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中国药理学与毒理学杂志 2013年第3期 595-596页

作者： hu Miao-miao xing Guo-zhen Matthew SKINNER YU Hong WANG Shao-dong ZHAO Li ZHENG Wei-jun REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park MacclesfieldUK

OBJECTIVE Moxifloxacin is a fluoroquinolone with a broad spectrum of antibacterial *** aim of this study was to investigate the cardiovascular effects of moxifloxacin,administered to conscious,jacketed cynomolgus monkeys as single oral *** was a validation study performed to assess the new DSI Jacketed External Telemetry(JET) system recently installed at *** There were 6 animals(3 males and 3 females) in two *** of the same gender were group-housed in the same *** received 4 doses of vehicle control(3 fe-males) or vehicle control followed by moxifloxacin(3 males) with single ascending doses at 15,45 and 135 mg·*** animals had at least 3 to 4 dose-free days between each dose *** JET system(Data Science International,US),including two receivers and 6 devices,was used for continuous ECG data and body temperature(surface) collection for approximately 1 h before,until 24 h after each *** Administration of moxifloxacin to group-housed conscious male primates was associated with a dose-dependent prolongation of QTc interval(increase of 9 and 16% vs timematched vehicle data after 45 and 135 mg·kg-1,respectively).In female monkeys,administered multiple doses of vehicle,QTc was comparable across consecutive dosing *** results demonstrate the usefulness of the JET system in conscious monkeys for evaluating the cardiovascular effects of drugs under normal physiological conditions.

关键词： moxifloxacin cardiovascular effects

Microstructure and Orientation Evolution of Unidirectional Solidification Pure Copper during ECAP

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稀有金属材料与工程 2011年第S3期40卷 171-175页

作者： Guo Tingbiao, Ding Yutian, Yuan Xunfeng, hu yong State Key Lab. of Gansu Advanced Non-ferrous Metal Materials, Lanzhou University of Technology, Lanzhou 730050,China Lanzhou Univ Technol State Key Lab Gansu Adv Nonferrous Met Mat Lanzhou 730050 Peoples R China

Experiment were conducted to unidirectional solidification pure copper during ECAP by route C, the samples were investigated by XRD and EBSD. The results shown that the effect of original microstructure on the subgrains orientation decrease with the increasing of strain. At low strain, in the column grain interiors first formed a band structure that the orientation quite different with the matrix. With the strain increasing, the boundaries of the band structure expanding towards to two sides, gradually partition the original column grains into subgrains, the distribution of the subgrains possesses a directional distribution characteristics and the twins occurring in subgrains. Keep on increasing strain, the original grain boundaries began to broken, low angles grain boundaries and high angles grain boundaries both occur simultaneously shows a diffusion distribution characteristics.

关键词： equal channel angular extrusion (ECAE) electron back-scattering diffraction (EBSD) grain boundaries (GBs) texture

Metabolic syndrome in patients with atrial fibrillation in the absence of structural heart disease from a tertiary hospital in China

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Chinese Medical Journal 2009年第22期122卷 2744-2747页

作者： TANG Ri-bo GAO Ling-yun DONG Jian-zeng LIU Xiao-hui LIU xing-peng WU Jia-hui LONG De-yong YU Rong-hui DU Xin MA Chang-sheng Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Metabolic syndrome （MetS） and atrial fibrillation （AF） are causally related. This study aimed to determine the prevalence of MetS in patients with AF in the absence of structural heart disease from a tertiary hospital in China. Methods In a single center, 741 inpatients with AF in the absence of structural heart disease prior to catheter ablation were retrospectively reviewed. Among them, 588 （79.4%） patients had paroxysmal AF. Subgroup analyses were performed in paroxysmal AF and persistent/permanent AF.Results MetS was found in 343 （46.3%） patients （200 males, 143 females）; 0, 1, 2, 3, 4, 5 components of the MetS were found in 59 （8.0%）, 140 （18.9%）, 199 （26.9%）, 203 （27.4%）, 103 （13.9%） and 37 （5.0%） patients, respectively. The prevalences of overweight/obesity, high blood pressure, high glucose level, high triglyceride level and low high density lipoproteins cholesterol level were 53.8%, 47.6%, 23.2%, 40.6% and 72.1%, respectively. The prevalence of MetS was not significantly different between the paroxysmal AF group and the persistent/permanent AF group （44.6% vs 52.9%, P=0.064）. The five components of MetS except overweight/obesity （69.3% vs 49.8%, P 〈0.001） were not significantly different between the aforementioned two groups. The left atrium diameter increased with the sum of the MetS components. The left atrium diameter in the MetS group was significantly higher than that in the non-MetS group both in patients with paroxysmal AF and in patients with persistent/permanent AF.Conclusions The prevalence of MetS in patients with AF prior to catheter ablation is high. Further study and prevention are needed.

关键词： metabolic syndrome atrial fibrillation catheter ablation

Fundamentals of the Warburg Effect in Cancer

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Journal of Nutritional Oncology 2019年第3期4卷 108-114页

作者： Pi Xian Zhang Ya Qi xing yong Dong Niu Department of Biochemistry and Molecular Biology Shantou University Medical CollegeShantouGuangdong 515041China Department of Pharmacology Shantou University Medical CollegeShantouGuangdong 515041China

As the fundamental energy unit of most cells,the ATP generated from glucose is vital to maintain biological processes such as the synthesis of proteins and nucleic ***,a common feature of cancer cells is an altered metabolism with increased glucose uptake and the fermentation of glucose to lactate even in the presence of normal *** phenomenon is known as the‘Warburg effect’(now termed aerobic glycolysis).One simple explanation for this effect is that it permits cells to more easily produce energy to support rapid *** can also help to meet the biosynthetic requirements for pyruvate as a major building *** a well-known metabolic hallmark of cancer cells,the role of the Warburg effect in oncology is a newly-emerging area of growing *** this perspective,we provide some new understanding of these mechanisms based on recent progress in research on cancer *** better understanding of these mechanisms will support the development of new therapeutic strategies that take into account tumor nutrition and energy metabolism.

关键词： Warburg effect Cancer Glycolysis ATP Lactate

Enhancement of light output powers of GaN-based light emitting diodes with textured indium tin oxide transparent layer by using corrosive liquid

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Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1787-1790页

作者： LI Yun LI XiaoChan ZHANG Tao HE AnHe hu CanDong WANG Xin HE Miao ZHANG yong NIU QiaoLi ZHAO LingZhi LI ShuTi CHEN XianWen Key Laboratory of Electroluminescent Devices of Guangdong Provincial Education Department Institute of Optoelectronic Materials & Technology South China Normal University Guangzhou 510631 China College of Information Science and Engineering Wuhan University of Science & Technology Wuhan 430081 China Sanan Optoelectronics Co. Ltd. Xiamen 361009 China

In order to promote the light output powers of GaN-based light emitting diodes (LEDs), two kinds of novel corrosive liquidshave been developed in this paper to roughen the surface of the indium tin oxide (ITO) current spreading layer of LEDs. As aresult, the textured transparent ITO layer greatly enhanced the external quantum efficiency of the LEDs. Provided that a wafersample was dipped in a kind of corrosive liquid developed by us for only about 60 s, the light output powers of the LEDs canbe promoted by 24.7%, compared with conventional GaN-based LEDs. It is obvious that the presented method is simple, rapidand cost-effective.

关键词： GaN-based light emitting diodes (LEDs) corrosive liquid light output power textured ITO

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人大预算审议的宪政基础与制度完善

江西财经大学学报 2011年第4期 116-123页

作者：豆星星胡明江西财经大学法学院江西南昌330013

现代公共财政预算的目标,包括宪政的权力制约、人民主权、保障人权的诸多理念,而实现公共财政预算目标的根基是建立完善的人大预算审议制度,完善的预算审议制度对规制政府预算行为和保障公民权利有着重要意义。预算审议制度在民主宪政... 详细信息

现代公共财政预算的目标,包括宪政的权力制约、人民主权、保障人权的诸多理念,而实现公共财政预算目标的根基是建立完善的人大预算审议制度,完善的预算审议制度对规制政府预算行为和保障公民权利有着重要意义。预算审议制度在民主宪政体制中居于核心地位,其完善程度是现代国家民主宪政成熟度的重要标志。目前我国人大预算审议制度必须从厘清预算审议权限、建立人大预算审议的专门机构、明确预算审议的具体程序、强化预算审议的民主四个方面予以具体完善。这是人大预算审议的宪政精神在制度中具体体现,亦符合我国国情。完善我国人大预算审议制度是建设宪政与法治国家的紧迫需要。

关键词：预算审议预算修正预算民主宪政

Impurity scattering effect in Pd-doped superconductor SrPt3P

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Frontiers of physics 2016年第4期11卷 127-131页

作者： Kang-Kang hu Bo Gao Qiu-Cheng Ji yong-hui Ma hui Zhang Gang Mu Fu-Qiang huang Chuan-Bing Cai Xiao-Ming Xie Shanghai Key Laboratory of High Temperature Superconductors Shanghai University Shanghai 200444 China State Key Laboratory of Functional Materials for Informatics and Shanghai Center for Superconductivity Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China School of Physical Science and Technology ShanghaiTech University Shanghai 201210 China CAS Key Laboratory of Materials for Energy Conversion Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

We present a systematic study of the impurity scattering effect induced by Pd dopants in the super- conductor SrPt3P. Using a solid-state reaction method, we fabricated the Pd-doped superconductor Sr（Pt1-xPdx）3P. We found that the residual resistivity P0 increases quickly with Pd doping, whereas the residual resistance ratio （RRR） displays a dramatic reduction. In addition, both the nonlinear field-dependent behavior of the Hall resistivity Pxy and the strong temperature dependence of the Hall coefficient RH at low temperature are suppressed by Pd doping. All the experimental results can be explained by an increase in scattering by impurities induced by doping. Our results suggest that the Pt position is very crucial to the carrier conduction in the present system.

关键词： impurity scattering effect SrPt3P superconductors

Three-year Follow-up on the Safety and Effectiveness of Rituximab Plus Chemotherapy as First-Line Treatment of Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in Real-World Clinical Settings in China： A Prospective, Multicenter, Noninterventional Study

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Chinese Medical Journal 2018年第15期131卷 1767-1775页

作者： Jian-Qiu Wu yong-Ping Song Li-Ping Su Ming-Zhi Zhang Wei Li Yu hu Xiao-Hong Zhang Yu-huan Gao Zuo-xing Niu Ru FengTM Wei Wang Jie-Wen Peng Xiao-Lin Li Xue-Nong Ouyang Chang-Ping Wu Wei-Jing Zhang Yun Zeng Zhen Xiao Ying-Min Liang yong-Zhi Zhuang Ji-Shi Wang Zi-Min Sun Hai Bai Tong-Jian Cui Ji-Feng Feng Department of Oncology Jiangsu Cancer Hospital ＆ Jiangsu Institute of Cancer Research ＆ Nanjing Medical University Affiliated Cancer HospitalNanjing Jiangsu 210008China Department of Hematology Henan Cancer HospitalZhengzhouHenan 450000China Department of Hematology Shanxi Cancer HospitalTaiyuanShanxi 030013China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China Department of Oncology Jilin University First Affiliated HospitalChangchunJilin 130000China Department of Hematology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430072China Department of Hematology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Department of Hematology Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Oncology Affiliated Hospital of Shandong Academy of Medical SciencesJinanShandong 250000China Department of Hematology Medical University Nanfang HospitalGuangzhouGuangdong 510000China Department of Oncology Guangdong Foshan First HospitalFoshanGuangdong 528000China Department of Oncology Guangdong Zhongshan People＇s HospitalZhongshanGuangdong 528403China Department of Hematology Xiangya Hospital Central South UniversityChangshaHunan 410008China Department of Oncology Fuzhou General Hospital of Nanjing Military CommandFuzhouFujian 350001China Department of Oncology Changzhou First People＇s HospitalChangzhouJiangsu 213000China Department of Oncology 307 Hospital of Chinese People＇s Liberation ArmyBeijing 100070China TDepartment of Hematology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650221China Department of Hematology Affiliated Hospital of Neimenggu Medical CollegeHohhotHuhehaoteInner Mongolia 010050China Department of Hematology The Fourth Military Medical University Affiliated Tangdu HospitalXi＇anShaanxi 710038China Department of Oncology Daqing General Hospital Grou

Background： Prospective real-life data on the safety and effectiveness of rituximab in Chinese patients with diffuse large B-cell lymphoma （DLBCL） or follicular lymphoma （FL） are limited. This real-world study aimed to evaluate long-term safety and effectiveness outcomes ofrituximab plus chemotherapy （R-chemo） as first-line treatment in Chinese patients with DLBCL or FL. Hepatitis B virus （HBV） reactivation management was also investigated. Methods： A prospective, multicenter, single-arm, noninterventional study of previously untreated CD20-positive DLBCL or FL patients receiving first-line R-chemo treatment at 24 centers in China was conducted between January 17, 2011 and October 31, 2016. Enrolled patients underwent safety and effectiveness assessments after the last rituximab dose and were followed up for 3 years. Effectiveness endpoints included progression-free survival （PFS） and overall survival （OS）. Safety endpoints were adverse events （AEs）, serious AEs, drug-related AEs, and AEs of special interest. We also reported data on the incidence of HBV reactivation. Results： In total, 283 previously untreated CD20-positive DLBCL and 31 FL patients from 24 centers were enrolled. Three-year PFS was 59% （95% confidence interval [CI]： 50-67%） for DLBCL patients and 46% （95% CI： 20-69%） for FL patients. For DLBCL patients, multivariate analyses showed that PFS was not associated with international prognostic index, tumor maximum diameter, HBV infection status, or number ofrituximab treatment cycles, and OS was only associated with age 〉60 years （P 〈 0.05）. R-chemo was well tolerated. The incidence of HBV reactivation in hepatitis B surface antigen （HBsAg）-positive and HBsAg-negative/hepatitis B core antibody-positive patients was 13% （3/24） and 4% （3/69）, respectively. Conclusions： R-chemo is effective and safe in real-world clinical practice as first-line treatment for DLBCL and FL in China, and that HBV reactivation during R-chemo is manageable with preventive measur

关键词： Asian Hematopoietic Malignancy Hepatitis B Virus Observational Study Rituximab

Relationship between neuromyelitis optica-IgG status and spinal cord magnetic resonance imaging in patients with neuromyelitis optica

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Chinese Medical Journal 2012年第2期125卷 270-274页

作者： Zhong Xiao-nan Wang Hong-hao Bao Tian Li Rui Long You-ming Lu Zheng-qi Dai yong-qiang Qiu Wei hu Xue-qiang Sun Yat Sen Univ Affiliated Hosp 3 Multiple Sclerosis Ctr Dept Neurol Guangzhou 510630 Guangdong Peoples R China

Background Despite the large scale technical innovations that have been made,a number of patients with neuromyelitis optica （NMO） are lacking NMO-IgG in both serum and cerebrospinal *** extensive spinal cord （LESC） lesions and linear lesions are associated with ***,differences of spinal cord magnetic resonance imaging （MRI） features,including LESC lesions and linear lesions,between NMO-IgG positive and negative patients still remain *** aim of the present study was to analyze the relationship between NMO-IgG status and spinal cord MRI features in NMO patients,particularly concerned about LESC lesions and linear *** Clinical data and spinal cord MRI of 52 NMO patients were retrospectively *** patients were NMO-IgG negative in both serum and cerebrospinal fluid,while 44 were NMO-IgG *** data between the two cohorts were compared by the Student＇s t test or Mann-Whitney U test,the chi-square test or Fisher＇s exact test was used to evaluate qualitative *** NMO-IgG negative patients had a higher sex ratio （male/female）（P=0.014）.On axial MRI,lesions in the NMO-IgG negative group were mostly located in the peripheral cord （50%）,and central lesions （55%） were more common in the NMO-IgG positive group （P=-0.051）.LESC lesions were common in both *** of linear lesions was found in NMO-IgG negative patients,while the NMO-IgG positive cohort had significantly more linear lesions （48%）（P=0.016）.Conclusions Patients with NMO-IgG negativity may have different spinal cord lesion features compared to NMO-IgG positive *** of NMO cannot be excluded even when NMO-IgG negativity and non-specific spinal lesions occur.

关键词： neuromyelitis optica neuromyelitis optica-IgG spinal cord magnetic resonance imaging

经皮内镜下经椎间孔椎体间融合术与后入路椎体间融合术治疗单节段腰椎管狭窄症的临床疗效及椎旁肌的变化

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中国脊柱脊髓杂志 2024年第6期34卷 585-594页

作者：庞大明杨晋才海涌范哲轩黄继旋尹鹏首都医科大学附属北京朝阳医院骨科北京市100020

目的:比较后入路腰椎椎体间融合术(posterior lumbar interbody fusion,PLIF)和经皮内镜下经椎间孔腰椎椎体间融合术(percutaneous endoscopic transforaminal lumbar interbody fusion,PE-TLIF)治疗单节段腰椎管狭窄症的临床疗效及其对椎旁肌的影响。方法:本前瞻性研究纳入本院2019年1月~2022年1月收治的52例L4/5单节段腰椎管狭窄症患者。其中,PLIF组22例,女性10例,男性12例,年龄60.2±10.3岁;PE-TLIF组30例,女性14例,男性16例,年龄60.4±12.3岁。对比两组手术时间、术中出血量、术后引流量、术后卧床时间等围手术期指标;比较术前与术后1d及1周血清肌酸激酶(creatine kinase,CK),术前与术后6个月及12个月多裂肌(multifidus,MF)横截面积(cross-sectional area,CSA)、脂肪浸润(fatty infiltration,FI)评分及肌肉CT密度等椎旁肌评估指标;比较两组患者术前、术后1d、1周、6个月及12个月腰痛视觉模拟评分(visual analogue scale on low back pain,VAS-LBP)、腿痛视觉模拟评分(visual analogue scale on leg pain,VAS-LP)、Oswestry功能障碍指数(Oswestry disability index,ODI)。对两组术后并发症发生情况进行比较,术后12个月根据Bridwell标准评估两组椎间融合情况。结果:PE-TLIF组与PLIF组手术时间(211.2±38.5min vs 98.9±31.6min,P=0.000)、术后卧床时间(25.9±8.3h vs 52.4±14.8h,P=0.001)、术中失血量(112.8±79.6mL vs 232.5±122.5mL,P=0.002)、术后引流量(46.5±28.2mL vs 283.6±142.1mL,P=0.000)相比,差异均具有统计学意义。PE-TLIF组与PLIF组术前、术后6个月及12个月目标节段MF CSA组间比较均无明显差异(P>0.05),两组术前与术后6个月及12个月的目标节段MF CSA组内比较无明显差异(P>0.05)。PE-TLIF组与PLIF组术前、术后6个月目标节段MF FI评分组间比较无统计学差异(P>0.05),术后12个月,PLIF组目标节段MF FI评分较PE-TLIF组高,差异具有统计学意义[3.0(3.0,4.0)vs 3.0(2.8,3.0),P=0.031];PE-TLIF组术前与术后6个月、12个月目标节段MF FI评分组内比较无明显差异(P>0.05),PLIF组术前与术后6个月目标节段MF FI评分组内比较未发现明显差异(P=0.257),而术前与术后12个月比较,差异具有统计学意义[3.0(2.0,3.3)vs 3.0(3.0,4.0),P=0.016]。术前、术后6个月两组患者MF CT密度相比较无明显差异(P>0.05)。术后12个月,PLIF组目标节段MF密度明显降低,差异具有统计学意义[PE-TLIF:34.2(31.8,36.9)hu;PLIF:30.5(28.5,32.1)hu,P=0.000]。组内比较,PE-TLIF组术前与术后6个月、12个月目标节段MF肌肉密度比较差异无显著统计学意义(P>0.05)。PLIF组术前与术后6个月目标节段MF CT密度比较,未发现明显差异(P=0.516),术后12个月较术前明显升高,差异具有统计学意义[34.6(30.5,36.4)hu vs 30.5(28.5,32.5)hu,P=0.017]。PE-TLIF组与PLIF组术前CK值无明显差异(P=0.712)。术后1d、7d,PE-TLIF组CK值低于PLIF组(P0.05)。两组患者的VAS-LP评分以及ODI在随访时无明显差异(P>0.05)。两组患者术后并发症发生率比较无统计学差异(P=0.379),术后12个月两组患者椎间融合情况比较无统计学差异(P=0.877)。结论:PE-TLIF治疗单节段腰椎管狭窄症可获得与传统PLIF手术相同的临床疗效,且减小了对椎旁肌的影响,可减轻手术创伤。

关键词：腰椎管狭窄症经皮内镜下经椎间孔椎体间融合术椎旁肌