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Prevalence and risk factors of dry eye disease in young and middle-aged office employee:a Xi’an Study

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 567-573页

作者： Jing-Wen Hu xiu-ping zhu Shi-Yin Pan Hua Yang Xiang-Hua Xiao Department of Cardiology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Xi’an City First HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Key Lab of Ophthalmology Xi’an 710002Shaanxi ProvinceChina Clinical Center for Ophthalmology of Shaanxi Province Xi’an 710002Shaanxi ProvinceChina

AIM:To estimate the prevalence of and risk factors for dry eye disease(DED)in young and middle-aged office employee in Xi’***:This cross-sectional study of the prevalence of and risk factors for DED investigated 486 young and middle-aged Chinese office employee in Xi’*** symptoms and potential risk factors were assessed using the ocular surface disease index combined with a risk factors questionnaire,and tear function was evaluated using the tear film break-up time and Schirmer’s *** risk factors for DED were estimated by binary Logistic regression ***:DED was diagnosed in 100 females and 96 males,giving a prevalence of 40.3%[95%confidence interval(CI)=36.0%-44.7%].The multivariate binary Logistic regression model indicated that the possible risk factors for DED were being female(OR=1.592,95%CI=1.034-2.451,P=0.035),being aged≥40 y(OR=1.593,95%CI=1.034-2.454,P=0.035),using a VDT daily for>6 h(OR=1.990,95%CI=1.334-2.971,P=0.001),the presence of central air conditioning(OR=1.548,95%CI=1.053-2.276,P=0.026),and self-reported dryness of the mouth and nose(OR=1.589,95%CI=1.071-2.357,P=0.021).CONCLUSION:There is a high prevalence of clinically diagnosed DED in young and middle-aged video displayterminal(VDT)*** against the modifiable risk factors should be taken to prevent the occurrence and development of DED in this population.

关键词： dry eye disease prevalence office employee video display terminal central air conditioning age female

The pathogenic spectrum of fungal keratitis in northwestern China

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1846-1848页

作者： Na An Xian-Ning Liu Ya-Ni Wang Juan-Li zhu Hua Yang Jie Wu Xiao-Zhao Yang xiu-ping zhu Xi'an No.1 Hospital Xi'an 710002 Shaanxi ProvinceChina Shaanxi Key Lab of Ophthalmology Shaanxi Institute of Ophthalmology Xi'an 710002 Shaanxi Province China

I am Na An, from the Shaanxi Key Lab of Ophthalmology, Shaanxi Institute of Ophthalmology,Xi＇an City First Hospital, Xi＇an, Shaanxi Province, China. Fungal keratitis is a severe problem in most developing countries.

关键词： The pathogenic spectrum of fungal keratitis in northwestern China

Expression of visual system homeobox 1 in human keratoconus

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 201-206页

作者： Ya-Ni Wang Xian-Ning Liu Xiao-Dong Wang Yong Yin Yan Chen Xiang-Hua Xiao Kun Xu xiu-ping zhu Xi’an No.1 Hospital Shaanxi Institute of Ophthalmology Shaanxi Key Laboratory of Ophthalmology Clinical Research Center for Ophthalmology Diseases of Shaanxi Province First Affiliated Hospital of Northwestern University

AIM: To investigate the expression of visual system homeobox 1(VSX1) and myofibroblast marker alpha smooth muscle actin(α-SMA) in keratoconus(KC). METHODS: Thirty corneal tissue were collected from KC patients after corneal transplantation and 15 normal donor corneas were obtained. All corneal tissues divided into 4 parts for different detections. Scanning electron microscopy was used to observe the ultrastructure of the specimens. VSX1 and α-SMA localization in cornea tissues was detected using immunofluorescence histochemistry. Reverse transcription-quantitative polymerase chain reaction(RT-qPCR) and Western blot were performed to analyze the expression level of VSX1 and α-SMA. RESULTS: Compared to normal cornea tissue, the collagen fibers in KC stroma were distortional and attenuated and keratocytes were abnormally changed. VSX1 and α-SMA located in the corneal stroma. The mRNA and protein expression level of VSX1 in KC were about 3 times as high as that of normal tissue(P<0.001). α-SMA was hardly expressed in the normal corneas, however, its expression in the KC was about 1.5 times higher than that of the normal corneas(P<0.0001). CONCLUSION: Compared with normal corneal the expression of VSX1 and α-SMA in KC both increased. VSX1 is related to the activation of keratocytes and involved in the pathogenesis of keratoconus.

关键词： visual system homeobox 1 keratoconus alpha smooth muscle actin keratocytes

Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1122-1127页

作者： Shi-Yin Pan Yang-Zheng Wang Jun Li Xue-Hui Zhang Jin Wang xiu-ping zhu Xiang-Hua Xiao Jun-Tian Liu Department of Pharmacology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an 710061Shaanxi PronvinceChina Shaanxi Provincial Clinical Research Center for Ophthalmology Xi’an First HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Key Laboratory of Ophthalmology Shaanxi Institute of OphthalmologyXi’an 710002Shaanxi ProvinceChina

AIM: To investigate the effect of 0.01% atropine sulphate eye gel on myopia progression and axial elongation in a 6-month treatment in ***: Totally 185 children aged 6-12 y with binocular myopia of 3.0 D or less in both eyes were enrolled in this prospective cohort study. The atropine group(n=125) received one drop of 0.01% atropine sulphate eye gel in each eye before bedtime daily. The control group included 60 matched children without drug intervention during the same period. The spherical equivalent and axial length was recorded at baseline and the sixth month of treatment. The efficacy was evaluated by the change of the spherical equivalent and axial length. Adverse events were also ***: The average spherical equivalent and axial length at baseline were not statistically significant between the atropine group(-1.64±0.80 D, 24.13±0.76 mm) and the control group(-1.59±0.94 D, 24.06±0.77 mm, P>0.05). After 6 mo, there was significantly difference in the spherical equivalent progression between the atropine and the control group(-0.27±0.33 vs-0.60±0.35 D, P<0.001),with a relative reduction of 55.0% in myopia progression. The increase in axial elongation in the atropine group was significantly less than control group(0.19±0.14 vs 0.26±0.14 mm, P<0.001), with a relative reduction of 26.9% in axial length. The 84.4% and 38.4% of the eyes progressed by less than 0.50 D and remained stable in the atropine group, compared with 51.7% and 4.2% in the control group. No adverse events were ***: Atropine sulphate eye gel 0.01% can slow down myopia progression and axial elongation in children with a 6-month treatment.

关键词： atropine sulphate eye gel myopia spherical equivalent axial length

Acellular ostrich corneal stroma used as scaffold for construction of tissue-engineered cornea

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 325-331页

作者： Xian-Ning Liu xiu-ping zhu Jie Wu Zheng-Jie Wu Yong Yin Xiang-HuaXiao Xin Su Bin Kong Shi-Yin Pan Hua Yang Yan Cheng Na An Sheng-Li Mi Shaanxi Institute of Ophthalmology Xi'an 710002 Shaanxi Province China Shaanxi Key Laboratory of Eye Xi'an 710002 Shaanxi Province China Xi'an First Hospital Xi'an 710002 Shaanxi Province China Biomanufacturing Engineering Laboratory Graduate School at Shenzhen Tsinghua University Shenzhen 518055Guangdong Province China

AIM： To assess acellular ostrich corneal matrix used as a scaffold to reconstruct a damaged cornea. METHODS： A hypertonic saline solution combined with a digestion method was used to decellularize the ostrich cornea. The microstructure of the acellular corneal matrix was observed by transmission electron microscopy （TEM） and hematoxylin and eosin （H＆E） staining. The mechanical properties were detected by a rheometer and a tension machine. The acellular corneal matrix was also transplanted into a rabbit cornea and cytokeratin 3 was used to check the immune phenotype, RESULTS： The microstructure and mechanical properties of the ostrich cornea were well preserved after the decellularization process, in vitro, the methyl thiazolyl tetrazoUum results revealed that extracts of the acellular ostrich corneas （AOCs） had no inhibitory effects on the proliferation of the corneal epithelial or endothelial cells or on the keratocytes, The rabbit lamellar keratoplasty showed that the transplanted AOCs were transparent and completely incorporated into the host cornea while corneal turbidity and graft dissolution occurred in the acellular porcine cornea （APC） transplantation, The phenotype of the reconstructed cornea was similar to a normal rabbit cornea with a high expression of cytokeratin 3 in the superficial epithelial cell layer, CONCLUSION： We first used AOCs as scaffolds to reconstruct damaged corneas. Compared with porcine corneas, the anatomical structures of ostrich corneas are closer to those of human corneas. In accordance with the principle that structure determines function, a xenograft lamellar keratoplasty also confirmed that the AOC transplantation generated a superior outcome compared to that of the APC graft.

关键词： ostrich acellular corneal stroma tissue engineering cornea

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急性闭角型青光眼并白内障手术方式的选择

国际眼科杂志 2013年第6期13卷 1233-1235页

作者：汪玲朱秀萍中国陕西省西安市第一医院眼科 710002

目的:探讨原发性急性闭角型青光眼并白内障两种手术方式的适应证和初步临床疗效观察。方法:对32例急性闭角型青光眼并白内障患者,行眼压、房水流畅系数、缩瞳前后房角镜及超声生物显微镜检查,选择超声乳化吸除人工晶状体植入术或联合小... 详细信息

目的:探讨原发性急性闭角型青光眼并白内障两种手术方式的适应证和初步临床疗效观察。方法:对32例急性闭角型青光眼并白内障患者,行眼压、房水流畅系数、缩瞳前后房角镜及超声生物显微镜检查,选择超声乳化吸除人工晶状体植入术或联合小梁切除术。术后择期检查视力、眼压、房角镜、UBM,观察至术后3mo。结果:患者32例中24例行超声乳化吸除人工晶状体植入术,8例行超声乳化吸除人工晶状体植入联合小梁切除术,各组均有1例术后眼压高,点降眼压药物控制。结论:房水流畅系数、缩瞳后房角镜及超声生物显微镜检查有助于选择急性闭角型青光眼并白内障的手术方式。

关键词：超声乳化吸除术急性闭角型青光眼白内障房角

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角膜上皮干细胞缺失动物模型的方法研究

国际眼科杂志 2009年第8期9卷 1583-1584页

作者：刘先宁吴洁朱秀萍陕西省眼科研究所中国陕西省西安市710002 中国陕西省西安市眼科医院 710002

目的:建立兔角膜上皮干细胞缺失动物模型,为人工生物角膜上皮实验研究奠定基础。方法:方法一,单纯去除角膜缘浅板层环周内外宽各2mm,深约100～150μm角膜组织;方法二,在方法一的基础上,再去除角膜中央浅板层组织约100～150μm。术后,裂... 详细信息

目的:建立兔角膜上皮干细胞缺失动物模型,为人工生物角膜上皮实验研究奠定基础。方法:方法一,单纯去除角膜缘浅板层环周内外宽各2mm,深约100～150μm角膜组织;方法二,在方法一的基础上,再去除角膜中央浅板层组织约100～150μm。术后,裂隙灯显微镜下观察,以角膜混浊、上皮荧光素染色及新生血管为参数评价,3项参数得分之和为该动物时间点总评分。以角膜新生血管评分在3分以上,角膜上皮混浊在2分以上,采用印迹细胞法角膜面取材行角蛋白K3单克隆抗体间接免疫荧光法检测表达为阴性的。结果:单纯去除角膜缘的动物模型10眼有4眼成功(40%),从制作至成功平均时间29.5±1.3d。角膜缘联合角膜中央板层组织共同去除组,10眼均成功(100%),从制作至成功平均时间为15.8±0.8d,两组成功率对比差异有统计学意义(χ2=8.58,P<0.01);成功天数比较差异有统计学意义(t=24.5,P<0.01)。两组成功模型角膜采用印迹细胞法取材行角蛋白K3单克隆抗体间接免疫荧光法检测表达均为阴性。结论:采用角膜缘联合角膜中央上皮共同去除法制备角膜上皮干细胞缺乏模型成功率高,周期短,值得推广应用。

关键词：角膜上皮干细胞兔动物模型

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泪液乳铁蛋白的研究进展

国际眼科杂志 2008年第5期8卷 1012-1014页

作者：安娜朱秀萍陕西省眼科研究所西安市眼科研究所西安市第一医院眼科中国陕西省西安市710002

乳铁蛋白是一种可以结合铁离子的糖基化蛋白,它广泛存在于人体的多种体液和分泌液中,是泪液蛋白中的主要成分之一。它具有抗菌、抗病毒、免疫调节等生理作用,而且它在泪液中的含量还是临床上诊断干眼的重要标准。本文就人乳铁蛋白的生... 详细信息

乳铁蛋白是一种可以结合铁离子的糖基化蛋白,它广泛存在于人体的多种体液和分泌液中,是泪液蛋白中的主要成分之一。它具有抗菌、抗病毒、免疫调节等生理作用,而且它在泪液中的含量还是临床上诊断干眼的重要标准。本文就人乳铁蛋白的生理功能、制备提纯以及泪液中乳铁蛋白的鉴定方法及其在干眼诊断中的重要作用等方面的研究进展加以综述。

关键词：乳铁蛋白泪液干眼

糖尿病患者565例视网膜病变初步调查及早期诊断

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国际眼科杂志 2009年第1期9卷 156-158页

作者：吕沛霖朱秀萍石维华燕芳中国陕西省西安市第一医院眼科西安市眼科医院陕西省眼科研究所 710002

目的:初步调查门诊2型糖尿病(diabetes mellitus,DM)患者糖尿病视网膜病变(diabetic retinopathy,DR)的发生情况,并探讨早期诊断的方法。方法:对我院眼科门诊及住院治疗的2型DM患者,经WHO有关IDDM诊断标准确诊,共565例1130眼,通过询问... 详细信息

目的:初步调查门诊2型糖尿病(diabetes mellitus,DM)患者糖尿病视网膜病变(diabetic retinopathy,DR)的发生情况,并探讨早期诊断的方法。方法:对我院眼科门诊及住院治疗的2型DM患者,经WHO有关IDDM诊断标准确诊,共565例1130眼,通过询问获得病史以及相关检查和诊断资料,常规进行视力、眼压,以及散瞳检眼镜检查眼底,并采用眼底视网膜彩色照相检查,对镜下可疑及有明确视网膜病变的患者行荧光素血管造影(fundus fluorescein angiography,FFA)检查。结果:DM患者565例1130眼中检眼镜下有视网膜病变417例825眼,9例为单侧患者,发生率73.80%。病程5a以上患者中,存在1期以上DR占78.0%。417例明确DR患者除造影禁忌证外,372例进行了荧光素眼底血管造影检查,其中1,2,3,4期患者造影确定病情程度与眼底镜下符合率90.6%(337例),9.4%(35例)严重于检眼镜下确定病情程度。检眼镜下无眼底改变0期糖尿病患者148例296眼,病程<5a患者61例,行造影检查38例,确诊DR为1期者12例,占检查人数32%;病程高于5a患者87例,26例行造影检查发现微血管瘤存在,占30%。565例患者中血糖不稳定和控制不好者共327例,占57.9%。结论:门诊2型DM患者DR并发症的高发生率需要密切关注。为避免患者视力丧失,常规检眼镜检查,尤其是数码眼底彩色照相图像分析对早期诊断有重要价值,需引起内科医师重视。

关键词：糖尿病视网膜病变糖尿病数码眼底检查荧光素血管造影诊断