Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report
作者机构：Department of PathologyLiaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Thoracic SurgeryLiaocheng Tumor HospitalLiaocheng 252000Shandong ProvinceChina Department of RadiologyLiaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2021年第9卷第14期
页 面：3449-3457页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Neuroendocrine carcinoma Large cell Large cell neuroendocrine carcinoma Endometrial Therapy Prognosis Case report
摘 要：BACKGROUND Large cell neuroendocrine carcinoma(LCNEC)of the endometrium is an uncommon and highly aggressive tumor that has not been comprehensively *** report a case of pure endometrial LCNEC and review the current literature of similar cases to raise awareness of the histological features,treatment,and prognosis of this *** SUMMARY We report the case of a 73-year-old woman who presented with irregular postmenopausal vaginal *** showed an enlarged uterus and a 5.1 cm×3.3 cm area of medium and low echogenicity in the uterine *** by dilatation and curettage suggested poorly differentiated *** resonance imaging revealed a heterogeneously enhanced uterine tumor with diffuse infiltration of the posterior wall of the uterine myometrium and enlarged pelvic lymph *** patient underwent a hysterectomy and bilateral adnexal *** observation revealed an ill-defined white solid mass of the posterior wall of the uterus infiltrating into the serosa with multiple solid nodules on the serous ***,the tumor cells showed neuroendocrine morphology(organoid nesting).Immunohistochemistry revealed the tumor cells were diffusely positive for the neuroendocrine markers CD56,chromogranin A,and ***,the tumor was diagnosed as stage IIIC endometrial *** Pathologic findings and immunohistochemistry are essential in making a diagnosis of endometrial LCNEC.
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