Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration

作     者：Dandan Wang Yaru Guo Boon Chin Heng Xuehui Zhang Yan Wei Ying He Mingming Xu Bin Xia Xuliang Deng Dandan Wang;Yaru Guo;Boon Chin Heng;Xuehui Zhang;Yan Wei;Ying He;Mingming Xu;Bin Xia;Xuliang Deng

作者机构：Department of Pediatric DentistryPeking University School and Hospital of StomatologyBeijing 100081P.R.China Department of Geriatric DentistryPeking University School and Hospital of StomatologyNational Center for StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081P.R.China Department of Dental Materials&Dental Medical Devices Testing CenterPeking University School and Hospital of StomatologyNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081P.R.China 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2024年第12卷第2期

页      面：361-371页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.U22A20160,82221003,81991505,82201123) China Postdoctoral Science Foundation(2022M720290,2021M700279) Hubei Provincial Key Laboratory of Oral and Maxillofacial Development and Regeneration Open Fund(2022kqhm004) 

主　　题：hinder apparent vesicles 

摘      要：Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells(BMSCs)and vascular endothelial cells(ECs).However,there are apparent limitations in stem cell-based therapy which hinder its clinic ***,we investigated the potential of alternative stem cell substitutes for facilitating bone *** this study,we successfully prepared cell membrane vesicles(CMVs)from BMSCs and *** results showed that BMSC-derived cell membrane vesicles(BMSC-CMVs)possessed membrane receptors involved in juxtacrine signaling and growth factors derived from their parental ***-derived cell membrane vesicles(EC-CMVs)also contained BMP2 and VEGF derived from their parental ***-CMVs enhanced tube formation and migration ability of hUVECs,while EC-CMVs promoted the osteogenic differentiation of hBMSCs in *** a rat skull defect model,we found that co-transplantation of BMSC-CMVs and EC-CMVs could stimulate angiogenesis and bone formation in ***,our research might provide an innovative and feasible approach for cell-free therapy in bone tissue regeneration.