The application of sulfur-containing peptides in drug discovery

作     者：Jiaoyan Zhao Xuefeng Jiang 

作者机构：Shanghai Key Laboratory of Green Chemistry and Chemical ProcessSchool of Chemistry and Molecular EngineeringEast China Normal University State Key Laboratory of Elemento-organic ChemistryNankai University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2018年第29卷第7期

页      面：1079-1087页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 0703[理学-化学] 10[医学] 

基　　金：financial support provided by The National Key Research and Development Program of China (No. 2017YFD0200500) the National Natural Science Foundation of China (Nos. 21722202, 21672069, 21472050) S&TCSM of Shanghai (No. 18JC1415600),S&TCSM of Shanghai(No.18JC1415600) Fok Ying Tung Education Foundation(No. 141011) DFMEC(No. 20130076110023) Professor of Special Appointment(Eastern Scholar) at Shanghai Institutions of Higher Learning,National Program for Support of Top-Notch Young Professionals 

主　　题：Peptides Disulfide Thioether Thiazole Drug discovery 

摘      要：In recent decades, peptides as potential drugs were more and more explored with the development of non-oral medicine. There into, sulfur-containing peptide is one of the most popular aspects in peptide drugs due to the introduction of sulfur atoms leading unique properties.The purpose of the present review is to focus on the discovery of various sulfur-containing peptides with particular emphasis on their pharmacological mechanisms. This review is organized according to the structures of the sulfurcontaining peptides.