Mechanisms of tigecycline resistance in Gram-negative bacteria:A narrative review

作     者：Wenya Su Wenjia Wang Ling Li Mengge Zhang Hai Xu Chengzhang Fu Xiuhua Pang Mingyu Wang 

作者机构：State Key Laboratory of Microbial TechnologyMicrobial Technology InstituteShandong UniversityQingdao 266237PR China Helmholtz Institute for Pharmaceutical Research Saarland(HIPS)Helmholtz Centre for Infection Research(HZI)and Department of PharmacySaarland UniversitySaarbrücken 66123Germany 

出 版 物：《Engineering Microbiology》 (工程微生物学（英文）)

年 卷 期：2024年第4卷第3期

页      面：54-61页

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the National Key Research and De-velopment Program of China[grant number 2022YFE0199800] Key R&D Program of Shandong Province[grant number 2020CXGC011305] Shandong Provincial Natural Science Foundation[grant number ZR2020MH308] the National Natural Science Foundation of China[grant number 82,271,658] 

主　　题：Gram-negative bacteria Tigecycline Tigecycline resistance Resistance mechanisms RND efflux pump 

摘      要：Tigecycline serves as a critical“final-resortantibiotic for treating bacterial infections caused by multidrug-resistant bacteria for which treatment options are severely *** increasing prevalence of tigecycline resistance,particularly among Gram-negative bacteria,is a major *** mechanisms have been iden-tified as contributors to tigecycline resistance,including upregulation of nonspecific Resistance Nodulation Divi-sion(RND)efflux pumps due to mutations in transcriptional regulators,enzymatic modification of tigecycline by monooxygenase enzymes,and mutations affecting tigecycline binding *** review aims to consolidate our understanding of tigecycline resistance mechanisms in Gram-negative bacteria and offer insights and perspectives for further drug development.