Nickel/Photoredox Dual Catalytic Chan-Lam Coupling of Aryl Azides and Arylboric Acids
作者机构：Schoolof Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210093China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2024年第42卷第18期
页 面：2228-2234页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：financial support by the National National Natural Science Foundation of China(22271148 22071100)
主 题：Azides Chan-Lam reaction Nickel Iridium Redox-neutral Photochemistry
摘 要：Unsymmetrical diarylamines are crucial components in many pharmaceuticals and functional *** this study,we introduce an efficient Chan-Lam cross-coupling method that utilizes phenylboronic acids and aryl azides as coupling agents in a redox-neutral environment,enabled by a synergistic nickel/photoredox catalytic *** approach leverages a proton-coupled electron transfer mechanism to bypass the typical nitrene pathway associated with aryl azides,which is prone to intramolecular rearrangement,C-H amination,and reductive ***,our method exhibits broad compatibility with a variety of functional groups,including those derived from pharmaceuticals,demonstrating its versatile potential in organic synthesis and drug modification.
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