An electrochemical and Raman spectroscopic study on involvement of La^(3+) ions in lactate dehydrogenase catalysis

作     者：WANG Xunqing XU Zhenhua GAO Xiaoxia 

作者机构：College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China. 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：1998年第43卷第19期

页      面：1625-1630页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (GrantNo .2 9392 6 0 5 ) 

主　　题：La 3+ ion LDH catalysis electrochemistry FT-Raman technique. 

摘      要：The influence of La 3+ on lactate dehydrogenase catalysis was investigated by electrochemical and FT-Raman techniques. The results showed that La 3+ ions bind preferably with phosphate moiety and ribose group (3′-OH) connected to nicotinamide in coenzyme NAD +/NADH, destabilize the enzyme-coenzyme complex and inhibit LDH activity.