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Nickel-catalyzed enantioselective reductive amination of benzylic ketones in alcohols

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Science China Chemistry 2024年第8期67卷 2566-2570页

作者： xiuhua Wang Jianrong Steve Zhou State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Asymmetric reductive amination directly converts ketones and amines to alkylamines, which are important motifs in *** report that cationic nickel complexes of chiral diphosphines promote enantioselective reductive amination of benzylic ketones with both arylamines and benzhydrazide. Isopropanol was used as a safe and cheap source of hydrogen instead of formic acid. The reaction can be readily applied to a concise synthesis of diarylethylamines, a class of neuroactive substances.

关键词： transfer hydrogenation nickel catalysis chiral alkylamine reductive amination synthetic method

DNA Amplification in Streptomyces hygroscopicus 10-22

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DNA Amplification in Streptomyces hygroscopicus 10-22

Functional analysis of the EspR binding sites upstream of espR in Mycobacterium tuberculosis

第四届泛环渤海生物化学与分子生物学会学术交流会

作者： Guangxiang Cao Chuanqing Zhong Yuanxin Gu xiuhua pang The State Key Laboratory of Microbial Technology Shandong University Shandong Academy of Medical Sciences School of Municipal and Environmental Engineering Shandong Jianzhu University

T110,obtained through mutational cloning of Streptomyces hygroscopicus 10-22 with pIJ702 derivatives containing 10-22 genomic DNA fragment(1-9kb in size),was found to contain amplified DNA sequence with c.300 copies p...

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Functional analysis of the EspR binding sites upstream of es...

Study on the oxidation mechanism of Al-SiC composite at elevated temperature

第四届泛环渤海生物化学与分子生物学会学术交流会

作者： Guangxiang Cao Susan T.Howard Peipei Zhang Guihua Hou xiuhua pang The State Key Laboratory of Microbial Technology Shandong University Shandong Academy of Medical Sciences Department of Microbiology University of Texas Health Science Center at Tyler School of Medicine Shandong University

The ESX-1 secretion system exports substrate proteins into host cells and is crucial for the pathogenesis of Mycobacterium *** is one of the characterized transcriptional regulators that modulates the ESX-1 system by binding the conserved EspR binding sites in the promoter of espA,the encoding gene of EspA,which is also a substrate protein of the ESX-1 system and is required for the ESX-1 *** is

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2077-2087页

作者： Jishuo Han Yong Li Chenhong Ma Qingyao Zheng xiuhua Zhang Xiaofang Wu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Vesuvius Advanced Ceramics(China)Co. LtdSuzhou 215000China

Resin-bonded Al-SiC composite was sintered at 1100,1300,and 1500℃ in the air,the oxidation mechanism was *** reaction models were also *** oxidation resistance of the Al-SiC composite was significantly enhanced with temperature *** in the exterior of the composite was partially oxidized slightly,while the transformation of metastable Al_(4)C_(3) to stable Al_(4)SiC_(4) existed in the *** 1100℃,Al in the interior reacted with residual C to form Al_(4)C_(3).With increasing to 1300℃,high temperature and low oxygen partial pressure lead to active oxidation of SiC,and internal gas composition transforms to Al_(2)O(g)+CO(g)+SiO(g)as the reaction *** Al_(4)C_(3) is formed,CO(g)and SiO(g)are continuously deposited on its surface,transforming to Al_(4)SiC_(4).At 1500℃,a dense layer consisting of SiC and Al_(4)SiC_(4) whiskers is formed which cuts off the diffusion channel of *** active oxidation of SiC is accelerated,enabling more gas to participate in the synthesis of Al_(4)SiC_(4),eventually forming hexagonal lamellar Al_(4)SiC_(4) with mutual accumulation between SiC *** Al enhances the oxidation resistance of *** addition,the in situ generated non-oxide is uniformly dispersed on a micro-scale and bonds SiC stably.

关键词： Al-SiC composite kiln furniture Al_(4)SiC_(4) Al_(4)C_(3) oxidation mechanism

Comprehensive Risk Assessment of Sea Level Rise and Tropical Cyclones in Dongzhaigang Mangroves,China

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Chinese Geographical Science 2024年第4期34卷 631-646页

作者： DING Ruyi CAI Rongshuo YAN xiuhua LI Cuihua WANG Cui NIE Xinyu Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China

Mangroves play a pivotal role in tropical and subtropical coastal ecosystem,yet they are highly vulnerable to the effects of climate change,particularly the accelerated global sea level rise(SLR)and stronger tropical cyclones(TCs).However,there is a lack of research addressing future simultaneous combined impacts of the slow-onset of SLR and rapid-onset of TCs on China's *** order to develop a comprehensive risk assessment method considering the superimposed effects of these two factors and analyze risk for mangroves in Dongzhaigang,Hainan Island,China,we used observational and climate model data to assess the risks to mangroves under low,intermediate,and very high greenhouse gas(GHG)emission scenarios(such as SSP1-2.6,SSP2-4.5,and SSP5-8.5)in 2030,2050,and 2100,and compiled a risk assessment scheme for mangroves in Dongzhaigang,*** results showed that the combined risks from SLR and TCs will continue to rise;however,SLRs will increase in intensity,and TCs will *** comprehensive risk of the Dongzhaigang mangroves posed by climate change will remain low under SSP1-2.6 and SSP2-4.5 scenarios by 2030,but it will increase substantially by *** under SSP5-8.5 scenario,the risks to mangroves in Dongzhaigang are projected to increase considerably by 2050,and approximately 68.8%of mangroves will be at very high risk by *** risk to the Dongzhaigang mangroves is not only influenced by the hazards but also closely linked to their exposure and *** therefore propose climate resilience developmental responses for mangroves to address the effects of climate *** study for the combined impact of TCs and SLR on mangroves in Dongzhaigang,China can enrich the method system of mangrove risk assessment and provide references for scientific management.

关键词： mangrove climate change risk assessment combined hazards sea level rise(SLR) tropical cyclones(TCs) resilience development Dongzhaigang China

TET1 Participates in Complete Freund’s Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model

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Neuroscience Bulletin 2024年第6期40卷 707-718页

作者： Dengcheng Zhan Jingjing Zhang Songxue Su xiuhua Ren Sen Zhao Weidong Zang Jing Cao Department of Human Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China Neuroscience Research Institute Zhengzhou UniversityZhengzhou450001China

Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans;however,the underlying mechanisms remain largely *** this study,we investigated the possible contribution of interaction between ten-eleven translocation methylcytosine dioxygenase 1(TET1)and the voltage-gated K^(+)channel Kv7.2(encoded by Kcnq2)to orofacial inflammatory pain in *** found that complete Freund’s adjuvant(CFA)injection reduced the expression of Kcnq2/Kv7.2 in the trigeminal ganglion(TG)and induced orofacial inflammatory *** involvement of Kv7.2 in CFA-induced orofacial pain was further confirmed by Kv7.2 knockdown or ***,TET1 knockdown in Tet1^(flox/flox)mice significantly reduced the expression of Kv7.2 and M currents in the TG and led to pain-like ***,TET1 overexpression by lentivirus rescued the CFA-induced decreases of Kcnq2 and M currents and alleviated mechanical *** data suggest that TET1 is implicated in CFA-induced trigeminal inflammatory pain by positively regulating Kv7.2 in TG neurons.

关键词： Facial pain KCNQ2 potassium channel TET1 protein

对中医治疗过敏性紫癜的三点认识——周耀庭治疗过敏性紫癜经验

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北京中医 2006年第4期25卷 208-209页

作者：庞秀花北京门头沟区中医院内科 102300

过敏性紫癜是一种较常见的免疫性疾病,以学龄前及学龄儿童为多见,但也可见于成人.它以成批出现的、以双下肢为主对称性分布的紫斑或瘀点为主要特点,皮损多时可发展到腰背臀部乃至上肢,可并发内脏出血、腹痛、关节痛及肾炎,而以后者为严... 详细信息

过敏性紫癜是一种较常见的免疫性疾病,以学龄前及学龄儿童为多见,但也可见于成人.它以成批出现的、以双下肢为主对称性分布的紫斑或瘀点为主要特点,皮损多时可发展到腰背臀部乃至上肢,可并发内脏出血、腹痛、关节痛及肾炎,而以后者为严重,部分病例最终可演变为肾功能衰竭.西医以对症、激素及环磷醯胺等免疫抑制剂治疗为主,但仍有相当一部分患者,迁延难愈,治疗棘手.

关键词：过敏性紫癜病因病机老中医经验

Integrating Bimetallic Nanoparticles with Covalent Organic Frameworks as Multifunctional Nanozyme for Colorimetric Detection of Hydrogen Peroxide and Glutathione

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Journal of Analysis and Testing 2024年第3期8卷 278-287页

作者： Yuying Yuan Xiaoxue Xi Ting Bao Pingguan Bian Feng Pei xiuhua Zhang Shengfu Wang Wei Wen Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei University Hubei Yihua Chemical Co. Ltd

The controllable growth of metal nanoparticles on nanomaterials is becoming an effective strategy for developing nanocomposites with designated performance. Herein, a simple and mild strategy for the in situ growth of Pt–Pd bimetallic nanoparticles on covalent organic frameworks（COFs） to regulate the nanozyme activity was designed for colorimetric detection of hydrogen peroxide（H2O2） and glutathione（GSH）. The COFs not only offer sufficient loading sites for the uniform dispersion of Pt–Pd bimetallic nanoparticles, but also increase the adsorption of substrate to promote the catalytic reaction. With the bimetallic synergistic effect of Pt–Pd nanoparticles, the prepared multifunctional nanozyme（Pt–Pd/COFs nanozyme） simultaneously exhibited superior peroxidase（POD）-like activity and oxidase（OXD）-like activity. Using the multifunctional nanozyme, a colorimetric sensing system was constructed for sensitive detection of H2O2and GSH, with the wide linear ranges of 5–1000 μmol/L and 1–40 μmol/L, and the detection limits were 1.14 μmol/L and 0.43 μmol/L, respectively. It was successfully used for the detection of real samples in environmental water and serum, providing a simple method for disease diagnosis and environmental monitoring.

关键词： Bimetallic synergistic effect H2O2 and GSH detection Oxidase-like activity Peroxidase-like activity Pt–Pd/COFs nanozyme

升清降糖方对2型糖尿病患者胰岛素抵抗影响的临床观察

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北京中医 2006年第9期25卷 546-548页

作者：庞铁良庞秀花北京市大兴区中医医院内科 102618 北京市门头沟区中医医院内科 102300

目的寻觅中医药治疗2型糖尿病胰岛素抵抗更有效的理论和方法,进一步论证脾气升清理论在2型糖尿病治疗中的重要性。方法将112例2型糖尿病患者随机分为2组,治疗组采用自拟升清降糖方治疗,对照组采用拜唐苹治疗,对两组的血糖胰岛素敏感指... 详细信息

目的寻觅中医药治疗2型糖尿病胰岛素抵抗更有效的理论和方法,进一步论证脾气升清理论在2型糖尿病治疗中的重要性。方法将112例2型糖尿病患者随机分为2组,治疗组采用自拟升清降糖方治疗,对照组采用拜唐苹治疗,对两组的血糖胰岛素敏感指数及不良反应进行对比观察。结果两组对胰岛素敏感性指数影响方面及治疗90d后降糖效果方面,治疗组明显优于对照组,有显著性差异;发生不良反应方面,治疗组明显少于对照组,有显著性差异。结论升清降糖方能够提高2型糖尿病胰岛素敏感性、降低血糖,且疗效肯定,不良反应少,从而证实了脾气升清理论在2型糖尿病治疗中所起的重要作用。

关键词： 2型糖尿病胰岛素抵抗健脾升清法