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Structure-design and theoretical-calculation for ultrasmall Co_(3)O_(4) anchored into ionic liquid modified graphene as anode of flexible lithium-ion batteries

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Nano Research 2022年第3期15卷 2104-2111页

作者： Longda Cong Shichao Zhang Hengyao Zhu Weixin Chen xueyan huang Yalan Xing Jun Xia Puheng Yang Xia Lu School of Materials Science and Engineering Beihang UniversityBeijing 100191China School of Physics Science and Nuclear Energy Engineering Beihang UniversityBeijing 100191China School of Materials Sun Yat-sen UniversityShenzhen 518107China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

Cobalt oxide(Co_(3)O_(4))is currently suitable in energy storage applications because of its high capacity based on the conversion reaction mechanism.However,unmodified Co_(3)O_(4)suffers from distinctly inferior rate capability and poor cycling stability.On the basis of the aforementioned considerations and density functional theory(DFT)simulations,the three-dimensional hierarchical porous structure(HPS)ultrasmall Co_(3)O_(4)anchored into ionic liquid(IL)modified graphene oxide(GO)has been successfully prepared(ultrasmall/Co_(3)O_(4)-GA-IL).The ultrasmall/Co_(3)O_(4)-GA-IL consists of Co_(3)O_(4)co-assembled with IL modified GO to generate the HPS which can facilitate ion transfer channels through reduction of the electron and ion transportation path and transmission impedance.In addition,N-doping graphene can enhance the inherent electrical conductivity of Co_(3)O_(4),which is proved by the DFT calculations.By virtue of the novel superstructure,the ultrasmall/Co_(3)O_(4)-GA-IL electrode demonstrates a high reversible capacity of 1,304 mAh·g^(−1),an enhanced high-rate capability(715 mAh·g^(−1)at 5 C),and a capacity retention of 98.4%even after 500 cycles at 5 C rate,which corresponds to 0.0003%capacity loss per cycle.Pouch cells based on the cathode are further fabricated and demonstrate excellent mechanical and electrochemical properties under bent and folded state,highlighting the practical application of our deliberately designed electrode in wearable electronics.

关键词： co-assembly ultrasmall cobalt oxide ionic liquid flexible lithium-ion batteries hierarchical porous structure density functional theory simulations

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The exquisite integration of ESIPT, PET and AIE for constructing fluorescent probe for Hg(II) detection and poisoning

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Chinese Chemical Letters 2022年第4期33卷 1861-1864页

作者： Xiang Cheng Shuai huang Qian Lei Fei Chen Fan Zheng Shibo Zhong xueyan huang Bin Feng Xueping Feng Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China The Molecular Imaging Research Center Central South UniversityChangsha 410013China Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases Central South UniversityChangsha 410013China Xiangya Hospital Central South UniversityChangsha 410013China

Excessive mercury ions(Hg^(2+)) in the environment can accumulate in human body along with the food chain to cause serious physiological reactions.The fluorescence probes were considered as convenient tool with great potential for Hg^(2+) detection.Most existing probes suffer from aggregation-induced quenching(ACQ) effects and insufficient sensitivity.Herein,a novel type of fluorophore was developed by combining the aggregation-induced emission(AIE) and excited state intramolecular proton transfer(ESIPT) characteristics.Subsequently,a phenyl thioformate group with photoinduced electron transfer(PET)effect was connected to give an efficient "turn-on" probe(HTM),which exhibited good selectivity toward Hg^(2+),short response time(30 min),coupled with extremely low detection limit(LOD=1.68 nmol/L).In addition,HTM was used successfully in real samples,cells and drug evaluation,underlying the superiority of HTM to detect Hg^(2+) in practical applications.

关键词： Aggregation-induced emission Excited state intramolecular proton transfer Photoinduced electron transfer Mercury ions Fluorescent imaging

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Monitoring intracellular pH fluctuation with an excited-state intramolecular proton transfer-based ratiometric fluorescent sensor

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Chinese Chemical Letters 2021年第10期32卷 3057-3060页

作者： Bin Feng Yingli Zhu Jiaxin Wu xueyan huang Rong Song Liu huang Xueping Feng Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China The Molecular Imaging Research Center Central South UniversityChangsha 410013China Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases Central South UniversityChangsha 410013China Xiangya Hospital Central South UniversityChangsha 410013China

Intracellular pH is a key parameter related to various biological and pathological processes.In this study,a ratiometric pH fluorescent sensor ABTT was developed harnessing the amino-type excited-state intramolecular proton transfer(ESIPT) process.Relying on whether the ESIPT proceeds normally or not,ABTT exhibited the yellow fluorescence in acidic media,or cyan fluorescence in basic condition.According to the variation,ABTT behaved as a promising sensor which possessed fast and reversible response to pH change without interference from the biological substances,and exported a steady ratiometric signal(I_(478)/I_(546)).Moreover,due to the ESIPT effect,large Stokes shift and high quantum yield were also exhibited in ABTT.Furthermore,ABTT was applied for monitoring the pH changes in living cells and visualizing the pH fluctuations under oxidative stress successfully.These results elucidated great potential of ABTT in understanding pH-dependent physiological and pathological processes.

关键词： Excited-state intramolecular proton transfer Intracellular pH Sulfonamide Ratiometric sensor Fluorescent imaging

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三螺旋理论下高职院校工匠精神培育策略

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继续教育研究 2024年第7期 68-72页

作者：谭燕萍黄雪言广西师范大学广西桂林541000 澳门大学中国澳门519000

弘扬工匠精神是培育大国工匠、能工巧匠的重要一环。高职院校是高素质技术技能人才培养主阵地,应该致力于技术技能人才工匠精神的培育。采用理论研究方法分析三螺旋理论与高职院校工匠精神培育适切性,对我国高职院校工匠精神培育现状进... 详细信息

弘扬工匠精神是培育大国工匠、能工巧匠的重要一环。高职院校是高素质技术技能人才培养主阵地,应该致力于技术技能人才工匠精神的培育。采用理论研究方法分析三螺旋理论与高职院校工匠精神培育适切性,对我国高职院校工匠精神培育现状进行梳理。研究发现:三螺旋内部工匠精神培育缺乏动力;三螺旋之间工匠精神培育协同不足;三边网络组织工匠精神培训体系不健全。为此,需要健全工匠精神培育激励和保障制度,激发螺旋内部积极性和可持续性;健全培养培训体系与质量评价体系,强化校政企协同育人;加强职教集团及高水平培育基地建设,优化三边网络组织。

关键词：高职院校工匠精神培育策略三螺旋理论

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2009—2018年广西壮族自治区医疗机构放射作业人员心电图改变分析

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实用预防医学 2024年第6期31卷 718-720页

作者：黄雪雁欧军荣卢小燕陆华媛广西壮族自治区职业病防治研究院广西南宁530021

目的分析2009—2018年广西壮族自治区医疗机构放射作业人员职业健康检查的心电图改变情况,为防范放射作业人员的职业因素对心脏的危害提供依据。方法收集2009—2018年广西壮族自治区医疗机构放射作业人员职业健康检查的心电图检查资料... 详细信息

目的分析2009—2018年广西壮族自治区医疗机构放射作业人员职业健康检查的心电图改变情况,为防范放射作业人员的职业因素对心脏的危害提供依据。方法收集2009—2018年广西壮族自治区医疗机构放射作业人员职业健康检查的心电图检查资料进行统计并分析。结果共检查放射工作人员15372人,工种涉及诊断放射、介入放射、放射治疗、牙科放射、核医学;放射作业人员心电图异常检出率为17.50%,以T波异常和ST-T改变为主,不同性别、不同年龄、不同工种、不同工龄的体检异常率差异有统计学意义(P<0.05)。结论2009—2018年广西壮族自治区医疗机构放射作业人员的心电图异常检出率较高,表明心脏可能因遭受低剂量电离辐射影响,需要进一步加强职业健康管理与监督。

关键词：医疗机构放射作业人员职业健康心电图

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Molybdenum and cadmium co-induce necroptosis through Th1/Th2 imbalance-mediated endoplasmic reticulum stress in duck ovaries

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Journal of Environmental Sciences 2024年第8期142卷 92-102页

作者： Ting Cui xueyan Dai Huiling Guo Dianyun Wang Bingyan huang Wenjing Pu Xuesheng Chu Caiying Zhang Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045China

Cadmium(Cd)and excess molybdenum(Mo)pose serious threats to animal health.Our previous study has determined that Cd and/or Mo exposure can cause ovarian damage of ducks,while the specific mechanism is still obscure.To further investigate the toxic mechanism of Cd and Mo co-exposure in the ovary,forty 8-day-old female ducks were randomly allocated into four groups for 16 weeks,and the doses of Cd and Mo in basic diet per kg were as follows:control group,Mo group(100 mg Mo),Cd group(4 mg Cd),and Mo+Cd group(100 mg Mo+4 mg Cd).Cadmium sulfate 8/3-hydrate(CdSO_(4)·8/3H_(2)O)and hexaammonium molybdate((NH_(4))_(6)Mo_(7)O_(24)·4H_(2)O)were the origins of Cd and Mo,respectively.At the 16th week of the experiment,all ovary tissues were collected for the detection of related indexes.The data indicated that Mo and/or Cd induced trace element disorders and Th1/Th2 balance to divert toward Th1 in the ovary,which activated endoplasmic reticulum(ER)stress and then provoked necroptosis through triggering RIPK1/RIPK3/MLKL signaling pathway,and eventually caused ovarian pathological injuries and necroptosis characteristics.The alterations of above indicators were most apparent in the joint group.Above all,this research illustrates that Mo and/or Cd exposure can initiate necroptosis through Th1/Th2 imbalance-modulated ER stress in duck ovaries,and Mo and Cd combined exposure aggravates ovarian injuries.This research explores the molecular mechanism of necroptosis caused by Mo and/or Cd,which reveals that ER stress attenuation may be a therapeutic target to alleviate necroptosis.

关键词： Molybdenum Cadmium Th1/Th2 imbalance Endoplasmic reticulum stress Necroptosis Ovary

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失眠症中医辨证施护方案的构建

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全科医学临床与教育 2024年第3期22卷 279-281,285页

作者：骆文慧冯莺黄雪燕周海芳董玉红李艳娟浙江中医药大学附属杭州市中医院护理部浙江杭州310012

中医将失眠定义为“不寐”[1],在我国有43.4%的成年人受到不同程度失眠的困扰,睡眠障碍患者数量高达3亿[2],对日常生活造成极大的影响[3]。中医护理对失眠症有较好的疗效[4~6],如艾灸、拔罐、刮痧、耳穴贴压等,具有简单便捷的特点,易于... 详细信息

中医将失眠定义为“不寐”[1],在我国有43.4%的成年人受到不同程度失眠的困扰,睡眠障碍患者数量高达3亿[2],对日常生活造成极大的影响[3]。中医护理对失眠症有较好的疗效[4~6],如艾灸、拔罐、刮痧、耳穴贴压等,具有简单便捷的特点,易于临床护士掌握与实践,且具有较好的成本效益。辨证施护是中医临床护理的基本原则[7],临床上护理人员应用中医护理适宜技术改善失眠患者症状时.

关键词：中医临床护理辨证施护中医护理耳穴贴压失眠患者拔罐刮痧睡眠障碍

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Metformin:A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 52-68页

作者： Tingting Yang Jiayu Yuan Yuting Peng Jiale Pang Zhen Qiu Shangxiu Chen Yuhan huang Zhenzhou Jiang Yilin Fan Junjie Liu Tao Wang xueyan Zhou Sitong Qian Jinfang Song Yi Xu Qian Lu Xiaoxing Yin Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhouJiangsu221004China Department of Pharmacy Affiliated Lianyungang Hospital of Xuzhou Medical UniversityLianyungangJiangsu222061China Department of Pharmacy The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu221006China New Drug Screening Center Jiangsu Center for Pharmacodynamics Research and EvaluationChina Pharmaceutical UniversityNanjing210009China School of Life Sciences University of EssexEssex CO43SQUnited Kingdom Department of Urology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu221006China Department of Pharmacy Affiliated Hospital of Jiangnan UniversityWuxiJiangsu214000China

The occurrence of benign prostate hyperplasia(BPH)was related to disrupted sex steroid hormones,and metformin(Met)had a clinical response to sex steroid hormone-related gynaecological disease.However,whether Met exerts an antiproliferative effect on BPH via sex steroid hormones remains unclear.Here,our clinical study showed that along with prostatic epithelial cell(PEC)proliferation,sex steroid hormones were dysregulated in the serum and prostate of BPH patients.As the major contributor to dysregulated sex steroid hormones,elevated dihydrotestosterone(DHT)had a significant positive relationship with the clinical characteristics of BPH patients.Activation of adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)by Met restored dysregulated sex steroid hormone homeostasis and exerted antiproliferative effects against DHT-induced proliferation by inhibiting the formation of androgen receptor(AR)-mediated Yes-associated protein(YAP1)-TEA domain transcription factor(TEAD4)heterodimers.Met’s anti-proliferative effects were blocked by AMPK inhibitor or YAP1 overexpression in DHT-cultured BPH-1 cells.Our findings indicated that Met would be a promising clinical therapeutic approach for BPH by inhibiting dysregulated steroid hormone-induced PEC proliferation.

关键词： Metformin Benign prostatic hyperplasia Sex steroid hormones homeostasis Proliferation DHT YAP1-TEAD4 heterodimer

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固态锂金属电池中原位聚合电解质的研究进展

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高等学校化学学报 2023年第5期44卷 49-60页

作者：徐攀孔伟进黄雪妍孙硕黄文泽赵辰孜清华大学化学工程系北京100084 清华大学车辆与运载学院北京100084

在下一代电池体系中,固态金属锂电池具有高能量密度潜力,同时有望避免目前电池面临的燃烧、爆炸等安全隐患.其中,固态电解质和电极材料之间的固-固界面接触差是其实用化面临的重要挑战.近年来,经电池内部原位聚合反应制得的原位聚合电... 详细信息

在下一代电池体系中,固态金属锂电池具有高能量密度潜力,同时有望避免目前电池面临的燃烧、爆炸等安全隐患.其中,固态电解质和电极材料之间的固-固界面接触差是其实用化面临的重要挑战.近年来,经电池内部原位聚合反应制得的原位聚合电解质用于固态锂金属电池具备界面一体化提升固-固界面相容性、抑制枝晶的形成、抑制正极过渡金属离子/多硫化物/氧化还原介质的溶解/穿梭并提升电池电化学性能多种优势.本文首先讨论了聚合电解质的反应机理,然后分析了电池内部常见电解质的原位聚合原理,总结了固态锂金属电池中原位聚合电解质的最新研究进展.最后,对未来原位聚合电解质的发展方向和商业化应用进行了展望.

关键词：固态锂金属电池原位聚合固态电解质固-固界面

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SiRAP2-12,a Positive Regulatory Factor,Effectively Improves the Waterlogging Tolerance of Foxtail Millet(Setaria italica)

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 445-465页

作者： xueyan Xia Xiaohong Fu Yu Zhao Jihan Cui Nuoya Xiao Jingxin Wang Yiwei Lu Meihong huang Cheng Chu Jia Zhang Mengxin Yang Shunguo Li Jianfeng Liu Institute of Millet Crops Hebei Academy of Agriculture and Forestry Sciences/Key Laboratory of Genetic Improvement and Utilization for Featured Coarse Cereals(Co-Construction byMinistry and Province)Ministry of Agriculture and Rural Affairs/The Key Research Laboratory of Minor Cereal Crops of Hebei ProvinceShijiazhuang050035China School of Life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding071002China

Foxtail millet(Setaria italica)growth was inhibited because of waterlogging stress,which has caused yield reduc-tion.ERF family plays an important role to plant adversity tolerance.In our study,we obtained 19,819 differential expressed genes(DEGs)between the two treatments based on the RNA-seq sequencing of foxtail millet of water-logging stress.Furthermore,a total of 28 ERF family members were obtained,which have a complete open read-ing frame.We studied the evolution and function of SiERF family and how they affected the waterlogging tolerance.It was found that SiERF1A/B/C(GenBank ID:OR775217,OR775219,OR775218)and SiRAP2-12(GenBank ID:OR775216)have similar functions to the known waterlogging tolerance genes of other plants.Among them,the SiRAP2-12 expression was obviously signiﬁcantly up-regulated in foxtail millet after 5d water-logging stress.After SiRAP2-12 was silenced,the activity of defense enzymes in millet decreased signiﬁcantly.In details,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),the osmotic regulator proline(Pro),and the activity of the anaerobic respiratory enzyme alcohol dehydrogenase(ADH)content were decreased by 78.61%,29.52%,79.95%,19.41%and 54.77%,respectively.In contrast,the relative electrical conductivity contents(REC),malondialdehyde(MDA),and hydrogen peroxide(H_(2)O_(2))of the foxtail millet subjected to virus-induced gene silencing clearly increased by 1.03-fold,36.09%,and 15.21%,respectively.The content of sodium(Na^(+))in the SiRAP2-12-silenced foxtail millet also increased,but that of potassium(K^(+))decreased.Interestingly,we found that ethylene content was signiﬁcantly reduced.Further,the SiAOC1 expression,an essential gene for ethylene synthesis,was inhibited in SiRAP2-12-silenced foxtail millet after waterlogging stress.Taken together,we hypothesized that SiRAP2-12 might be a positive regulator of millet tolerance to waterlogging stress.

关键词： Foxtail millet waterlogging SiRAP2-12 VIGS ethylene

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