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International Journal of Digital Earth 2023年第1期16卷 1469-1490页

作者： xinyao zhou Wenzuo zhou Xiaoli Fu Yichen Hu and Jinlian Liu of Geographical Sciences Southwest UniversityChongqingPeople's Republic of China

Hyperspectral images carry numerous spectral bands,and their wealth of band data is a valuable source of information for the accurate classification of ground ***-dimensional(3D)convolution,although an excellent spectral information extraction method,is limited by its huge number of parameters and long model training *** allow better integration of 3D convolution with the most popular transformer models currently available,a new architecture called mobile 3D convolutional vision transformer(MDvT)is *** MDvT introduces inverted residual structure to reduce the number of model parameters and balance the data mining efficiency of low-dimensional data ***,a square patch is used to cut the sequence of tokens to accelerate the model *** extensive experiments,we evaluated the classification overall performance of the proposed MDvT on the WHU-Hi and Pavia University datasets,and demonstrated significant improvements in classification accuracy and model runtime compared with classical deep learning *** is worth noting that compared with directly integrating 3D convolution into the transformer model,the MDvT architecture improves the accuracy while reducing the time to train an epoch by approximately 58.54%.To facilitate the reproduction of the work in this paper,the model code is available at https://***/gloryofroad/MDvT.

关键词： Hyperspectral image Classification Convolutional neural network Transformer

Study on the rapid detection of irradiated rice based on RVA

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Nuclear Science and Techniques 2013年第B12期24卷 58-62页

作者： FU Junjie zhou xinyao FENG Duhua WANG Qing DENG Li Zhejiang institute of Nuclear-Agricultural Sciences Hangzhou 310029 China The center of biotechnology of Wuxi and Zhejiang University Wuxi 214105 China

In this paper, the changes of rice-starch's viscosity at different dose irradiation treatment were studied, the rice can be easily distinguished whether it has been irradiated or not with the control of pH. The results showed that the starch's viscosity was significantly declined with increasing irradiation absorb dose. With the control of pH 2.5, the irradiated starch's viscosity was apparently higher than the un-irradiated ones, there are significant differences in terms of viscosity between the two parts. The rice absorbed dose can be estimated using the relationship among peak viscosity, hot pasting viscosity and absorbed dose. © 2013, Science Press. All rights reserved.

关键词：辐照处理快速检测水稻 RVA 吸收剂量大米淀粉高粘度 pH值

Preparation of copper nano-particle powder by γ-irradiation

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Nuclear Science and Techniques 2012年第3期23卷 163-168页

作者： FU Junjie LIU Yajian TAN Yuanyuan zhou xinyao XU Furong Institute of Nuclear Agricultural Sciences Zhejiang University Hangzhou 310021 China Energy and Nuclear Technology Application Institute Hangzhou 310012 China

Copper nano-particles were prepared by 100 kGy room temperature γ-ray irradiation of CuSO4 aqueous solution added with surfactant and inactive *** of the surfactants and pH value on particle size and morphology of the Cu powder,and the storage stability,were ***,morphology,particle size and melting point of the copper nano-particles were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),laser particle size analyzer and differential scanning calorimetry(DSC),*** results show that the Cu nano-particles prepared with PCM as surfactant and N,N-bis-hydroxyethyl dodecyl amide as inactive agent,in pH=4.0-6.5 of the aqueous solution,can be stored in air for 140 days.

关键词：铜纳米颗粒制备粉末表面活性剂铜纳米粒子透射电子显微镜差示扫描量热法激光粒度分析仪

Preparation of copper nanoparticles by radiation

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Nuclear Science and Techniques 2013年第6期24卷 29-35页

作者： LIU Yajian GUO Xiongbin FU Junjie TAN Yuanyuan LI Zhaolong zhou xinyao XU Furong Zhejiang Insitute of Application Energy and Nuclear Technology The Institute of Nuclear Agriculture Science Zhejiang University

Copper nanoparticles were successfully synthesized by 60Co-γradiation with aqueous solution of cupric sulfate under inert nitrogen-purged *** nanoparticles were characterized by using X-ray diffraction(XRD),transmission electron microscopy(TEM),laser particle size distribution analyzer(LSPSDA)and differential scanning calorimeter(DSC)techniques,*** effects of solution system,pH,additive of surfactant and absorbed doses on the particle size and its distribution as well as stored stability of Cu naoparticles were *** resolution TEM pictures showed the formation of homogeneous cubic-structured copper nanoparticles with different sizes depends on the synthetic *** new kind of synthesis method shows the excellent stability,which may provide an efficient way to improve the fine tuning of the structure and size of copper nanoparticles.

关键词：铜纳米粒子辐射透射电子显微镜差示扫描量热计铜纳米颗粒储存稳定性制备合成条件

Feedback and contribution of vegetation, air temperature and precipitation to land surface temperature in the Yangtze River Basin considering statistical analysis

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International Journal of Digital Earth 2023年第1期16卷 2941-2961页

作者： Jinlian Liu xinyao zhou Hanya Tang Fengqin Yan Shiwei Liu Xuguang Tang Zhi Ding Ke Jiang Pujia Yu Chongqing Jinfo Mountain Karst Ecosystem National Observation and Research Station School of Geographical SciencesSouthwest UniversityChongqingPeople’s Republic of China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingPeople’s Republic of China Chongqing Key Laboratory of Karst Environment School of Geographical SciencesSouthwest UniversityChongqingPeople’s Republic of China

Land surface temperature(LST),especially day-night LST difference(LSTd-LSTn),is a key variable for the stability of terrestrial ecosystems,affected by vegetation and climate *** the contribution and feedback of vegetation and climate to LST changes is critical to developing mitigation *** on LST,Normalized vegetation index(NDVI),land use(LU),air temperature(AT)and precipitation(Pre)from 2003 to 2021,partial correlation was used to analyze the response of LST to vegetation and *** feedback and contribution of both to LST were further quantifed by using spatial linear relationships and partial derivatives *** results showed that both interannual LST(LSTy)and LSTd-LSTn responded negatively to vegetation,and vegetation had a negative feedback effect in areas with significantly *** was also a major contributor to the decline of *** the advantage of positive partial correlation area of 94.99%,AT became the main driving factor and contributor to LSTy change *** contributed negatively to both LSTy and LSTd-LSTn,with contributions of-0.004℃/y and-0.022℃/y,*** played a decisive role in LST warming of YRB,which was partially mitigated by vegetation and *** present research contributed'to,the,detection,of LST changes and improved understanding of the driving mechanism.

关键词： Land surface temperature vegetation dynamics climate change land use contribution feedback

Efficacy of Lushi Runzao decoction(路氏润燥汤)on ameliorating Sjogren's syndrome:a network pharmacology and experimental verification-based study

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Journal of Traditional Chinese Medicine 2023年第4期43卷 751-759页

作者： PANG Fengtao LI Kesong ZHANG Yi TANG Xiaopo zhou xinyao Department of Rheumatology Guang’anmen HospitalChinese Academy of Chinese Medical SciencesBeijing 100053China

OBJECTIVE:To investigate the possible mechanism underlying the effect of the Lushi Runzao decoction(路氏润燥汤)on Sjogren's syndrome using network pharmacology and to verify the mechanisms via animal ***:Available biological data on each drug in the Lushi Runzao decoction were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and the target proteins of Sjogren's syndrome were retrieved from the GeneCards *** regarding Sjogren's syndrome and the targets of the drugs were compared to obtain overlapping *** information was imported into the STRING platform to obtain a proteinprotein interaction network diagram,following which a“component-target”network diagram was constructed using screened drug components and target information via Cytoscape *** database for annotation,visualization,and integrated discovery was used for Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathways *** information predicted by network pharmacology was verified using animal ***:The Lushi Runzao decoction ameliorated Sjogren's syndrome mainly by influencing tumor necrosis factor as well as certain cytokines and *** decoction also influenced the interleukin-17 and advanced glycosylation end products(AGE)-receptor for AGE signaling ***:The Lushi Runzao decoction ameliorates Sjogren's syndrome via multiple targets and multiple signaling *** pharmacology is useful for making a comprehensive prediction regarding the efficacy of the Lushi Runzao decoction,and this information may be helpful in clinical research.

关键词： immune system diseases tumor necrosis factors network pharmacology Lushi Runzao decoction experimental verification

Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids

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Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen Wang Lei Zhang Guanglan Wu Jinni Wu xinyao zhou Xiaolin Chen Yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang Shi Xueqing Wu Junjiu Huang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center of Reproductive Medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： CADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

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子女教养观念、入学门槛与市民化意愿

劳动经济研究 2022年第5期10卷 87-113页

作者：向宽虎周鑫瑶上海大学经济学院

市民化进程不仅受到制度性劳动力流动障碍的影响,还会受观念因素的制约。本文利用2010年、2012年和2013年中国综合社会调查(CGSS)数据、2017年全国流动人口动态监测调查数据以及城市特征数据,研究了流动人口来源地子女教养观念对市民化... 详细信息

市民化进程不仅受到制度性劳动力流动障碍的影响,还会受观念因素的制约。本文利用2010年、2012年和2013年中国综合社会调查(CGSS)数据、2017年全国流动人口动态监测调查数据以及城市特征数据,研究了流动人口来源地子女教养观念对市民化的作用。研究发现,协作培养型的教养观念令流动人口流入入学门槛更低的城市,并促使流动人口离开当前居住的入学门槛较高的城市,这一作用在高教育水平的群体中更强。本文的政策含义是,可通过降低外来人员子女的入学门槛来加速市民化的进程。

关键词：子女教养观念入学门槛市民化意愿

六版高中新教材中“表观遗传”内容的分析与思考

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生物学教学 2024年第10期49卷 81-84页

作者：周欣瑶王任翔广西师范大学生命科学学院桂林541006

“表观遗传”作为教材新增内容,紧随中心法则,为基因选择性表达提供了可能性,也是对经典遗传学的补充。本文选取并统合了人教版、浙科版、北师大版、苏教版、沪科技版、沪科教版六版教材的内容,从“概念”“调控机制”“影响因素”“影... 详细信息

“表观遗传”作为教材新增内容,紧随中心法则,为基因选择性表达提供了可能性,也是对经典遗传学的补充。本文选取并统合了人教版、浙科版、北师大版、苏教版、沪科技版、沪科教版六版教材的内容,从“概念”“调控机制”“影响因素”“影响及应用”和“思考”五个部分系统分析表观遗传,并提供相关教学建议。

关键词：表观遗传调控机制教材分析高中生物学

2000—2018年西秦岭景观格局变化及生态系统健康评价

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生态学报 2023年第4期43卷 1338-1352页

作者：李凤周文佐邵周玲周新尧付小丽西南大学地理科学学院重庆400715

西秦岭地区生态环境脆弱,人地矛盾日益加剧,区域景观格局变化及其生态系统健康演变趋势关系到区域生态安全。研究探讨2000—2018年西秦岭景观格局和生态系统健康状况的时空演变,采用2000—2018年的遥感数据,分析西秦岭的景观格局及其演... 详细信息

西秦岭地区生态环境脆弱,人地矛盾日益加剧,区域景观格局变化及其生态系统健康演变趋势关系到区域生态安全。研究探讨2000—2018年西秦岭景观格局和生态系统健康状况的时空演变,采用2000—2018年的遥感数据,分析西秦岭的景观格局及其演变;并且在活力-组织力-反弹力(VOR)框架模型的基础上,结合生态系统服务能力和人类胁迫指标,分析西秦岭的生态系统健康状态及变化趋势。研究结果表明:西秦岭有三种优势景观,包括林地、耕地和草地,2000—2018年景观类型转移主要发生在这三者的互相转换;城镇用地的面积也处于增加的态势且增势较大。西秦岭景观扩张是通过大量小规模零散的斑块扩张实现的。由于秦岭生态保护的加强,西秦岭的景观异质性和破碎化程度在2005年出现转折点,景观类型呈均衡发展趋势。研究区超过60%面积的地区生态景观属于健康状态,且2000—2018年西秦岭的生态系统健康指数呈增加态势,生态系统的状态逐渐向好发展,但西秦岭的高寒山地以及秦岭与黄土高原复合边缘地带的生态脆弱区处于亚健康或不健康状态。研究成果对西秦岭生态脆弱敏感地带的生态保护与治理具有重要意义。

关键词：景观格局指数 VOR模型生态系统健康西秦岭

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