检索结果-南通市图书馆

From aniline to phenol: carbon-nitrogen bond activation via uranyl photoredox catalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第6期9卷 74-80页

作者： Deqing Hu Yilin Zhou xuefeng jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry Nankai University

Carbon-nitrogen bond activation, via uranyl photoredox catalysis with water, enabled the conversion of 40 protogenetic anilines, 8 N-substituted anilines and 9 aniline-containing natural products/pharmaceuticals to the corresponding phenols in an ambient environment. A single-electron transfer process between a protonated aniline and uranyl catalyst, which was disclosed by radical quenching experiments and Stern-Volmer analysis, facilitated the following oxygen atom transfer process between the radical cation of protonated anilines and uranyl peroxide originating from water-splitting.18O labeling and15N tracking unambiguously depicted that the oxygen came from water and amino group left as ammonium salt. The 100-fold efficiency of the flow operation demonstrated the great potential of the conversion process for industrial synthetic application.

关键词： C−N bond activation C−O bond formation uranyl cations photoredox catalysis

C-Aryl Glycosylation via Interrupted Pummerer Rearrangement

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第21期41卷 2843-2847页

作者： Jiagen Li xuefeng jiang State Key Laboratory of Molecular&Process Engineering School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062 China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin300071 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

C-aryl glycosides are an important kind of carbohydrate derivatives for drug discovery,due to their distinctive attributes of resistance to hydrolysis from ***,C-aryl glycosylation was established for the synthesis of 2-sulfur C-aryl glycals and 1,2-dihydrobenzofuran-fused C-aryl glycosides via interrupted Pummerer process,featured with sulfonium-tethered[3,3]-sigmatropic rearrangement between sulfoxide glycals and *** protocol offers a broad substrate scope with diverse glycosyl and ***,Empagliflozin,and Ipragliflozin analogs were straightforward achieved,respectively.

关键词： Glycal Glycosylation Interrupted pummerer Rearrangement Sulfoxide Carbohydrates C-Glycosides Drug discovery

The application of sulfur-containing peptides in drug discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第7期29卷 1079-1087页

作者： Jiaoyan Zhao xuefeng jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal University State Key Laboratory of Elemento-organic Chemistry Nankai University

In recent decades, peptides as potential drugs were more and more explored with the development of non-oral medicine. There into, sulfur-containing peptide is one of the most popular aspects in peptide drugs due to the introduction of sulfur atoms leading unique *** purpose of the present review is to focus on the discovery of various sulfur-containing peptides with particular emphasis on their pharmacological mechanisms. This review is organized according to the structures of the sulfurcontaining peptides.

关键词： Peptides Disulfide Thioether Thiazole Drug discovery

维普期刊数据库

Advances in the construction of diverse SuFEx linkers

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第6期10卷 226-244页

作者： Daming Zeng Wei-Ping Deng xuefeng jiang Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism School of Pharmacy East China University of Science and Technology Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University

Sulfur fluoride exchange(SuFEx),a new generation of click chemistry,was first presented by Sharpless,Dong and co-workers in *** to the high stability and yet efficient reactivity of the SⅥ-F bond,SuFEx has found widespread applications in organic synthesis,materials science,chemical biology and drug discovery.A diverse collection of SuFEx linkers has emerged,involving gaseous SO2F2and SOF4hubs;SOF4-derived iminosulfur oxydifluorides;O-,N-and C-attached sulfonyl fluorides and sulfonimidoyl fluorides;and novel sulfondiimidoyl *** review summarizes the progress of these SuFEx connectors,with an emphasis on analysing the advantages and disadvantages of synthetic strategies of these connectors based on the SuFEx concept,and it is expected to be beneficial to researchers to rapidly and correctly understand this field,thus inspiring further development in SuFEx chemistry.

关键词： SuFEx SuFEx linker SVI–F bond synthetic strategy

How does aggregation-induced emission aggregate interdisciplinary research?

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第2期5卷 301-315页

作者： Jing Zhu xuefeng jiang Department of Philosophy East China Normal UniversityShanghaiP.R.China State Key Laboratory of Molecular and Process Engineering School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghaiP.R.China

It is a matter of debate whether the discipline independence in discipline formation narrows its *** is also less well understood how disruptive works emerge in investigative practice rather than a theory-driven *** emission(AIE)is an atypical photophysical phenomenon,in which the whole(aggregate)is brighter than the sum of its parts(single molecule).Through measuring and computing the cognitive extent and evolution of research on AIE,including topics,epistemic-social collaborative networks,interdisciplinarity,emergent concepts,core concept networks and knowledge flow,this study shows that a cross-research scales concept and its practice can establish new bridges in the sciences and promote disruptive *** on mesoscale entities,scientists from many different branches of science are involved in theoretical research on mechanisms,as well as developing different AIE systems for *** data analysis in this study provides details showing how non-reductionist concepts based on new scientific discoveries cross traditional disciplinary boundaries and aggregate interdisciplinary *** emergence and evolution of the AIE field implies that scientists may be motivated to embrace nonreductionist ideas at different research scales,leading to a more permeable field boundary.

关键词： aggregation-induced emission(AIE) interdisciplinarity levels of explanation network analysis reductionism

Pd-Catalyzed C-S Cyclization via C-H Functionalization Strategy： Access to Sulfur-containing Benzoheterocyclics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2018年第10期36卷 921-924页

作者： Shihao then Ming Wang xuefeng jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal Uni- versity 3663 North Zhongshan Road Shanghai 200062 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China

A C-H sulfurated cyclization protocol starting from thioacetates is developed for straightforward construction of sulfur-containing benzo- heterocyclics. The diversiform functional dihydrobenzothiophenes and thiochromans were comprehensively achieved through the Pd-catalyzed carbon- sulfur cyclization. Mechanistic studies indicated that C-H bond cleavage was involved in the rate-determining step. [1]Benzothieno-[3,2-b]- [1]benzothiophene （BTBT） and benzo[b]thieno[2,3-d]thiophene （BTT） were efficiently established as the well-known organic field-effect transistor （OFET） material molecules through this methodology.

关键词： C-S cyclization C-H functionalization dihydrobenzothiophene thiochromans palladium

Straightforward Sulfonamidation via Metabisulfite-Mediated CrossCoupling of Nitroarenes and Boronic Acids under Transition-Metal-Free Conditionst

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2020年第12期38卷 1521-1525页

作者： Yaping Li Ming Wang xuefeng jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Norm al University3663 North Zhongshan RoadShanghai 200062China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China

of main observation and conclusion A straightforward multicomponent sufonamidation of nitroarenes,sodium metabisulfite and boronicacids was established under transition-mnetal-free conditions to access diverse sulfonamides from readily avilable and low-cost materials *** salt sodium metabisulfite not only served as a sulfur dioxide source,but also played a key role for both activator and reductant ***,naturlly occuring biomolecules and pharmaceuticals with multiple heteroatorms and sensitive functional groups were intensivly investigated in this transformtion providing versatile sulionamides collectively,further mechanistic studies demonstrated that nitrosoarene is thekey intermediate,and the activation of boronic acid is the rate-determining step in the transformation.

关键词： boron Transition straight

A whispering-gallery scanning microprobe for Raman spectroscopy and imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第11期12卷 2402-2410页

作者： Wenbo Mao Yihang Li xuefeng jiang Zhiwen Liu Lan Yang Department of Electrical and Systems Engineering Washington UniversitySt LouisMO 63130USA Department of Electrical Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA

Optical whispering-gallery-mode microsensors are a promising platform for many applications,such as biomedical monitoring,magnetic sensing,and vibration ***,like many other micro/nanosensors,they cannot simultaneously have two critical properties–ultrahigh sensitivity and large detection area,which are desired for most sensing ***,we report a novel scanning whispering-gallery-mode microprobe optimized for both features and demonstrate enhanced Raman spectroscopy,providing high-specificity information on molecular fingerprints that are important for numerous sensing *** the superiorities of whispering-gallery modes and nanoplasmonics,the microprobe exhibits a two-orders-of-magnitude sensitivity improvement over traditional plasmonics-only enhancement;this leads to molecular detection demonstrated with stronger target signals but less optical power required than surface-enhanced-Raman-spectroscopy ***,the scanning microprobe greatly expands the effective detection area and realizes two-dimensional micron-resolution Raman imaging of molecular *** versatile and ultrasensitive scanning microprobe configuration will thus benefit material characterization,chemical imaging,and quantum-enhanced sensing.

关键词： microprobe scanning spectroscopy

Visible light-promoted, iodine-catalyzed selenoalkoxylation of olefins with diselenides and alcohols in the presence of hydrogen peroxide/air oxidant: an efficient access to α-alkoxyl selenides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2018年第3期61卷 294-299页

作者： Mingxuan Liu Yiming Li Lei Yu Qing Xu xuefeng jiang Institute of Pesticide School of Chemistry and Chemical Engineering and School of Horticulture and Plant Protection Yangzhou University Shanghai Key Laboratory of Green Chemistry and Chemical Process Department of Chemistry East China Normal University

Under iodine-catalyzed and visible light-irradiated aerobic conditions, selenoalkoxylation of olefins with diselenides and alcohols can be efficiently achieved to afford the useful α-alkoxyl selenides in the presence of only 0.5 equiv. of H_2O_2. Controlling the sub-stoichiometric H_2O_2 amount is crucial to avoid the non-selective over-oxidation of the diselenides that leads to the ineffective hyper-valent selenium compounds. Meanwhile, under visible light irradiation, the green, safe, and low-cost air can work as a supplemental mild oxidant in the reaction to ensure selective oxidation of the diselenides, full conversion of the reactants, and ultimately good yield of the products.

关键词： selenium alkoxyl selenide aerobic oxidation visible light iodine catalysis

维普期刊数据库