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文献详情 >C-Aryl Glycosylation via Inter... 收藏

C-Aryl Glycosylation via Interrupted Pummerer Rearrangement

作     者:Jiagen Li Xuefeng Jiang Jiagen Li;Xuefeng Jiang

作者机构:State Key Laboratory of Molecular&Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062 China State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin300071 China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China 

出 版 物:《Chinese Journal of Chemistry》 (中国化学(英文版))

年 卷 期:2023年第41卷第21期

页      面:2843-2847页

核心收录:

学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基  金:The authors are grateful for financial support provided by NSFC(22125103and21971065) STCSM(22JC1401000,20xD1421500 and 20JC1416800) the Fundamental Research FundsfortheCentral Universities 

主  题:Glycal Glycosylation Interrupted pummerer Rearrangement Sulfoxide Carbohydrates C-Glycosides Drug discovery 

摘      要:C-aryl glycosides are an important kind of carbohydrate derivatives for drug discovery,due to their distinctive attributes of resistance to hydrolysis from ***,C-aryl glycosylation was established for the synthesis of 2-sulfur C-aryl glycals and 1,2-dihydrobenzofuran-fused C-aryl glycosides via interrupted Pummerer process,featured with sulfonium-tethered[3,3]-sigmatropic rearrangement between sulfoxide glycals and *** protocol offers a broad substrate scope with diverse glycosyl and ***,Empagliflozin,and Ipragliflozin analogs were straightforward achieved,respectively.

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