EFFECT OF AROTINOLOL ON LEFT VENTRICULAR FUNCTION IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY

作     者：Chao-mei Fan Hong Yang Yi-shi Li Li Xu Ke-fei Dou Jing-lin Zhao Xian-qi Yuan Yan-fen Zhao Rong-fang Shi Xiu-qing Du Na-qiang Lu 

作者机构：Key Laboratory of Clinical Trials Research in Cardiovascular Drug of Ministry of Health Clinical Pharmacology Center Cardiovascular Institute ＆ Fuwai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 Department of Medicine Beijing Nuclear Industry Hospital Beijing 100042 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：2007年第22卷第4期

页      面：224-227页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：arotinolol dilated cardiomyopathy left ventricular function 

摘      要：Objective To evaluate the efficacy and safety of long-term treatment with arotinolol in patients with idiopathic dilated cardiomyopathy(IDCM).Methods Sixty-three patients with IDCM were evaluated at baseline and after 12-month therapy with *** conventional therapy for congestive heart failure was continued throughout the study with arotinolol as the only β-*** ventricular function was assessed with the New York Heart Association functional class and two-dimensional *** After 12-month arotinolol treatment,there was a significant improvement in left ventricular systolic *** ventricular end-systolic dimension significantly decreased from 59.52±8.83 mm to 50.89±8.17 mm(P0.001).Left ventricular ejection fraction significantly increased from 27.39%±7.94% to 41.13%±9.45%(P0.001).Left ventricular mass index decreased from 150.47±42.42 g/m2 to 141.58±34.36 g/m2(P0.01).No adverse events leading to premature discontinuation of study drug *** In this preliminary study,12-month arotinolol treatment has a favorable effect on left ventricular function in patients with IDCM,and it is safe and well tolerated.