Fundamentals of the Warburg Effect in Cancer

作     者：Pi Xian Zhang Ya Qi Xing Yong Dong Niu 

作者机构：Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041China Department of PharmacologyShantou University Medical CollegeShantouGuangdong 515041China 

出 版 物：《Journal of Nutritional Oncology》 (肿瘤营养学杂志（英文）)

年 卷 期：2019年第4卷第3期

页      面：108-114页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China(81772972,81572703) Guangdong Natural Science Foundation(2015A030313449) Guangdong Provincial Science and Technology Program(2014A020212285) the Department of Education,and the Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases(2016026,2015060,2015089) 

主　　题：Warburg effect Cancer Glycolysis ATP Lactate 

摘      要：As the fundamental energy unit of most cells,the ATP generated from glucose is vital to maintain biological processes such as the synthesis of proteins and nucleic ***,a common feature of cancer cells is an altered metabolism with increased glucose uptake and the fermentation of glucose to lactate even in the presence of normal *** phenomenon is known as the‘Warburg effect’(now termed aerobic glycolysis).One simple explanation for this effect is that it permits cells to more easily produce energy to support rapid *** can also help to meet the biosynthetic requirements for pyruvate as a major building *** a well-known metabolic hallmark of cancer cells,the role of the Warburg effect in oncology is a newly-emerging area of growing *** this perspective,we provide some new understanding of these mechanisms based on recent progress in research on cancer *** better understanding of these mechanisms will support the development of new therapeutic strategies that take into account tumor nutrition and energy metabolism.