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Advances in the construction of diverse SuFEx linkers

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National Science Review 2023年第6期10卷 226-244页

作者： Daming Zeng Wei-Ping Deng xuefeng jiang Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism School of Pharmacy East China University of Science and Technology Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University

Sulfur fluoride exchange(SuFEx),a new generation of click chemistry,was first presented by Sharpless,Dong and co-workers in 2014.Owing to the high stability and yet efficient reactivity of the SⅥ-F bond,SuFEx has found widespread applications in organic synthesis,materials science,chemical biology and drug discovery.A diverse collection of SuFEx linkers has emerged,involving gaseous SO2F2and SOF4hubs;SOF4-derived iminosulfur oxydifluorides;O-,N-and C-attached sulfonyl fluorides and sulfonimidoyl fluorides;and novel sulfondiimidoyl fluorides.This review summarizes the progress of these SuFEx connectors,with an emphasis on analysing the advantages and disadvantages of synthetic strategies of these connectors based on the SuFEx concept,and it is expected to be beneficial to researchers to rapidly and correctly understand this field,thus inspiring further development in SuFEx chemistry.

关键词： SuFEx SuFEx linker SVI–F bond synthetic strategy

C-Aryl Glycosylation via Interrupted Pummerer Rearrangement

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Chinese Journal of Chemistry 2023年第21期41卷 2843-2847页

作者： Jiagen Li xuefeng jiang State Key Laboratory of Molecular&Process Engineering School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062 China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin300071 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

C-aryl glycosides are an important kind of carbohydrate derivatives for drug discovery,due to their distinctive attributes of resistance to hydrolysis from enzymes.Herein,C-aryl glycosylation was established for the synthesis of 2-sulfur C-aryl glycals and 1,2-dihydrobenzofuran-fused C-aryl glycosides via interrupted Pummerer process,featured with sulfonium-tethered[3,3]-sigmatropic rearrangement between sulfoxide glycals and phenols.This protocol offers a broad substrate scope with diverse glycosyl and phenols.Dapagliflozin,Empagliflozin,and Ipragliflozin analogs were straightforward achieved,respectively.

关键词： Glycal Glycosylation Interrupted pummerer Rearrangement Sulfoxide Carbohydrates C-Glycosides Drug discovery

Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： Miao Liu Haiqing Zhang Zhichao Wang Tingting Mo xuefeng Lai Yaling He Minghui jiang Meian He Weijia Kong Tangchun Wu Xiaomin Zhang Department of Occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was lacking.The present study included 15,827 participants from the Dongfeng–Tongji cohort study.Genetic risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing loss.We conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with PRS.Results showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 p.***.to 10:00 p.***.compared to those with bedtime>10:00 p.***.to 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

Total Synthesis of Trabectedin,Lurbinectedin,and Renieramycin T

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CCS Chemistry 2023年第9期5卷 2152-2158页

作者： Dong Li Jiaolong Meng xuefeng jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process East China Normal UniversityShanghai 200062 State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032 State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071

Trabectedin and lurbinectedin are therapeutic antitumor pharmaceuticals approved by the Food and Drug Administration for treating soft tissue sarcomas and metastatic small cell lung cancer and have been facing synthesis challenges over the past three decades.In this report,the total synthesis of trabectedin,lurbinectedin,and renieramycin T were accomplished in 22-27 steps.The synthetic strategy features stereocontrolled Pictet-Spengler(PS)reaction leading to the multisubstituted tetrahydroisoquinoline fragment(DE ring),aldol condensation for C4-C10 bond formation,and a second PS cyclization with asymmetric oxomalonate for the fully substituted B ring,in which palladium complex-induced stereoselectivity is achieved via decarboxylative protonation anchoring the C1 stereocenter.The pentacyclic skeleton(A-E)was efficiently effectuated at a gramscale,displaying superior potential for further drug development.

关键词： trabectedin lurbinectedin renieramycin T total synthesis decarboxylative protonation

FeS@LAB-35@Ti_(3)C_(2)as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing

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Nano Research 2023年第2期16卷 2840-2850页

作者： Gaoqi Sun xuefeng jiang Cheng Liu Saijie Song Jun Zhang Jian Shen National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Medical School Nanjing UniversityNanjing 210093China jiangsu Engineering Research Center of Interfacial Chemistry Nanjing UniversityNanjing 210023China

The abuse of antibiotics leads to a significant increase in bacterial resistance,which makes it difficult to treat bacterial infections.Therefore,it is urgent to develop new strategies for efficient antibacterial and wound healing.Recently,nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high efficiency.In this study,we report a FeS@lauramidopropyl betaine(LAB-35)@Ti_(3)C_(2)nanozyme as a high-efficiency antibacterial agent for near infrared(NIR)light induced photothermal enhanced chemodynamic antibacteria and wound healing.The FeS@LAB-35@Ti_(3)C_(2)nanozyme possesses peroxidase-like catalysis activity,which can promote the generation of hydroxyl radicals(·OH)through catalyzing the decomposition of H_(2)O_(2).FeS@LAB-35@Ti_(3)C_(2)has photothermal conversion efficiency(η=65.1%),and it exhibits enhanced catalytic activity under NIR light irradiation.The in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti_(3)C_(2)against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus.The animal experiments indicate that FeS@LAB-35@Ti_(3)C_(2)nanozyme can effectively inhibit wound ulceration and promote wound healing.Overall,this study proposes FeS@LAB-35@Ti_(3)C_(2)nanozyme that integrates chemodynamic and photothermal therapy,which provides an efficient strategy for bacterial inhibition and wound healing.

关键词： MXene FeS nanozyme photothermal enhanced chemodynamic antibacterial activity wound healing

Full-Spectrum Fluoromethyl Sulfonation via Modularized Multicomponent Coupling

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CCS Chemistry 2022年第5期4卷 1526-1534页

作者： Kejie Li Ming Wang xuefeng jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062 State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071

Modular free-assembly construction of mono-,di-,and tri-fluoromethyl sulfones was comprehensively achieved by a combination of halides,a sulfur dioxide surrogate,and halofluorocarbons.The industrial raw material thiourea dioxide served as the sulfur dioxide source,combined with readily available fluorocarbon sources such as 2-bromo-2-fluoroacetate and chlorodifluoromethane(ClCF_(2)H,Freon)employed as fluoromethyl reagents.Notably,four methyl sulfone-containing pharmaceuticals were modified into three types of fluoromethyl sulfones,displaying their great potential for drug discovery via the current strategy.Mechanistic studies further demonstrated that C-F…H-N interactions between thiourea dioxide and halofluorocarbons play a key role in stabilizing monofluoromethyl electrophiles and difluorocarbene species.

关键词： sulfone trifluoromethyl sulfone difluoromethyl sulfone monofluoromethyl sulfone thiourea dioxide

Research strategies in click chemistry: Measuring its cognitive contents and knowledge flow

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Chinese Chemical Letters 2023年第2期34卷 3-6页

作者： Jing Zhu Ming Chen He Liang Quanmin Li xuefeng jiang Department of Philosophy East China Normal UniversityShanghai 200241China School of Journalism Fudan UniversityShanghai 200433China Shanghai Key Laboratory of Green Chemistry and Chemical Process Department of ChemistryEast China Normal UniversityShanghai 200062China

The issue about how outstanding scientists obtained innovative findings has drawn the interest of researchers in science, policy and scientometrics. Here, we attempt to address this question by using computational methods to measure the cognitive content and concepts of K. Barry Sharpless’ research and estimate the knowledge flow of his click chemistry to other fields. First, we traced Sharpless’ conceptual journey over time through topic modeling approach, mapping and clustering of the epistemic network from distant reading his publications. We find that connectivity and functions, the core features of click chemistry, are embodied in his constant search for simplicity. What makes simplicity possible is his continuous work with collaborators on reactivity and reaction mechanisms. Moreover, citation and link analysis show that click chemistry had a much richer impact on other research fields than what is generally acknowledged, and drew solutions to significant and practical questions back to chemistry from biology.Together with these findings, we propose that the click chemistry philosophy follows the way that values nature’s principle. Chemistry has a clear-cut epistemic domain in modeling Nature. Thus, click chemistry as a concept on doing science beyond a connective technology goes across the boundaries between disciplines and impacts many other fields.

关键词： Click chemistry K.B.Sharpless Research strategies Connectivity History and philosophy of chemistry

Optothermal dynamics in whispering-gallery microresonators

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Light(Science & Applications) 2020年第1期9卷 1760-1774页

作者： xuefeng jiang Lan Yang Department of Electrical and System Engineering Washington University in St.LouisSt.LouisMO 63130USA

Optical whispering-gallery-mode microresonators with ultrahigh quality factors and small mode volumes have played an important role in modern physics.They have been demonstrated as a diverse platform for a wide range of applications in photonics,such as nonlinear optics,optomechanics,quantum optics,and information processing.Thermal behaviors induced by power build-up in the resonators or environmental perturbations are ubiquitous in high-quality-factor whispering-gallery-mode resonators and have played an important role in their operation for various applications.In this review,we discuss the mechanisms of laser-field-induced thermal nonlinear effects,including thermal bistability and thermal oscillation.With the help of the thermal bistability effect,optothermal spectroscopy and optical nonreciprocity have been demonstrated.By tuning the temperature of the environment,the resonant mode frequency will shift,which can also be used for thermal sensing/tuning applications.The thermal locking technique and thermal imaging mechanisms are discussed briefly.Finally,we review some techniques employed to achieve thermal stability in a high-quality-factor resonator system.

关键词： oscillation optics nonlinear

Parallel photoreactor development with enhanced photon efficiency and reproducibility based on laws of optics

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绿色合成与催化(英文)

绿色合成与催化(英文) 2023年第2期4卷 169-172页

作者： Rizvi Syed Aal E Ali Yilin Zhou Kai Gong xuefeng jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai200062China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A lab-scale parallel photoreactor model has been developed for broad applications in organic chemistry.Position,angle,and distance in the reactor are systematically optimized for achieving high reproducibility under the guidance of the Inverse Square Law and Lambert’s Cosine Law,which were first applied in the design of the photoreactor.Improvement of photon efficiency is realized via 3-point irradiation and broad-band light reflector of aluminum.Photon flux is measured with an optical power meter with its display and adjustment suggested being integrated into the photoreactor for the first time.

关键词： Photochemistry Parallel photo reactor Photo reactor design Photon efficiency Optical laws