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靛红衍生物与水杨醛的串联反应

山东化工 2015年第1期44卷 30-35,37页

作者：孙洲李松刘芸薛吉军李瀛邢雅成青岛大学化学科学与工程学院山东青岛266071 兰州大学化学化工学院甘肃兰州370000

以靛红为原料,通过Wittig反应合成了两种不同取代基的靛红衍生物。再通过这两种靛红衍生物与水杨醛发生串联Michael-Aldol反应,高效的构建了螺[5,6]环的骨架结构。通过对照实验,总结了取代基团对靛红与水杨醛的Michael-Aldol反应的影响... 详细信息

以靛红为原料,通过Wittig反应合成了两种不同取代基的靛红衍生物。再通过这两种靛红衍生物与水杨醛发生串联Michael-Aldol反应,高效的构建了螺[5,6]环的骨架结构。通过对照实验,总结了取代基团对靛红与水杨醛的Michael-Aldol反应的影响。通过筛选不同的碱和溶剂,最终确定在K2CO3、DMF、室温条件下以62%的产率得到目标分子。产物都经1H-NMR、13CNMR进行表征,目标分子还用X-射线单晶衍射表征。

关键词：靛红衍生物水杨醛串联反应

应变响应抗冻保水海藻酸钙/聚乙烯醇导电水凝胶

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山东化工 2023年第7期52卷 12-14页

作者：贾新宇战艺伟邢雅成马晓梅青岛大学化学化工学院山东青岛266071

针对传统水凝胶耐候性差及易失去柔性等问题,以海藻酸钠(Sodium Alginate,SA)、聚乙烯醇(Polyvinyl Alcohol,PVA)为基质,单宁酸(Tannic Acid,TA)和氯化钙(Calcium Chloride,CaCl_(2))为交联剂,甘油(Glycerol,GL)和水为溶剂,制备了多重交联海藻酸钙(Calcium Alginate,CA)/聚乙烯醇(CA/PVA)水凝胶。研究显示该水凝胶具有优异的力学性能、抗冻保水性及导电性。其拉伸断裂伸长率可达~808%;常温电导率达0.32 S/m;-60℃时仍不冻结,且较宽温度范围内具备良好导电性能;25℃、相对湿度60%的环境中放置一周仅失水35%。该水凝胶应变传感性良好,可作为柔性传感器稳定监测人体细微动作。

关键词：导电水凝胶保水抗冻柔性传感器

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

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N,B-协同阻燃豌豆淀粉/聚乙烯醇复合气凝胶

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山东化工 2023年第7期52卷 59-61,65页

作者：姜莹莹石绍坤马晓梅邢雅成青岛大学化学化工学院山东青岛266071

为改善豌豆淀粉(Pea Starch,PS)-聚乙烯醇(Polyvinyl Alcohol,PVA)复合气凝胶(PS-PVA)的阻燃性能,采用酸解法制备甲壳素晶须(Chitin Whisker,CW)并将其引入PS-PVA水凝胶,通过冻融-冻干技术制备CW改性PS-PVA复合气凝胶(CW/PS-PVA)。此外,为进一步提高PS-PVA气凝胶的阻燃效果,将CW/PS-PVA复合水凝胶用硼砂溶液处理再冷冻干燥,得到含氮(N)和硼(B)的复合气凝胶(CW/PS-PVA-B)。结果表明,CW/PS-PVA气凝胶和CW/PS-PVA-B复合气凝胶的极限氧指数分别为27.8%和35.6%,比PS-PVA气凝胶分别提高42%和82%。热稳定分析表明CW/PS-PVA-B复合气凝胶在800℃残炭量为45.7%,比PS-PVA气凝胶提高266.8%。微型量热表明CW/PS-PVA-B复合气凝胶的PHRR和THR比PS-PVA气凝胶分别下降了72.1%和69.6%。因此,N和B协同可使PSPVA气凝胶具有较高的阻燃性能,有利于气凝胶的实际应用。

关键词：阻燃气凝胶豌豆淀粉聚乙烯醇甲壳素晶须

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： xing Wang Wei Pi Sheng Hu Haifeng Bao Na Yao Wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 35-41页

作者：夏海艳 HUANG Yin YANG Hua WANG Xintian SHI Jianping LIU Lixia FU yacheng 全昌云李苏原 Cofoe Medical Technology Company Limited Institute of New Energy Hexi University Chemistry and Chemical Engineering Central South University

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C （CuO/Ag-C） disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM-1·cm-2,and a low limit of detection （0.68 mM） in a wide linear response range of 0.68 mM and 3 mM （signal/noise=3）,*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang Zhou Xin Huang xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan Juan xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

健全全面从严治党体系:基本概念、内在要素与实践路径

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学习论坛 2025年第1期 25-32页

作者：罗星中国纪检监察学院党建教研部北京100877

全面从严治党体系是一个由诸多要素按照一定结构形成的复杂整体,是管党治党各领域各方面相互贯通、有机结合形成的体系。全面从严治党体系生成于中国共产党管党治党的具体实践中,具有理论基础深厚性、参与主体多元性、任务布局全面性、... 详细信息

全面从严治党体系是一个由诸多要素按照一定结构形成的复杂整体,是管党治党各领域各方面相互贯通、有机结合形成的体系。全面从严治党体系生成于中国共产党管党治党的具体实践中,具有理论基础深厚性、参与主体多元性、任务布局全面性、治理过程常态性、方法路径多样性的特点。新时代全面从严治党体系包含了组织体系、教育体系、监管体系、制度体系、责任体系五大部分。“五大体系”相互联系、有机贯通,明确了全面从严治党的基本内容、重点领域与内在逻辑。健全全面从严治党体系,要坚持和加强党的全面领导,持续深化党的建设制度改革,在铲除腐败滋生土壤和条件上下更大功夫,丰富全面从严治党体系的理念方法和工作机制,加强对全面从严治党体系的学理阐释。

关键词：全面从严治党体系监督责任党的领导