Azalomycin F_(4a) 2-ethylpentyl ester,a new macrocyclic lactone,from mangrove actinomycete Streptomyces sp.211726

作     者：Gan Jun Yuan Kui Hong Hai Peng Lin Jia Li 

作者机构：Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikou 571101China Department of PharmacyHainan Medical CollegeHaikou 571101China National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2010年第21卷第8期

页      面：947-950页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 090403[农学-农药学(可授农学、理学学位）] 100705[医学-微生物与生化药学] 07[理学] 09[农学] 0904[农学-植物保护] 071005[理学-微生物学] 10[医学] 

基　　金：supported by The National High Technology Development Project(863)(No. 2007AA09Z415) The National Natural Science Foundation of China(No.U0633008) 

主　　题：Streptomyces sp.211726 Azalomycin F4a 2-ethylpentyl ester Antifungal activity Cytotoxity 

摘      要：Azalomycin F4a 2-ethylpentyl ester,a new 36-membered macrocyclic lactone antibiotic,was isolated from mangrove actinomycete Streptomyces *** structure was elucidated on the basis of spectroscopic *** compound showed broad-spectrum antifungal activity and moderate cytotoxicity against human colon tumor cell HCT-116.