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Journal of Shanghai Jiaotong university(Science) 2018年第S1期23卷 85-94页

作者： SONG Ya SHI Guo CHEN Leyi HUANG xinpei XIA Tangbin State Key Laboratory of Mechanical System and Vibration Department of Industrial EngineeringSchool of Mechanical Engineering Shanghai Jiao Tong University

Turbofan engine is a critical aircraft component with complex structure and high-reliability requirements. Effectively predicting the remaining useful life(RUL) of turbofan engines has essential significance for developing maintenance strategies and reducing maintenance costs. Considering the characteristics of large sample size and high dimension of monitoring data, a hybrid health condition prediction model integrating the advantages of autoencoder and bidirectional long short-term memory(BLSTM) is proposed to improve the prediction accuracy of RUL. Autoencoder is used as a feature extractor to compress condition monitoring data. BLSTM is designed to capture the bidirectional long-range dependencies of features. A hybrid deep learning prediction model of RUL is constructed. This model has been tested on a benchmark dataset. The results demonstrate that this autoencoder-BLSTM hybrid model has a better prediction accuracy than the existing methods, such as multi-layer perceptron(MLP), support vector regression(SVR), convolutional neural network(CNN) and long short-term memory(LSTM). The proposed model can provide strong support for the health management and maintenance strategy development of turbofan engines.

关键词： remaining useful life(RUL) autoencoder bidirectional long short-term memory(BLSTM) deep learning

Water-driven photoluminescence reversibility in CsPbBr_(3)/PDMSPUa composite

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Nano Research 2022年第7期15卷 6466-6476页

作者： Junhu Cai Chenhui Wang xinpei Hu Yuanyuan Ye Lijuan Zhong Enguo Chen Yun Ye Sheng Xu Jie Sun Qun Yan Tailiang Guo National and Local United Engineering Laboratory of Flat Panel Display Technology College of Physics and Information EngineeringFuzhou UniversityFuzhou 350108China

Strong ionic character endows all-inorganic perovskite nanocrystals(NCs)with particular optoelectronic features when interacting with common polar solvents,such as ***,the interaction mechanism of water affecting perovskite NCs is still lack of in-depth *** study systematically explores the roles of water on CsPbBr_(3) nanocrystals(CNCs)by finely controlling the polymer coating degree of polydimethylsiloxane-based polyurea(PDMS-PUa).Through this coating,the effect of water on CNCs is found to experience from“fluorescence quenching”owing to irreversible crystal decomposition towards“forward fluorescence reversibility”by crystal destruction and *** gradually enhanced coating,a phenomenon of“reverse fluorescence reversibility”is further observed in that water begins to passivate the CNCs’defect ***,“fluorescent balance”can be achieved with a thick enough coating,where water can hardly contact with the *** by the fluorescence reversible mechanism discovered,a new wearable intelligent sensing skin is demonstrated by using the CsPbBr_(3)/PDMS-PUa composite as raw *** water contact and humidity change can be perceived through photoluminescence(PL)intensity,corresponding to stimuli-responsive sensory nerves of human *** is expected that these findings will shed some new lights on perovskite NCs.

关键词： CsPbBr_(3) polydimethylsiloxane-based polyurea(PDMS-PUa) photoluminescence reversibility water and humidity sensing intelligent skin

Rapid one-step enzyme immunoassay and lateral flow immunochromatographic assay for colistin in animal feed and food

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Journal of Animal Science and Biotechnology 2020年第1期11卷 280-289页

作者： Jiayi Wang Jinyu Zhou Yiqiang Chen xinpei Zhang Yongpeng Jin Xiaojing Cui Dongting He Wenqing Lai Lidong He Beijing Advanced Innovation Center for Food Nutrition and Human Health and State Key Laboratory of Animal NutritionCollege of Animal Science and TechnologyChina Agricultural UniversityBeijingChina Department of Chemistry and Biochemistry Florida State UniversityTallahasseeFLUSA.

Background:Colistin(polymyxin E)is a kind of peptide antibiotic which has been approved in animal production for the purposes of disease prevention,treatment,and growth ***,the wide use of colistin in animal feed may accelerate the spread of colistin-resistance gene MCR-1 from animal production to human beings,and its residue in animal-origin food may also pose serious health hazards to ***,it is necessary to develop corresponding analytical methods to monitor the addition of colistin in animal feed and the colistin residue in animal-origin ***:A one-step enzyme-linked immunosorbent assay(ELISA)and a lateral flow immunochromatographic assay(LFIA)for colistin were developed based on a newly developed monoclonal *** ELISA showed a 50%inhibition value(IC50)of 9.7 ng/m L with assay time less than 60 min,while the LFIA had a strip reader-based detection limit of 0.87 ng/m L in phosphate buffer with assay time less than 15 *** reducing the non-specific adsorption of colistin onto sample vial,the components of sample extraction solution were optimized and proved to greatly improve the assay *** spiked recovery experiment showed that the recoveries of colistin from feed,milk and meat samples were in the range of 77.83%to 113.38%with coefficient of variations less than 13%by ELISA analysis and less than 18%by LFIA analysis,***,actual sample analysis indicated that the two immunoassays can produce results consistent with instrumental ***:The developed assays can be used for rapid qualitative or quantitative detection of colistin in animal feed and food.

关键词： Colistin ELISA Feed Food Gold nanoparticle Lateral flow immunochromatographic assay Monoclonal antibody

Screening for urinary markers predicting hematopoietic stem cell injury induced by busulfan using genetically diverse mice

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Animal Models and Experimental Medicine 2023年第2期6卷 146-154页

作者： Yuhang Sun Bowen Guan Xing Liu Lingyan Zhang xinpei Wang Aimin Meng Ran Gao National Human Diseases Animal Model Resource Center NHC Key Laboratory of Human Disease Comparative MedicineBeijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInstitute of Laboratory Animal Sciences Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)National Center of Technology Innovation for Animal ModelBeijingChina

Background:Busulfan(BU)is an alkylating agent used as a conditioning agent prior to hematopoietic stem cell(HSC)transplantation as it is known to be cytotoxic to host hematopoietic stem and progenitor *** susceptibility of HSCs to BU injury plays an important role in the myeloablative efficacy of *** susceptibilities were demonstrated in genetically diverse(GD)mice in our preliminary ***:Three strains of GD mice with different susceptibilities to BU-i nduced HSC injury were used for screening biological markers of HSC injury susceptibility in *** urine proteins were analyzed using liquid chromatography coupled with tandem mass spectrometry to screen for differentially expressed *** for possible biomarkers based on differences in protein expression abundance was validated using enzyme-l inked immunoassay(ELISA).Results:Functional analysis showed that the differential proteins were all involved in a series of biological pathways related to cellular senescence,apoptosis,and angiogenesis;whereas the differential proteins of the high-susceptible strain were enriched for the regulation of bone marrow microenvironment pathways,those of low-susceptible strain were enriched for the proapoptotic effect of GTPase *** on protein abundance differences,several urinary proteins that may be indicative of susceptibility were screened,and ELISA validation results showed that angiotensin-converting enzyme may be a potential biomarker predicting HSC susceptibility for BU ***:This study indicates that urinary protein levels can reflect differences in susceptibility to BU-i nduced HSC *** GD mice to construct genetic difference models will provide preclinical data for screening BU-related biological markers.

关键词： angiotensin I converting enzyme busulfan hematopoietic stem cell injury inbred genetic diversity mice urinary marker

Chemical characteristics of haze particles in Xi＇an during Chinese Spring Festival： Impact of fireworks burning

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Journal of Environmental Sciences 2018年第9期30卷 179-187页

作者： Can Wu Gehui Wang Jiayuan Wang Jianjun Li Yanqin Ren Lu Zhang Cong Cao Jin Li Shuagshuang Ge Yuning Xie xinpei Wang Guoyan Xue State Key Laboratory of Loess and Quaternary Geology Key Lab of Aerosol Chemistry and Physics Institute of Earth Environment Chinese Academy of Sciences Xi' an 710061 China Key Laboratory of Geographic Information Science of the Ministry of Education School of Geographic Sciences East China Normal University Shanghai 210062 China Center for Excellence in Regional Atmospheric Environment Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China University of Chinese Academy of Sciences Beijin9 100049 China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012 China

Fireworks burning releases massive fine particles and gaseous pollutants, significantly deteriorating air quality during Chinese Lunar New Year （LNY） period. To investigate the impact of the fireworks burning on the atmospheric aerosol chemistry, 1-hr time resolution of PM2.5 samples in Xi＇an during the winter of 2016 including the LNY were collected and detected for inorganic ions, acidity and liquid water content （LWC） of the fine aerosols. PM2.5 during the LNY was 167 ± 87 μg/m^3, two times higher than the China National Ambient Air Quality Standard （75 μg/m^3）. K^＋（28 wt.% of the total ion mass） was the most abundant ion in the LNY period, followed by SO^2-4 （25 wt.%） and C1^- （18 wt.%）. In contrast, NO^-3 （34 wt.%） was the most abundant species in the haze periods （hourly PM2.5 〉 75 μg/m^3）, followed by SO^2-4 （29.2 wt.%） and NH^＋4 （16.3 wt.%）, while SC94 （35 wt.%） was the most abundant species in the clean periods （hourly PM2.5 〈 75 μg/m^3）, followed by NO^-3 （23.1 wt.%） and NH^＋4 （11 wt.%）. Being different from the acidic nature in the non-LNY periods, aerosol in the LNY period presented an alkaline nature with a pH value of 7.8 ± 1.3. LWC during the LNY period showed a robust linear correlation with K2SO4 and KC1, suggesting that aerosol hygroscopicity was dominated by inorganic salts derived from fireworks burning. Analysis of correlations between the ratios of NO^-3/SO^2-4 and NH^＋4/SO^2-4 indicated that heterogeneous reaction of HNO3 with NH3 was an important formation pathway of particulate nitrate and ammonium during the LNY period.

关键词： Inorganic ions Aerosol acidity Liquid water content Composition and source Nitrate formation

Designing and deploying a mixed-reality aquarium for cognitive training of young children with autism spectrum disorder

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Science China(Information Sciences) 2021年第5期64卷 209-211页

作者： Juan LIU Yulong BIAN Yanran YUAN Yuting XI Wenxiu GENG xinpei JIN Wei GAI Xiangmin FAN Feng TIAN Xiangxu MENG Chenglei YANG Software College Shandong University Jining No.1 People's Hospital Institute of Software Chinese Academy of Sciences

Autism spectrum disorder (ASD), a developmental disorder severely affecting cognition and social behavior, is increasing in prevalence [1]. This increasing trend is especially severe in children, making the early intervention crucial to ASD treatment. Children with ASD have been found impairments in several aspects of cognition functions.

关键词： Information Systems and Communication Service

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预应力碳纤维布加固混凝土梁的试验研究

西北工业大学学报 2007年第4期25卷 492-497页

作者：姜新佩刘丽娜邓子辰西北工业大学力学与土木建筑学院陕西西安710072 河北工程大学河北邯郸056038

采用自行研制的碳纤维布预应力张拉机具,对10根混凝土梁受力性能进行了试验研究。对比分析了未加固、非预应力碳纤维布加固、预应力碳纤维布加固、施加不同的预应力水平、不同的附加锚固方式梁的开裂荷载、极限荷载、抗弯刚度等受力性... 详细信息

采用自行研制的碳纤维布预应力张拉机具,对10根混凝土梁受力性能进行了试验研究。对比分析了未加固、非预应力碳纤维布加固、预应力碳纤维布加固、施加不同的预应力水平、不同的附加锚固方式梁的开裂荷载、极限荷载、抗弯刚度等受力性能。试验结果表明:粘贴预应力碳纤维布加固可使梁的承载能力有一定程度提高,可大大提高梁的开裂荷载、抗弯刚度,减小梁的挠度和裂缝宽度,能充分发挥碳纤维布高强度特性;在相同预应力水平下,合适的附加锚固方式,可有效防止碳纤维的剥离破坏,进一步提高梁的承载力;所研制的预应力碳纤维布加固技术可用于实际工程。

关键词：预应力碳纤维布加固混凝土梁

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Guest Editorial

High Voltage 2016年第2期1卷 61-61页

作者： PROFESSOR xinpei LU Huazhong University of Science and Technology China

Low temperature plasmas(LTP)are typically plasmas in the gas phase with electron density from 108 cm3 to 1018 cm3,and electron temperature under 10 *** ionisation degree of the low temperature plasma is quite low,which means the number density of electrons is much lower than the number density of neutral *** main feature of low temperature plasma is the different temperatures of various types of particles inside the plasma such as electrons,ions and *** fact the gas temperature of plasma is close to room temperature for many ***,low temperature plasmas have been used for an enormous range of practical applications,from bio-medicine and environment protection to light sources and making computer *** technical and commercial value of low temperature plasma is well *** world today would be less advanced without low temperature *** greatly depends on empirical *** the technology becomes more complex,empiricism becomes insufficient to advance the state of the *** aim of this Special Issue is to introduce recent developments in low temperature plasma technologies on a solid scientific *** Special Issue provides a high-level intellectual and scientific overview of key challenges,and discusses how meeting these challenges can improve the scientific understanding of this field,which includes.

关键词： particles. neutral typically

Effect of gas components on the postdischarge temporal behavior of OH and O of a non-equilibrium atmospheric pressure plasma driven by nanosecond voltage pulses

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Plasma Science and Technology 2024年第5期26卷 72-81页

作者：王兰萍聂兰兰卢新培 State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

OH radicals and O atoms are two of the most important reactive species of non-equilibrium atmospheric pressure plasma(NAPP),which plays an important role in applications such as plasma ***,experimental studies on how the gas content affects the postdischarge temporal evolutions of OH and O in the noble gas ns-NAPP are very *** this work,the effect of the percentages of O_(2),N_(2),and H_(2)O on the amounts of OH and O productions and their post-discharge temporal behaviors in ns-NAPP is investigated by laser-induced fluorescence(LIF)*** results show that the productions of OH and O increase and then decrease with the increase of O_(2)*** OH and O densities reach their maximum when about 0.8%O_(2)is *** increase of the O_(2)concentration results in a decrease of the initial densities of both OH and O,and leads to their faster *** increase of N_(2)percentage also results in the increase and then decrease of the OH and O densities,but the change is ***,when the H_(2)O concentration is increased from 100 to 3000 ppm,the initial OH density increases slightly,but the OH density decays much faster,while the initial density of O decreases with the increase of the H_(2)O *** analysis,it is found that OH and O are mainly produced through electron collisional dissociation.O(^(1)D)is critical for OH generation.O_(3)accelerates the consumption processes of OH and O at high O_(2)*** addition of H_(2)O in the NAPP considerably enhances the electronegativity,while it decreases the overall plasma reactivity,accelerates the decay of OH,and reduces the O atom density.

关键词： O atom OH radical post-discharge temporal behavior laser-induced fluorescence

Immune phenotypes of prostate cancer cells: Evidence of epithelial immune cell-like transition?

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Asian Journal of Urology 2016年第4期3卷 195-202页

作者： Dong Lin Xinya Wang Stephen Yiu Chuen Choi xinpei Ci Xin Dong Yuzhuo Wang Vancouver Prostate Centre&Department of Urologic Sciences University of British ColumbiaVancouverBCCanada Department of Experimental Therapeutics BC Cancer AgencyVancouverBCCanada

Prostate cancers(PCa)have been reported to actively suppress antitumor immune responses by creating an immune-suppressive *** is mounting evidence that PCas may undergo an‘‘Epithelial Immune Cell-like Transition’’(EIT)by expressing molecules conventionally associated with immune cells(e.g.,a variety of cytokines/receptors,immune transcription factors,Ig motifs,and immune checkpoint molecules),which subsequently results in the suppression of anti-cancer immune activity within the tumor *** progress within the field of immune therapy has underscored the importance of immune checkpoint molecules in cancer development,thus leading to the development of novel immunotherapeutic ***,we review the expression of select immune checkpoint molecules in PCa epithelial and associated immune cells,with particular emphasis on clinical data supporting the concept of an EIT-mediated phenotype in ***,we summarize current advances in anti-immune checkpoint therapies,and provide perspectives on their potential applicability.

关键词： Prostate cancer Immune checkpoint Epithelial immune cell-like transition Immune suppression Immune therapy