays. Inrecent years, the concept of diffusion has been extended to time-series applications, and many powerful models havebeen developed. Considering the deficiency of a methodical summary and discourse on these models, we providethis survey as an elementary resource for new researchers in this area and to provide inspiration to motivate futureresearch. For better understanding, we include an introduction about the basics of diffusion models. Except forthis, we primarily focus on diffusion-based methods for time-series forecasting, imputation, and generation, andpresent them, separately, in three individual sections. We also compare different methods for the same applicationand highlight their connections if applicable. Finally, we conclude with the common limitation of diffusion-basedmethods and highlight potential future research directions.

关键词： Diffusion models Time-series forecasting Time-series imputation Denoising diffusion probabilistic models Score-based generative models Stochastic differential equations

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Reduced-Order Observer-Based LQR Controller Design for Rotary Inverted Pendulum

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 305-323页

作者： Guogang Gao LeiXu Tianpeng Huang xuliang Zhao Lihua Huang College of Engineering China University of Petroleum-Beijing at KaramayKaramay834000China School of Electrical Engineering and Information Southwest Petroleum UniversityChengdu610500China

The Rotary Inverted Pendulum(RIP)is a widely used underactuated mechanical system in various applications such as bipedal robots and skyscraper stabilization where attitude control presents a significant challenge.Despite the implementation of various control strategies to maintain equilibrium,optimally tuning control gains to effectively mitigate uncertain nonlinearities in system dynamics remains elusive.Existing methods frequently rely on extensive experimental data or the designer’s expertise,presenting a notable drawback.This paper proposes a novel tracking control approach for RIP,utilizing a Linear Quadratic Regulator(LQR)in combination with a reduced-order observer.Initially,the RIP system is mathematically modeled using the Newton-Euler-Lagrange method.Subsequently,a composite controller is devised that integrates an LQR for generating nominal control signals and a reduced-order observer for reconstructing unmeasured states.This approach enhances the controller’s robustness by eliminating differential terms from the observer,thereby attenuating unknown disturbances.Thorough numerical simulations and experimental evaluations demonstrate the system’s capability to maintain balance below50Hz and achieve precise tracking below1.4 rad,validating the effectiveness of the proposed control scheme.

关键词： Rotary inverted pendulum(RIP) linear quadratic regulator(LQR) reduced-order observer states estimate

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The bioelectrical properties of bone tissue

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Animal Models and Experimental Medicine 2023年第2期6卷 120-130页

作者： Boon Chin Heng Yunyang Bai Xiaochan Li Yanze Meng Yanhui Lu Xuehui Zhang xuliang deng Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingPR China Central Laboratory Peking University School and Hospital of StomatologyBeijingPR China School of Medical and Life Sciences Sunway UniversitySubang JayaMalaysia Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingPR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingPeople's Republic of China

Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries,as well as improving the design and fabrication of scaffold implants for bone tissue engineering.The bioelectrical properties of bone tissue can be attributed to the interaction of its various cell lineages(osteocyte,osteoblast and osteoclast)with the surrounding extracellular matrix,in the presence of various biomechanical stimuli arising from routine physical activities;and is best described as a combination and overlap of dielectric,piezoelectric,pyroelectric and ferroelectric properties,together with streaming potential and electro-osmosis.There is close interdependence and interaction of the various electroactive and electrosensitive components of bone tissue,including cell membrane potential,voltage-gated ion channels,intracellular signaling pathways,and cell surface receptors,together with various matrix components such as collagen,hydroxyapatite,proteoglycans and glycosaminoglycans.It is the remarkably complex web of interactive cross-talk between the organic and non-organic components of bone that define its electrophysiological properties,which in turn exerts a profound influence on its metabolism,homeostasis and regeneration in health and disease.This has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering,to recapitulate the natural electrophysiological microenvironment of healthy bone tissue to facilitate bone defect repair.

关键词： bone dielectric electric ferroelectric homeostasis metabolism piezoelectric pyroelectric regeneration

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Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation

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Bioactive Materials 2023年第2期20卷 81-92页

作者： Xiaochan Li Boon Chin Heng Yunyang Bai Qianqian Wang Min Gao Ying He Xinwen Zhang xuliang deng Xuehui Zhang Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijing100081PR China Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijing100081PR China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing100081PR China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081PR China Center of Implant Dentistry School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang110002PR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical MaterialsPeking University School and Hospital of StomatologyBeijing100081PR China

Stem cells from human exfoliated deciduous teeth(SHED)uniquely exhibit high proliferative and neurogenic potential.Charged biomaterials have been demonstrated to promote neural differentiation of stem cells,but the dose-response effect of electrical stimuli from these materials on neural differentiation of SHED remains to be elucidated.Here,by utilizing different annealing temperatures prior to corona poling treatment,BaTiO_(3)/P(VDF-TrFE)ferroelectric nanocomposite membranes with varying charge polarization intensity(d_(33)≈0,4,12 and 19 pC N^(-1))were fabricated.Enhanced expression of neural markers,increased cell elongation and more prominent neurite outgrowths were observed with increasing surface charge of the nanocomposite membrane indicating a dose-response effect of surface electrical charge on SHED neural differentiation.Further investigations of the underlying molecular mechanisms revealed that intracellular calcium influx,focal adhesion formation,FAK-ERK mechanosensing pathway and neurogenic-related ErbB signaling pathway were implicated in the enhancement of SHED neural differentiation by surface electrical charge.Hence,this study confirms the dose-response effect of biomaterial surface charge on SHED neural differentiation and provides preliminary insights into the molecular mechanisms and signaling pathways involved.

关键词： Surface charge Electric polarization Dose-response effect Electrical microenvironment Neurogenesis

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Metal–Organic Gel Leading to Customized Magnetic‑Coupling Engineering in Carbon Aerogels for Excellent Radar Stealth and Thermal Insulation Performances

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Nano-Micro Letters 2024年第3期16卷 36-52页

作者： Xin Li Ruizhe Hu Zhiqiang Xiong Dan Wang Zhixia Zhang Chongbo Liu Xiaojun Zeng Dezhi Chen Renchao Che xuliang Nie Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Environmental and Chemical Engineering Nanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Department of Materials Science and Collaborative Innovation Center of Chemistry for Energy Materials and Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438People’s Republic of China School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403People’s Republic of China College of Chemistry and Materials Jiangxi Agricultural UniversityNanchang 330045People’s Republic of China

Metal–organic gel(MOG)derived composites are promising multi-functional materials due to their alterable composition,identifiable chemical homogeneity,tunable shape,and porous structure.Herein,stable metal–organic hydrogels are prepared by regulating the complexation effect,solution polarity and curing speed.Meanwhile,collagen peptide is used to facilitate the fabrication of a porous aerogel with excellent physical properties as well as the homogeneous dispersion of magnetic particles during calcination.Subsequently,two kinds of heterometallic magnetic coupling systems are obtained through the application of Kirkendall effect.FeCo/nitrogen-doped carbon(NC)aerogel demonstrates an ultra-strong microwave absorption of−85 dB at an ultra-low loading of 5%.After reducing the time taken by atom shifting,a FeCo/Fe3O4/NC aerogel containing virus-shaped particles is obtained,which achieves an ultra-broad absorption of 7.44 GHz at an ultra-thin thickness of 1.59 mm due to the coupling effect offered by dual-soft-magnetic particles.Furthermore,both aerogels show excellent thermal insulation property,and their outstanding radar stealth performances in J-20 aircraft are confirmed by computer simulation technology.The formation mechanism of MOG is also discussed along with the thermal insulation and electromagnetic wave absorption mechanism of the aerogels,which will enable the development and application of novel and lightweight stealth coatings.

关键词： Metal-organic gels Heterometallic magnetic coupling Radar stealth Thermal insulation Computer simulation technology

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External cervical resorption-a review of pathogenesis and potential predisposing factors

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International Journal of Oral Science 2021年第2期13卷 163-172页

作者： Yiming Chen Ying Huang xuliang deng Department of Geriatric Dentistry Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina

External cervical resorption(ECR)refers to a pathological state in which resorption tissues penetrate into the dentin at the cervical aspect of the root.Despite being latent in its initial phase,ECR could cause severe damage to mineralized dental tissue and even involve the pulp if not given timely diagnosis and treatment.Nevertheless,the etiology of ECR is still poorly understood,which adds to the difficulty in early diagnosis.ECR has received growing attention in recent years due to the increasing number of clinical cases.Several potential predisposing factors have been recognized in cross-sectional studies as well as case reports.In the meantime,studies on histopathology and pathogenesis have shed light on possible mechanisms of ECR.This review aims to summarize the latest findings in the pathogenesis and potential predisposing factors of ECR,so as to provide pragmatic reference for clinical practice.

关键词： pathogenesis cervical diagnosis

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Room-temperature synthesis of full-component APbX_(3)perovskite nanocrystal inks for optoelectronic applications

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Journal of Energy Chemistry 2024年第5期92卷 87-94页

作者： Xinyu Zhao Du Li xuliang Zhang Hehe Huang Chenyu Zhao Wanli Ma Jianyu Yuan Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123JiangsuChina Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Soochow UniversitySuzhou 215123JiangsuChina Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123JiangsuChin

Lead halide perovskite nanocrystals(PNCs)have received great research interests due to their excellent optoelectronic properties.However,high temperature,inert gas protection and insulating long-chain ligands are used during the conventional hot-injection synthesis of PNCs,which limits their practical applications.In this work,we first develop a simple and scalable polar-solvent-free method for the preparation of full-component APbX_(3)(A=Cs,methylammonium(MA),formamidinium(FA),X=Cl,Br,I)PNCs under ambient condition.Through an exothermic reaction between butylamine(BA)and propionic acid(PA)short ligands,the PbX_(2) precursors could be well dissolved without use of any polar solvent.Meanwhile,the relatively lower growth rate of PNCs in our room-temperature reaction enables us to modulate the synthetic procedure to enhance the scalability(40-fold)and achieve large-scale synthesis.The resultant short ligands passivated PNC inks are compatible with varying solution depositing technique like spray coating for large-area film.Finally,we showcase that adopting the as-prepared MAPbI_(3) PNC inks,a self-powered photodetector is fabricated and shows a high photoresponsivity.These results demonstrate that our ambient-condition synthetic approach can accelerate the preparation of tunable and ready-to-use PNCs towards commercial optoelectronic applications.

关键词： Room-temperaturesynthesis Perovskite nanocrystals Short-chainligands Large-scale Photodetector

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牙齿修复新纪元:原位生长

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Science Bulletin 2024年第1期69卷 17-21页

作者：邓菁菁于唯一卫彦邓旭亮 Beijing Laboratory of Biomedical Materials Department of Geriatric DentistryPeking University School and Hospital of StomatologyBeijing 100081China

Suffering from various pathological risks in daily life,such as cariogenic bacteria,traumatic force,and extreme pH values,tooth enamel defect has a stunning global prevalence of over 85%.Even worse,the enamel defect in most vertebrates cannot be self-regenerated to restore both exquisite hierarchical structures and exceptional mechanical properties throughout their lifetime[1].As such,a series of esthetic and functional complications caused by enamel defects exist persistently,such as dysfunction of the oral and maxillofacial system,reduced chewing efficiency,dentine hypersensitivity,periodontitis,etc.Reliable and sustainable enamel repair techniques are urgently needed to improve life quality and ease the financial burden[2].

关键词： enamel exceptional defect

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The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules

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Nano Research 2023年第1期16卷 991-998页

作者： Nuo Chen Jingjing deng Shengjie Jiang Xiang-Yu Kong Teng Zhou Kai Zhao Zuohui Xiao Huimin Zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei xuliang deng Lei Jiang Beijing Laboratory of Biomedical Materials Department of Geriatric DentistryPeking University School and Hospital of StomatologyBeijing 100081China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Mechanical and Electrical Engineering College Hainan UniversityHainan 570228China School of Future Technology University of Chinese Academy of Sciences Beijing 100049China

Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.

关键词： dentine hypersensitivity cation transport dentinal tubules Ionic-current-rectification

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