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Design and Parameter Optimization of Zero Position Code Considering Diffraction Based on Deep Learning Generative Adversarial Networks

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Nanomanufacturing and Metrology 2024年第1期7卷 15-27页

作者： Shengtong Wang Linbin Luo xinghui Li Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055China

Absolute measurement has consistently been the primary focus in the development of precision linear and angular displace-ment measurements.The scheme design of binary zero position codes is an important factor for absolute measurement.Designing and optimizing high-bit zero position codes with over 100 bits face considerable challenges.Simultaneously,the working parameters of zero position codes[unit code width(b),distance(d),and yaw angle(α)]remarkably affect their post-installation performance,particularly in absolute positioning and limit code application in multi-degree-of-freedom measurement schemes.This study addresses these challenges by proposing a design method for zero position codes that considers diffraction based on generative adversarial networks and aims to explore a design with increased efficiency and accuracy as well as optimization for high-bit zero position codes.Additionally,the tolerance range of zero positioning per-formance for each working parameter is examined.By leveraging the adversarial network structure,this study generates the optimization of a 150-bit code and processes the tests of the zero position code by using simulation results.The following working parameter ranges for code design are recommended on the basis of theoretical and experimental results:b greater than 10μm,d andαwithin 1000μm and 3490μrad,and avoidance of intervals with sharp changes in the full width at half maximum.The proposed code design and parameter optimization lay a solid foundation for research and engineering appli-cations in absolute measurement field and have considerable potential for generalization and wide applicability.

关键词： Absolute measurement Zero position code Deep learning Generative adversarial networks Tolerance range Parameter optimization

Superconvergence of Direct Discontinuous Galerkin Methods:Eigen-structure Analysis Based on Fourier Approach

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Communications on Applied Mathematics and Computation 2024年第1期6卷 257-278页

作者： Xuechun Liu Haijin Wang Jue Yan xinghui Zhong School of Mathematical Sciences Zhejiang UniversityHangzhou310027ZhejiangChina School of Science Nanjing University of Posts and TelecommunicationsNanjing210023JiangsuChina Department of Mathematics Iowa State UniversityAmes50011IAUSA

This paper investigates superconvergence properties of the direct discontinuous Galerkin(DDG)method with interface corrections and the symmetric DDG method for diffusion equations.We apply the Fourier analysis technique to symbolically compute eigenvalues and eigenvectors of the amplification matrices for both DDG methods with different coefficient settings in the numerical fluxes.Based on the eigen-structure analysis,we carry out error estimates of the DDG solutions,which can be decomposed into three parts:(i)dissipation errors of the physically relevant eigenvalue,which grow linearly with the time and are of order 2k for P^(k)(k=2,3)approximations;(ii)projection error from a special projection of the exact solution,which is decreasing over the time and is related to the eigenvector corresponding to the physically relevant eigenvalue;(iii)dissipative errors of non-physically relevant eigenvalues,which decay exponentially with respect to the spatial mesh sizeΔx.We observe that the errors are sensitive to the choice of the numerical flux coefficient for even degree P^(2)approximations,but are not for odd degree P^(3)approximations.Numerical experiments are provided to verify the theoretical results.

关键词： Direct discontinuous Galerkin(DDG)method with interface correction Symmetric DDG method Superconvergence Fourier analysis Eigen-structure

Impact of baseline blood pressure on all-cause mortality in patients with atrial fibrillation:results from a multicenter registry study

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Chinese Medical Journal 2023年第6期136卷 683-689页

作者： Wei Xu Qirui Song Han Zhang Juan Wang Xinghui Shao Shuang Wu Jun Zhu Jun Cai Yanmin Yang Emergency Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular DiseasesNational Clinical Research Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Hypertension Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular Diseases of ChinaNational Clinical Research Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background:The ideal blood pressure(BP)target for patients with atrial fibrillation(AF)is still unclear.The present study aimed to assess the effect of the baseline BP on all-cause mortality in patients with AF.Methods:This registry study included 20 emergency centers across China and consecutively enrolled patients with AF from 2008 to 2011.All participants were followed for 1 year±1 month.The primary endpoint was all-cause mortality.Results:During the follow-up,276(13.9%)all-cause deaths occurred.Kaplan-Meier curves showed that a systolic blood pressure(SBP)110 mmHg or>160 mmHg was associated with a higher risk of all-cause mortality(log-rank test,P=0.014),and a diastolic blood pressure(DBP)<70 mmHg was associated with the highest risk of all-cause mortality(log-rank test,P=0.002).After adjusting for confounders,the multivariable Cox regression model suggested that the risk of all-cause mortality was increased in the group with SBP110 mmHg(hazard ratio[HR],1.963;95%confidence interval[CI],1.306-2.951),and DBP<70 mmHg(HR,1.628;95%CI,1.163-2.281).In the restricted cubic splines,relations between baseline SBP or DBP and all-cause mortality showed J-shaped associations(non-linear P<0.001 and P=0.010,respectively).The risk of all-cause mortality notably increased at a lower baseline SBP and DBP.Conclusions:Having a baseline SBP110 mmHg or DBP<70 mmHg was associated with a significantly higher risk of all-cause mortality in patients with AF.An excessively low BP may not be an optimal target for patients with AF.

关键词： All-cause death All-cause mortality Atrial fibrillation Blood pressure Diastolic blood pressure Hypertension Systolic blood pressure

Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

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Cancer Biology & Medicine 2024年第4期21卷 331-346页

作者： Shuangcheng Li Tianci Wang xinghui Xiao Xiaodong Zheng Haoyu Sun Rui Sun Hongdi Ma Zhigang Tian Xiaohu Zheng Hefei National Research Center for Physical Sciences at Microscale The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Institute of Immunology University of Science and Technology of ChinaHefei 230027China Hefei TG ImmunoPharma Corporation Limited Hefei 230601China Research Unit of NK Cell Study Chinese Academy of Medical SciencesBeijing 100864China Key Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(NK) cells targeting hematologic malignancies(HMs).Methods: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine(PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings. Furthermore, we explored the association between CD300A and HM progression in patients.Results: Our findings indicated that PS hampers the function of NK cells. Increased CD300A expression inhibited HM lysis by NK cells. CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells. Blocking PS–CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells, thereby augmenting the ability to lyse HMs. Clinically, heightened CD300A expression correlated with shorter survival and an “exhausted” phenotype of intratumoral NK cells in patients with HMs or solid tumors.Conclusions: These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.

关键词： NK cell CD300A phosphatidylserine immune checkpoint hematologic malignancy

A novel mouse model of PEDF-associated serious liver inflammation,hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis

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Genes & Diseases 2024年第1期11卷 11-14页

作者： xinghui Li Haiping Wang Yandi Wu Li Zou Shijie Dengg Xintu Fu Tongsheng Huang Conghui Shen Teng Wu Weibin Cai Guangdong Engineering&Technology Research Center for Disease-Model Animals Laboratory Animal CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

There are no approvedtherapeuticdrugs for nonalcoholic steatohepatitis(NASH)due to the many bottlenecks,including the lack of preclinical animal models that can perfectly mimic human NASH features,such as systemic metabolic disorders,hepatic steatosis,intense liver inflammation and fibrosis,liver tumorigenesis,and cardiovascularcomplications.i,2"Pigment"epitheliumderived factor(PEDF)is a lipid metabolism regulator with high expression in the liver,and its reduced expression in the liver is closely related to the development of nonalcoholic fatty liver disease(NAFLD).

关键词： inflammation PEDF hepatic

The genesis and resource potential of gold deposits in the Liaodong Peninsula

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Science China Earth Sciences 2024年第3期67卷 657-672页

作者： Rixiang ZHU Jin-Hui YANG Gongwen WANG Qingdong ZENG Guoqiang XUE Tao XU xinghui LI Peng ZHANG Da LEI Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Shenyang Center China Geological SurveyShenyang 110034China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Plenty of gold deposits related to Late Mesozoic craton destruction are widely distributed in eastern North China Craton. However, significant differences in research degrees, ore-forming characteristics, and proven reserves exist among different regions in the North China Craton. The Liaodong Peninsula has similar regional geological characteristics to those of the Jiaodong Peninsula, with both experiencing craton destruction during Late Mesozoic, but the two areas have substantial differences in terms of gold mineralization and the proven gold resources. Based on regional geology, Mesozoic magmatictectonic evolution and ore geology, combined with integrated geophysical exploration and big data AI resource prediction, in this paper, we propose that the ore-forming materials of Late Mesozoic gold deposits in Liaodong were mainly originated from mantle-derived melts and/or fluids induced by craton destruction. The gold deposits were primarily controlled by NE-NNEtrending faults, mainly classified as fracture-controlled altered rock-type and sulfide-bearing quartz vein-type. Moreover, our study predicts that the Yalu River fault zone and its related secondary faults, as well as the periphery and deeper parts of known goldfields, are the important regions for future gold resource exploration. The Yalu River metallogenic belt has an enormous potential for gold resources, and the Liaodong Peninsula has a potential to add thousands of tons of gold resources.

关键词： Liaodong Peninsula Gold deposit Integrated geophysical exploration Prospecting potential Direction for prospecting breakthroughs

Flavonoids from mulberry leaves inhibit fat production and improve fatty acid distribution in adipose tissue in finishing pigs

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Animal Nutrition 2024年第1期16卷 147-157页

作者： Yingying Liu Yinglin Peng Chen Chen Huibo Ren Ji Zhu Yuan Deng Qingming Cui Xionggui Hu Jianhua He Huali Li xinghui Zhu Yulong Yin Jun He Yi Xiao College of Animal Science and Technology Hunan Agricultural University Hunan Institute of Animal and Veterinary Science Key Laboratory of Conservation and Genetic Analysis of Local Pig Breed Germplasm Resources College of Information and Intelligence Hunan Agricultural University Institute of Subtropical Agriculture Chinese Academy of Sciences

This study evaluated the effects of flavonoids from mulberry leaves (FML) on plasma biochemical indices,serum activities of lipid metabolism-related enzymes,fat morphology,fatty acid composition,and lipid metabolism in different adipose tissues of finishing pigs.We used 120 Chinese hybrid barrows of Berkshire and Bama mini-pigs with an average initial body weight of 45.11±4.23 kg.The pigs were randomly assigned to five treatment groups and fed a control diet based on corn,soybean meal,and wheat bran or a control diet supplemented with 0.02%,0.04%,0.08%,or 0.16%FML.Each experimental group had six replicates (pens),with four pigs per pen.After a 7-d adaptation period,the feeding trial was conducted for 58 d.Blood and adipose tissue samples were collected from 30 pigs (one pig per pen)at the end of the test.The results showed that FML supplementation significantly decreased the feed intake to body gain ratio,the plasma concentrations of total cholesterol and free fatty acids,and the serum activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (linear or quadratic effects,P<0.05),and decreased the plasma triglyceride concentration (quadratic,P=0.07).Increasing FML supplementation increased the average daily gain and serum activities of lipoprotein lipase (linear and quadratic effects,P<0.05) and adipose triglyceride lipase (linear,P<0.05).Dietary FML supplementation decreased the adipocyte area in the dorsal subcutaneous adipose (DSA) tissue of finishing pigs (linear,P=0.05) and increased the adipocyte area in the visceral adipose tissue (quadratic,P<0.01).Increasing FML supplementation decreased the C20:1 content in DSA,abdominal subcutaneous adipose,and visceral adipose tissues of finishing pigs (P<0.05) and increased the C18:3n3 and n-3 PUFA contents(P<0.05).The lipid metabolism genes were regulated by the PPARγ-LXRa-ABCA1 signaling pathway,and their expressions differed in different adipose tissues.These findings suggest that FML improved growth performance,regulated lipid metabolism,inhibited fat production

关键词： Finishing pig Mulberry leaf Flavonoid Lipid metabolism Fatty acid Lard

Characteristics and influencing factors of greenhouse gas emissions from reservoirs in the Yellow River Basin: A Meta-analysis

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Science China Earth Sciences 2024年第7期67卷 2210-2225页

作者： Shurui HUANG Peijia ZHANG Wenxiu ZHENG Jiajia ZHANG Yang LI Yuanjian WANG Enhui JIANG shaoda LIU xinghui XIA State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal University Yellow River Institute of Hydraulic Research Yellow River Conservancy Commission

Reservoir construction and operation profoundly alter the hydrological,hydrodynamic,and carbon and nitrogen cycling processes of rivers.However,current research still lacks a systematic understanding of the characteristics of greenhouse gas (GHG) emissions from reservoirs in arid/semi-arid regions.This study integrates existing monitoring data to discuss the characteristics of GHG emissions from reservoirs in the Yellow River Basin and illustrate the controlling factors and underlying mechanism of these processes.The results indicate that while CO2emission flux from reservoirs is lower than that from river channels,the emission fluxes of CH4and N2O are 1.9 times and 10 times those from rivers,respectively,indicating that the emission of GHG with stronger radiative effect is significantly enhanced in reservoirs.Compared to the reservoirs in humid climates (e.g.,the Three Gorges Reservoir),reservoirs in the Yellow River Basin exhibit relatively lower emissions of CO2and CH4due to lower organic matter concentrations,but significantly higher N2O emissions due to higher nitrogen loads.Monte Carlo simulations for 237 reservoirs in the Yellow River Basin showed that total emission of the three GHGs is 3.05 Tg CO2-eq yr-1,accounting for 0.39% of the total emission from global reservoirs and lower than the area percentage of the basin (0.53%).This study has important implications on revealing the GHG emission characteristics and control mechanisms of reservoirs in arid/semi-arid regions.

关键词： Yellow River Basin Reservoir Greenhouse gas Emission flux Water quality

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高校“形势与政策”课的场域干扰及排除

当代教育论坛 2024年第2期 95-102页

作者：贺星辉湖南省教育厅长沙410001

当前,“形势与政策”课建设离打造高校思政示范课的要求还有较大差距。文献研究与社会调研表明,该课程场域尚存在场域构造虚化、场域内部劣化、场域形式固化、场域内涵浅化、场域技术老化、场域建设弱化等多项干扰。“形势与政策”课建... 详细信息

当前,“形势与政策”课建设离打造高校思政示范课的要求还有较大差距。文献研究与社会调研表明,该课程场域尚存在场域构造虚化、场域内部劣化、场域形式固化、场域内涵浅化、场域技术老化、场域建设弱化等多项干扰。“形势与政策”课建设要在思政课整体场域,同其他思政课程保持综合平衡与协调发展;在课程思政场域,形成与专业知识双向渗透的新态势;在校园文化场域,完善师资多元结构,促使多点生发与持续不断地释放课堂教学的内在张力;在社会生活场域,以学生为主体,高质量开展以问题为导向的贴近实践的教学活动;在网络信息场域,紧跟时代脉搏,持续保持高端运行。

关键词：形势与政策课程建设场域分析