Lithocarpinols A and B,a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508

作     者：Jianlin Xu Haibo Tan Yuchan Chen Saini Li Heng Guo Zilei Huang Haohua Li Xiaoxia Gao Hongxin Liu Weimin Zhang 

作者机构：State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied Microbiology Guangdong Institute of Microbiology College of PharmacyGuangdong Pharmaceutical University Program for Natural Products Chemical BiologyKey Laboratory of Plant Resources Conservation and Sustainable Utilization Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第2期

页      面：439-442页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：financially supported by the Science and Technology Program of Guangzhou, China(No. 201607020018) the Team Project of the Natural Science Foundation of Guangdong Province (No. 2016A030312014) the National Natural Science Foundation of China (No. 31272087) the Guangdong Provincial Project for Science and Technology (Nos. 2015A030302061, 2016A020222022) the Guangdong Provincial Innovative Development of Marine Economy Regional Demonstration Projects (No. GD2012-D01-002) 

主　　题：Marine-derived fungus Phomopsis lithocarpus Tenellone derivatives Diastereoisomers Cytotoxicity 

摘      要：Lithocarpinols A(1) and B(2), a pair of tenellone diastereoisomers with novel fused skeleton were isolated from the deep-sea derived fungus Phomopsis lithocarpus FS508. Their structures were elucidated by comprehensive spectroscopic analyses, X-ray diffraction and quantum molecular calculation. Their plausible biogenetic pathway featured an intriguing carbonyl-ene cyclization. Lithocarpinol A exhibited moderate inhibitory effect against HepG-2 and A549 tumor cell lines with IC_(50) values of 9.4 μmol/L and10.9 μmol/L,respectively.