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Smoking, alcohol consumption, and the risk of extrahepatic cholangiocarcinoma:A meta-analysis

World Journal of Gastroenterology 2013年第46期19卷 8780-8788页

作者： Xiao-Hua Ye Jia-Ping Huai Jin Ding Yan-Ping Chen xue-cheng sun Department of Gastroenterology and Hepatology Jinhua Municipal Central Hospital Jinhua Hospital of Zhejiang University Department of Critical Care Medicine Jinhua Municipal Central Hospital Department of Gastroenterology and Hepatology First Affiliated Hospital of Wenzhou Medical University

AIM:To assess the association between smoking and alcohol consumption and extrahepatic cholangiocarcinoma(ECC)through a meta-analysis of clinical observational ***:A literature search was conducted using Embase and MEDLINE databases from inception to 31May 2013 without language limitations,and by manually searching the references of retrieved *** and cohort studies that investigated the association between smoking or alcohol consumption and ECC were *** quality of these studies was assessed using the Newcastle-Ottawa quality assessment *** relative risks and corresponding95%CI were calculated using a random-effects *** bias was assessed by Begg’s funnel plot and Egger’s ***:A total of 12 eligible articles(11 case-control studies and one cohort study)were included in this *** studies reported the association between smoking and *** analysis indicated that smokers had an increased risk of ECC development as compared with non-smokers(summary RR=1.23;95%CI:1.01-1.50).This correlation was present in population-based studies(n=5;summary RR=1.47;95%CI:1.06-2.05)but not in hospital-based studies(n=6;summary RR=1.10;95%CI:0.88-1.37)and in non-Asian regions(n=7;summary RR=1.39;95%CI:1.03-1.87)but not in Asia(n=4;summary RR=1.08;95%CI:0.85-1.38).Seven studies reported an association between consuming alcohol and *** analysis indicated that alcohol drinkers had a similar risk of ECC development as did individuals who did not drink alcohol(summary RR=1.09;95%CI:0.87-1.37).There was moderate heterogeneity among the studies and no evidence of publication ***:Smoking is associated with an increased risk of ECC,but alcohol consumption is *** population-based studies,particularly cohort studies,are warranted to enable definitive conclusions.

关键词： Extrahepatic cholangiocarcinoma Smoking Alcohol consumption Meta-analysis Relative risk

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Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice

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World Journal of Gastroenterology 2013年第15期19卷 2340-2347页

作者： xue-cheng sun Jing-Yi Yan Xiao-Lei Chen Ying-Peng Huang Xian Shen Xiao-Hua Ye Department of Gastroenterology and Hepatology the First Affiliated Hospital of Wenzhou Medical College Department of Gastroenterology and General Surgery the First Affiliated Hospital of Wenzhou Medical College

AIM: To explore effects of telomerase RNA-targeting phosphorothioate antisense oligodeoxynucleotides (PS-ASODN) on growth of human gastrointestinal stromal tumors transplanted in mice. METHODS: A SCID mouse model for transplantation of human gastrointestinal stromal tumors (GISTs) was established using tumor cells from a patient who was diagnosed with GIST and consequently had been treated with imatinib. GIST cells cultured for 10 passages were used for inoculation into mice. Transfection of PS-ASODN was carried out with Lipotap Liposomal Transfection Reagent. GISTs that subsequently developed in SCID mice were subjected to intratumoral injection once daily from day 7 to day 28 postinoculation, and mice were divided into the following four groups according to treatment: PS-ASODN group (5.00 μmoL/L of oligonucleotide, each mouse received 0.2 mL once daily); imatinib group (0.1 mg/g body weight); liposome negative control group (0.01 mL/g); and saline group (0.01 mL/g). On day 28, the mice were sacrificed, and tumor attributes including weight and longest and shortest diameters were measured. Tumor growth was compared between treatment groups, and telomerase activity was measured by enzyme-linked immunosorbent assay. Apoptosis was examined by flow cytometry. Real-time polymerase chain reaction was used to detect expression of the mRNA encoding the apoptosis inhibition B-cell leukemia/lymphoma 2 (bcl-2 ) gene. RESULTS: In the PS-ASODN group, tumor growth was inhibited by 59.437%, which was markedly higher than in the imatinib group (11.071%) and liposome negative control group (2.759%) [tumor inhibition=(mean tumor weight of control group - mean tumor weight of treatment group)/(mean tumor weight of control group) × 100%]. Telomerase activity was significantly lower (P < 0.01) in the PS-ASODN group (0.689 ± 0.158) compared with the imatinib group (1.838 ± 0.241), liposome negative control group (2.013 ± 0.273), and saline group (2.004 ± 0.163). Flow cytometry revealed

关键词： Gastrointestinal stromal tumor Phosphorothioate antisense oligonucleotides Imatinib Tumor inhibitory rate Telomerase activity

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Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22

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World Journal of Gastroenterology 2012年第36期18卷 5122-5128页

作者： Jia-Ping Huai xue-cheng sun Meng-Jun Chen Yin Jin Xiao-Hua Ye Jian-Sheng Wu Zhi-Ming Huang Department of Gastroenterology First Affiliated Hospital of Wenzhou Medi- cal College Wenzhou 325000 Zhejiang Province China

AIM： To investigate whether therapeutic treatment with melatonin could protect rats against acute pan- creatitis and its associated lung injury. METHODS： Seventy-two male Sprague-Dawley rats were randomly divided into three groups： the sham op- eration （SO）, severe acute pancreatitis （SAP）, and mel- atonin treatment （MT） groups. Acute pancreatitis was induced by infusion of 1 mL/kg of sodium taurocholate （4% solution） into the biliopancreatic duct. Melatonin （50 mg/kg） was administered 30 min before pancre- atitis was induced, and the severity of pancreatic and pulmonary injuries was evaluated 1, 4 and 8 h after induction. Serum samples were collected to measure amylase activities, and lung tissues were removed to measure levels of mRNAs encoding interleukin 22 （IL-22） and T helper cell 22 （Th22）, as well as levels of *** IL-22 and Th22 were significantly higher （P 〈 0.001） in the MT group than in the SAP group （0.526 ± 0.143 vs 0.156 ± 0.027, respectively, here and throughout, after 1 h; 0.489 ± 0.150 vs 0.113 ± 0.014 after 4 h; 0.524 ± 0.168 vs 0.069 ± 0.013 after 8 h, 0.378 ± 0.134 vs 0.122 ± 0.015 after 1 h; 0.205 ± 0.041 vs 0.076 ± 0.019 after 4 h; 0.302 ± 0.108 vs 0.045 ± 0.013 after 8 h, respectively） and significantly lower （P 〈 0.001） in the SAP group than in the SO group （0.156 ± 0.027 vs 1.000 ± 0.010 after 1 h; 0.113 ± 0.014 vs 1.041 ± 0.235 after 4 h; 0.069 ± 0.013 vs 1.110 ± 0.213 after 8 h, 0.122 ± 0.015 vs 1.000 ± 0.188 after 1 h; 0.076 ± 0.019 vs 0.899 ± 0.125 after 4 h; 0.045 ± 0.013 vs 0.991 ± 0.222 after 8 h, respectively）. The mean pathologi- cal scores for pancreatic tissues in the MT group were significantly higher （P 〈 0.01） than those for samples in the SO group （1.088 ± 0.187 vs 0.488 ± 0.183 after 1 h, 2.450 ± 0.212 vs 0.469 ± 0.242 after 4 h; 4.994 ± 0.184 vs 0.513 ± 0.210 after 8 h）, but were significantly lower （P 〈 0.01） than those for samples in the SAP group at each time point （1.088 ± 0.187 vs 1.969 ± 0.290 after 1 h; 2.450 ±

关键词： Interleukin 22 Melatonin Pancreatitis-associated lung injury Severe acute pancreatitis Thelper 22 cell

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Genetically engineered FGF1-sericin hydrogel material treats intrauterine adhesion and restores fertility in rat

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Regenerative Biomaterials 2022年第1期9卷 67-80页

作者： Chun-Yi Guan Feng Wang Lu Zhang xue-cheng sun Dan Zhang Hu Wang Hong-Fei Xia Qing-You Xia Xu Ma Reproductive and Genetic Center of National Research Institute for Family Planning Beijing 100081People’s Republic of China Graduate School Peking Union Medical CollegeBeijing 100005People’s Republic of China Biological Science Research Center Chongqing Key Laboratory of Sericultural ScienceChongqing Engineering and Technology Research Center for Novel Silk MaterialsSouthwest UniversityChongqing 400715People’s Republic of China

Endometrial injury can cause intrauterine adhesions(IUA)and induce the formation of endometrial fibrosis,leading to infertility and *** present,there is no effective treatment method for severe IUA and uterine basal injury with adhesion area larger than one-third of the *** this study,we prepared FGF1 silk sericin hydrogel material(FGF1-SS hydrogel)to treat endometrial injury and prevent endometrial *** with the silk sericin hydrogel material(WT-SS hydrogel),FGF1-SS hydrogel significantly promotes the cell migration and infiltration ability of endometrial stromal cells(ESCs).More importantly,FGF1-SS hydrogel can release FGF1 stably for a long time and inhibit the ESCs injury model forms fibrosis through the TGF-β/Smad *** the IUA rat model,FGF1-SS hydrogel treatment effectively restored the number of uterine glands and uterine wall thickness in rats,with a fertility rate of 65.1%66.4%.The results show that FGF1-SS hydrogel is expected to be a candidate to prevent IUA.

关键词： intrauterine adhesions FGF1-sericin hydrogel fibrosis TGF-β/Smad

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Uptake,transport and distribution of molybdenum in two oilseed rape (Brassica napus L.) cultivars under different nitrate/ammonium ratios

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第6期18卷 512-521页

作者： Shi-yu QIN xue-cheng sun cheng-xiao HU Qi-ling TAN Xiao-hu ZHAO Microelement Research Center Huazhong Agricultural UniversityWuhan 430070China Hubei Provincial Engineering Laboratory for New-Type Fertilizer College of Resources and EnvironmentHuazhong Agricultural UniversityWuhan 430070China MOA Key Laboratory of Arable Land Conservation(Middle and Lower Reaches of Yangtze River) Wuhan 430070China

Objectives：To investigate the effects of different nitrate sources on the uptake,transport,and distribution of molybdenum（Mo）between two oilseed rape（Brassica napus L.）cultivars,L0917 and ***：A hydroponic culture experiment was conducted with four nitrate/ammonium（NO3^-：NH4^＋）ratios（14：1,9：6,7.5：7.5,and 1：14）at a constant nitrogen concentration of 15 mmol/*** examined Mo concentrations in roots,shoots,xylem and phloem sap,and subcellular fractions of leaves to contrast Mo uptake,transport,and subcellular distribution between ZS11and ***：Both the cultivars showed maximum biomass and Mo accumulation at the 7.5：7.5 ratio of NO3^-：NH4^＋ while those were decreased by the 14：1 and 1：14 ***,the percentages of root Mo（14.8%and 15.0%for L0917 and ZS11,respectively）were low under the 7.5：7.5 treatment,suggesting that the equal NO3^-：NH4^＋ratio promoted Mo transportation from root to *** xylem sap Mo concentration and phloem sap Mo accumulation of L0917 were lower than those of ZS11 under the 1：14 treatment,which suggests that higher NO3^-：NH4^＋ratio was more beneficial for *** the contrary,a lower NO3^-：NH4^＋ratio was more beneficial for ZS11 to transport and remobilize ***,the Mo concentrations of both the cultivars’leaf organelles were increased but the Mo accumulations of the cell wall and soluble fraction were reduced significantly under the 14：1 treatment,meaning that more Mo was accumulated in organelles under the highest NO3^-：NH4^＋***：This investigation demonstrated that the capacities of Mo absorption,transportation and subcellular distribution play an important role in genotype-dependent differences in Mo accumulation under low or high NO3^-：NH4^＋ratio conditions.

关键词： Brassica napus L Nitrogen source Transport Subcellular distribution Xylem Phloem

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Determination of reaction heat on the hydrolytic polymerization of chromium(Ⅲ) ion by microcalorimetric method

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Chinese Journal of Chemistry 1996年第3期14卷 286-288页

作者： YU, Xiu-Fang ZHANG, Hong-LinDepartment of Chemistry, Qufu Normal University, Qufu, Shandong 273165, ChinaLU, cheng-xue sun, Si-XiuDepartment of Chemistry, Shandong University, Jinan, Shandong 250100, China Department of Chemistry Qufu Normal University Qufu Shandong 273165 China Department of Chemistry Shandong University Jinan Shandong 250100 China

Thermochemistry is the study of the energy changes which occur during a chemi-cal reaction. For example, in the hydrolytic polymerization of Cr, Cr[Cr（OH）],Cr[Cr（OH）]and Cr[Cr（OH）]were formed at concentration ra... 详细信息

关键词： Chromium(Ⅲ) hydrolytic polymerization reaction heat thermodynamical function

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软基场地地铁车站地震响应及参数敏感性分析

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铁道工程学报 2017年第3期34卷 92-98,105页

作者：崔春义程学磊孙宗光许成顺大连海事大学大连116026 北京工业大学城市与工程安全减灾省部共建教育部重点实验室北京100124

研究目的:为更加全面地探讨软土场地中地铁车站结构地震动力响应特性和灾变机理,分析软基土性参数变化对土体特征点处动孔压比、地铁车站结构特征位置处内力等动力响应指标变化影响规律,本文采用两相介质动力分析方法和多指标综合平衡... 详细信息

研究目的:为更加全面地探讨软土场地中地铁车站结构地震动力响应特性和灾变机理,分析软基土性参数变化对土体特征点处动孔压比、地铁车站结构特征位置处内力等动力响应指标变化影响规律,本文采用两相介质动力分析方法和多指标综合平衡法对饱和软土地基-地铁车站结构动力相互作用体系进行数值分析与参数敏感性分析,旨在为认识地铁车站结构地震动力灾变机理提供参考。研究结论:(1)结构底板附近存在环状动孔压比峰值区域,引起两侧远场土体向内部侧向流动,对结构底部产生挤压上抬作用;(2)结构体系中底板、剪力墙下端和中柱为受力破坏薄弱部位;(3)软基土性因素中黏聚力对典型动力响应指标影响最为显著,参考体积模量次之;(4)该研究成果可用于指导软土地基地铁车站结构抗震设计。

关键词：饱和软土地铁车站结构动力响应分析正交试验设计敏感性

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Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu sun Weichen Zheng Liangwei Zhang Yanling xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

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功能食品与饮品中牛磺酸的柱前衍生-高效毛细管电泳法快速测定

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分析测试学报 2010年第4期29卷 386-389,393页

作者：薛勇薛丰孙成均四川大学华西公共卫生学院卫生检验教研室四川成都610041

建立了功能食品和饮品中牛磺酸的高效毛细管电泳陕速分析方法。以邻苯二甲醛（OPA）为衍生剂进行柱前衍生，采用45mmol／L（pH9．5）的硼砂缓冲溶液为运行缓冲溶液，熔融石英毛细管（50cm×50μm，有效长度41cm，未涂层）为分离柱；柱... 详细信息

建立了功能食品和饮品中牛磺酸的高效毛细管电泳陕速分析方法。以邻苯二甲醛（OPA）为衍生剂进行柱前衍生，采用45mmol／L（pH9．5）的硼砂缓冲溶液为运行缓冲溶液，熔融石英毛细管（50cm×50μm，有效长度41cm，未涂层）为分离柱；柱上紫外睑测波长：335nm，分离电压19kV，电泳温度20℃，重力进样，进样时间10s。牛磺酸的质量浓度在5．0～100．0mg／L范围内呈良好线性关系（r〉0．999），检出限（S／N=3）为1．6mg／L，迁移时问和峰面积的相对标准偏差（n=7）分别为2．4％和3．8％。用该法测定了功能食品、乳制饮品和饮料等样品中的牛磺酸，相对标准偏差为0．7％～3．7％，加标回收率为93％～111％。

关键词：牛磺酸高效毛细管电泳法柱前衍生功能食品饮品

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Regulation of graphdiyne-based nanozymes with enhanced oxidaselike activity by cobalt and nitrogen codoping

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Nano Research 2025年第1期18卷 21-29页

作者： Jiali Liu Xiaoli Wang Yongfu Lian xue Wang Xiuxiu Wang Xingfa Gao Baoyun sun Xihong Guo CAS Key Laboratory for Biomedical Effects of Nanomaterial&Nanosafety Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of nanozymes with excellent intrinsic oxidase-like activity and specificity has received increasing ***(GDY)could be a promising choice for designing nanozymes with enhanced oxidase(OXD)-like activity due to its unique structure and ***,Co-N-GDY with high OXD activity but no peroxidase(POD)activity was synthesized by codoping of cobalt(Co)and nitrogen(N)into GDY and compared with other GDY-based nanozymes(including GDY,Co-GDY,and N-GDY).Upon analyzing the doping effect of Co and N on the OXD-like and POD-like activities,we found that the combination of Co and N in GDY played a significant role in enhancing the OXD-like activity,and even reversed the POD-like activity of N-GDY to OXD-like activity of *** electrochemical experiment and the theoretical calculations provided an explanation for the mechanism and showed that the activity was closely linked to the reduction ability of O_(2) or H_(2)O_(2) on the nanozyme substrates,which was determined by the ratedetermining step of the catalytic reaction.

关键词： nanozymes oxidase-like activity graphdiyne heteroatom doping regulation

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