The exquisite integration of ESIPT, PET and AIE for constructing fluorescent probe for Hg(II) detection and poisoning

作     者：Xiang Cheng Shuai Huang Qian Lei Fei Chen Fan Zheng Shibo Zhong Xueyan Huang Bin Feng Xueping Feng Wenbin Zeng Xiang Cheng;Shuai Huang;Qian Lei;Fei Chen;Fan Zheng;Shibo Zhong;Xueyan Huang;Bin Feng;Xueping Feng;Wenbin Zeng

作者机构：Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410013China The Molecular Imaging Research CenterCentral South UniversityChangsha 410013China Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic DiseasesCentral South UniversityChangsha 410013China Xiangya HospitalCentral South UniversityChangsha 410013China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第4期

页      面：1861-1864页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

基　　金：financial supports from the National Natural Science Foundation of China (Nos. 81971678 and 81671756) the Innovation Fund for Post graduate Students of Central South University (No. 2020zzts827) 

主　　题：Aggregation-induced emission Excited state intramolecular proton transfer Photoinduced electron transfer Mercury ions Fluorescent imaging 

摘      要：Excessive mercury ions(Hg^(2+)) in the environment can accumulate in human body along with the food chain to cause serious physiological *** fluorescence probes were considered as convenient tool with great potential for Hg^(2+) *** existing probes suffer from aggregation-induced quenching(ACQ) effects and insufficient ***,a novel type of fluorophore was developed by combining the aggregation-induced emission(AIE) and excited state intramolecular proton transfer(ESIPT) ***,a phenyl thioformate group with photoinduced electron transfer(PET)effect was connected to give an efficient turn-on probe(HTM),which exhibited good selectivity toward Hg^(2+),short response time(30 min),coupled with extremely low detection limit(LOD=1.68 nmol/L).In addition,HTM was used successfully in real samples,cells and drug evaluation,underlying the superiority of HTM to detect Hg^(2+) in practical applications.