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HE4、CA125及CA153在卵巢良性肿瘤诊断中的临床应用价值分析

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中国实用医药 2024年第19期19卷 29-32页

作者：欧阳海红刘晔崔秀青上栗县人民医院检验科 337009

目的研究血清人附睾蛋白4(HE4)、糖类抗原125(CA125)及糖类抗原153(CA153)在卵巢良性肿瘤诊断中的临床应用价值。方法选取41例卵巢良性肿瘤患者作为研究对象,将其按照病理检查结果的差异分为子宫内膜异位症组(n=18)及其他卵巢良性肿瘤... 详细信息

目的研究血清人附睾蛋白4(HE4)、糖类抗原125(CA125)及糖类抗原153(CA153)在卵巢良性肿瘤诊断中的临床应用价值。方法选取41例卵巢良性肿瘤患者作为研究对象,将其按照病理检查结果的差异分为子宫内膜异位症组(n=18)及其他卵巢良性肿瘤组(n=23)。检测并对比两组血清HE4、CA125、CA153水平。以受试者工作特征曲线(ROC曲线)分析血清HE4、CA125、CA153水平诊断子宫内膜异位症的效能。对比两组患者手术前后血清HE4、CA125、CA153水平。以Pearson相关性分析明确子宫内膜异位症患者血清HE4、CA125、CA153三项指标间的相关性。结果子宫内膜异位症组血清HE4、CA125、CA153水平分别为(115.10±12.73)pmol/L、(46.71±6.29)U/ml、(28.58±4.60)U/ml,均高于其他卵巢良性肿瘤组的(86.97±10.30)pmol/L、(38.63±4.80)U/ml、(16.83±3.01)U/ml(P<0.05)。经ROC曲线分析证实,血清HE4、CA125、CA153联合诊断子宫内膜异位症的灵敏度、约登指数、曲线下面积均优于HE4、CA125、CA153单独诊断。子宫内膜异位症组及其他卵巢良性肿瘤组患者术后血清HE4、CA125、CA153水平均低于术前(P<0.05)。经Pearson相关性分析证实,子宫内膜异位症患者血清HE4与CA125、HE4与CA153、CA125与CA153均呈正相关(r=0.735、0.766、0.801, P<0.05)。结论血清HE4、CA125、CA153应用于卵巢良性肿瘤诊断中的价值较高,有利于子宫内膜异位症与其他卵巢良性肿瘤的鉴别诊断,且在评估疗效方面可能存在一定价值。

关键词：卵巢良性肿瘤子宫内膜异位症人附睾蛋白4 糖类抗原125 糖类抗原153

拉玛泽减痛呼吸法联合健康教育对初产妇妊娠结局影响的Meta分析

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河西学院学报 2024年第2期40卷 8-18页

作者：郑海燕徐梦李秀霞河西学院护理学院甘肃张掖734000 兰州大学循证医学中心甘肃兰州730000 兰州大学公共卫生学院甘肃兰州730000

目的:运用系统评价的方法分析拉玛泽减痛呼吸法联合健康教育对初产妇妊娠结局的干预效果,为临床提出最优的助产干预方法。方法:通过计算机全面检索了12个中英文数据库,搜集拉玛泽减痛呼吸法联合健康教育的随机对照试验的文献,时间从建... 详细信息

目的:运用系统评价的方法分析拉玛泽减痛呼吸法联合健康教育对初产妇妊娠结局的干预效果,为临床提出最优的助产干预方法。方法:通过计算机全面检索了12个中英文数据库,搜集拉玛泽减痛呼吸法联合健康教育的随机对照试验的文献,时间从建库起至2021年12月22日,采用Cochrane风险偏倚评估工具对纳入文献质量进行评价,通过RevMan 5.3软件和Stata 14.0软件进行纳入文献的敏感性分析和异质性检验,并采用固定效应模型或随机效应模型进行效应量的合并计算。结果:共纳入43项研究,包括11144例初产妇。经过Meta分析结果显示,与健康教育相比,拉玛泽减痛呼吸法联合健康教育能明显缩短初产妇第一产程时间[SMD=-1.63,95%CI(-1.99,-1.26)]、第三产程时间[SMD=-0.56,95%CI(-0.80,-0.32)]和总产程时间[SMD=-2.24,95%CI(-2.84,-1.64)],可减轻产痛[RR=0.94,95%CI(0.79,1.12)],提高自然分娩率[RR=1.25,95%CI(1.21,1.28)],差异有统计学意义(P<0.05)。结论基于现有的证据表明,拉玛泽减痛呼吸法联合健康教育在初产妇分娩中具有明显的优势,可以降低妊娠不良结局,有效提高助产质量,保障母婴安全。但受到纳入研究质量和数量的限制,未来仍需要高质量大样本研究进一步验证。

关键词：初产妇拉玛泽呼吸法健康教育妊娠结局 Meta分析

北京市工业园区VOCs污染特征及健康风险评估案例:高新技术产业的环境影响

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环境科学 2024年第4期45卷 2019-2027页

作者：王洁姚震王敏燕陈速敏龙腾王海林李红郭秀锐郝江虹聂磊北京工业大学环境与生命学部北京100124 北京市生态环境保护科学研究院城市大气挥发性有机物污染防治技术与应用北京市重点实验室北京100037 中国环境科学研究院北京100012

随着国家产业结构的不断调整和工业企业入驻园区刚性要求的不断强化,以高新技术为支柱产业的高新技术产业园区不断增加,为分析涉VOCs高新技术产业对园区环境质量的影响,选取北京市典型高新技术产业园区作为研究案例,采用BCT-7800A PLUS... 详细信息

随着国家产业结构的不断调整和工业企业入驻园区刚性要求的不断强化,以高新技术为支柱产业的高新技术产业园区不断增加,为分析涉VOCs高新技术产业对园区环境质量的影响,选取北京市典型高新技术产业园区作为研究案例,采用BCT-7800A PLUS挥发性有机物在线监测系统对园区环境VOCs(共计115种)进行了监测,分析了园区环境VOCs污染水平和臭氧生成潜势,并计算毒性VOCs的危害指数(HI)和终生癌症风险(Risk).利用气相色谱-质谱/氢离子火焰检测器联用(GC-MS/FID)和高效液相色谱(HPLC)的方法检测了园区不同点位的环境VOCs,并对不同点位的环境VOCs污染特征进行了分析.结果表明:(1)连续监测期间高新技术产业园区φ(TVOCs)为(72.71±52.51)×10^(-9),VOCs主要贡献组分为烷烃和OVOCs,占比分别为38.3%和21.8%,主要受燃料燃烧源影响,园区OFP均值为404.13μg·m^(-3).(2)健康风险评价表明,连续监测期间园区毒性VOCs造成的非致癌风险(HI)均低于1,处于可接受水平;1,2-二氯乙烷平均致癌风险超过安全阈值,表示该物种存在致癌风险,三氯甲烷、1,2-二溴乙烷、1,2-二氯丙烷和苯的均值低于安全阈值,但最高值超过安全阈值,表明这4个物种在特定高排放时段同样存在致癌风险,需要引起重点关注.(3)离线采样检测结果显示,园区不同点位环境φ(TVOCs)的均值为(37.62±11.01)×10^(-9),4个点位VOCs体积分数大于其他研究中的市区环境监测点位(30.34×10^(-9)).OFP均值为246.38μg·m^(-3),5个点位OFP均高于市区监测点位,园区高新技术企业排放的VOCs对环境存在一定的影响.

关键词：高新技术产业园区溶剂使用挥发性有机物污染特征健康风险

Theoretical analysis and experimental study of an air inflated membrane structure

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第1期11卷 25-33页

作者： Jing-hai GONG xiu-ying YANG Zi-zhao ZHANG Jin-cheng ZHAO Department of Civil Engineering Shanghai Jiao Tong University Sharighai 200240 China

In this paper,an experimental study of an air inflated membrane was carried out based on the China National Stadium (the Bird's Nest). After the 2008 Olympic Games,it was apparent that the future use of the Bird's Nest would be enhanced if rainfall could be prevented from entering the stadium. The installation of an air inflated membrane across the opening of the steel structure was proposed as a solution to this problem. To verify the scheme,a theoretical analysis and experimental study of an air inflated membrane was carried out. Experimental and computational models were developed,form-finding was carried out using both experimental and theoretical methods,and the results from the two approaches,including the deflection of the air inflated membrane and deformation of the support structure,were analyzed and compared. The force-transfer path and deformation of the air inflated membrane under loads was studied. Conclusions and suggestions are presented.

关键词： China National Stadium Air inflated membrane Form-finding

灰楸光合指标的无性系变异及其与环境因子的关系

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西北林学院学报 2024年第3期39卷 138-143页

作者：贠慧玲杨海裕张一麻文俊李银梅戴秀芳甘肃省小陇山林业科学研究所甘肃小陇山森林生态系统国家定位观测研究站甘肃省次生林培育重点实验室甘肃天水741020 西北农林科技大学林学院陕西杨陵712100 中国林业科学研究院林业研究所林木遗传育种国家重点实验室北京100091

分析灰楸无性系光合特性、叶绿素含量与环境因子的关系及遗传变异,旨在鉴定高光合效率、低蒸腾耗散的灰楸优良无性系,为灰楸光合高效育种和优质高效栽培管理提供理论依据。利用LI-6400便携式光合作用测定仪测定光合和气体交换参数,采用S... 详细信息

分析灰楸无性系光合特性、叶绿素含量与环境因子的关系及遗传变异,旨在鉴定高光合效率、低蒸腾耗散的灰楸优良无性系,为灰楸光合高效育种和优质高效栽培管理提供理论依据。利用LI-6400便携式光合作用测定仪测定光合和气体交换参数,采用SPAD-502叶绿素仪测定叶绿素含量。结果表明,灰楸无性系间净光合速率、蒸腾速率、气孔导度和水分利用效率等4个主要指标存在极显著差异。净光合速率与蒸腾速率、气孔导度、水分利用效率呈极显著正相关,与胞间CO_(2)浓度呈极显著负相关。净光合速率与空气CO_(2)浓度呈负相关。通过回归方程确定了光照强度对瞬时净光合速率、气孔导度、胞间CO_(2)浓度均有较大正贡献。叶绿素含量与瞬时净光合速率呈正显著相关,说明叶绿素含量的高低直接决定楸树光合能力和生长状况。光合指标与环境因子的相关关系显著,光照强度对灰楸无性系瞬时净光合速率影响最大。灰楸无性系光合指标变异系数和重复力均较高,无性系光合能力选择潜力较大。叶绿素含量可作为灰楸早期选育的一个重要参考技术指标,与树高、胸径等共同作为开展灰楸良种选择的关键指标。

关键词：灰楸光合指标环境因子叶绿素含量遗传变异

同方期刊数据库博看期刊评论

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碳材料增强聚丙烯复合材料的研究进展

塑料科技 2024年第3期52卷 116-120页

作者：詹修淦陈必承宫玉梅郭忱拖晓航大连工业大学纺织与材料工程学院大连116034 大连地铁运营有限公司大连116000

碳材料作为多功能性填料在增强聚丙烯基复合材料综合性能方面发挥重要作用。但平衡不同碳材料的添加量与复合材料制品的成形性和功能性之间的关系是重要课题。文章分别论述了碳纤维、碳纳米管和石墨烯的性状特点以及这些碳材料对聚丙烯... 详细信息

碳材料作为多功能性填料在增强聚丙烯基复合材料综合性能方面发挥重要作用。但平衡不同碳材料的添加量与复合材料制品的成形性和功能性之间的关系是重要课题。文章分别论述了碳纤维、碳纳米管和石墨烯的性状特点以及这些碳材料对聚丙烯基多尺度复合材料制品的力学、热学和电学等性能影响的研究进展。文章指出,未来利用熔融沉积3D打印成形工艺制备高含量且混杂的碳材料填充聚丙烯基复合材料是具有挑战性的研究方向。

关键词：聚丙烯碳纤维碳纳米管石墨烯力学性能

Azalomycin F_(4a) 2-ethylpentyl ester,a new macrocyclic lactone,from mangrove actinomycete Streptomyces sp.211726

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Chinese Chemical Letters 2010年第8期21卷 947-950页

作者： gan Jun Yuan Kui Hong hai Peng Lin Jia Li Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural SciencesHaikou 571101China Department of Pharmacy Hainan Medical CollegeHaikou 571101China National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Azalomycin F4a 2-ethylpentyl ester,a new 36-membered macrocyclic lactone antibiotic,was isolated from mangrove actinomycete Streptomyces *** structure was elucidated on the basis of spectroscopic *** compound showed b... 详细信息

关键词： Streptomyces sp.211726 Azalomycin F4a 2-ethylpentyl ester Antifungal activity Cytotoxity

A Physically Based Dynamic Recrystallization Model Considering Orientation Effects for a Nitrogen Alloyed Ultralow Carbon Stainless Steel during Hot Forging

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Journal of Iron and Steel Research International 2016年第4期23卷 364-371页

作者： gan-lin XIE An HE hai-long ZHANG Gen-qi WANG Xi-tao WANG State Key Laboratory for Adwmced Metals and Materials Universily of Science and Technology BeijingBeijing 100083China Yantai Taihai Manoir Nuclear Power Equipment Corporation Yantai 264003ShandongChina Collaborative Innovation Center of Steel Technology Universily of Science and Technology BeijingBeijing 100083China

The nitrogen alloyed ultralow carbon stainless steel is a good candidate material for primary loop pipes of AP1000 nuclear power plant. These pipes arc manufactured by hot forging, during which dynamic recrystallization acts as the most important microstructural evolution mechanism. A physically based model was proposed to describe and predict the microstructural evolution in the hot forging process of those pipes. In this model, the coupled effects of dislocation density change, dynamic recovery, dynamic recrystallization and grain orientation function were con sidered. Besides, physically based simulation experiments were conducted on a Gleeble 3500 thermo-mcchanical sire ulator, and the specimens after deformation were observed by optical metallography （OM） and clectron back scat toted diffraction （EBSD） method. The results confirm that dynamic recrystallization is easy to occur with increasing deformation temperature or strain rate. The grains become much finer after full dynamic recrystallization. The model shows a good agreement with experimental results obtained by OM and EBSD in terms of stress strain curves, grain size, and recrystallization kinetics. Besides, this model obtains an acceptable accuracy and a wide applying scope for engineering calculation.

关键词： stainless sled dynamic recrystallization hot forging EBSD orientation effect

Global sensitivity analysis of wheat grain yield and quality and the related process variables from the DSSAT-CERES model based on the extended Fourier Amplitude Sensitivity Test method

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Journal of Integrative Agriculture 2019年第7期18卷 1547-1561页

作者： LI Zhen-hai JIN xiu-liang LIU hai-long XU Xin-gang WANG Ji-hua Key Laboratory of Agri-lnformatics Ministry of Agriculture and Rural AffairsBeijing 100097P.R. China Beijing Research Center for Information Technology in Agriculture Beijing Academy of Agriculture and Forestry SciencesBeijing 100097P R.China UMR EMMAH INRANAPVAvignon 84914France Agricultural Information Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Agri-lnformation Service TechnologyMinistry of Agriculture and Rural AffairsBeijing 100081P.R. China Beijing Research Center for Agri-Food Testing and Farmland Monitoring Beijing Academy of Agriculture and Forestry SciencesBeijing 100097P.R.China

A crop growth model,integrating genotype,environment,and management factor,was developed to serve as an analytical tool to study the influence of these factors on crop growth,production,and agricultural planning.A major challenge of model application is the optimization and calibration of a considerable number of *** analysis(SA) has become an effective method to identify the importance of various *** this study,the extended Fourier Amplitude Sensitivity Test(EFAST) approach was used to evaluate the sensitivity of the DSSAT-CERES model output responses of interest to 39 crop genotype parameters and six soil *** outputs for the SA included grain yield and quality(take grain protein content(GPC) as an indicator) at maturity stage,as well as leaf area index,aboveground biomass,and aboveground nitrogen accumulation at the critical process *** key results showed that:(1) the influence of parameter bounds on the sensitivity results was slight and less than the impacts from the significance of the parameters themselves;(2) the sensitivity parameters of grain yield and GPC were different,and the sensitivity of the interactions between parameters to GPC was greater than those between the parameters to grain yield;and(3) the sensitivity analyses of some process variables,including leaf area index,aboveground biomass,and aboveground nitrogen accumulation,should be performed ***,some parameters,which improve the model’s structure and the accuracy of the process simulation,should not be ignored when maturity output as an objective variable is studied.

关键词： global sensitivity analysis DSSAT EFAST wheat yield grain protein content