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EFFECT OF AROTINOLOL ON LEFT VENTRICULAR FUNCTION IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY

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Chinese Medical Sciences Journal 2007年第4期22卷 224-227页

作者： Chao-mei Fan Hong Yang Yi-shi Li Li Xu Ke-fei Dou Jing-lin Zhao Xian-qi Yuan Yan-fen Zhao Rong-fang Shi xiu-qing du Na-qiang Lu Key Laboratory of Clinical Trials Research in Cardiovascular Drug of Ministry of Health Clinical Pharmacology Center Cardiovascular Institute ＆ Fuwai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 Department of Medicine Beijing Nuclear Industry Hospital Beijing 100042

Objective To evaluate the efficacy and safety of long-term treatment with arotinolol in patients with idiopathic dilated cardiomyopathy(IDCM).Methods Sixty-three patients with IDCM were evaluated at baseline and after 12-month therapy with *** conventional therapy for congestive heart failure was continued throughout the study with arotinolol as the only β-*** ventricular function was assessed with the New York Heart Association functional class and two-dimensional *** After 12-month arotinolol treatment,there was a significant improvement in left ventricular systolic *** ventricular end-systolic dimension significantly decreased from 59.52±8.83 mm to 50.89±8.17 mm(P<0.001).Left ventricular ejection fraction significantly increased from 27.39%±7.94% to 41.13%±9.45%(P<0.001).Left ventricular mass index decreased from 150.47±42.42 g/m2 to 141.58±34.36 g/m2(P<0.01).No adverse events leading to premature discontinuation of study drug *** In this preliminary study,12-month arotinolol treatment has a favorable effect on left ventricular function in patients with IDCM,and it is safe and well tolerated.

关键词： arotinolol dilated cardiomyopathy left ventricular function

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen xiu-qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia xiu-Jun Zhan Charity Ngina qing-Rui Zhang Xiao-Ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Empirical Likelihood in Generalized Linear Models with Working Covariance Matrix

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Acta Mathematicae Applicatae Sinica 2022年第1期38卷 87-97页

作者： xiu-qing ZHOU Qi-bing GAO Chun-hua ZHU xiu-li du Liu-liu MAO School of Mathematical Science Nanjing Normal UniversityNanjing 210097China School of Statistics and Mathematics Nanjing Audit UniversityNanjing 211815China

Empirical likelihood in generalized linear models with multivariate responses and working covariance matrix is *** the weakest assumption on eigenvalues of Fisher’s information matrix and some other regular conditions,we prove that the non-parametric Wilk’s property still holds,that is,the empirical log-likelihood ratio at the true parameter values converges to the standard chi-square *** simulations are given to verify our theoretical result.

关键词： generalized linear models empirical likelihood multivariate response working covariance matrix

Synthesis, Crystal Structure and Fluorescene of a One-dimensional Compound {CdI_2(2,2′-bipy)}_n

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Chinese Journal of Structural Chemistry 2007年第2期26卷 211-213页

作者： GUO Hong-Xu du Zi-Xian YOU xiu-Li WANG qing-Hua Department of Chemistry ＆ Environmental Scicence Zhangzhou Teachers College Zhangzhou 363000 China Fujian Longyan Center for Disease Control ＆ Prevention Longyan 364000 China

The title compound, {CdI2（2,2＇-bipy）}n, was prepared by the hydrothermal reaction of CdI2 and 2,2＇-bipy in an aqueous solution, and its crystal structure was determined by X-ray single-crystal analysis. Crystallographic data for 1： C10H8N2CdI2, monoclinic system, space group C2/c, a = 16.927（1）, b = 10.0925（7）, c = 7.7422（3） A, β = 106.0629（4）°, V = 1271.00（14） A^3, Z = 4, F（000） = 944,/a = 6.546 mm^-1, Dc= 2.730 g/cm^3, Mr = 522.38, the final R = 0.0309 and wR = 0.0805 for 1310 observed reflections （I 〉 20（I））. X-ray crystal structure analysis shows that the Cd atom is coordinated by four iodines and two N atoms from one 2,2＇-bipy to form an 1-D chain-like structure through bridging iodines. The fluorescene of the title compound was also discussed.

关键词： cadmium( Ⅱ ) iodide 2,2'-bipyridine one-dimensionalchain-like crystal structure fluorescence

Preconcentration of Rare Earth Elements with 8-Hydroxyquinoline-5-sulfonic Acid Chelated Cellulose Filter Prior to Determination by Inductively Coupled Plasma Atomic Emission Spectrometry

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Chemical Research in Chinese Universities 2000年第3期16卷 208-212页

作者： LIU Chun ming GAO xiu qing du Yao guo GUO Yi hang Department of Chemistry Changchun Normal CollegeChangchun 130032P.R.China Department of Environment Sciences Jilin UniversityChangchun 130023P.R.China

Hydroxyquinoline 5 sulfonic acid, covalently bound to filter cellulose, was used for preconcentrating trace rare earth element(REE) ions from complex matrices and matrix separation, respectively. Multi REE ions were preconcentrated on the column filled with 8 hydroxyquinoline 5 sulfonic acid cellulose filter and analysed by ICP AES after being eluted with dilute HNO 3. In the given pH range, alkali and alkaline earth metal ions can be separated as matrix elements; a high concentration factor is obtained and the eluates can be measured without interference. The usefulness of the method is shown by the control analyses of standard reference materials. [WT5FZ]

关键词： Hydroxyquinoline 5 sulfonic acid cellulose filter Preconcentration REE ICP AES

Turn-on fluorescence detection of specific inorganic anions by Zr(Ⅳ)-MOF with amino-functional group

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Tungsten 2023年第2期5卷 217-224页

作者： Jing Dong Shi-qing Wang Xiao-Yu Zhang Zi-qing Huang xiu-du Zhang Wei-Yin Sun Coordination Chemistry Institute State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical EngineeringNanjing National Laboratory of MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China Scientific Research Institute Nanjing Tech UniversityNanjing 211816China College of Chemistry and Materials Science Key Laboratory of Functional Molecular Solids Ministry of EducationAnhui Laboratory of Molecule-Based MaterialsAnhui Key Laboratory of Functional Molecular SolidsAnhui Normal UniversityWuhu 241002China

Inorganic anions such as phosphates and carbonates are essential in the natural system and it is important for the detec-tion of such *** this work,the fluorescence sensing capacity of Zr(IV)framework with an amino-functional group,namely UiO-66-NH_(2),towards specific inorganic anions was investigated in aqueous *** results revealed that the fluorescence emission intensity of UiO-66-NH2 could be strongly enhanced by phosphate and carbonate anions including HPO_(4)^(2-),H_(2)PO_(4)^(-),PO_(4)^(3-),P_(2)O_(7)^(4-),HCO_(3)^(-)and CO_(3)^(2-),implying its sensing capacity towards phosphate and carbonate ***,fluorescence titration experiments exhibit that the emission intensity enhancement ratio depends linearly on the concentration of anions,suggesting the possibility of quantitative detection of these *** studies suggest that the sensing of UiO-66-NH,towards HPO_(4)^(2-)/PO_(4)^(3-)/P_(2)O_(4)^(-)/HCO_(3)^(-)/CO_(2)-could be ascribed to the collapse of the framework,while that for H_(2)PO_(4)-could be attributed to the adsorption of H,PO4-by UiO-66-NH2 with hydrogen bonding interactions between H,PO4-and the amino group of UiO-66-NH_(2) supported by the different fluorescence response of UiO-66 and UiO-66-NH,towards the anions.

关键词： Zr(IV)framework UiO-66-NH_(2) Anions Sensing Turn-on fluorescence

Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report

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World Journal of Clinical Cases 2021年第14期9卷 3449-3457页

作者： Ran du Feng Jiang Zheng-Yan Wang Yan-qing Kang xiu-Yu Wang Ying du Department of Pathology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Thoracic Surgery Liaocheng Tumor HospitalLiaocheng 252000Shandong ProvinceChina Department of Radiology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

BACKGROUND Large cell neuroendocrine carcinoma(LCNEC)of the endometrium is an uncommon and highly aggressive tumor that has not been comprehensively *** report a case of pure endometrial LCNEC and review the current literature of similar cases to raise awareness of the histological features,treatment,and prognosis of this *** SUMMARY We report the case of a 73-year-old woman who presented with irregular postmenopausal vaginal *** showed an enlarged uterus and a 5.1 cm×3.3 cm area of medium and low echogenicity in the uterine *** by dilatation and curettage suggested poorly differentiated *** resonance imaging revealed a heterogeneously enhanced uterine tumor with diffuse infiltration of the posterior wall of the uterine myometrium and enlarged pelvic lymph *** patient underwent a hysterectomy and bilateral adnexal *** observation revealed an ill-defined white solid mass of the posterior wall of the uterus infiltrating into the serosa with multiple solid nodules on the serous ***,the tumor cells showed neuroendocrine morphology(organoid nesting).Immunohistochemistry revealed the tumor cells were diffusely positive for the neuroendocrine markers CD56,chromogranin A,and ***,the tumor was diagnosed as stage IIIC endometrial *** Pathologic findings and immunohistochemistry are essential in making a diagnosis of endometrial LCNEC.

关键词： Neuroendocrine carcinoma Large cell Large cell neuroendocrine carcinoma Endometrial Therapy Prognosis Case report

Non-existence of Multi-peak Solutions to the Schrödinger-Newton System with L2-constraint

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Acta Mathematicae Applicatae Sinica 2023年第4期39卷 868-877页

作者： qing GUO Li-xiu duAN College of Science Minzu University of ChinaBeijing 100081China

In this paper, we are concerned with the the Schrödinger-Newton system with L^(2)-constraint. Precisely, we prove that there cannot exist multi-peak normalized solutions concentrating at k different critical points of V(x) under certain assumptions on asymptotic behavior of V(x) and its first derivatives near these points. Especially, the critical points of V(x) in this paper must be *** main tools are a local Pohozaev type of identity and the blow-up analysis. Our results also show that the asymptotic behavior of concentrated points to Schrödinger-Newton problem is quite different from the classical Schrödinger equations, which is mainly caused by the nonlocal term.

关键词： Schrödinger-Newton equation Non-existence Multi-peak solutions Normalized solutions Pohozaev identity