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Unveiling microplastic distribution and interactions in the benthic layer of the Yangtze River Estuary and East China Sea

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Environmental Science and Ecotechnology 2024年第4期20卷 114-122页

作者： Xinyu ge Feng xu Bo Li Lili Liu Xiao Lu Lijuan Wang Yunxiao Zhang Jiangpeng Li Jiawei Li Yuanyuan Tang School of Environmental Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055China State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resource and Environmental EngineeringEast China University of Science and TechnologyShanghai200237China School of Marine Science and Technology Zhejiang Ocean UniversityZhoushan316004China

Microplastics(MPs),recognized as an emerging global environmental concern,have been extensively detected worldwide,with specific attention directed towards the Yangtze River Estuary(YRE)and East China Sea(ECS)*** their critical research significance,there remains a knowledge gap concerning the distribution of MPs in the benthic layer within this area,particularly regarding interactions governing their *** we illuminate the distribution of MPs within the benthic layer and unravel the intricate interplay between bottom water and sediment in the YRE and *** find that MPs are notably more abundant in bottom water,ranging from 8 to 175 times higher than in surface *** MPs predominantly consist of polyester fibers,exhibit a size range between 0.5 and 5.0 mm,and display distinct ***-occurrence network analysis and Principal Coordinate Analysis confirm a robust correlation between MPs in bottom water and sediment,signifying the pivotal role of bottom water in mediating the distribution and transportation of MPs within the benthic ***,a positive correlation between MPs in sediment and bottom water turbidity underscores the impact of surface sediment resuspension and upwelling on MPs *** study clarifies the intricate interactions within the benthic layer and highlights the crucial role of bottom water as a mediator in the vertical distribution of MPs,advancing our understanding of the“source-to-sink”transport processes governing MPs within water-sediment systems.

关键词： Microplastics Bottom water Sediment Distribution Correlation analysis

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Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ

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Frontiers of Medicine 2024年第3期18卷 465-483页

作者： Fei xu Han Chen Changyi Zhou Tongtong Zang Rui Wang Shutong Shen Chaofu Li Yue Yu Zhiqiang Pei Li Shen Juying Qian Junbo ge Department of Cardiology and Laboratory of Heart Valve Disease West China HospitalSichuan UniversityChengdu610041China Department of Cardiology Zhongshan HospitalFudan UniversityResearch Unit of Cardiovascular Techniques and DevicesChinese Academy of Medical SciencesShanghai200032China Shanghai Institute of Cardiovascular Diseases Shanghai200032China National Clinical Research Center for Interventional Medicine&Shanghai Clinical Research Center for Interventional Medicine(19MC1910300) Shanghai200032China

Atherosclerosis is a chronic artery disease that causes various types of cardiovascular *** smooth muscle cells(VSMCs),the main components of atherosclerotic plaque,switch from contractile to synthetic phenotypes during *** is crucial in regulating VSMC phenotypes in atherosclerosis,and it can be reversely regulated by ***,the specific effects of deubiquitinases on atherosclerosis have not been thoroughly *** this study,RNAi screening in human aortic smooth muscle cells was performed to explore the effects of OTU family deubiquitinases,which revealed that silencing OTUB1 inhibited PDGF-BB-stimulated VSMC phenotype *** in vivo studies using Apoe−/−mice revealed that knockdown of OTUB1 in VSMCs alleviated atherosclerosis plaque burden in the advanced stage and led to a stable plaque ***,VSMC proliferation and migration upon PDGF-BB stimulation could be inhibited by silencing OTUB1 in *** RNA-sequencing data indicated that knocking down OTUB1 influenced VSMC differentiation,adhesion,and *** spectrometry of ubiquitinated protein confirmed that proteins related to cell growth and migration were differentially ***,we found that OTUB1 recognized the K707 residue ubiquitylation of PDGFRβwith its catalytic triad,thereby reducing the K48-linked ubiquitylation of PDGFRβ.Inhibiting OTUB1 in VSMCs could promote PDGFRβdegradation via the ubiquitin–proteasome pathway,so it was beneficial in preventing VSMCs’phenotype *** findings revealed that knocking down OTUB1 ameliorated VSMCs’phenotype switch and atherosclerosis progression,indicating that OTUB1 could be a valuable translational therapeutic target in the future.

关键词： atherosclerosis vascular smooth muscle cell ubiquitylation deubiquitinase OTUB1 PDGFRβ

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Gut microbiota dysbiosis contributes toα-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2024年第9期19卷 2081-2088页

作者： Xiaoli Fang Sha Liu Bilal Muhammad Mingxuan Zheng Xing ge Yan xu Shu Kan Yang Zhang Yinghua Yu Kuiyang Zheng Deqin geng Chun-Feng Liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Neuropsychiatric Disease and Institute of Neuroscience Soochow UniversitySuzhouJiangsu ProvinceChina

Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal *** dysfunction can precede the onset of motor symptoms by several *** microbiota dysbiosis is involved in the pathogenesis of Parkinson’s disease,whether it plays a causal role in motor dysfunction,and the mechanism underlying this potential effect,remain ***/enhancer binding proteinβ/asparagine endopeptidase(C/EBPβ/AEP)signaling,activated by bacterial endotoxin,can promoteα-synuclein transcription,thereby contributing to Parkinson’s disease *** this study,we aimed to investigate the role of the gut microbiota in C/EBPβ/AEP signaling,α-synuclein-related pathology,and motor symptoms using a rotenone-induced mouse model of Parkinson’s disease combined with antibiotic-induced microbiome depletion and fecal microbiota *** found that rotenone administration resulted in gut microbiota dysbiosis and perturbation of the intestinal barrier,as well as activation of the C/EBP/AEP pathway,α-synuclein aggregation,and tyrosine hydroxylase-positive neuron loss in the substantia nigra in mice with motor ***,treatment with rotenone did not have any of these adverse effects in mice whose gut microbiota was depleted by pretreatment with ***,we found that transplanting gut microbiota derived from mice treated with rotenone induced motor deficits,intestinal inflammation,and *** of fecal microbiota from healthy control mice alleviated rotenone-induced motor deficits,intestinal inflammation,endotoxemia,and intestinal barrier *** results highlight the vital role that gut microbiota dysbiosis plays in inducing motor deficits,C/EBPβ/AEP signaling activation,andα-synuclein-related pathology in a rotenone-induced mouse model of Parkinson’s ***,our findings suggest that supplementing with healthy microbiota may be a safe and effective treatment that c

关键词： C/EBP/AEP signaling pathway endotoxemia fecal microbiota transplantation intestinal barrier intestinal inflammation microbiota-gut-brain axis Parkinson’s disease

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Association between central serous chorioretinopathy and Helicobacter pylori infection: a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1120-1127页

作者： Da-Wen Wu Fei-Peng Jiang ge ge Mei-Xia Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To investigate the association between central serous chorioretinopathy(CSC)and Helicobacter pylori(Hp)by summarizing all available ***:The Scopus,Embase,EBSCO,PubMed,Web of Science,and Cochrane Library databases for all relevant studies published from inception to October 2022 were searched,and manually searched for relevant reference lists as a *** investigating the association between CSC and Hp infection were ***,8 case-control studies were included in the Meta-analysis after study ***:The results showed no significant correlation between Hp infection and CSC[odds ratio(OR)1.89,95%confidential interval(CI)0.58–6.15,I2=96%,P=0.29].After subgroup analysis based on the degree of development of the study(developing/developed countries),it was found that the results of the two subgroups were the same as the whole,and no significant difference between the two subgroups ***-regression showed that the effect of sample size on heterogeneity among studies was more prominent(P<0.01,adjusted R^(2)=89.72%),which can explain 89.72%of the sources of ***:This Meta-analysis reveals no significant correlation between Hp infection and CSC,which still warrants further well-designed extensive sample studies to reach a more reliable conclusion and promote a better understanding of the treatment of CSC.

关键词： central serous chorioretinopathy Helicobacter pylori infection retinal diseases Meta-analysis

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Nickel/Photoredox Dual Catalytic Chan-Lam Coupling of Aryl Azides and Arylboric Acids

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Chinese Journal of Chemistry 2024年第18期42卷 2228-2234页

作者： Xia ge Haojie Ji Hongjian Lu Schoolof Chemistry and Chemical Engineering Nanjing UniversityNanjingJiangsu 210093China

Unsymmetrical diarylamines are crucial components in many pharmaceuticals and functional *** this study,we introduce an efficient Chan-Lam cross-coupling method that utilizes phenylboronic acids and aryl azides as coupling agents in a redox-neutral environment,enabled by a synergistic nickel/photoredox catalytic *** approach leverages a proton-coupled electron transfer mechanism to bypass the typical nitrene pathway associated with aryl azides,which is prone to intramolecular rearrangement,C-H amination,and reductive ***,our method exhibits broad compatibility with a variety of functional groups,including those derived from pharmaceuticals,demonstrating its versatile potential in organic synthesis and drug modification.

关键词： Azides Chan-Lam reaction Nickel Iridium Redox-neutral Photochemistry

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Endovascular embolization by a magnetic microfiberbot

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National Science Review 2024年第5期11卷 95-96页

作者： Shuning Zhang Wenlong Yang Junbo ge Department of Cardiology Zhongshan HospitalFudan University Shanghai Institute of Cardiovascular Diseases Key Laboratory of Viral Heart Diseases National Health Commission Key Laboratory of Viral Heart Diseases Chinese Academy of Medical Sciences National Clinical Research Center for Interventional Medicine Institutes of Biomedical Sciences Fudan University

The evolving landscape of embolization therapy for treating cerebral aneurysms and brain tumors represents a pivotal stride towards enhancing the efficacy and safety of minimally invasive treatments [1]. Conventional endovascular embolization methods [2], characterized by the manual maneuvering of catheters through the vascular system, present notable limitations in steerability and precision, compounded by the potential health risks associated with prolonged exposure to radiation for surgeons.

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Exponential Synchronization of Delayed Stochastic Complex Dynamical Networks via Hybrid Impulsive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 785-787页

作者： Yao Cui Pei Cheng Xiaohua ge the School of Mathematic Science Anhui UniversityHefei 230601China IEEE the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia

Dear Editor,This letter addresses the synchronization problem of a class of delayed stochastic complex dynamical networks consisting of multiple drive and response *** aim is to achieve mean square exponential synchronization for the drive-response nodes despite the simultaneous presence of time delays and stochastic noises in node dynamics.

关键词： dynamics stochastic letter

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Molecular packing tuning via chlorinated end group enables efficient binary organic solar cells over 18.5%

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Carbon Energy 2024年第3期6卷 196-203页

作者： Yafeng Li Zhenyu Chen Xingzheng Yan Ziyi ge Zhejiang Business Technology Institute NingboZhejiangChina Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiangChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina

Designing novel nonfullerene acceptors(NFAs)is of vital importance for the development of organic solar cells(OSC).Modification on the side chain and end group are two powerful tools to construct efficient ***,based on the high-performance L8BO,we selected 3-ethylheptyl to substitute the inner chain of 2-ethylhexyl,obtaining the backbone of *** we introduced different halogen atoms of fluorine and chlorine on 2-(3-oxo-2,3-dihydro-1Hinden-1-ylidene)malononitrile end group(EG)to construct efficient NFAs named BON3-F and BON3-Cl,*** donor D18 was chosen to combine with two novel NFAs to construct OSC ***,D18:BON3-Cl-based device shows a remarkable power conversion efficiency(PCE)of 18.57%,with a high open-circuit voltage(V_(OC))of 0.907 V and an excellent fill factor(FF)of 80.44%,which is one of the highest binary PCE of devices based on D18 as the ***,BON3-F-based device shows a relatively lower PCE of 17.79%with a decreased FF of 79.05%.The better photovoltaic performance is mainly attributed to the red-shifted absorption,higher electron and hole mobilities,reduced charge recombination,and enhanced molecular packing in the D18:BON3-Cl ***,we performed stability tests on two binary systems;the D18:BON3-Cl and D18:BON3-F devices maintain 88.1%and 85.5%of their initial efficiencies after 169 h of storage at 85°C in an N2-filled glove box,*** work demonstrates the importance of selecting halogen atoms on EG and provides an efficient binary system of D18:BON3-Cl for further improvement of PCE.

关键词： binary organic solar cell chlorinated end group molecular packing

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Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2842-2861页

作者： Qiang-Qiang Fu Le Ma Xiao-Min Niu Hua-Xin Zhao xu-Hua ge Hua Jin De-Hua Yu Sen Yang Department of general Practice Yangpu HospitalSchool of MedicineTongji UniversityShanghai 200090China Shanghai general Practice and Community Health Development Research Center Shanghai 200090China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200090China

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and *** the evolution and current state of research in this field is *** To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic *** This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and *** analysis focused on the distribution of publications,contributions by institutions and countries,and trends in *** methods included data synthesis,network analysis,and visualization of international collaboration *** This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and *** highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer *** last five years,substantial advancements have been made,representing nearly 45%of the examined *** rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research *** study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical Oncology standing out as a key publication *** shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN *** This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research *** calls for enhanced global collaboration and integration of artificial intelligence to improve cancer p

关键词： Gastrointestinal neoplasms Bibliometric analysis Risk assessment Network analysis Research trends

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Oxygenated carbon nitride-based high-energy-density lithium-metal batteries

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Interdisciplinary Materials 2024年第5期3卷 791-800页

作者： Mengnan Shen Ying Wei Man ge Shengdong Yu Ronghui Dou Liuhua Chen Feng Wang Yunhui Huang Henghui xu School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhanChina School of Chemistry and Material Science Hubei Engineering UniversityXiaoganChina

Lithium(Li)-metal batteries with polymer electrolytes are promising for high-energy-density and safe energy storage ***,current polymer electrolytes suffer either low ionic conductivity or inadequate ability to suppress Li dendrite growth at high current *** study addresses both issues by incorporating two-dimensional oxygenated carbon nitride(2D OCN)into a polyvinylidene fluoride(PVDF)-based composite polymer electrolyte and modifying the Li anode with *** OCN nanosheets incorporated PVDF electrolyte exhibits a high ionic conductivity(1.6×10^(-4)S cm^(-1)at 25℃)and Li+transference number(0.62),wide electrochemical window(5.3),and excellent fire ***,the OCN-modified Li anode in situ generates a protective layer of Li_(3)N during cycling,preventing undesirable reactions with PVDF electrolyte and effectively suppressing Li dendrite *** cells using the upgraded PVDF polymer electrolyte and modified Li anode demonstrate long cycling stability over 2500 h at 0.1 mA cm^(-2).Full cells with a high-voltage LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode exhibit high energy density and long-term cycling stability,even at a high loading of 8.2 mg cm^(-2).Incorporating 2D OCN nanosheets into the PVDF-based electrolyte and Li-metal anode provides an effective strategy for achieving safe and high-energy-density Li-metal batteries.

关键词： additive lithium protection oxygenated carbon nitride polymer electrolytes

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