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Effect of solidification mode on microstructure evolution and properties of magnesium alloy with long-period stacking ordered phase

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Journal of Iron and Steel Research International 2024年第5期31卷 1127-1138页

作者： Hao Li Hong-mei Chen Xu Zhang Qian-hao Zang Jing Zhang Di Feng yan-xin Qiao yu-hang Guo School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina School of Metallurgy.and Materials Engineering Jiangsu University of Science and TechnologySuzhou215600JiangsuChina

The solidification methods of electromagnetic stirring(EMS)and non-electromagnetic stirring were employed to prepare Mg–6Gd–3y–xZn–0.6Zr(x=1,1.5,2,3)*** evolution of alloy microstructures and the changes in properties were analyzed for different Zn *** has been observed that in alloys without electromagnetic stirring,as the Zn content increases,the alloy structure gradually *** primary second phase transitions from Mg5RE phase to long-period stacking ordered(LPSO)phase,resulting in improved hardness and *** alloys subjected to electromagnetic stirring,there is a relatively higher content of the second phase,primarily consisting of LPSO *** applying electromagnetic stirring,the quantity.and the type of LPSO phase in the alloy *** alloy structure becomes more uniform with electromagnetic stirring,resulting in increased hardness and reduced hardness gradients within the *** mechanical properties of alloys with electromagnetic stirring are superior to those without electromagnetic stirring.

关键词： Rare earth magnesium alloy LPSO phase Electromagnetic stirring Casting Property

A Versatile BenzimidazoleSubstituted Spirolactam Mechanophore:When Excited State Intramolecular Proton Transfer Couples with Rhodamine

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CCS Chemistry 2024年第7期6卷 1798-1809页

作者： Huan Hu xin Cheng Zhimin Ma Qingy.an yang Rint PSijbesma Zhiyong Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 College of Engineering Peking UniversityBeijing 100871 Department of Chemical Engineering and Chemistry Institute for Complex Molecular SystemsEindhoven University of Technology5600 MBEindhoven

Exploration of multicolor mechanochromic bulk polymers based on a single mechanophore is a big challenge to ***,we report a versatile benzimidazole-substituted spirolactam mechanophore where excited state intramolecular proton transfer(ESIPT)coupled with *** mechanophore was facilely synthesized and then covalently linked to polyurethane(PU)*** PU film containing the mechanophore(1@PU)showed cooperative photochromism upon irradiation involving simultaneous enhancement of normalized enol and rhodol emissions based on a cooperative ESIPT process and the ring-opening reaction of ***,the film exhibited dual-mode multicolor mechanochromism upon stretching and *** normalized intensity of enol emission increased and the fluorescence turned from light green to cyan after stretching,then red coloration appeared from colorless after *** experiments and density functional theory calculations confirmed that the stretch-induced increase of enol emission was attributed to torsion of the dihedral angle between xanthene and benzimidazole in the mechanophore via force-induced disaggregation and direct force action on the isolated *** of the dihedral angle and the ring-opening reaction of spirolactam in a single mechanophore occurred sequentially during compression,resulting in an observed red *** study might provide a glimpse into the design of novel multicolor mechanochromic mechanophores.

关键词： mechanophore rhodamine excited state intramolecular proton transfer cooperative photochromism dual-mode mechanochromism

NF-κB in biology.and targeted therapy:new insights and translational implications

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1322-1358页

作者： Qing Guo yizi Jin xinyu Chen Xiaomin ye xin Shen Mingxi Lin Cheng Zeng Teng Zhou Jian Zhang Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key Laboratory of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κB signaling has been discovered for nearly 40 ***,NF-κB signaling was identified as a pivotal pathway in mediating inflammatory ***,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety of signaling mechanisms,biological processes,human diseases,and treatment *** this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory mechanism of NF-κB *** investigate the interaction of NF-κB signaling with other important pathways,including PI3K/AKT,MAPK,JAK-STAT,TGF-β,Wnt,Notch,Hedgehog,and TLR *** physiological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate how NF-κB signaling is involved in a variety of human diseases,including cancers,inflammatory.and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,TKls,non-coding RNAs,immunotherapy.and ***,we provide an outlook for research in the field of NF-κB *** hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.

关键词： PI3K/AKT diseases involvement

Innovative Mn_(3-x)O_(4-y)@NCA design:Leveraging Mn/O vacancies and amorphous architecture for enhanced sodium-ion storage

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Journal of Energy Chemistry 2024年第10期97卷 747-756,I0015页

作者： Kaijun Xie xin Liu Kai Xia Lipeng Diao Ping Lu Mengmeng Wang Long Fang yihui Zou Dongjiang yang Xiaodong Zhang College of Chemistry.and Chemical Engineering College of Environmental Science and EngineeringState Key Laboratory of Bio-fibers and Eco-textilesShandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsQingdao UniversityQingdao 266071ShandongChina Institute of Micro/Nano Materials and Devices Ningbo University of TechnologyNingbo 315211ZhejiangChina

Manganese-based oxide electrode materials suffer from severe Jahn-Teller(J-T)distortion,leading to severe cycle instability in sodium ion ***,it is difficult to adjust the electron at d orbitals exactly to a low spin state to eliminate orbital degeneracy.and suppress J-T distortion *** article constructed concentration-controllable Mn/O coupled vacancy.and amorphous network in Mn_(3)O_(4) and coated it with nitrogen-doped carbon aerogel(Mn_(3-x)O_(4-y)@NCA).The existence of Mn/O vacancies has been confirmed by scanning transmission electron microscopy(STEM)and positron annihilation lifetime spectroscopy(PALS).Atomic absorption spectroscopy(AAS)and X-ray photoelectron spectroscopy(XPS)determine the most optimal ratio of Mn/O vacancies for sodium ion storage is 1:*** functional theory(DFT)calculations prove that Mn/O coupled vacancies with the ratio of 1:2could exactly induce a low spin states and a d~4 electron configuration of Mn,suppressing the J-T distortion *** abundant amorphous regions can shorten the transport distance of sodium ions,increase the electrochemically active sites and improve the pseudocapacitance *** the synergetic effect of Mn/O coupled vacancies and amorphous regions,Mn_(3-x)O_(4-y)@NCA exhibits an energy density of 37.5 W h kg^(-1)and an ultra-high power density of 563 W kg^(-1)in an asymmetric *** sodium-ion batteries,it demonstrates high reversible capacity.and exceptional cycling *** research presents a new method to improve the Na^(+)storage performance in manganese-based oxide,which is expected to be generalized to other structural distortion.

关键词： Manganese-based metal oxide Concentration-controllable Mn/O coupled vacancies Amorphous network Sodium ion supercapacitor Sodium ion battery

Artificial optical microfingerprints for advanced anticounterfeiting

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Nano Research 2024年第5期17卷 4371-4378页

作者： Xueke Pang Qiang Zhang Jingyang Wang xin Jiang Menglin Wu Mingyue Cui Zhixia Feng Wenxin Xu Bin Song yao He Suzhou Key Laboratory of Nanotechnology.and Biomedicine Institute of Functional Nano&Soft Materials&Collaborative Innovation Center of Suzhou Nano Science and Technology(NANO-CIC)Soochow UniversitySuzhou 215123China School of Sensing Science and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Artificial optical microfingerprints,known as physically unclonable functions(PUFs)offer a groundbreaking approach for ***,these PUFs artificial optical microfingerprints suffer from a limited number of challenge-response pairs,making them vulnerable to machine learning(ML)attacks when additional error-correcting units are *** study presents a pioneering demonstration of artificial optical microfingerprints that combine the advantages of PUFs,a large encoding capacity algorithm,and reliable deep learning authentication against ML *** approach utilizes the triple-mode PUFs,incorporating bright-field,multicolor fluorescence wrinkles,and the topography of surface enhanced Raman scattering in the mechanical and optical ***,the quaternary encoding of these PUFs artificial microfingerprints allows for an encoding capacity of 6.43×10^(24082) and achieves 100%deep learning recognition ***,the PUFs artificial optical microfingerprints exhibit high resilience against ML attacks,facilitated by generative adversarial networks(GAN)(with mean prediction accuracy of~85.0%).The results of this study highlight the potential of utilizing up to three PUFs in conjunction with a GAN training system,paving the way for achieving encoded information that remains resilient to ML attacks.

关键词： artificial microfingerprints physically unclonable functions deep learning anti-counterfeiting

A BBS4 mutation causes autosomal dominant polycystic liver disease

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Genes & Diseases 2024年第1期11卷 72-75页

作者： yalu Cui Wenping Xu Jinpei Liu Shuqing Liu Wei Huang yihai Shi xin Zhang Cuihua Lu Weifen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Gastroenterology Gongli Hospital of Shanghai Pudong New AreaShanghai 200135China Department of Gastroenterology Affiliated Hospital of Nantong UniversityNantong UniversityNantongJiangsu 226001China

Autosomal dominant polycystic liver disease(ADPLD)refers to a condition characterized by the presence of numerous cholangiocytes-lined and fluid-filled cysts in the liver and the absence of polycystic kidney disease.1 Although patients with ADPLD may be asymptomatic,some patients suffer from abdominal pain,gastroesophageal reflux,and nausea,because of hepatomegaly.

关键词： liver polycystic patients

Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model

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Journal of Genetics and Genomics 2024年第4期51卷 419-432页

作者： Qing yang Qiang Cao yue yu Xianxin Lai Jiahao Feng xinjie Li yinan Jiang yazhou Sun Zhong-Wei Zhou xin Li School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous *** methylation and hydroxymethylation play important roles in regulating cerebral cortex ***,it remains unclear whether abnormal cerebral cortex development,such as microcephaly,could rescale the epigenetic landscape,potentially contributing to dysregulated gene expression during brain *** this study,we characterize and compare the DNA methylome/hydroxymethylome and transcriptome profiles of the cerebral cortex across several developmental stages in wild-type(WT)mice and Mcph1 knockout(Mcph1-del)mice with severe ***,we discover a global reduction of 5′-hydroxymethylcytosine(5hmC)level,primarily in TET1-binding regions,in Mcph1-del mice compared to WT mice during juvenile and adult ***,genes exhibiting diminished 5hmC levels and concurrently decreased expression are essential for neurodevelopment and brain ***,genes displaying a delayed accumulation of 5hmC in Mcph1-del mice are significantly associated with the establishment and maintenance of the nervous system during the adult *** findings reveal that aberrant cerebral cortex development in the early stages profoundly alters the epigenetic regulation program,which provides unique insights into the molecular mechanisms underpinning diseases related to cerebral cortex development.

关键词： Microcephaly Epigeneticmodification Tet1 Cerebral cortexdevelopment DNA hydroxymethylome Transcriptome

Synthesis of Long-Chain Oligomeric Donor and Acceptors via Direct Arylation for Organic Solar Cells

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Chinese Journal of Chemistry 2024年第5期42卷 523-532页

作者： yu Wu xin-yu He Xu-Min Huang Ling-Jun yang Peng Liu Na Chen Chang-Zhi Li Shi-yong Liu Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry College of MaterialsMetallurgical and ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi341000 China Department of Polymer Science and Engineering Zhejiang UniversityHangzhouZhejiang310027 China

The rapid synthesis of structurally complicated electron donors&acceptors still remains a major challenge in organic solar cells(OSC).In this work,we developed a highly efficient strategy to access long-chain oligomeric donor and acceptors for OSC applications.A series of cyclopentadithiophene(CPDT)and benzothiadiazole(BT)-basedπ-conjugated oligomers,i.e.,three oligomeric acceptors(BTDT)n-IC(n=1—3)and one long-chain oligomeric donor(BTDT)4-RD,are facilely synthesized by.an atom-and step-economical,and labor-saving direct C—H arylation(DACH)reaction(i.e.,C—H/C—Br cross coupling).Note that(BTDT)4-RD involving five CPDT,four BT and two rhodamine(RD)building blocks is the longest oligomeric donor in the fullerene-free OSC devices ever *** dependence of the structure-property-performance correlation of(BTDT)n-IC(n=1—3)and(BTDT)4-RD on theπ-conjugation lengths is thoroughly investigated by opto-electrochemical measurements,bulk heterojunction(BHJ)OSC devices and ***(BTDT)1-IC:PBDB-T and(BTDT)4-RD:y6 BHJs achieve power conversion efficiencies of 9.14%and 4.51%,*** findings demonstrate that DACH reaction is a powerful tool to tune the opto-electronic properties and device performances by regulating the lengths ofπ-conjugated oligomers with varied numbers of repeating units.

关键词： Long-chainπ-conjugated oligomer Organic solar cells Direct arylation Atom-economical synthesis Cyclopentadithiophene Benzothiadiazole C—H activation Conjugation Oligomers

Non-transcriptional regulatory activity of SMAX1 and SMXL2 mediates karrikin-regulated seedling response to red light in Arabidopsis

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Molecular Plant 2024年第7期17卷 1054-1072页

作者： Wenwen Chang Qiao Qiao Qingtian Li xin Li yanyan Li Xiahe Huang yingchun Wang Jiayang Li Bing Wang Lei Wang Key Laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei050021China Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyThe Innovative Academy for Seed DesignChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing 100049China yazhouwan National Laboratory SanyaHainan 572024China

Karrikins and strigolactones govern plant development and environmental responses through closely related signaling *** transcriptional repressor proteins SUPPRESSOR OF MAX21(SMAX1),SMAX1-like2(SMXL2),and D53-like SMXLs mediate karrikin and strigolactone signaling by directly binding downstream genes or byinhibiting the activities of transcription *** this study,we characterized the non-transcriptional regulatory activities of SMXL proteins in *** discovered that SMAX1 and SMXL2 with mutations in their ethylene-responsefactor-associated amphiphilic repression(EAR)motif had undetectable or weak transcriptional repression activities but still partially rescued the hypocotyl elongation defects and fully reversed the cotyledon epinasty defects of the smax1 smxl2 ***1 and SMXL2 directly interact with PHyTOCHROME INTERACTION FACTOR4(PIF4)and PIF5 to enhance their protein stability by interacting with phytochrome B(phyB)and suppressing the association of phyB with PIF4 and *** karrikin-responsive genes were then identified by treatment with GR24ent-ssa,GR24 analog showing karrikin ***,INDOLE-3-ACETIC ACID INDUCIBLE 29(IAA29)expression was repressed by GR24^(ent-5D)streatment in a PIF4-and PIF5-dependent and EARindependent manner,whereas KARRIKIN UPREGULATED F-BOX 1(KUF1)expression was induced in a PIF4-and PIF5-independent and EAR-dependent ***,the non-transcriptional regulatory activity of SMAX1,which is independent of the EAR motif,had a global effect on gene *** together,these results indicate that non-transcriptional regulatory activities of SMAX1 and SMXL2 mediate karrikin-regulated seedling response to red light.

关键词： karrikin signaling SMAX1 and SMXL2 non-transcriptional repression activity PIF4 and PIF5 gene expression red light