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辽宁高职学报 2017年第1期19卷 67-69页

作者：詹立平赵鑫刘志梅辽宁医药职业学院辽宁沈阳110101 辽宁林业职业技术学院辽宁沈阳110101

药用植物学是高职院校药学及,相关专业的一门专业基础课程。针对药用植物学教材编写过程中存在的问题,剖析了问题产生的原因,并提出了解决问题的措施:明确高职教育的培养目标,大力开发实践教材,优化教材编写队伍。在教材编写体例、图片... 详细信息

药用植物学是高职院校药学及,相关专业的一门专业基础课程。针对药用植物学教材编写过程中存在的问题,剖析了问题产生的原因,并提出了解决问题的措施:明确高职教育的培养目标,大力开发实践教材,优化教材编写队伍。在教材编写体例、图片运用以及项目化教材开发方面提出了一些建议,为高职药用植物学教材编写工作提供参考。

关键词：高职院校药用植物学教材编写

两类领导反馈何以带来不同的员工创新绩效?趋近-回避理论框架下的一个整合型解释

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管理工程学报 2025年第2期39卷 27-40页

作者：辛迅刘婷婷西南政法大学商学院重庆401120

领导情境因素对于员工创新有着重要影响,领导积极反馈和消极反馈在影响员工创新绩效过程中发挥着不同作用。为在同一框架下揭示这种差异性作用,本文在趋近-回避理论框架下构建了两类领导反馈对员工创新绩效影响的综合模型,首先考察了员... 详细信息

领导情境因素对于员工创新有着重要影响,领导积极反馈和消极反馈在影响员工创新绩效过程中发挥着不同作用。为在同一框架下揭示这种差异性作用,本文在趋近-回避理论框架下构建了两类领导反馈对员工创新绩效影响的综合模型,首先考察了员工趋近-回避工作重塑的平行中介作用,然后结合自我决定理论考察了员工的绩效趋近-回避目标导向在其中发挥的调节作用。通过对230名科技员工的三阶段数据分析,本文发现:领导积极反馈通过提升员工趋近型重塑促进员工创新绩效,领导消极反馈通过员工回避型重塑抑制员工创新绩效;绩效趋近目标导向在领导积极反馈通过趋近重塑影响创新绩效中具有互补效应,而绩效回避目标导向在领导消极反馈通过回避重塑影响创新绩效中具有强化效应。本文针对两类领导反馈影响创新绩效的差异作用给出了整合性的解释,打开了领导反馈影响创新的行为过程性“黑箱”,同时也为管理者如何审慎、合理利用两种领导反馈以促进员工创新提供一定启发。

关键词：领导反馈员工创新绩效趋近型工作重塑回避型工作重塑绩效目标导向

以噻吩[3,4-b]并噻吩为核的近红外电子受体及其高性能光探测器

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高分子学报 2022年第4期53卷 424-432页

作者：潘幼文陶利婷高健何程亮刘智鑫方彦俊施敏敏陈红征高分子合成与功能构造教育部重点实验室浙江大学高分子科学与工程学系杭州310027 浙江大学硅材料国家重点实验室浙江大学材料科学与工程学院杭州310027

为了实现在近红外区的良好光电响应,设计合成了一种A-D-A型有机电子受体TCIC.由于采用具有强醌式效应的噻吩[3,4-b]并噻吩单元为核,TCIC在780~1000 nm的近红外区具有强吸收以及合适的能级结构,可与常用的聚合物给体PCE10的吸收和能级相... 详细信息

为了实现在近红外区的良好光电响应,设计合成了一种A-D-A型有机电子受体TCIC.由于采用具有强醌式效应的噻吩[3,4-b]并噻吩单元为核,TCIC在780~1000 nm的近红外区具有强吸收以及合适的能级结构,可与常用的聚合物给体PCE10的吸收和能级相匹配.于是,采用2种器件结构,制备了基于PCE10:TCIC共混膜的自供电式(0 V偏压下)有机光探测器,并发现,相比于正型器件,反型器件更有利于抑制暗电流与总噪声电流.最终,反型器件在410~1000 nm的宽光谱范围内的比探测率均达到了10^(13) Jones以上,而且,在940 nm波长下,器件表现出超宽的线性动态范围(~180 dB)以及极快的响应速度(~6.5μs),这些指标都处于目前有机光探测器的最优行列.所以,本工作为高性能近红外受体的分子设计提供了重要指导.

关键词：近红外电子受体噻吩[3,4-b]并噻吩有机光探测器比探测率

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-Jian Tang Yuan-Ming Pan Wei Li Rui-Qiong Ma Jian-liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Electro-optic tuning in ferroelectric capacitor with photonic crystal nanobeam cavity

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Science China(Information Sciences) 2025年

作者： Tongtong WANG Yong ZHANG Danyang YAO zhi JIANG Dongxin TAN Jie WEN Qiyu YANG Xuetao GAN Yan liu Yue HAO Genquan HAN State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University Hangzhou Institute of Technology Xidian University

Silicon photonics has provided a platform for the convergency of photonic devices and electronic circuits, facilitating the development of optical telecommunications and optical interconnects on chip[1]. As the basic building block of optical communication systems, electro-optic tuning is expected to be more compact, high bandwidth, energy efficient, and allow for CMOS-compatible fabrication in the future[2]. Resonator-based electro-optic tuning has attracted more and more interest due to the small footprint, enhanced light-matter interactions and high energy efficiency. Compared with microring and microdisk resonators, photonic crystal nanobeam cavities （PCNBCs） realize higher quality factors, stronger light-matter interactions, ultrasmall mode volume and a much larger free spectral range （FSR）[3].

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Exact Convergence Rate of the Local Limit Theorem for a Branching Random Walk in Z^(d)with a Random Environment in Time

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Chinese Annals of Mathematics,Series B 2024年第5期45卷 805-822页

作者： Jian-xin liu zhi-qiang GAO School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875China

Consider a branching random walk with a random environment in time in the d-dimensional integer *** branching mechanism is governed by a supercritical branching process,and the particles perform a lazy random walk with an independent,non-identical increment *** A■Z^(d),let Z_(n)(A)be the number of offsprings of generation n located in *** exact convergence rate of the local limit theorem for the counting measure Z_(n)(·)is *** partially extends the previous results for a simple branching random walk derived by Gao(2017,*** Appl.).

关键词： Branching random walk Random environment Local limit theorems Exact convergence rate

Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China Life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia Zhang Jiayi Li Jingli Yang Zisheng Huang zhijun Wu Baitao liu Hongjie Huang Haijun Wang Yongjian Wang Dingge liu zhihua Zhang Kaiping liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong xin Zhang Yan Zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： Yi Jing xin-Ran liu xing-Hua Wang Hui Han Sha-Sha Liang Xi-Meng Chen Dong-Hui Wei Lai-Sheng Wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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