Relationship between neuromyelitis optica-IgG status and spinal cord magnetic resonance imaging in patients with neuromyelitis optica

作     者：Zhong Xiao-nan Wang Hong-hao Bao Tian Li Rui Long You-ming Lu Zheng-qi Dai Yong-qiang Qiu Wei Hu Xue-qiang 

作者机构：Sun Yat Sen Univ Affiliated Hosp 3 Multiple Sclerosis Ctr Dept Neurol Guangzhou 510630 Guangdong Peoples R China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第2期

页      面：270-274页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：This study was supported by a grant from the Technology Project of Guangzhou City (No.2060402) 

主　　题：neuromyelitis optica neuromyelitis optica-IgG spinal cord magnetic resonance imaging 

摘      要：Background Despite the large scale technical innovations that have been made,a number of patients with neuromyelitis optica （NMO） are lacking NMO-IgG in both serum and cerebrospinal *** extensive spinal cord （LESC） lesions and linear lesions are associated with ***,differences of spinal cord magnetic resonance imaging （MRI） features,including LESC lesions and linear lesions,between NMO-IgG positive and negative patients still remain *** aim of the present study was to analyze the relationship between NMO-IgG status and spinal cord MRI features in NMO patients,particularly concerned about LESC lesions and linear *** Clinical data and spinal cord MRI of 52 NMO patients were retrospectively *** patients were NMO-IgG negative in both serum and cerebrospinal fluid,while 44 were NMO-IgG *** data between the two cohorts were compared by the Student＇s t test or Mann-Whitney U test,the chi-square test or Fisher＇s exact test was used to evaluate qualitative *** NMO-IgG negative patients had a higher sex ratio （male/female） （P=0.014）.On axial MRI,lesions in the NMO-IgG negative group were mostly located in the peripheral cord （50%）,and central lesions （55%） were more common in the NMO-IgG positive group （P=-0.051）.LESC lesions were common in both *** of linear lesions was found in NMO-IgG negative patients,while the NMO-IgG positive cohort had significantly more linear lesions （48%）（P=0.016）.Conclusions Patients with NMO-IgG negativity may have different spinal cord lesion features compared to NMO-IgG positive *** of NMO cannot be excluded even when NMO-IgG negativity and non-specific spinal lesions occur.