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Characterization of multiple chemical components of GuiLingJi by UHPLC-MS and ^(1)H NMR analysis

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Journal of Pharmaceutical Analysis 2022年第3期12卷 460-469页

作者： Jingchao Shi xiaoxia gao Airong Zhang Xuemei Qin Guanhua Du Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan030006China School of Traditional Chinese Materia Medica and Food Engineering Shanxi University of Chinese MedicineJinzhongShanxi030619China Shanxi Guangyuyuan Chinese Medicine Co. Ltd.JinzhongShanxi030800China Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

GuiLingJi(GLJ),a classic traditional Chinese medicine(TCM)formula,is composed of over 20 herbs,according to the Pharmacopeia of the People's Republic of *** to its various activities,GLJ has been used in clinical settings for more than 400 years in ***,the ambiguous chemical material basis limits the development of studies on the quality control and pharmacological mechanisms of ***,comprehensive characterization of the multiple chemical components of GLJ is of great significance for the modernization of this *** the great variety of herbs in GLJ,both UHPLCMS and ^(1)H NMR techniques were employed in this *** addition,solvent extraction with different polarities was used to eliminate signal interference and the concentration of trace components.A variety of MS analytic methods were also used,including implementation of a self-built compound database,diagnostic ion filtering,mass defect filtering,and Compound Discoverer 3.0 analysis *** on the above strategies,a total of 150 compounds were identified,including 5 amino acids,13 phenolic acids and glycosides,11 coumarins,72 flavones,20 triterpenoid and triterpenoid saponins,23 fatty acids,and 6 other ***,13 compounds were identified by ^(1)H NMR *** UHPLC-MS and ^(1)H NMR results supported and complemented each *** strategy provides a rapid approach to analyzing and identifying the chemical composition of Chinese herbal *** current study provides basis for further research on the quality control and pharmacological mechanism of GLJ.

关键词： GuiLingJi Chemical component UHPLC-MS ^(1)H NMR Traditional Chinese medicine

Integrating a weighted-average method into the random walk framework to generate individual friend recommendations

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Science China(Information Sciences) 2017年第11期60卷 43-64页

作者： Jibing GONG xiaoxia gao Hong CHENG Jihui LIU Yanqing SONG Mantang ZHANG Yi ZHAO School of Information Science and Engineering Yanshan University The Key Lab for Computer Virtual Technology and System Integration Yanshan University State Key Lab of Mathematical Engineering and Advanced Computing Department of Systems Engineering and Engineering Management The Chinese University of Hong Kong

Friend recommendation is a fundamental service in both social networks and practical applications,and is influenced by user behaviors such as interactions, interests, and activities. In this study, we first conduct in-depth investigations on factors that affect recommendation results. Next, we design Friend++, a hybrid multi-individual recommendation model that integrates a weighted average method(WAM) into the random walk(RW) framework by seamlessly employing social ties, behavior context, and personal information. In Friend++, the first plus signifies recommending a new friend through network features, while the second plus stands for using node features. To verify our method, we conduct experiments on three social datasets crawled from the Sina microblog system(Weibo). Experimental results show that the proposed method significantly outperforms six baseline methods in terms of recall, precision, F1-measure, and MAP. As a final step, we describe a case study that demonstrates the scalability and universality of our method. Through discussion, we reach a meaningful conclusion: although common interests are more important than user activities in making recommendations, user interactions may be the most important factor in finding the most appropriate potential friends.

关键词： multi-individual friend recommendation architecture behavior context analysis Intimacy degree random walk framework social networks

Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase

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Journal of Pharmaceutical Analysis 2023年第6期13卷 640-659页

作者： Congcong Chen Wenxia Gong Junshen Tian xiaoxia gao Xuemei Qin Guanhua Du Yuzhi Zhou Modern Research Center for Traditional Chinese Medicine The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan030006China Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province Shanxi UniversityTaiyuan030006China Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Radix Bupleuri(RB)is commonly used to treat depression,but it can also lead to hepatotoxicity after longterm *** many anti-depression prescriptions,RB is often used in combination with Radix Paeoniae Alba(RPA)as an herb ***,whether RPA can alleviate RB-induced hepatotoxicity remain *** this work,the results confirmed that RB had a dose-dependent antidepressant effect,but the optimal antidepressant dose caused ***,RPA effectively reversed RB-induced ***,the mechanism of RB-induced hepatotoxicity was *** results showed that saikosaponin A and saikosaponin D could inhibit GSH synthase(GSS)activity in the liver,and further cause liver injury through oxidative stress and nuclear factor kappa B(NF-kB)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)***,the mechanisms by which RPA attenuates RBinduced hepatotoxicity were *** results demonstrated that RPA increased the abundance of intestinal bacteria with glycosidase activity,thereby promoting the conversion of saikosaponins to saikogenins in *** from saikosaponin A and saikosaponin D,which are directly combined with GSS as an inhibitor,their deglycosylation conversion products saikogenin F and saikogenin G exhibited no GSS binding *** on this,RPA can alleviate the inhibitory effect of saikosaponins on GSS activity to reshape the liver redox balance and further reverse the RB-induced liver inflammatory response by the NFkB/NLRP3 *** conclusion,the present study suggests that promoting the conversion of saikosaponins by modulating gut microbiota to attenuate the inhibition of GSS is the potential mechanism by which RPA prevents RB-induced hepatotoxicity.

关键词： Radix Bupleuri Radix Paeoniae Alba Hepatotoxicity Gut microbiota Saikosaponins Combination mechanisms

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1562-1576页

作者： Jiajun Chen Tian Li Dehua Huang Wenxia Gong Junsheng Tian xiaoxia gao Xuemei Qin Guanhua Du Yuzhi Zhou Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan030006China The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi UniversityTaiyuan030006China The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province Taiyuan030006China Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Chaigui granules(CG)are a compound composed of six herbal medicines with significant antidepressant ***,the antidepressant mechanism of CG remains *** the present study,we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergic ***,the regulatory effect of CG on purine metabolites in the prefrontal cortex(PFC)of chronic unpredictable mild stress(CUMS)rats was analyzed by ultra high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)targeted quantitative ***,purinergic receptors(P2X7 receptor(P2X7R),A1 receptor(A1R)and A2A receptor(A2AR))and signaling pathways(nod-like receptor protein 3(NLRP3)inflammasome pathway and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)pathway)associated with purine metabolism were analyzed by western blotting and enzyme-linked immunosorbent assay(ELISA).Besides,antidepressant mechanism of CG by modulating purine metabolites to activate purinergic receptors and related signaling pathways was dissected by exogenous supplementation of purine metabolites and antagonism of purinergic receptors in *** in vivo study showed that the decrease in xanthine and the increase in four purine nucleosides were closely related to the antidepressant effects of ***,purinergic receptors(P2X7R,A1R and A2AR)and related signaling pathways(NLRP3 inflammasome pathway and cAMP-PKA pathway)were also significantly regulated by *** results of exogenous supplementation of purine metabolites and antagonism of purinergic receptors showed that excessive accumulation of xanthine led to activation of the P2X7R-NLRP3 inflammasome pathway,and the reduction of adenosine and inosine inhibited the A1R-cAMP-PKA pathway,which was significantly ameliorated by ***,CG could promote neuroprotection and ultimately play an antidepressant role by inhibiting the xanthine-P2X7R-NLRP3 inflammasome pathway and activating the adenosine/inosi

关键词： Chaigui granules Traditional Chinese medicine Antidepressant mechanism Purine metabolism Purinergic signaling

Production of gasoline range hydrocarbons from methanol on hierarchical ZSM-5 and Zn/ZSM-5 catalyst prepared with soft second template

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Journal of Energy Chemistry 2015年第4期24卷 490-496页

作者： Xiaodong Wang xiaoxia gao Mei Dong Hongbin Zhao Wei Huang Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province Taiyuan University of Technology State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of Sciences Department of Chemistry College of ScienceShanghai University

Nano hierarchical mesoporous ZSM-5 catalysts were prepared with cationic dimethyldiallyl ammonium chloride acrylamide copolymer（PDDA） as a soft second template. Using ZSM-5 catalyst as a matrix,Zn/ZSM-5 catalysts were also obtained by the wet impregnation method. The effect of the PDDA amount and Zn loadings on the properties of the catalysts,including crystallinity,morphology,textural properties,acid nature and catalytic activity in MTG reaction,was investigated by XRD,FESEM,TEM,Nitrogen adsorption–desorption isotherms and NH3-TPD method,respectively. The MTG reaction was performed in a fixed bed reactor,and the result revealed that the nano hierarchical ZSM-5 catalyst prepared with a PDDA/Si molar ratio of 0.070 possesses longer stable phase of 70 h with a liquid hydrocarbon selectivity of 29.8%.Zn/ZSM-5 catalyst with a Zn/ZSM-5 ratio of 0.07 wt.% shows the highest liquid hydrocarbon selectivity,reaching 62.5%.

关键词： Soft second template MTG reaction Nano hierarchical ZSM-5

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Lithocarpinols A and B,a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508

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Chinese Chemical Letters 2019年第2期30卷 439-442页

作者： Jianlin Xu Haibo Tan Yuchan Chen Saini Li Heng Guo Zilei Huang Haohua Li xiaoxia gao Hongxin Liu Weimin Zhang State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied Microbiology Guangdong Institute of Microbiology College of Pharmacy Guangdong Pharmaceutical University Program for Natural Products Chemical Biology Key Laboratory of Plant Resources Conservation and Sustainable Utilization Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences

Lithocarpinols A(1) and B(2), a pair of tenellone diastereoisomers with novel fused skeleton were isolated from the deep-sea derived fungus Phomopsis lithocarpus FS508. Their structures were elucidated by comprehensive spectroscopic analyses, X-ray diffraction and quantum molecular calculation. Their plausible biogenetic pathway featured an intriguing carbonyl-ene cyclization. Lithocarpinol A exhibited moderate inhibitory effect against HepG-2 and A549 tumor cell lines with IC_(50) values of 9.4 μmol/L and10.9 μmol/L,respectively.

关键词： Marine-derived fungus Phomopsis lithocarpus Tenellone derivatives Diastereoisomers Cytotoxicity

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THE POLAROGRAPHIC ADSORPTIVE COMPLEX WAVES OF RARE EARTHS WITH CARBOXYNITRAZO (CNA)~*

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Science in China,Ser.B 1986年第8期29卷 795-805页

作者：焦奎高小霞 Department of Chemistry Peking University Department of Chemistry Shandong College of Chemical Engineering Qingdao

The single-sweep polarographic adsorptive complex wave of Nd3+-CNA and the differential pulse polarographic wave of La3+-CNA are studied. 5×10-7-8×10-6 M Nd3+ and 1×10-8-1×10-6 M La3+ can be determined respectively. Lanthanum content in leaves of water-cultured cucumber has been determined. Experimental facts showed that CNA and the complex of Nd3+-CNA can be adsorbed on the mercury electrode. The reduction mechanism of the adsorptive complex wave is proposed.

关键词： CNA Nd THE POLAROGRAPHIC ADSORPTIVE COMPLEX WAVES OF RARE EARTHS WITH CARBOXYNITRAZO La

Study on the Activation of Communication in Spoken English Class of Vocational College

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Journal of Zhouyi Research 2014年第1期 27-29页

作者： You xiaoxia gao juan Handan Vocational Technology Institute Handan Hebei China 056000

Analysis of Intemet Language with Meme Theory

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Journal of Zhouyi Research 2014年第1期 30-32页

作者： Juan gao xiaoxia You (Handan Vocational Technology College Handan Hebei China 056000)