Genetically engineered FGF1-sericin hydrogel material treats intrauterine adhesion and restores fertility in rat
作者机构：Reproductive and Genetic Center of National Research Institute for Family PlanningBeijing 100081People’s Republic of China Graduate SchoolPeking Union Medical CollegeBeijing 100005People’s Republic of China Biological Science Research CenterChongqing Key Laboratory of Sericultural ScienceChongqing Engineering and Technology Research Center for Novel Silk MaterialsSouthwest UniversityChongqing 400715People’s Republic of China
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2022年第9卷第1期
页 面：67-80页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程]
基 金：funded by grants from the National Key Research and Development Program of China(2016YFC1000803) the National Natural Science Foundation of China(No.32030103)
主 题：intrauterine adhesions FGF1-sericin hydrogel fibrosis TGF-β/Smad
摘 要：Endometrial injury can cause intrauterine adhesions(IUA)and induce the formation of endometrial fibrosis,leading to infertility and *** present,there is no effective treatment method for severe IUA and uterine basal injury with adhesion area larger than one-third of the *** this study,we prepared FGF1 silk sericin hydrogel material(FGF1-SS hydrogel)to treat endometrial injury and prevent endometrial *** with the silk sericin hydrogel material(WT-SS hydrogel),FGF1-SS hydrogel significantly promotes the cell migration and infiltration ability of endometrial stromal cells(ESCs).More importantly,FGF1-SS hydrogel can release FGF1 stably for a long time and inhibit the ESCs injury model forms fibrosis through the TGF-β/Smad *** the IUA rat model,FGF1-SS hydrogel treatment effectively restored the number of uterine glands and uterine wall thickness in rats,with a fertility rate of 65.1%66.4%.The results show that FGF1-SS hydrogel is expected to be a candidate to prevent IUA.
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